Deuterated Compounds

Applications Dexamethasone Hemisuccinate-d4 is the isotope labelled analog of Dexamethasone Hemisuccinate (D298855); a derivative of Dexamethasone (D298800) which is a glucocorticoid used as an anti-inflammatory agent. It regulates T cell survival, growth, and differentiation. Dexamethasone also inhibits the induction of nitric oxide synthase.
References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995); Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999); Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)

Applications 3',4'-Dimethoxyacetophenone-d3 (methyl-d3) (CAS# 350818-54-1) is a useful isotopically labeled research compound.

Applications 2,2-Bis(4-hydroxyphenyl)propanol-d11 is labelled 2,2-Bis(4-hydroxyphenyl)propanol (B447360) which is a metabolite of bisphenol A (B519495). It works as an endocrine disruptor.
References Krishnan, A.V., et al.: Endocrinology, 132, 2279 (1993), Steinmetz, R., et al.: Trends Endocrinol. Metab., 9, 124 (1998); Kitamura, S., et al.: Toxicol. Sci., 84, 249 (2005)

Applications (±)-Carazolol-d7 is labelled (±)-Carazolol (C175810, HCl salt) which is a promising high-affinity beta-adrenergic receptor ligand for the noninvasive determination of beta receptor status using PET.
References Berridge, M.S., et al.: J. Nucl. Med., 35(10), 1665 (1994)

Applications Labelled Aldicarb Sulfoxide (A514665). Aldicarb Sulfoxide is an analog of Aldicarb (A514650) detected in agricultural products as pesticide residue.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ashby, J., et al.: Environ. Mutagen., 7, 919 (1985), Ashby, J., et al.: Mutat. Res., 257, 229 (1991), Kazius, J., et al.: J. Med. Chem., 48, 312 (2005), Benigni, R., et al.: Mutagenesis, 25, 335 (2010),

Applications 3-Pentanone-d10 (CAS# 54927-77-4) is a useful isotopically labeled research compound.

Applications 4-Chloro-N-(methyl-d3)pyridine-2-carboxamide (cas# 1189858-48-7) is a compound useful in organic synthesis.

Applications 1-Bromopentadecane-d31 (CAS# 349553-93-1) is a useful isotopically labeled research compound.

Applications Fenuron-d5 (phenyl-d5) (CAS# 1219802-06-8) is a useful isotopically labeled research compound. It can be used for the preparation of difunctionalized indoles.
References Lv, H., et al.: Org. Biomol. Chem., 15, 8054 (2017)

Applications Dimethyl chlorothiophosphate-D6 is a labelled analog of Dimethyl chlorothiophosphate (D473292). Dimethyl chlorothiophosphate is an organophosphorus reagent that is used to synthesize phosphorus analogues of γ-aminobutyric acid, compounds that exhibit anticonvulsant properties. Dimethyl chlorothiophosphate is also used as a reagent to synthesize Parathion (P192220), a widely used pesticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cates, L., et al.: J. Med. Chem., 27, 654 (1984); DeBruin, K. & Boros, E.: J. Org. Chem., 55, 609 (1990); Hall, S.: J. Am. Chem. Soci., 72, 2768 (1950); Kotronarou, A. & Hoffmann, M.: Env. Sci. Tech., 26, 1460 (1992)

Applications Tetrabromobisphenol A Diglycidyl Ether-d10 is the isotope labelled analog of Tetrabromobisphenol A Diglycidyl Ether (T291305); a brominated flame retardant (BFR) with good stability and a thermal decomposition temperature over 300°.
References Oleszek S., et al.: Waste Manag., 33, 1835 (2013); Jia, X., et al.: Henan Daxue Xuebao, Ziran Kexueban, 36, 44 (2006)

Applications An intermediate for the synthesis of analogs of retinoid lactone.
References Lewin, A.H., et al.: Pharm. Res., 12, 983 (1995).

Applications n-Hexadecyl-2,2,16,16,16-d5 Alcohol (CAS# 1219799-18-4) is a useful isotopically labeled research compound.

Applications trans,trans-Muconic-d4 Acid (CAS# 1955496-83-9) is a useful isotopically labeled research compound.

Applications Octanoic-8,8,8-d3 Acid (CAS# 156779-05-4) is a useful isotopically labeled research compound.

Applications Insecticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nishizawa, Y., et al.: Agric. Biol. Chem., 25, 605 (1961),

Applications Cycrimine Hydrochloride-d5 is the isotope labelled analog of Cycrimine Hydrochloride (C991450); a cholinolytic anti-Parkinson drug which can cause neuromuscular blockades in isolated rat diaphragms.
References Das, M., et al.: Toxicol. Appl. Pharm., 39, 149 (1977); Vedasiromoni, J.R., et al.: Arch. Int. Pharmacod. T., 219, 64 (1976)

Applications 4-Fluorotoluene-alpha,alpha,alpha-d3 (CAS# 4202-91-9) is a useful isotopically labeled research compound.

Applications 1-Iodopropane-d7 is the labelled analogue of 1-Iodopropane [I718790] which is used in the synthesis of a new class of cesium selective ionophores. Also used to preparation of secondary amines and diamines.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Casnati, A. et al.: J. Am. Chem. Soc., 117, 2767 (1995); Fukuyama, T. et al.: Tetrahedron Lett., 38, 5831 (1997);

Applications N,N-Diethylbenzamide-d5 is an intermediate in the synthesis of Benz[a]anthracene-7,12-dione-D4 (B197942), a polycyclic aromatic hydrocarbon that is present in the emission soot of biomass fuels combustion.

Applications 1,3-Dioleoyl-2-stearoylglycerol-d5 is the isotope labelled analog of 1,3-Dioleoyl-2-stearoylglycerol (D484305); a triglyceride found in various natural sources such as coconut oil, palm oil, rice bran oil, sunflower oil and sesame oil.
References Reena, M.B. et al.: Eur. J. Lipid Sci. Technol., 111, 346 (2009); Huey, S. et al.: J. Food Sci., 74, E177 (2009)

Applications n-Butyl-3,3,4,4,4-d5 Alcohol (CAS# 64118-16-7) is a useful isotopically labeled research compound.

Applications Phenylboronic Acid-13C6 is the isotope labelled 13C6 analog of Phenylboronic Acid (P319590); a compound used in the organic synthesis of various pharmaceutical goods.
References Ainley, A.D., et al.: J. Chem. Soc., 2171 (1930)

Applications 2-Chloroaniline-d6 (CAS# 1276197-37-5) is a useful isotopically labeled research compound.

Applications A labelled metabolite of the antihypertensive agent, Labetalol (L096500). Ractopamine impurity.
References Gal, J., et al.: Res. Comm. Chem. Pathol. Pharmacol., 62, 3 (1988),

Applications n-Nonyl-d19 Alcohol (CAS# 349553-86-2) is a useful isotopically labeled research compound.

Applications 1,14-Tetradecanedioic-d24 Acid (CAS# 130348-88-8) is a useful isotopically labeled research compound.

Applications 3-(2,6-Dimethylphenyl)-2-oxazolidinone-d6 is an intermediate used in the synthesis of Dimethachlor Ethane Sulfonic Acid Sodium Salt-d6 (D460284), which is the deuterium labelled form of Dimethachlor Ethane Sulfonic Acid Sodium Salt (D460283), which is a pesticide metabolite and pollutant found in groundwater, surface water, and wastewater.
References Huntscha, S., et al.: J. Chromatogr. A, 1268, 74 (2012); Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013);

Applications N,N,N',N'-Tetramethyl-1,3-propanediamine-d18 (CAS# 1398065-52-5) is a useful isotopically labeled research compound.

Applications 1,3,5-Triphenylbenzene-d18 (CAS# 34496-33-8) is a useful isotopically labeled research compound.

Applications N2'-Deacetyl-N2'-[3-[(1-ethyl-2,5-dioxo-3-pyrrolidinyl)thio]-1-oxopropyl]-maytansine-d5 is labelled N2'-​Deacetyl-​N2'-​[3-​[(1-​ethyl-​2,​5-​dioxo-​3-​pyrrolidinyl)​thio]​-​1-​oxopropyl]​-maytansine (D199030), a derivative of Mertansine (M257800) which is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug conjugates.
References Erickson, H., et al.: Cancer Res., 66, 4426 (2006); Kellogg, B., et al.: Bioconjugate Chem., 22, 717 (2011)

Applications Unlabeled 3,3'-Dibromodiphenyl-d8 is used in the synthesis of novel aromatic compounds as electroluminescent materials and organic semiconductor materials for organic light emitting devices.
References Ham, H.; et al.: PCT Int. Appl. 64pp. Patent 2016 CODEN:PIXXD2

Applications 1,2,4,5-Benzenetetracarboxylic Dianhydride-d2 (CAS# 106426-63-5) is a useful isotopically labeled research compound.

Applications 1-Bromo-3,4-difluorobenzene-d3 (CAS# 1219799-14-0) is a useful isotopically labeled research compound.

Applications 1,2-Propylene-d6 Carbonate (cas# 202480-74-8) is a compound useful in organic synthesis.

Applications (4-Carboxybutyl-d4)triphenylphosphonium Bromide is a reactant in the preparation of deuterated nocloprost.
References Krause, W., et. al.: Prostaglandins, 40, 283 (1990)