Organic Halides

<p>Applications N-(1-Chloro-2-oxo-2-phenylethyl)benzamide is an amidophenacylating reagent used in various organic reactions, e.g. in the synthesis of thiohydantoin derivatives.<br>References Balya, A.G., et al.: Russ. J. Gen. Chem., 78, 1427 (2008); Belyuga, A.G., et al.: Zhurnal Organichnoi ta Farmatsevtichnoi Khimii, 2, 25 (2004)<br></p>

<p>Applications 4,5-Dichlorothiophene-2-carboxylic Acid is used in the preparation of compounds that have therapeutic BACE1 and BACE2 inhibitors which are used for the treatment of Alzheimer’s disease, type 2 diabetes and other metabolic disorders.<br>References Banner, D., et al.: PCT Int. Appl., 2011:1438553 (2013)<br></p>

<p>Applications 2-amino-5-oxohexanoic acid hydrochloride (cas# 1394040-02-8) is a useful research chemical.<br></p>

<p>Applications 9,9-Dimethyl-N-phenyl-9H-fluoren-2-amine is useful for the synthetic preparation of secondary amines.<br>References Yao, W., et al.: Catal. Sci., 9, 3874 (2019)<br></p>

<p>Applications 2,2,2-Trifluoroethyl trifluoroacetate is a reagent that is used in the synthesis of Dimethyl Diazomethylphosphonate (D470900).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Intermediate in the preparation of Ximelagatran.<br>References Smits, R., et al.: J. Med. Chem., 51, 7855 (2008), Sander, K., et al.: Bioorg. Med. Chem., 17, 7186 (2009), Selness, S., et al.: Bioorg. Med. Chem. Lett., 19, 5851 (2009),<br></p>

<p>Applications o-Bromophenoxyacetic acid<br></p>

<p>Applications 1-Bromo-2-fluorobenzene is used as a reagent in the synthesis of organic compounds inlcuding that of brominated N-arylated carbazoles which are widely useful in organic chemistry.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, L., Synthesis, pages ahead of print, (2015);<br></p>

<p>Applications 2-Nitro-5-(trifluoromethyl)aniline is a reagent in the synthesis of benzo[d]imidazole derivatives which has vasorelaxant activity and antihypertensive effects.<br>References Navarrete-Vazquez, G., et al.: Bioorg. Med. Chem., 18, 3985 (2010);<br></p>

<p>Applications Methyl adipoyl chloride is a reagent that is used for improved heme-mimetics based on BAY 58-2667 (cinaciguat) and their effects on soluble guanylyl cyclase (sGC) activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References von Wantoch Rekowski, M., et al.: J. Med. Chem., 56, 8948 (2013);<br></p>

<p>Applications 1,7-Dichloro-octamethyltetrasiloxane 95% (cas# 2474-02-4) is a useful research chemical.<br></p>

<p>Applications (1S,3R)-3-(4-Bromophenyl)cyclopentanamine is a stereoisomer of (1R,3S)-3-(4-Bromophenyl)cyclopentanamine, used in the synthesis of pharmaceutical agents.<br></p>

<p>Applications methyl 5-(chloromethyl)-2-furoate (cas# 2144-37-8) is a useful research chemical.<br></p>

<p>Applications Ethyl 4-bromoacetoacetate<br></p>

<p>Applications 2,2-Dichloro-3,3-dimethylbutane is an intermediate used in the synthesis of terbinafine (T107500, HCl salt).<br>References Han, Y., et al.: Zhongguo Yaoke Daxue Xuebao, 32, 8 (2001)<br></p>

<p>Applications 3-FLUORO-PROPYLAMINE HCL (cas# 64068-31-1) is a useful research chemical.<br></p>

<p>Applications 1-Iodohexane (cas# 638-45-9) is a compound useful in organic synthesis.<br></p>

<p>Applications A Wittig reagent.<br></p>

<p>Applications Ammonium 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonate (CAS# 29081-56-9) is a fluorosurfactant used as an additive to increase heat stability and resistance of materials.<br>References Gloeckner, V.; et al.: Tenside, Surfactants, Detergents, 26, 376 (1989).<br></p>

<p>Applications 2,3,5-Trichloroaniline (cas# 18487-39-3) is a useful research chemical.<br></p>

<p>Applications Chloromethanesulfonyl Chloride is a very useful intermediate for organic synthesis. It enhances citric acid production by Aspergillus niger NCIM-1696 and increases the yield of citric acid. It also functions as a useful intermediate for pharmaceutical synthesis.<br>References Mahato, J., et al.: J. Chemtracks, 16, 245 (2014); Shealy, Y. F., et al.: J. Med. Chem., 26, 1168 (1983); Johnson, J. K., et al.: ACS Med. Chem. Lett., 7, 785 (2016)<br></p>

<p>Applications 2-​Bromo-4-​thiazolesulfonyl chloride is a useful chemical for research.<br></p>

<p>Applications 4-(4-Chlorophenyl)phenylacetic acid<br></p>

<p>Applications 4-(Trifluoromethoxy)phenol is used as a reactant in the preparation of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors.<br>References Guo, X., et. al.: Eur. J. Med. Chem., 81 (2014)<br></p>

<p>Applications 2-Deoxy-2-fluoro-D-mannopyranose Tetraacetate is an intermediate in the synthesis of 2-Deoxy-2-fluoro-D-mannose (D235150). 2-Deoxy-2-fluoro-D-mannopyranose Tetraacetate is used in the synthesis of 2-deoxy-2-fluoroglycoside phosphodiesters as tunable aglycons for fluoro sugar inactivators of β-glycosidases.<br>References Rempel, B. P. &amp; Withers, S. G., Org. &amp; Bio. Chem., 12(16), 2592-2595 (2014)<br></p>

<p>Applications 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL (cas# 75144-12-6) is a useful research chemical.<br></p>

<p>Impurity Amiodarone EP Impurity H / Amiodarone USP Related Compound H<br>Stability Moisture Sensitive, Hygroscopic<br>Applications 2-Chloro-N,N-diethylethylamine Hydrochloride (Amiodarone EP Impurity H) is a related compound of Amiodarone, a non-selective ion channel blocker.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bonati, M., et al.: J. Pharm. Sci., 73, 829 (1984), Plomp, T.A., Anal. Profiles Drug Subs., 20, 1 (1991), Chow, M., et al.: Ann. Pharmacother., 30, 637 (1996), Singh, B.N., et al.: Clin. Cardiol., 20, 608 (1997)<br></p>

<p>Stability Hygroscopic<br>Applications N-Benzyl-bis(2-chloroethyl)amine hydrochloride (cas# 10429-82-0) is a useful research chemical.<br></p>

<p>Applications 1-Chloroanthraquinone is used to characterize anthraquinone intercalators as carrier molecules for second-generation platinum anticancer drugs.<br>References Gibson, D., et al.: J. Med. Chem., 34, 414 (1991); Gibson, D., et al.: Eur. J. Med. Chem., 32, 823 (1997); Alderden, R., et al.: Biochem. Pharmacol., 71, 1136 (2006)<br></p>

<p>Applications 4-(Trifluoromethyl)benzonitrile is used in the synthesis of quinazolines for amidines. Also used in the synthesis of s-transferase p1-1 and cancer cell proliferation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lv, Y. et al.: Chem. Comm., 49, 6349 (2013); Yang, X. et al.: J. Med. Chem., 53, 1015 (2010);<br></p>

<p>Applications 2-Chloro-3,4-dihydroxybenzoic acid (cas# 87932-50-1) is a useful research chemical.<br></p>

<p>Stability Hygroscopic, Water Sensitive<br>Applications A useful synthetic intermediate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Chloro-N,N-diethylacetamide is used as a reagent in organic synthesis including that of 6-arylmethyl-3-(4-alkoxyphenyl)-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives which act as acetylcholinesterase inhibitors. It is also used in the synthesis of triazoles as herbicides against Panicum crus-galli, Scirpus juncoides, Monochoria vaginalis and other weeds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xu, H., et al.: Zhongguo Xinyao Zazhi, 22, 2692 (2013); Ishikawa, H., et al.: Preparation of triazoles as herbicides, JP Patent 05163253, Jun 29, 1993;<br></p>

<p>Impurity Nizatidine EP Impurity H<br>Applications 2-(Dimethylamino)thioacetamide (Nizatidine EP Impurity H) is used in the preparation of thiazole derivatives. 2-(Dimethylamino)thioacetamide is an impurity of the histamine H2-receptor antagonist Nizatidine (N598500).<br>References Johnson, R.A. et al.: J. Org. Chem., 57, 2869 (1992):<br></p>

<p>Applications 2-amino-1-(4-fluorophenyl)propan-1-ol (cas# 109515-15-3) is a useful research chemical. Also, it is an intermediate used in the synthesis of p-Fluoro-4-methylaminorex (F791850), which is a derivative of Aminorex (A629200), an anorectic stimulant drug of the 2-amino-5-aryl oxazoline class. Aminorex has been shown to have locomotor stimulant effects similar to Methamphetamine (M258795).<br>References Poos, G., et al.: J. Med. Chem., 6, 266 (1963), Watson, A., et al.: Res. Vet. Sci., 45, 411 (1988), Russell, B., et al.: Pharmacol. Biochem. Behav., 51, 375 (1995),<br></p>

<p>Applications Pentachlorophenyl Cyanoacetate is an intermediate used in the synthesis of Cefacetrile (C231500), which is a cephalosporin antibiotic. Antibacterial.<br>References Dajan, A., et al.: Vet. Microbiol., 35, 213 (1993), Becker, M., et al.: Anal. Chim. Acta, 520, 19 (2004), El-Shaboury, S., et al.: J. Pharm. Biomed. Anal., 45, 1 (2007),<br></p>

<p>Applications Dimethylthiocarbamoyl Chloride is used as a reagent in the synthesis of Fluticasone Propionate (F599500); an anti-allergic, anti-asthmatic, and anti-inflammatory agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Meltzer, E.O., et al.: J. Allergy Clin. Immunol., 86, 221 (1990); Mitchison, H.C., et al.: Gut, 32, 260 (1991); Phillipps, G.H., et al.: J. Med. Chem., 37, 3717 (1994)<br></p>

<p>Applications 2-Chloro-5-(2,3-dihydro-3-oxo-1H-isoindol-1-yl)benzenesulfonyl chloride is a reagent used to prepare phthalimidines.<br>References Auerbach, J., et al: Eur. Pat. Appl. (1982), EP 51215 A2 19820512<br></p>

<p>Applications Methyl 5-bromo-4-chloro-2-fluorobenzoate<br></p>

<p>Applications 2-Fluorophenyl cyclopentyl ketone (cas# 111982-45-7) is a useful research chemical.<br></p>

<p>Applications 3,6-Dibromo-9H-carbazole is used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent.<br>References Naidoo, J., et al.: Tetrahedron Lett., 54, 4429 (2013)<br></p>

<p>Applications 2-Fluoropropiophenone (cas# 446-22-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Aminopentanenitrile Hydrochloride is a useful research chemical.<br></p>

<p>Applications 6-Bromohexene is used as a reagent in the synthesis of carbendazim dithioate analogs which can exhibit antibacterial, antifungal, and soil dehydrogenase activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zahran, M.A H., et al.: Res. J. Pharm., Biol. Chem. Sci., 6, 1084 (2015)<br></p>

<p>Applications 2-chloro-5-(dimethylsulfamoyl)benzoic acid (cas# 37088-27-0) is a useful research chemical.<br></p>

<p>Applications 1-Bromo-4-(methylsulfinyl)benzene<br></p>

<p>Applications 2-Fluoroiodobenzene is used as a reagent in various organic reactions. It is used in the synthesis of spirocyclic [1,2,3]-triazolooxazine nucleosides which have antiviral properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dell'Isola, A., et al.: Chem-Eur. J., 20, 11685 (2014)<br></p>

<p>Applications 2-Amino-5-chlorobenzonitrile is a reactant that has been used in the synthesis of pyrazine semicarbazide derivatives with herbicidal activity.<br>References Ma, Q., et. al.: Youji Huaxue, 33, 1749 (2013)<br></p>

<p>Applications 1-Bromo-2-(2,5-dimethylphenoxymethyl)benzene is an intermediate used in the synthesis of Mandestrobin (M162555), which is a novel fungicide having a methoxyacetamid structure. Mandestrobin also shows safer profiles for human health and the environment.<br>References Hirotomi, D., &amp; Kiguchi, S.: PCT Int. Appl., WO 2017026526 A1 20170216 (2017)<br></p>

<p>Applications 2,4-dihydroxy-3,5,5-bromobiphenyl is a useful building block and reactant.<br></p>

<p>Applications 2-Acetoxyisobutyryl Bromide is used as a reagent in the preparation of didehydro-dideoxyinosine phosphoramidate produgs which have anticancer activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Borek, W., et al.: Nucleos. Nucleot. Nucl., 33, 507 (2014)<br></p>

<p>Stability Hygroscopic<br>Applications 3-(Dimethylamino)propionic Acid Hydrochloride is a useful reagent for the preparation of biological active small molecules.<br>References Salado, I. G., et al.: J. Med. Chem., 57, 2755 (2014)<br></p>

<p>Applications 3,4-Dichloro-2-fluoroaniline<br></p>

<p>Impurity Mefenamic Acid EP Impurity C<br>Applications 4-Bromo-2-chlorobenzoic Acid (cas# 59748-90-2) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications 3,3,3-Trifluoro-2-(trifluoromethyl)propionyl chloride (cas# 382-19-4) is a useful research chemical.<br></p>

<p>Applications 1-Bromo-2-chloro-3-fluoro-4-(trifluoromethyl)-benzene is a useful synthetic intermediate.<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-​(Chloromethyl)​allyl-​trimethylsilane is one of the reagents to synthesize Leucasandrolide A Macrolide (I) via Mukaiyama aldol coupling.2-​(Chloromethyl)​allyl-​trimethylsilane was used in catalytic Sakurai reaction of α,​β-​enones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kopecky, D., et al.: J. Am. Chem. Soc., 123, 8420 (2001).Lee, P., et al.: J. Org. Chem., 66, 8646 (2001).<br></p>

<p>Applications 2,6-Dichloro-α-(4-chlorophenyl)(cyano)methylbenzenediazonium Chloride is an intermediate used in the synthesis of Diclazuril-13C3,15N2 (D436202), which is the labelled analogue of Diclazuril (D436200). Diclazuril is a nucleotide analogue with broad-spectrum anticoccidial activity and a coccidiostat.<br>References Maes, L., et al.: J. Parasitol., 74, 931 (1988)<br></p>

<p>Applications Octafluoroadiponitrile (cas# 376-53-4) is a useful research chemical.<br></p>

<p>Applications 2-(Diethylamino)ethyl 3-Nitro-4-propoxybenzoate Hydrochloride is a useful intermediate used in the preparation of proxymetacaine.<br>References Monguzzi, R., et al.: Eur. J. Med. Chem., 9, 214 (1974)<br></p>

<p>Applications 7-bromohept-1-yne (cas# 81216-14-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1,2,4,5-Tetrafluorobenzene (cas# 327-54-8) is a useful research chemical.<br></p>

<p>Applications N-Fluorobenzenesulfonimide is a mild electrophilic fluorinating reagent<br></p>

<p>Applications 3-(Chloromethyl)-2,4,6-trimethylbenzoic Acid (cas# 52411-49-1) is a useful research chemical.<br></p>

<p>Applications 2-Iodo-m-xylene is used in the preparation of p-(arylethynyl)arylpropanoic acid derivatives as free fatty acid receptor 1 agonists with low lipophilicity and high oral bioavailability.<br>References Christiansen, E., et al.; J. Med. Chem., 56, 982 (2013);<br></p>

<p>Applications 2-(2,2,2-Trifluoroethoxy)phenol is a reactant used for the preparation of phenyl acetate compounds with short sedative and hypnotic effect.<br></p>

<p>Applications (Bromomethyl)cyclohexane is a reagent that is used in the synthesis of cyano thiouracils as SecA inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chaudhary, A. S., et al.: Bioorg. Med. Chem., 23, 105 (2015);<br></p>

<p>Applications 2-(4-Fluoro-2-hydroxyphenyl)isonicotinic acid<br></p>

<p>Applications 2-Amino-1-(4-trifluoromethoxyphenyl)ethanone Hydrochloride is a reagent for the preparation of 4-phenylimidazole-2-thiones as tyrosinase inhibitors, their pharmaceutical and cosmetics compositions for the treatment or the prevention of the pigmentary disorders.<br>References Boiteau, J. G., et al.: From Fr. Demande (2008), FR 2917087 A1 20081212<br></p>

<p>Applications 1,1-dimethylguanidine hydrochloride (cas# 22583-29-5) is a useful research chemical.<br></p>