Nicotine and Nicotine Derivatives

<p>Applications Sorbicillin analog. A bioactive secondary metabolites from terrestrial Streptomyces species TN262.<br>References Ma, L. et al. : J. Anitibiot. 64, 645 (2011); Elleuch, L. et al.: Appl. Biochem. Biotech. 162, 579 (2010)<br></p>

<p>Stability Hygroscopic, Light Sensitive<br>Applications (R,S)-Anatabine is a metabolite of Nicotine (N412420).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Quan, P.M., et al.: J. Org. Chem., 30, 2769 (1965), Maciuk, A., et al.: J. Pharm. Biomed. Anal., 48, 238 (2008),<br></p>

<p>Stability Very Hygroscopic<br>Applications Nicotine N-β-D-Glucuronide is a Nicotine (N412420) metabolite in rat brain. Nicotine N-β-D-Glucuronide is used as a Nicotine biomarker in rat brain.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Alexandrov, K., et al.: Toxicol. Lett., 198, 63 (2010), Huang, L., et al.: J. Neurochem., 109, 826 (2009), Quik, M., et al.: Biochem. Pharmacol., 78, 677 (2009), Weems, J., et al.: Chem. Res. Toxicol., 23, 696 (2010),<br></p>

<p>Applications A labelled major metabolite of nicotine in humans. Carcinogen.<br>References Sugasawa, S., et al.: Pharma. Bull., et al.: 2, 39 (1954), Thompson, J.A., et al.: J. Chromatog., 231, 53 (1982); Seeman, J.I., et al.: J. Org. Chem., 51, 1548 (1986)<br></p>

<p>Applications 2-Chloro-rac-Nicotine is a metabolite of rac-Nicotine (N412420); an active stimulant having both addictive and carcinogenic properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lowry, T., et al.: J. Chem. Soc., 319 (1931);<br></p>

<p>Stability Light Sensitive<br>Applications Labelled (RS)-Nornicotine (N757000). (RS)-Nornicotine is a tobacco alkaloid and the major Nicotine (N412420) metabolite in brain. Nornicotine appears to activate different nAChR subtypes, has a better pharmacokinetic profile, and produces less toxicity than Nicotine. Nornicotine shows a significant analgesic activity.<br>References Hecht, S., et al.: Carcinogenesis, 9, 875 (1988), Rivenson, A., et al.: Cancer Res., 48, 6912 (1988), Hoffmann, D., et al.: Chem. Res. Toxicol., 14, 767 (2001), Kool, J., et al.: J. Med. Chem., 49, 3287 (2006), Kool, J., et al.: Drug Metab. Dispos., 35, 640 (2007),<br></p>

<p>Applications Used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.<br>References Denny, W., et al.: J. Med. Chem., 33, 814 (1990), Maurya, M., et al.: J. Chem. Res., 446 (1998),<br></p>

<p>Applications Glucosides of Nicotine (N412420). A representative lot was a 1:1 mixture of alpha and beta.<br></p>

<p>Stability Light Sensitive<br>Applications (±)-Nicotine-d7 (N-methyl-d3; pyridine-d4) is the labelled version of Nicotine (N412420(M)) is an alkaloid isolated from plants. Nicotine is an active stimulant, having both addictive and carcinogenic properties. Nicotine can be absorbed through the alimentary canal, respiratory tract and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.<br>References Ferretti, G., et al.: J. Med. Chem., 45, 4724 (2002), Guillen, M., et al.: J. Agric. Food Chem., 53, 1093 (2005), Ramunno, A., et al.: Bioorg. Med. Chem. Lett., 15, 3237 (2005), Alburges, M., et al.: Eur. J. Pharmacol., 573, 124 (2007),<br></p>

<p>Applications Nicotine analog.<br>References Yamamoto, I., et al.: Agr. Biol. Chem., 27, 446 (1963)<br></p>

<p>Applications A nicotine metabolite.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kool, J., et al.: J. Med. Chem., 49, 3287 (2006), Newman, D., et al.: J. Nat. Prod., 70, 461 (2007), Kool, J., et al.: Drug Metab. Dispos., 35, 640 (2007),<br></p>

<p>Applications (±)-Cotinine-2,4,5,6-d4 (pyridine-d4) (CAS# 350818-68-7) is a useful isotopically labeled research compound.<br></p>

<p>Stability Hygroscopic<br>Applications Nicotine-N-(4-deoxy-4,5-didehydro)-β-D-glucuronide is a possible metabolite of Nicotine (N412420).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-Chloro-6-nitrosoresorcinol-d1 is the labeled analogue of 4-Chloro-6-nitrosoresorcinol (C374860). 4-Chloro-6-nitrosoresorcinol-d1 is an intermediate in the synthesis of 6-Hydroxy Chlorzoxazone-d2 (H825123), a labeled analogue of 6-Hydroxy Chlorzoxazone (H825120), A major metabolite of chlorzoxazone and formed by the actions of cytochrome P450IIE1.<br>References Twele, et al.: Arzneim.-Forsch., 32, 759 (1982); Peter, et al.: che. Res. Toxicol., 3, 566 (1990)<br></p>

<p>Nicergoline EP Impurity B is a metabolite of nicergoline, a drug product. It has been synthesized for use as an impurity standard for analytical and pharmacopoeia purposes. Nicergoline EP Impurity B is not found in nature and has been shown to be metabolically stable in vitro. It can be used as a reference substance for the determination of nicergoline concentrations in human plasma samples.</p>