Organic Halides

<p>Applications 1-Iodooctane is used as a reagent to react with polyethylenimine to form ultrasensitive MRI probes that are amphiphilic in nature. These probes are then used to label chondrocyte cells for further study.<br>References Liu, G., et al.: J. Mat. Sci., Mat. Med., 22, 601 (2011)<br></p>

<p>Applications A cell-permeable, selective and irreversible PPARγ antagonist (IC50 = 3.3 nM, 32 nM, and 2 µM for PPARγ, PPARα, and PPARδ, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 µM, also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor-a (LXRa), retinoic acid receptor (RAR), retinoid X receptor-a (RXRa) and thyroid receptors a and b (TRa and TRb<br>References Huang, J.T., et al.: Nature, 400, 378 (1999), Wilson, T.M., et al.: J. Med. Chem., 43, 527 (2000), Leesnitzer, L.M., et al.: Biochemistry, 41, 6640 (2002)<br></p>

<p>Applications 4-Fluorophenethylamine<br></p>

<p>Applications (2-Fluorophenoxy)acetic acid<br></p>

<p>Applications 4-Amino-2-fluorophenol is an reagent used in various synthetic preparations such as the synthesis of Amodiaquine (A634200), an antimalarial agent.<br>References O’Neill, P.M., et al.: J. Med. Chem., 37, 1362 (1994); Berg, S.S., et al.: J. Chem. Soc., 642 (1949);<br></p>

<p>Applications 4-Bromobutyric Acid is used in the preparation of analgesic and anti-inflammatory agents as nitroalkyl ethers. It is also used in the synthesis of Autotaxin (ENPP2) inhibitors, used in tissue fibrosis regulation, cancer cell invasion and metastasis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anzini, M. et al.: J. Med. Chem., 56, 4821 (2013); Kawaguchi, M. et al.: ACS Chem. Biol. et al.: 8, 1713 (2013);<br></p>

<p>Applications 2-(4-Bromophenyl)cyclohexanone is used in the synthesis of arylcyclohexanones.<br>References Zhou, L. et al.: J. Am. Chem. Soc., 134, 17023 (2012);<br></p>

<p>Applications METHYL 2-HYDROXY-4-IODOBENZOATE (cas# 18179-39-0) is a useful research chemical.<br></p>

<p>Applications 4-Fluoro-2-formylphenylboronic acid<br></p>

<p>Applications 7-Chlorokynurenic acid is an NMDA receptor antagonist and inhibitor of EAAT.<br></p>

<p>Applications 2,5-Difluoro-1,4-phenylenediboronic acid, pinacol ester<br></p>