Deuterated Compounds

Applications 2-(2-Propynyloxy)tetrahydropyran-13C3 is an intermediate in the synthesis of N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine-13C4 (A173713). N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine-13C4 is labelled N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (A173710), which is a metabolite of butadiene.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Heavner, D., et al.: J. Pharm. Biomed. Anal., 40, 928 (2006); Carmella, S., et al.: Chem. Res. Toxicol., 22, 734 (2009)

Applications Tetrahydrofuran-2,2,5,5-d4 (CAS# 20665-63-8) is a useful isotopically labeled research compound.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2-Chloroacetonitrile-13C2 is an intermediate in the synthesis of Indole-3-carboxaldehyde-13C8 (I614993), the labelled version of Indole-3-carboxaldehyde (I615020) which is a tryptophan (T947200) metabolite from Streptomyces staurosporeus and it is chemical constituent from Inula wissmanniana. Indole-3-carboxaldehyde and other tryptophan metabolites play an important role in mammalian gut immune homeostasis.
References Yang, S., et al.: J. Nat. Prod., 60, 44 (1997); Cheng, X. et al.: Chem. Nat. Compd., 49, 815 (2013); Zelante, T., et al,: Immunity, 39, 372 (2013)

Applications 3-​Methylbutyryl-​d9 Chloride is an intermediate for the synthesis of Isovaleryl L-Carnitine-d9 Chloride (I917582), which is labelled Isovaleryl L-Carnitine Chloride (I917580), and it is used to prepare carnitine benzyl esters as neuroprotectant prodrugs.
References Gong, X., et al.: J. Chem. Res., 6, 327 (2008)

Applications Loratadine-d5 (ethyl-d5) (CAS# 1398065-63-8) is a useful isotopically labeled research compound.

Applications Carbon 13 Labelled analogue of Adenosine (A280400), a purine nucleoside that plays an important role in various biochemical processes.
References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010)

Applications 4-Bromo-alpha,alpha,alpha-trifluorotoluene-d4 (CAS# 1219799-09-3) is a useful isotopically labeled research compound.

Applications 1-Bromo-3,5-dichlorobenzene-d3 (CAS# 1219803-83-4) is a useful isotopically labeled research compound.

Applications n-Heptyl-d15 Alcohol (CAS# 194793-95-8) is a useful isotopically labeled research compound.

Applications 2,3-Dimethylphenol-13C8 is an isotope labelled analog of 2,3-Dimethylphenol. 2,3-Dimethylphenol is a useful synthetic intermediate. It was used in the synthesis of hydroxychalcones and flavones with antiinflammatory activities. It was also used to prepare 3,3-bisaryloxindole analogs as mineralocorticoid receptor antagonists.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ballesteros, J., et al.: J. Med. Chem., 38, 2794 (1995); Neel, D., et al.: Bioorg. Med. Chem. Lett., 15, 2553 (2005)

Applications N,N-Bis(2-chloroethyl)benzenesulfonamide-d5 is the isotope labelled analog of N,N-Bis(2-chloroethyl)benzenesulfonamide (B418910); a novel intermediate in the synthesis of Cetirizine (C281100).

Applications 4-n-Pentyl-d11-phenol (CAS# 1219805-30-7) is a useful isotopically labeled research compound.

Applications 3-Nitrobenzyl-d6 Alcohol (CAS# 1219795-18-2) is a useful isotopically labeled research compound.

Applications 4,4,5,5-Tetramethyl-2-[4-(2,2,2-trifluoroethyl)phenyl]-1,3,2-dioxaborolane-d4 is labelled 4,4,5,5-Tetramethyl-2-[4-(2,2,2-trifluoroethyl)phenyl]-1,3,2-dioxaborolane (T305500) which is an intermediate used to prepare fused imidazolone derivatives as possible allosteric modulators for metabotropic glutamate receptor subtype 2 (mGlu2 receptor).
References Matsuda, Y., et al.: PCT Int. Appl., WO 2013062074 A1 20130502 (2013)

Applications D-Phenyl-d5-alanine-N-t-BOC (CAS# 1213661-19-8) is a useful isotopically labeled research compound.

Applications Hexamethyl-d18-disilane (CAS# 61123-71-5) is a useful isotopically labeled research compound.

Applications Tetrahydro-4H-pyran-4-ol-3,3,4,5,5-d5 (CAS# 1219795-46-6) is a useful isotopically labeled research compound.

Applications 4-Benzyl- 2-thiophenecarboxylic Acid-d7 is labelled 4-Benzyl- 2-thiophenecarboxylic Acid (B315140) which is a derivative of 2-Thenoic Acid (T343505), used in the synthesis of pharmaceutical and biologically active compounds. 2-Thenoic Acid is also shown to be utilized by presumptive Rhodococcus bacterium in soil, as a sole source of carbon.
References huyop, F. Z., et al.: Malaysian J. Biochem. Mol. Bio., 2, 9 (1997)

Applications 4-Fluorobenzyl-alpha,alpha-d2 Chloride (CAS# 1219804-18-8) is a useful isotopically labeled research compound.

Applications Labeled 1-Iodoethane, which is used in a variety of organic chemical reactions including the synthesis if disubstituted α-amino acids through alkylation reaction. Also used in electrochemical reduction reactions in the preparation of carbamates.
References Feroci, M. et al.: J. Org. Chem., 72, 200 (2007); Xu, P. et al.: J. Org. Chem., 71, 4364 (2006);

Applications n-Nonyl-6,6,7,7-d4 Alcohol (CAS# 33975-46-1) is a useful isotopically labeled research compound.

Applications N,N-Dimethylaniline-d3 (N-methyl-d3) (CAS# 88889-00-3) is a useful isotopically labeled research compound.

Applications 2-(1-Cyanoethyl)indole-13C215N is an isotope labelled intermediate for the synthesis of pharmaceutical actives, intermediates and fine chemicals.
References Pezzuto, J.M., et al.: Biochem., 20, 298 (1981), Takeda, K., et al.: Chem. Pharm. Bull., 29, 1280 (1981),

Applications 3-Chloro-6-(chloromethyl)benzene-1,2,4,5-d4 is an isotope-labeled analog of 4-Chlorobenzyl Chloride (C364730), which is a benzylchloride derivative used in the preparation of various biologically active compounds such as bronchodilators and antibacterial agents.
References Adams, M. et al.: Synth. Comm., 29, 2419 (1999); Foroumadi, A. et al.: Arch. Pharm. Res., 30, 138 (2007);

Applications 2,5-Dichlorophenol-d3 is the labelled analogue of 2,5-Dichlorophenol (D436105), which is an intermediates in the manufacture of more complex chemical compounds such as fungicides.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, F., et al.: Bull. Enviro. Contamin. Toxicol., 89, 316 (2012); Zhong, W., et al.: J. Hazard. Mat., 217, 286 (2012);

Applications 4-Acetamidobenzene-d4-sulfonyl Chloride is the deuterium labelled form of 4-(Acetylamino)benzenesulfonyl Chloride (A170950), which is a sulfanilamide derivative of Chitosan with antifungal properties.
References Tashiro, T., et al.: Bioorg. Med. Chem., 16, 8896 (2008); Alcalde, E., et al.: J. Med. Chem., 52, 675 (2009);

Applications Isopropylaminosulfoni-d7 Acid is an intermediate in the synthesis of Bentazon-d7 (B120583). Bentazon-d7 is deuterium labelled Bentazon (B120580), which is a herbicide. Isopropylaminosulfoni-d7 Acid is also the labeled form of Isopropylaminosulfonic Acid (I824090), which is an reactant used in the synthesis of N-Alkylsulfamic Acid Derivatives.
References Ghirardello, D., et al.: Environ. Sci. Technol., 44, 9010 (2010); Frihauf, J., et al.: Weed Technol., 24, 262 (2010); Rotroff, D., et al.: Toxicol. Sci., 117, 348 (2010)

Applications 2,4,6-Trimethyl-1,3-benzenediamine-15N2 is the isotope labelled analogue of 2,4,6-Trimethyl-1,3-benzenediamine, a compound used in the synthesis of various polymers.
References Fritsch, D., et al.: Macromolec. Chem. Phys., 197, 701 (1996);

Applications Carboxymethoxyamine-d2 Hemihydrochloride (cas# 1246817-66-2) is a compound useful in organic synthesis.

Applications Ethyl-1,2,2,2-d4 Alcohol (CAS# 22544-43-0) is a useful isotopically labeled research compound.

Applications Isotope labelled Ethyl 3-Hydroxybutyrate is a useful synthetic intermediate. It is a reagent used to synthesize α-azido carboxylic acids. It is also used in Palladium mediated spiroketal synthesis.
References Evans, D., et al.: J. Am. Chem. Soc., 112, 4011 (1990); Conway, J., et al.: Tetrahedron, 61, 11910 (2005)

Applications N-(Ethyl-d2)-N-(propyl-d2)benzenemethanamine is an intermediate in the synthesis of N-Ethyl-N-nitroso-1-propanamine-d4 (E817997) and isotope labelled version of N-Ethyl-N-nitroso-1-propanamine. N-Ethyl-N-nitroso-1-propanamine is a derivative of N-Nitrosodiethylamine (N525465),a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver.
References Shirakami, Y., et al.: Bitamin, 87, 156 (2013); Fujii, Y., et al.: Toxicol., 305, 30 (2013); Uehara, T., et al.: Toxicol. Sci., 132, 53 (2013);

Applications 1,2-Cyclohexanedione-13C6 is the isotope labelled analog of 1,2-Cyclohexanedione (C988085), a compound used as a substrate to study enzyme cyclohexane-1,2-dione hydrolase as a new tool to degrade alicyclic compounds.
References Fraas, S., et al.: J. Molec. Cataly. B. Enzy., 61, 47 (2009); Steinbach, A., et al.: FEBS. J., 279, 1209 (2012);

Applications O-di-TMS 2-Arachidonyl Glycerol-d5 is an intermediate used in the synthesis of 2-Arachidonyl Glycerol-d5 (A765052), which is a labelled 2-Arachidonoylglycerol (A765050). It is a major endocannabinoid, which can inhibit synaptic transmission by presynaptic cannabinoid CB1 receptors. It plays an inhibitory role in the bombesin-induced activation of central adrenomedullary outflow in rats.
References Yokotani, K., et al.: Eur. J. Pharmacol., 512, 29 (2005), Jensen, R., et al.: Pharmacol. Rev., 60, 1 (2008), Lu, L., et al.: Eur. J. Pharmacol., 590, 177 (2008),

Applications O-Demethoxypropane Aliskiren-d6 is the labeled analog of O-Demethoxypropane Aliskiren is an impurity of Aliskiren Hemifumarate (A536001), an orally active, synthetic nonpeptide renin inhibitor. Antihypertensive.
References Kumar, N.U., et. al.: Chem. Biol. Interface, 3, 304 (2013); Lefevre, G., et al.: J. Immunoassay, 21, 65 (2000); Allikments, K., et al.: Curr. Opin. Invest. Drugs, 3, 1479 (2002); Wood, J.M., et al.: Biochem. Biophys. Res. Commun., 308, 698 (2003); Grandman, A.H., et al.: Circulation, 111, 1012 (2005)

Applications O-Desaryl Ranolazine-d5 is the isotope labelled analog of O-Desaryl Ranolazine (D422050); a metabolite of Ranolazine (R122500).
References Chaitman, B.R., et al.: J. Am. Coll. Cardial., 43, 1375 (2004); McCormack, J.G., et al.: Gen. Pharmacol., 30, 639 (1998); Schofield, J.A.H., et al.: Expert Opin. Invest. Drugs, 11, 117 (2002)

Applications DL-2-Aminobutyric-2,3,3,4,4,4-d6 Acid (CAS# 350820-17-6) is a useful isotopically labeled research compound.

Applications Phenol is purified here for molecular genetics applications. It is naturally found in tea leaves and plants, and has uses in the synthesis of antioxidant compounds due to the antioxidant activity caused by the phenol moiety. This structure also allows it to be used for syntheses of anti-bacterial & anti-carcinogenic compounds. This is the labelled analog.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nam, S. et al.: J. Agri. Chem., 60, 9097 (2012); Xia, J. et al.: J. Agri. Chem., 57, 99 (2009); Khanal, P. et al.: Carcinogenesis, 32, 545 (2011);