Organic Halides

<p>Applications 2-(4-Difluoromethoxy-3-fluoro-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (cas# 1162262-35-2) is used as a reagent in the preparation of imidazopyrazine derivatives as antibacterials.<br>References Cheng, Z., et al.: PCT Int. Appl. 375 pp. (2020)<br></p>

<p>Applications 6-Fluoronicotinic acid<br></p>

<p>Stability Light Sensitive, Volatile<br>Applications 2-​Bromo-​3,​3-​dimethyl-1-​butene is reagent used in synthetic chemistry.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Spaggiari, A. et al.: J. Org. Chem. 72, 2216-2219 (2007)<br></p>

<p>Applications Methyl 2-chloro-6-nitrobenzoate<br></p>

<p>Applications 2-Fluoro-5-iodobenzonitrile is a compound commonly used in synthetic chemistry and is also used as a reagent to synthesize 1-alkyl-1H-indazoles. 2-Fluoro-5-iodobenzonitrile reacts with sodium sulfide to produce mercaptobenzonitriles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, H., et al.: Tetrahedron, 19, 3907 (2013); Taldone, T., et al.: Tetrahedron Lett., 53, 2548 (2012)<br></p>

<p>Stability Moisture Sensitive<br>Applications n-Octadecyltrichlorosilane (cas# 112-04-9) is a useful research chemical.<br> E0<br></p>

<p>Applications Methyl trans-4-Bromo-2-butenoate is used as a reagent in the synthesis of several organic compounds including that of dimethoxy ketals and ketones via electrochemical oxidative decarboxylation of malonic acids.<br>References Ma, X., et al.: Org. Lett., 17, 4690 (2015);<br></p>

<p>Applications 1,3,5-Tribromobenzene, is a reagent that can be used in the preparation of different inhibitors. It is also a substituted Bromobenzene, a general reagent in palladium-catalyzed reactions and in the synthesis of Grignard reagents.<br>References Miyaura, N. et al.: Synth. Commun., 11, 513 (1981); Nahm, S. et al.: Tetra. Lett., 22, 3815 (1981);<br></p>

<p>Applications ethyl 4-aminopentanoate hydrochloride (cas# 119396-97-3) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications Di-tert-butyl chloromethyl phosphate (cas# 229625-50-7) is a useful research chemical.<br></p>

<p>Applications [4-(Trimethylammonium)benzyl] Alcohol Bromide is a compound useful in organic synthesis.<br></p>

<p>Applications 7-Chloro-4-oxo-4H-chromene-2-carboxylic acid (cas# 114741-22-9) is a useful research chemical.<br></p>

<p>Applications 1-(4-(2-Bromoethyl)phenyl)ethanone (cas# 40422-73-9) is a useful research chemical.<br></p>

<p>Applications 3,4-Dichlorophenoxyacetic acid is a synthesis reagent.<br></p>

<p>Applications Methyl 5-cyano-2-fluorobenzoate<br></p>

<p>Applications (1R,3S)-3-(4-Bromophenyl)cyclopentanamine is used in the synthesis of pharmaceutical agents.<br></p>

<p>Applications 1-(3-Chloropropoxy)-4-fluorobenzene was used as a reagent in the preparation of a library of hydantoin compds which has used to study Aurora kinase A inhibitory activity. It was also used as an alkylation agent in the preparation of tetracyclic quinoxaline butyrophenones as 5-HT2A and postsynaptic D2 antagonists and inhibitors of serotonin transporter for treatment of neuropsychiatric and neurological disorders.<br>References Li, Peng, et al.: J Med. Chem., 57(6), 2670-2682, 2014Bogolubsky, Andrey V., et al.: ACS Comb. Sci., 20(1), 35-43, 2018<br></p>

<p>Applications (5-Carboxypentyl)triphenylphosphonium Bromide (cas# 50889-29-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Fluorobenzoic Acid (cas# 455-38-9) is a compound useful in organic synthesis.<br></p>

<p>Applications (S)​-2-​Aminohexanedioic Acid 6-​Methyl Ester Hydrochloride is used to prepare amino acid containing thiophene derivatives as agonists for enhancing binding of integrin-expressing cells to integrin receptors.<br>References Biediger, R., et al.: PCT Int. Appl., WO 2012068251 A2 20120524 (2012)<br></p>

<p>Applications 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL (cas# 75144-12-6) is a useful research chemical.<br></p>

<p>Applications 6-Bromo-2-picoline is a halogenated pyridine derivative used is a building block in the preparation of nitrogen containing heterocyclic compounds.<br>References Long, G.V. et al.: J. Chem. Soc. Dalt. Trans. Inorg. Chem., 21, 3175 (1993); Uenishi, J. et al.: J. Org. Chem., 58, 4382 (1993);<br></p>

<p>Applications 2-(trifluoromethoxy)terephthalic acid (cas# 175278-21-4) is a useful research chemical.<br></p>

<p>Applications 1-(DIPHENYLMETHYL)-3-HYDROXYAZETIDINE HYDROCHLORIDE (cas# 90604-02-7) is a useful research chemical.<br></p>

<p>Applications 5-Cyano-1H-indole-3-butanoyl Chloride is a derivative of Vilazodone (V265000). Vilazodone (V265000) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist which is under clinical evaluation for the treatment of major depression. Antidepressant.<br>References Bartoszyk, G., et al.: Eur. J. Pharmacol., 322, 147 (1997);Heinrich, T., et al.: J. Med. Chem., 47, 4684 (2004);<br></p>

<p>Applications 1,7-Dichloroheptan-4-one (cas# 40624-07-5) is a useful research chemical.<br></p>

<p>Stability Air Sensitive, Moisture Sensitive, Temperature Sensitive<br>Applications 5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (cas# 1620086-77-2) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications 2,4-Difluoro-3-formylphenylboronic acid<br></p>

<p>Applications 1-Chloro-4-(methylsulfonyl)-2-nitrobenzene (cas# 97-07-4) is a useful research chemical.<br></p>

<p>Applications [(Methoxy)methyl]triphenylphosphonium Chloride is used in the synthesis of Cephalotaxine (C261050), an antiviral and antitumor agent. Also used in the synthesis of Taxol A fragment.<br>References Sells, M., et al.: J. Virol., 62, 2836 (1988), Kaneko, S., et al.: J. Clin. Microbiol., 27, 1930 (1989), Baba, Y., et al.: Bioorg. Med. Chem., 13, 5164 (2005), Romero, M., et al.: Antiviral Res., 68, 75 (2005); Hirai, S. et al.: Tetrahedron Lett., 54, 1888 (2013); Xing, P. et al.: Synth., 45, 596 (2013);<br></p>

<p>Applications 6-Chloro-1-benzofuran-2-carboxylic Acid is used to prepare cis-diaminocyclohexane derivatives as factor Xa inhibitors. It is also used to synthesize tachykinin NK2 receptor antagonists.<br>References Bioorg. Med. Chem., 17, 8206 (2009); Gensini, M., et al.: ChemMedChem, 5, 65 (2010)<br></p>

<p>Applications (4-Bromo-2-chlorophenoxy)acetic acid<br></p>

<p>Applications 1,5-Diiodo-3-oxopentane (cas# 34270-90-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(2-Chlorophenyl)-cyclohexanone is a reactant that is used in the preparation of benzofurans via palladium-phosphine-catalyzed intramolecular enolate O-arylation of α-arylketones.<br>References Willis, M.C., et al.: Tetrahedron, 62, 11513 (2006)<br></p>

<p>Applications 4,4,4-Trifluoro-3-(trifluoromethyl)butanoic Acid is used to prepare fluorinated analog of leucine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lazar, J., et al.: J. Med. Chem., 11, 138 (1968)<br></p>

<p>Applications Aminoacetonitrile is a useful synthetic intermediate. It is a reagent used to synthesize dipeptide nitriles as reversible and potent cathepsin S inhibitors. It can also used to prepare substituted cyclic ureas as possible HIV protease inhibitors.<br>References Ward, Y., et al.: J. Med. Chem., 45, 5471 (2002); Wilkerson, W., et al.: J. Med. Chem., 40, 4079 (1997)<br></p>

<p>Applications Hydrochloride salt of (S)-1-Cyclopentylethanamine, used in the preparation of renin inhibitors.<br></p>

<p>Applications Methyl 6-Chloronicotinate is used in the determination of Acetamiprid (A150800) and its metabolites in crop and soil.<br>References Tokieda, M., et al.: Nippon Noyaku Gakkaishi, 24, 115 (1999)<br></p>

<p>Applications (±)-Tetrahydrofurfuryl Bromide is a general chemical reagent used in the synthesis of tubulin polymerization inhibitors.<br>References Colley, H. et al.: J. Med. Chem., 58, 9309 (2015);<br></p>

<p>Applications 3-Phenylpropionyl Chloride is a derivative of phenylpropionic acid used in the preparation of a wide range of pharmaceutical compounds such as antivirals and antitumor agents.<br>References Ermolova, G.I. et al.: Khim.-Farm. Zh., 24, 35 (1990); Bernier, J.L. et al.: J. Med. Chem., 28, 497 (1985); Jung, J.-C. et al.: Bioorg. Med. Chem. Lett., 14, 5527 (2004);<br></p>

<p>Applications Methyl 5-Chloro-3-(Chlorosulfonyl)Thiophene-2-Carboxylate (cas# 126910-68-7) is a useful research chemical.<br></p>

<p>Applications tert-Butyl-(3-iodo-1,1-dimethyl-propoxy)-dimethyl-silane (cas# 105262-85-9) is used as a reagent in the preparation of Methyl Acetoacetate.<br>References Heslin, J. C., et al.: J. Chem. Soc. [Perkin 1]. 6, 1417 (1988)<br></p>

<p>Applications 3,4-Dichloro-6-aminotoluene is an building block reagent used in the synthesis of various drug analogues and pharmaceutical goods.<br>References PCT Int. Appl. (2013), WO 2013030138 A1 20130307.; Shimada, I., et al.: Bioorg. Med, Chem., 16, 1966 (2008);<br></p>

<p>Applications 2,5-Dibromothiophene (cas# 3141-27-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Bromopentyltrimethylammonium Bromide (cas# 15008-33-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Bromo-1-(2-hydroxy-5-(2-hydroxyethyl)phenyl)ethanone is an intermediate in the synthesis of 3-Hydroxy Darifenacin (Mixture of Diastereomers) (H825190), the hydroxylated metabolite of Darifenacin (D193400).<br>References Soudijn, W., et al.: Eur. J. Pharmacol., 1, 47 (1967), John, B., et al.: Xenobiotica, 22, 1339 (1992), Franz, P., et al.: Drug Metab. Dispos., 21, 249 (1993),<br></p>

<p>Applications 4-Amino-2-chlorobenzeneacetic Acid can be used as reactant/reagent in starting material in preparation of phenylacetamides as protein kinase inhibitors useful in treatment of various proliferative diseases.<br>References Bold, G., et al.: PCT Int. Appl., WO 2006108640 A1 20061019 (2006);<br></p>

<p>Applications 4-fluorobutanoic acid (cas# 462-23-7) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Methyl 4-(trifluoromethoxy)benzoate<br></p>

<p>Applications 2-Chloro-5-nitrobenzenesulfonamide (cas# 96-72-0) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications Oxalyl Bromide, is an acid halide that can be used in organic synthesis and in preparation of Carbon-substituted iminium salts. It is also used as a reactant for synthesis of aromatic and hydroaromatic angucyclinone via the Diels-Alder reaction, and in cyclization to produce CRF1 receptor antagonists.<br> E0<br>References Nelson, S. G. Science of Synthesis, Volume20a, ages15-52,Journal; General Review 2006; Joerg M.:Department of Organic ChemistryUniversity of Paderborn, Warburger Str. 100, Paderborn, Germany.<br></p>

<p>Applications 2,3,4,5-Tetrafluorobenzoic Acid is used in the synthesis of diterpenoid analogs as antitumor compounds. Also used in the synthesis of novel quinoline lactones.<br>References Li, D. et al.: Eur. J. Med. Chem., 64, 215 (2013); Zheng, H. et al.: Lett. Org. Chem., 10, 252 (2013);<br></p>

<p>Applications 2-Bromo-4-nitrotoluene<br></p>

<p>Applications 3,5-Diamino-4-chlorobenzonitrile is used in the preparation of glycolic amide derivatives as allergy inhibitors and antiinflammatory agents<br>References Ban, M., et al.: Bioorg. Med. Chem., 6, 1069 (1998); Takasugi, H. et al.: J. Antibio., 36, 846 (1983); Ban, M. et al.: Bioorg. Med. Chem., 6, 1069 (1998);<br></p>

<p>Applications 5-(Chloromethyl)-3-[1-(4-chlorophenyl)cyclopropyl]-1,2,4-oxadiazole is an intermediate used to prepare substituted oxadiazole analogs as calcium channel antagonists.<br>References Cai, C., et al.: PCT Int. Appl., WO 2008117148 A1 20081002 (2008)<br></p>

<p>Applications 2,6-Dimethyl-4-iodoaniline (cas# 138385-59-8) is a compound useful in organic synthesis.<br></p>

<p>Applications (R)-2,3-Dihydro-N-(phenylmethyl)-1H-Inden-1-amine Hydrochloride, can be used n the synthesis of racemic and optically active 1-aminoindans.<br>References Lidor, R. et al.: Org. Prep. Proc. Int. Vol. 29, Issue 6,P: 701-706 (1997)<br></p>

<p>Stability Unstable in solution. Small amounts of precipitate should have no effect on use.<br>Applications 1-Chloro-N,N-2-trimethylpropenylamine acts as a reagent in the synthesis and antitumor activity of (-)-bassianolide in human cancer cells through cell cycle arrest. Enantioselective total synthesis of nannocystins A and A0 as elongation factor 1 inhibitors. Total synthesis of (-)-caprazamycin A with antibacterial activity against Mycobacterium tuberculosis (TB) via diastereoselective aldol reaction.<br>References Mun, B., et al.: Bioorg. Chem., 69, 64 (2016); Huang, J., et al.: Org. Lett., 18, 4702 (2016); Nakamura, H., et al.: Angew. Chem., Int. Ed., 54, 3136 (2015)<br></p>

<p>Applications 1,5-Difluoro-2,4-dinitrobenzene acts as an oleanolic acid NO-releasing derivative used towards the treatment of colon cancer. Also used in the synthesis of beta blockers used as bronchodialators.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fu, J. et al.: RSC. Adv., 5,19445 (2015); Bhushan, R. et al.: Anal. Lett., 47, 202 (2014);<br></p>

<p>Applications 2-Deoxy-2-fluoro-D-mannopyranose Tetraacetate is an intermediate in the synthesis of 2-Deoxy-2-fluoro-D-mannose (D235150). 2-Deoxy-2-fluoro-D-mannopyranose Tetraacetate is used in the synthesis of 2-deoxy-2-fluoroglycoside phosphodiesters as tunable aglycons for fluoro sugar inactivators of β-glycosidases.<br>References Rempel, B. P. &amp; Withers, S. G., Org. &amp; Bio. Chem., 12(16), 2592-2595 (2014)<br></p>

<p>Applications 3-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzenemethanamine is a useful synthetic organic compound.<br></p>

<p>Stability Extremely Moisture Sensitive<br>Applications Hexylphosphonic Dichloride acts as a reagent for the preparation of enantiomeric phosphonates which are inhibitors of cholesterol esterase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gillespie, S. G., et al.: Phosphorus, Sulfur Silicon Relat. Elem., 122, 205 (1997)<br></p>

<p>Applications (2-Bromoethyl)trimethylsilane has been used as a reactant in the synthesis of strychnine, norfluorocurarine, dehydrodesacetylretuline and valparicine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Martin, D.B., et. al.: J. Org. Chem., 77, 17 (2012)<br></p>