Deuterated Compounds

<p>Applications Benzene-1,2,4,5-d4 (CAS# 14919-17-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 6-Hydroxy Nicorandil-d4 is the isotope labelled analog of 6-Hydroxy Nicorandil (H948550); a metabolite of the antianginal Nicorandil (N398500).<br>References Frydman, A., et al.: Am. J. Cardiol., 63, 25J (1989); Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008); Sudo, H., et al.: Biol. Pharm. Bull., 31, 2079 (2008); Iida, S., et al.: Brit. J. Clin. Pharmacol., 66, 352 (2008); Eguchi, Y., et al.: Ther. Res., 29, 316 (2008)<br></p>

<p>Applications The four-center reactions of alkanol-alkoxide negative ions with alkyl ethers and ortho-acetates. An ion cyclotron resonance study.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Ethylene Glycol Dilaurate-d4 is a deuterated version of Ethylene Glycol Dilaurate (E917476), a pearling agents for cosmetics.<br>References Onozaki, T., et al.: Journal of SCCJ, 15, 38-44 (1981)<br></p>

<p>Applications 1-Bromooctadecane-d37 (CAS# 187826-28-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Piperazine-N,N'-bis(2-ethanesulfonic Acid)-d18 (CAS# 352534-95-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3,5-Dibromopyridine-d3 (CAS# 1219799-05-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromoundecane-11,11,11-d3 (CAS# 1219805-63-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl 3-Amino-4-methylbenzoate-D6 is an intermediate in the synthesis of Nilotinib-d6 (N465303), which is the labeled analogue of Nilotinib (N465300), which might be useful in treatment of chronic myelogenous leukemia.<br>References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),<br></p>

<p>Applications (±)-2-Chlorobutane-d9 (CAS# 175540-77-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications iso-Propylamine-d9 DCl (CAS# 1219798-50-1) is a useful isotopically labeled research compound.<br>Chemical Name: iso-Propylamine-d9 DCl (CAS# 1219798-50-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled Isopropyl 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]phenylcarbamate is an impurity in the synthesis of Sorafenib (S676850), a multiple kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis. Antineoplastic.<br>References Richly, H., et al.: Int. J. Clin. Pharmacol. Ther., 41, 620 (2003), Khire, U.R., et al.: Bioorg. Med. Chem. Lett., 14, 783 (2004), Wilhelm, S.M., et al.: Cancer Res., 64, 7099 (2004), Rini, B.I., et al.: Expert Opin. Pharmacother., 7, 453 (2006),<br></p>

<p>Applications Tuberculostearic Acid Methyl-d3 Ester is labelled Tuberculostearic Acid Methyl Ester (T897100), the methyl ester of Tuberculostearic Acid (T897090) which is a saturated fatty acid produced by Actinomycetales bacteria.<br>References Frencha, G., et al.: The Lancet, 330, 117 (1987)<br></p>

<p>Applications Ethylmethyl-d3-amine (CAS# 223459-64-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications L-Serine (1-13c, 99%) (cas# 81201-84-5) is a useful research chemical.<br></p>

<p>Applications 2-Phenylpropane-2-d1 (CAS# 4019-54-9) is a useful isotopically labeled research compound.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications DL-Phenylalanine-2-13C (CAS# 64193-01-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications bis(2-Chloroethoxy)-d8-methane (cas# 93966-78-0) is a useful research chemical.<br></p>

<p>Applications Sodium n-Octyl-d17 Sulfate (CAS# 1219802-16-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Cyclopropylethyl-1,1,2,2-d4-amine (CAS# 1219795-00-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,4-Di(methyl-d3)-naphthalene has been used in the preparation of di(trideuteriomethyl)naphthalene derivatives. 1,4-Di(methyl-d3)-naphthalene is a labeled analogue of 1,4-Dimethylnaphthalene (D476380), a polycyclic aromatic hydrocarbon (PAH) that has been found to retard the development of epidermoid carcinomas in hamster buccal pouch and alter the genes associated with the maintenance of a G1/S phase block possibly through the induction of the cell cycle inhibitors KRP1 and KRP2 in potatoes.<br>References Dizabo, P., et. al.: J. Labelled Compd., 2, 272 (1966); Malament, D.S., Shklar, G.: Carcinogenesis, 2, 723 (1981); Campbell, M.A., et. al.: Fuct. Interg. Genomics, 12, 533 (2012); Andrysik, Z., et. al.: Mutat. Res-Fund. Mol. M., 714, 53 (2011)<br></p>

<p>Applications N-Propionylglycine-2,2-d2 (CAS# 1256842-51-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromononane-9,9,9-d3 (CAS# 1219799-20-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Butyryl-2,2-d2 Chloride (CAS# 90587-10-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Nonen-1-ol-D2 is a labelled analogue of 2-Nonen-1-ol. 2-Nonen-1-ol is an unsaturated alcohol that has antimicrobial properties. 2-Nonen-1-ol is also used as a flavour and fragrance agent, and has a “green” odour.<br>References Gigot, C., et al.: Biotechnol. Agron. Soc. Environ., 14, 451 (2010); Kalua, C., et al.: J. Agr. Food Chem., 53, 8054 (2005); Serrazanetti, D., et al.: Food Cont., 34, 336 (2013)<br></p>

<p>Applications 1-Cyclopentylethanone-d4, is the labeled analogue of 1-Cyclopentylethanone (C988475), that can be used in the preparation of small molecule inhibitors of rifampicin resistant Staphylococcus aureus. An antibacterial agent. Also used in the synthesis of non-quinoline leukotriene D4 (LTD4) receptor antagonists.<br>References Arhin, F. et al.: Bioorg. Med. Chem., 14, 5812 (2006); Lau, C. et al.: Bioorg. Med. Chem. Lett., 5, 1615 (1995);<br></p>

<p>Applications Labelled Pipazetate Hydrochloride, a pyridobenzothiazine derivative an antiarrhythmic characteristics. Pipazetate is used as a cough supressant.<br>References Giuliano, H.: Arch. Int. Pharmacodyn. Ther., 188, 189 (1970); Hahn, K.J. et al.: Med. Pharmacol. Exp., 14, 87 (1966);<br></p>

<p>Applications Hexanenitrile-6,6,6-d3 (CAS# 1219805-03-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Chlorotoluene-d7 (CAS# 84344-06-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5-(Hydroxymethyl-d2)uracil-6-d1 (CAS# 352438-73-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Ethoxyethanol-1,1,2,2-d4 (CAS# 1219805-07-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Benzene-1,3-d2 (CAS# 14941-51-6) is a useful isotopically labeled research compound.<br></p>