Deuterated Compounds

<p>Applications Fmoc-Phe-OH - 13C9, 15N is a useful labeled chemical.<br></p>

<p>Applications Cefathiamidine-d14 is an isotope labelled antibacterial agent that exhibits a broad spectrum of bactericidal activity against gram-positive bacteria.<br>References Chen, H.Y., et al.: J. Antimicrob. Chemother., 12, 19 (1983); Philpott-Howard, J., et al.: Scand. J. Infect. Dis. Suppl., 39, 109 (1983); Chen, H.Y., et al.: J. Med. Microbiol., 23, 141 (1987);<br></p>

<p>Applications Talaporfin-13C4-15N is labelled Talaporfin which is a photosensitizer used in photodynamic therapy.<br>References Yoshinori, N., et al.: Photochem. Photobio., 85, 714 (2009); Gomer, C., et al.: Cancer Res., 56, 2355 (1996)<br></p>

<p>Applications N-(Benzoyl)piperazine-2,2,3,3,5,5,6,6-d8 (CAS# 1219805-49-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Bromophenol Acetate-13C6, is the labeled analogue of 4-Bromophenol Acetate (1927-95-3), that can be used as a precursor in the synthesis of various pharmaceutical compounds and inhibitors.<br>References Ding, L. et al.: J. Arg. Food Chem., 61, 7453 (2013);<br></p>

<p>Applications 2-Chloro-10-[3-[[3-(dimethyl-d6-amino)propyl]methylamino]propyl]phenothiazine is the labeled analogue of 2-Chloro-10-[3-[[3-(dimethylamino)propyl]methylamino]propyl]phenothiazine (C367110), an impurity of Chlorpromazine (C424750), which is used as an antiemetic; antipsychotic. 2-Chloro-10-[3-[[3-(dimethylamino)propyl]methylamino]propyl]phenothiazine is also used in the synthesis of novel phenothiazine compounds with antimalarial activity.<br>References Anden, N.-E., et al.: Eur. J. Pharmacol., 11, 303 (1970); Curzon, G., et al.: Trends Pharmacol. Sci., 11, 61 (1990); Kalkanidis, M., et. al.: Biochem. Pharmacol., 63, 833 (2002)<br></p>

<p>Stability Volatile<br>Applications N-Pentane-D12 (D, 98%) (cas# 2031-90-5) is a useful research chemical.<br> E3<br></p>

<p>Applications 1,3-Propane-2,2-d2-diamine (CAS# 352438-78-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labeled 4-Bromo-1,2-dimethoxybenzene is a metabolite of bromobenzene, with a catechol moiety in the substructure. It also has use as a redox shuttle additive, essentially a component in lithium batteries that consumes excess current during overcharge.<br>References Billings, R.E. et al.: Drugs. Metab. Disp., 13, 287 (1985); Adachi, M. et al.: J. Electrochem. Soc., 146, 1256 (1999);<br></p>

<p>Applications Isotope labelled Isopropyl DL-Mandelate is used in nonporous silica/alumina amorphous material. Pregabalin (P704800) impurity.<br>References Wang, Z. et al.:; ACS Catal., 3, 1573 (2013);<br></p>

<p>Applications (4-n-Nonylphenoxy)acetic-alpha,alpha-d2 Acid (CAS# 1219798-75-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Acrylonitrile (D3, 98%) (+0.1% 4-Methoxyphenol) (cas# 53807-26-4) is a useful research chemical.<br></p>

<p>Applications 1,5-Dibromopentane-1,1,5,5-d4 (CAS# 1219803-90-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Bromopropionic-2,2,3,3-d4 Acid is the labeled analog of 3-Bromopropionic acid (B687705). 3-Bromopropionic Acid is used as a reagent in the synthesis of nitrogen containing diselenides which exhibit antioxidant activity. Also used as a reagent in the synthesis of indolin-2-one-based multi-targeted receptor tyrosine kinase inhibitors as potential anticancer agents.<br>References Nascimento, V., et al.: Eur. J. Med. Chem., 87, 131 (2014); Zhang, L., et al.: Eur. J. Med. Chem., 82, 139 (2014)<br></p>

<p>Applications 4-Hydroxy-2,2,6,6-tetramethylpiperidine-d17-1-oxyl (CAS# 100326-46-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-(Phenyl)-2-naphthylamine is a reagent in the preparation of unsymmetrical triaryldiamines as thermally stable hole transport layers for various organic LEDs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Koene, B. et al.: Chem. Mat., 10, 2235 (1998);<br></p>

<p>Applications (S)-Carbidopa Methyl-d3 Ester N-cyclohexylidene is the labeled analogue of (S)-Carbidopa Methyl Ester N-cyclohexylidene (C176015), an impurity of Carbidopa (C175915), a prodrug inhibitor of aromatic amino acid decarboxylase.<br>References Sletzinger, M., et al.: J. Med. Chem., 6, 101 (1963)<br></p>

<p>Applications Isotope labelled D-Glucitol is a sugar alcohol obtained from the reduction of glucose and is naturally found in various fruits such as apples, pears and peaches. D-Glucitol has been widely used as a sweetener, laxative, various medical applications and in cosmetic products.<br>References Wang, Z.J., et al.: Anal. BIoanal. Chem., 405, 3899 (2013); Vinarta, S.C., et al.: Carb. Poly., 92, 1107 (2013); Kaumanu, M.L., et al.: Soil. Biol. Biochem., 57, 644 (2013); Hailu, T., et al.: Anal. Biochem., 434, 181 (2013);<br></p>

<p>Applications Labelled Maleic Anhydride. A heterocyclic compound used in the manufacture of unsaturated polyester resins. Maleic Anhydride has a wide range of other applications; it is used in synthetic tensides, insecticides, herbicides and fungicides.<br>References Hanafi, W.Z.A. et al.: Plast. Rub. Comp. Proc. Appl., 19, 175 (1993); Noma, K. et al.: Shik. Kyok., 36, 225 (1963); Augustin, M. et al.: Wissen. Zeitsch., 25, 5 (1976); Jiang, Q. et al.: Nongyao, 49, 257 (2010);<br></p>

<p>Applications Compound has been shown to reversibly block voltage-dependent potassium channels, and is also a common impurity from the synthesis of compounds found in hair dyes<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Williams, D.M., et al.: J. Biol. Chem., 275, 38127 (2000), Munoz-Caro, C., et al.: Biophys. Chem., 96, 1 (2002),<br></p>

<p>Applications 1-Bromohexadecane-d33 (CAS# 284474-41-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Hexadecanoyl-2-amino-1,3-propane-d5-diol (CAS# 949524-35-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications N2-Methyl Trimethoprim-D3 is a labelled analogue of N2-Methyl Trimethoprim (M331190).<br></p>

<p>Applications A useful synthetic intermediate<br></p>

<p>Applications Methyl Alcohol-d4 is the labeled analog of methyl alcohol, a common laboratory solvent used primarily in spectroscopic techniques (UV/VIS, NMR, IR).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dawson, D.M. et al.: Phys. Chem. Chem. Phys., 15, 919 (2013);<br></p>

<p>Applications 4-Azidobutyl-d8-amine is the labeled analogue of 4-Azidobutylamine (A822560), which is weakly or non-mutagenic to Salmonella typhimurium.<br>References Owais, W.M., et. al.: Mutat. Res. Genetic Toxicol. Testing, 118, 229 (1983)<br></p>

<p>Applications L-Glutamic Acid Dimethyl Ester-13C5 Hydrochloride is an intermediate used in the synthesis of Folic Acid-13C5 (F680303), which is vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.<br>References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),<br></p>

<p>Applications 2-Nitropropane-1,1,1,3,3,3-d6 (CAS# 52809-86-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-(2-Pyridinyl)benzotriazole-15N3 (cas# 1189465-04-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethylene Glycol Dimyristate-d4 is a deuterated version of Ethylene Glycol Dimyristate (E917560), a pearling agents for cosmetics.<br>References Onozaki, T., et al.: Journal of SCCJ, 15, 38-44 (1981)<br></p>

<p>Applications Glyceryl Trihexadecanoate-13C2 [1,3-Di(hexadecanoate-1-13C)] (CAS# 339080-65-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Sulfolane-d8 is the labeled analogue of Sulfolane (S689220), which is used in lithium-ion batteries.<br>References Lewandowski, A., et. al.: J. Power Sources, 266, 132 (2014); Xing, L., et. al.: Electrochim. Acta, 133, 117 (2014)<br></p>