Organic Halides

<p>Applications Fluorosulfonyl Isocyanate is an intermediate used in the synthesis of 5-Chloro Acesulfame (C363250), which is an impurity of Acesulfame (A132500), the artificial sweetener, and a new sweet-tasting oxathiazinone dioxides. Acesulfame Potassium Impurity B<br>References Clauss, K., et al.: Liebigs Annalen der Chemie,4, 494 (1980); Armenta, S., et al.: J. Agric. Food Chem., 52, 7798 (2004);<br></p>

<p>Applications Tigoloyl Chloride is used in the polymerization of propylene as well as through a Freidel-Crafts reaction for the preparation of permethylindenyl complexes of transition metals. As well, it is primarily used as a reagent in the enantioselective synthesis of dihydropyrans.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References O'Hare, D. et al.: Organometallics, 11, 48 (1992); Kaminsky, W. et al.: J. Organomet. Chem., 487, 181 (1995); Evans, D. A. et al.: J. Am. Chem. Soc., 122, 1635 (2000);<br></p>

<p>Applications Methyl 5-Chloro-2-[(4-ethoxy-4-oxobutyl)amino]benzoate is a reactant in the synthesis of 7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepin, an intermediate in synthesis of Tolvaptan (T536650).<br>References Liu, Dengke, et al.: Tianjin Institute of Pharmaceutical Research, CN 103012265 A 20130403(2013);<br></p>

<p>Applications 1,5-Dibromopentane is used as an alkylating agent in organic synthesis. 1,5-Dibromopentane is also used as a reagent to synthesize benzo[b]xanthone derivatives, compounds that have potential anticancer activity.<br>References Luo, L., et al.: J. Serb. Chem. Soc., 78, 1301 (2013); Royer, G. &amp; Klotz, I.: J. Am. Chem. Soc., 91, 5885 (1969)<br></p>

<p>Applications 1-Bromo-3-phenylpropane is used in the synthesis of MraY natural inhibitors as antibacterial agents. Also used in the preparation of quinolinone derivatives as potent and selective MAO-B inhibitors.<br>References Fer, M. et al.: J. Org. Chem., 78, 10088 (2013); Meiring, L. et al.: Bioorg. Med. Chem. Lett., 23, 5498 (2013);<br></p>

<p>Applications 5-[2-(Trifluoromethoxy)phenyl]-2-furancarboxylic Acid is a reactant used in the preparation of (phenyl)-N-[(mercapto)(pyrrolyl)triazolyl]furancarboxamide and (phenoxy)-N-[(mercapto)(pyrrolyl)triazolyl]acetamide derivatives as herbicides.<br>References Xue, S., Lu, C.: Youji Huaxue, 28, 1083 (2008)<br></p>

<p>Applications 5-Fluoronicotinamide<br></p>

<p>Applications 3-Fluorobenzoic Acid (cas# 455-38-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Fluoro-2-(trifluoromethl)benzonitrile is a reagent used in the synthesis of 5-substituted-1H-tetrazoles as antibacterials.<br>References Sivaguru, P. et al.: Tetrahedron Lett., 56, 2203 (2015); Shi, G et al.: Org. Lett., 17, 38 (2015);<br></p>

<p>Applications N-(2-Chloroprop-2-en-1-yl)-2,3-dihydro-1H-inden-1-amine is related to the drug Rasagiline(R126030). Rasagiline is used to increase the availability of dopamine at striatal receptors as a method to treat Parkinson’s disease.<br>References Youdim, M.B.H., et al.: Br. J. Pharmacol., 132, 500 (2001); Finberg, J.P., Rambam Maimonides Med. J., 1 (2010)<br></p>

<p>Applications 4-Bromobiphenyl is used as a reagent in the synthesis of spirooxindole derivatives for use as AMPK activators. 4-Bromobiphenyl is also used as a reagent in the preparation of indenoindole derivatives as organic electroluminescent device materials.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Madanahalli Ranganath Rao, J., et al.: PCT Int. Appl. WO 2014202580 A1 20141224. Dec 24, 2014; Nagaoka, M., et al.: PCT Int. Appl. WO 2014196556 A1 20141211. Dec 11, 2014<br></p>

<p>Applications 3-Chloro-2,4-difluoronitrobenzene<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Dibenzosuberyl Chloride is used in the synthesis of atypical tricyclic antidepressant as well as dibenzosuberyl-substituted tropines as ligands for acetylcholine-binding protein. Dibenzosuberyl Chloride is also used in the preparation of amino protecting group for solid phase peptide synthesis.<br>References Gerdes, K. et al.: Int. Elec. Conf. Synth. Org. Chem., 596 (2004); Noda, M. et al.: Shim. Hyor., 54, 223 (1997); Edink, E. et al.: Bioorg. Med. Chem. Lett., 22, 1448 (2012);<br></p>

<p>Applications 2-Nitrobenzenediazonium Tetrafluoroborate (cas# 365-33-3) is a compound useful in organic synthesis.<br></p>

<p>Applications CHLOROMETHYL ISOBUTYRATE (cas# 61644-18-6) is a useful research chemical.<br></p>

<p>Applications 7-Fluoro-2,3,4,5-tetrahydro-1H-3-benzazepine is a metabolite of Lorcaserine (L469890), which is a novel selective 5-HT2C-receptor agonist for the treatment of obesity.<br>References Pauli, M., et al.: Formulary, 45, 180 (2010), Ioannides-Demos, L.L., et al.: J. Obesity, 18, 179674 (2011),<br></p>

<p>Stability Hygroscopic<br>Applications Cyclobutylmethylamine Hydrochloride<br></p>

<p>Applications 5-[2-(Trifluoromethyl)phenyl]-2-furoic Acid is a chemical reagent used in the preparation of novel TRPV1 antagonists. Also used in the preparation of potent inhibitors of FeII and MnII E, coli Methionine Aminopeptidase as antibacterial agents.<br>References Huguet, F. et al.: ChemMedChem. 7, 1020 (2012); Kim, N. et al.: Chem. Asian J., 8, 400 (2013);<br></p>

<p>Applications 2-Bromo-2-(2-chlorophenyl)acetic Acid is used as an intermediate in the preparation of biologically active compounds such as the antithrombotic Clopidogrel (C587250).<br>References Chen, J. et al.: Hech. Huax., 18, 586 (2010);<br></p>

<p>Applications 4-Chlorobutyl Acetate is a reagent used in the synthesis of novel cyclic ADP ribose derivatives. Also used in the synthesis of a transient receptor potential melastatin 2 antagonist involved in insulin secretion.<br>References Galeone, A. et al.: Tetra., 58, 363 (2002); Moreau, C. et al.: J. Med. Chem., 56, 10079 (2013); Togashi K, et al.: EMBO J., 25, 1804 (2006);<br></p>

<p>Applications 2-Chloro-5-nitrobenzenesulfonamide (cas# 96-72-0) is a compound useful in organic synthesis.<br></p>

<p>Applications N-(p-Fluorophenyl)-hydroxylamine, is a reactant used in various chemical synthesis, such as in preparation of spiro-isoxazoline and spiro-isoxazolidine derivatives of tomentosin.<br>References Zaki, M., et al.: RSC Advances, Vol. 7, Iss 11, P: 6523-6529 (2017);<br></p>

<p>Stability Light Sensitive<br>Applications 4-Chlorophenylacetylene (cas# 873-73-4) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2,5-Dibromothiophene (cas# 3141-27-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Bromo-2-ethylphenol (cas# 18980-21-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2,4-Dichloro-3-Nitrobenzotrifluoride is a useful reagent in the preparation of aryl ethers as HIF-2α inhibitors used in the treatment of cancers.<br>References Dixon, D. D., et al.: From PCT Int. Appl. (2015), WO 2015035223 A1 20150312<br></p>

<p>Applications (1R)-4-Bromo-2,3-dihydro-1H-inden-1-amine is used to prepare sphingosine 1 phosphate receptor modulators useful in treatment of S1P1-associated diseases.<br>References Boehm, M., et al.: PCT Int. Appl., WO 2012158550 A2 20121122 (2012)<br></p>

<p>Applications 3-Acetylbenzoyl Chloride is used in the synthesis of aminimdes as potential CNS acting agents. Also, it is an intermediate used in the synthesis of 3-[(Dimethylamino)carbonyl]phenol (D461635), which can be used in the synthesis of novel purine and bicyclic pyrimidine, which are factor Xa inhibitors, and also have high selectivity over thrombin and trypsin.<br>References Capuano, B., et al.: Aust. J. Chem., 60, 673-684 (2007); Buckman B. O., et al.: Bio. Med. Chem. Let., 8, 2235 (1998)<br></p>

<p>Stability Very Hygroscopic<br>Applications Magnesium Bromide is an inorganic salt used in the synthesis of superconductors and nanowires. Also present in polymer nanocomposites to improve conductivity.<br>References Alam, M. et al.: Polym. Int., 63, 1465 (2014); McDonald, T. et al.: J. Am. Chem. Soc., 135, 7056 (2012);<br></p>

<p>Stability Moisture Sensitive<br>Applications 2,4-Difluoro-3-formylphenylboronic acid<br></p>

<p>Applications 1,1',1''-[[(2-Bromoethyl)thio]methylidyne]trisbenzene is an intermediate in the synthesis of TETAC (P991915), a cyclen based compound used in paramagnetic NMR studies.<br>References Dhar, T. G., et al.: J. Med. Chem., 37, 2334 (1994);<br></p>

<p>Applications 3-(Chloromethyl)-2,4,6-trimethylbenzoic Acid (cas# 52411-49-1) is a useful research chemical.<br></p>

<p>Applications A new labelled substituted pyridazinone with tuberculostatic action.<br>References Wright, L., et al.: J. Antimicrob. Chemother., 12, 317 (1983), Choi, W., et al.: Anal. Biochem., 219, 368 (1994), Zacchino, S., et al.: J. Nat. Prod., 62, 1353 (1999), Urbina, J., et al.: Bioorg. Med. Chem., 8, 691 (2000),<br></p>

<p>Applications 2-Bromo-1-(3,5-dihydroxyphenyl)ethanone (cas# 62932-92-7) is a useful reagent for the preparation of terbutaline analogs.<br>References Zhang, B., et al.: PCT Int. Appl. (2020), WO 2020107913 A1<br></p>

<p>Applications 9,9-Dihexylfluorene (cas# 123863-97-8) is a useful research chemical.<br></p>

<p>Applications 3-Phenylpropionyl Chloride is a derivative of phenylpropionic acid used in the preparation of a wide range of pharmaceutical compounds such as antivirals and antitumor agents.<br>References Ermolova, G.I. et al.: Khim.-Farm. Zh., 24, 35 (1990); Bernier, J.L. et al.: J. Med. Chem., 28, 497 (1985); Jung, J.-C. et al.: Bioorg. Med. Chem. Lett., 14, 5527 (2004);<br></p>

<p>Applications 1-Iododecane (cas# 2050-77-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Fluorobenzamide<br></p>

<p>Applications 3-Bromotetrahydrofuran<br></p>

<p>Applications 3-Fluoro-5-trifluoromethylbenzonitrile is a reagent used in the synthesis of cholesteryl ester transfer protein (CETP) inhibitors in the treatment of high cholesterol. Also used in the preparation of substituted pyrimidines with dithioacetals for antimicrobial activity.<br>References Qiao, J. et al.: J. Med. Chem., 58, 9010 (2015); Gami, S. et al.: J. Hetero. Chem., 52, 751 (2015);<br></p>

<p>Applications 8-chloro-2,3-dihydro-1,4-benzodioxine-5-carboxylic Acid (cas# 66411-24-3) is a useful research chemical.<br></p>

<p>Applications Terephthaloyl chloride is used as a cross-linking agent to create polymers from various types of monomers.<br> E0<br>References Edwards-Lévy, F., et al.: Int. J. Pharm., 103, 253 (1994); Lee, J., et al.: Biomacromolecules, 7, 1729 (2006); So, Y.: J. Polym. Sci. Pol. Chem., Turska, E., et al.: J. Appl. Polym. Sci., 20, 1849 (1976)<br></p>

<p>Applications 2,2-BIS(3-AMINO-4-HYDROXYPHENYL)HEXAFLUOROPROPANE (cas# 83558-87-6) is a useful research chemical.<br></p>

<p>Applications 2-((3-Chloro-2-formylphenyl)thio)acetic Acid is a useful research chemical.<br></p>

<p>Applications N-[(2,4-Difluorophenyl)methylene]-2,4-difluoro-benzenemethanamine is derived from 2,4-Difluorobenzylamine (D450850), which acts as a reagent for the design of pyrazole derivatives as non-nucleoside heptatitis B virus inhibitors. It is also used as a reagent in the preparation, HIV antiviral activity, SAR, and molecular modelling of hydroxypyridonecarboxylic acids as HIV reverse transcriptase inhibitors.<br>References Jia, H., et al.: Eur. J. Med. Chem., 123, 202 (2016); Kankanala, J., et al.: J. Med. Chem., 59, 5051 (2016)<br></p>

<p>Applications 3-Bromo-4,5-difluorobenzoic Acid is a useful synthetic intermediate.<br></p>

<p>Applications A useful synthetic intermediate.<br></p>

<p>Applications Ethyl 2-(2,6-Dichlorophenyl)acetate (cas# 90793-64-9) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 2-Amino-5-Ethylphenol Hydrochloride (cas# 149861-22-3) is a useful research chemical.<br></p>

<p>Applications 4-bromo-1,1-difluorobutane (cas# 1457946-33-6) is a useful research chemical.<br></p>

<p>Applications 3-Amino-1-propanesulfonyl Chloride Hydrochloride is used in the synthesis of 5 and six membered sultams which can be used in large scale organic synthesis.<br>References Shewalkar, M. et al.: Lett. Org. Chem., 10, 518 (2013);<br></p>

<p>Applications D-NG-Nitroarginine Methyl Ester Hydrochloride is inactive stereoisomer of L-NAME NOS inhibitor. Also, it reduces the necrotic and hypersensitive response of tobacco induced by Ralstonia solanacearum.<br>References Chou, C., et al.: Plant Pathol. Bull., 15, 97-105 (2006)<br></p>

<p>Applications 4-Bromobenzotrifluoride is an aromatic compound that is used as a reagent to synthesize Bergenin (B318650), a compound that originates in Mallotus japonicus that exhibits hepatoprotective and antioxidant effects. 4-Bromobenzotrifluoride is also used as a reagent to prepare (±)-Preclamol, a partial dopamine D2 agonist that is used to treat Parkinson’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lim, H., et al.: Pharmacology, 63, 71 (2001); Parkan, K., et al.: Chem. Eur. J., 20, 4414 (2014); Pirtosek, Z., et al.: Clin. Neuro., 16, 550 (1993); Takahashi, H., et al.: Bioorg. Med. Chem., 11, 1781 (2003); Vasdev, N., et al.: Synapse, 60, 314 (2006)<br></p>

<p>Applications Formamidine Hydrobromide is used as a reactant in the synthesis of organometal halide perovskites (OHPs).<br>References Shi, Yifei, et al.: ACS App. Mat. &amp; Interfaces, 10(11), 9849-9857 (2018)<br></p>

<p>Applications (L)-2-Bromo-3-phenylpropionic Acid (cas# 35016-63-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Bromo-3-fluoroaniline is an intermediate used for the synthetic preparation of Tradizolid and various pharmaceuticals such as the synthesis of several lateral difluoro-substituted 4,4"-dialkyl- and 4,4"-alkoxyalkylterphenyls.<br>References Gray. G., et al.: Molec. Crystals. Liquid. Crystals., 204, 43 (1991); Ng, B.H., et al.: J. Chem. Soc., 2815 (1958);<br></p>

<p>Applications 2,3-Dichlorobenzal Chloride is used in the biological study of plant growth-promoting activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kemp, M. S., et al.: Ann. Appl. Biol., 80, 311-15 (1975)<br></p>

<p>Applications N-​Methylcyclopropanami​ne Hydrochloride can be used as reactant/reagent in preparation of substituted benzazinones as antibacterial compounds.<br>References Jin, Q., et al.: PCT Int. Appl., WO 2017098440 A1 20170615 (2017)<br></p>

<p>Applications 4-(2-Amino-3,3-dimethyl-1-oxobutyl)benzonitrile hydrochloride is used as a reagent to synthesize phenyloxobutanylpyridinylpiperazinecarboxamide derivatives, compounds that have TRPA1 receptor antagonistic properties.<br>References Svensson, M. &amp; Weigelt, D. Preparation of Phenyloxobutanylpyridinylpiperazinecarboxamide Derivatives for Use as TRPA1 Receptor Antagonist. PCT Int. Appl. 2012050512. Apr 19, 2012.<br></p>

<p>Applications 2-Fluoro-4-(methylsulfonyl)benzoic acid<br></p>

<p>Applications 2-BROMO-9,9-DIOCTYL FLUORENE (cas# 302554-80-9) is a useful research chemical.<br></p>

<p>Applications 5-Chloro-1-hexene is a reagent with difluoroacetic acid that results in the formation of 5-chloro-2-hexyl-2-d trifluoro-acetate and 1,4-chlorine shift.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Peterson, P. E., et al.: J. Am. Chem. Soc., 86, 4503-4 (1964)<br></p>

<p>Applications 2-Chloro-4-fluorobenzoic Acid s a useful synthetic intermediate. It can be used to prepare aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists. It can also be used to synthesize (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as arginine vasopressin V2 receptor agonists.<br>References Barnett, H., et al.: Bioorg. Med. Chem. Lett., 19, 158 (2009); Tsukamoto, I., et al.: Bioog. Med. Chem., 16, 9524 (2008)<br></p>

<p>Applications Bis(2,4,5-tribromophenyl)iodonium Hydrogen Sulfate is an intermediate in the synthesis of 2,2',4,4',5,6'-Hexabromodiphenyl ether (H290745), which is a hepatotoxic polybrominated diphenyl ester (PBDE) that is commonly used as a flame retardant. 2,2',4,4',5,6'-Hexabromodiphenyl ether is also sometimes found in food and meats as well, posing a significant risk to humans (especially during pregnancy) and/or animals that consume it. One of the new POPs under the Stockholm Convention<br>References Johnson, P., et al.: Sci. Total Environ., No vol. given, 445 (2013); Scott, L., et al.: Organo. Comp., 74, 1109 (2012); Zhao, Y., et al.: Env. Sci. Tech., 47, 5939 (2013)<br></p>

<p>Applications 4-{[(p-Fluorophenyl)imino]methyl}phenol is used in the preparation of benzylacetones which promote anti-fungal activity.<br>References Sandhar, R. et al.: J. Ind. Council Chem., 22, 32 (2005);<br></p>

<p>Applications It is useful in photochromic materials.<br></p>

<p>Applications Collidine-hydrogen fluoride complex (approx 1:2 collidine:HF) (cas# 45725-47-1) is a useful research chemical.<br></p>