Organic Halides

<p>Impurity Anastrozole 1,3-Dibromomethyl Impurity<br>Applications 1,​3-​Bis(bromomethyl)​-​5-​methylbenzene is a reagent used in the synthesis of sphingosine kinase 2 inhibitors. Anastrozole 1,3-Dibromomethyl Impurity<br>References Congdon, M. et al.: Bioorg. Med. Chem. Lett., 25, 4956 (2015);<br></p>

<p>Applications 2-Amino-5-cyanobenzotrifluoride is used in the design and synthesis of 4-phenylpyrrole derivatives as androgen receptor antagonists which show efficacy against prostate cancer cells.<br>References Yamamoto, S. et al.: Bioorg. Med. Chem. Lett., 20, 422 (2012), Chen, J. et al.: Synth. Met., 160, 1953 (2010);<br></p>

<p>Applications o-Tolylhydrazine Hydrochloride is a reagent used in the organic syntheses such as opioid receptor antagonists as well as adenosine receptor antagonists as well as adenosine receptor antagonists.<br>References Colotta, V. et al.: J. Med. Chem., 43, 3118 (2000); Portoghese, P. et al.: J. Med. Chem., 33, 1714 (1990);<br></p>

<p>Applications Carbonochloridic Acid 1,2,2,2-Tetrachloroethyl Ester is used in the synthesis of Doxorubicin (D558000), is used as an antineoplastic. Also used in the synthesis of metabolites of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antine oplastic.<br>References Di Marco, A., et al.: Cancer Chemother. Rep., (part 1), 53, 33 (1969), Mihich, E. and Ehrke, M.J.: Transplant. Proc., 16, 499 (1984); Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)<br></p>

<p>Applications Nonafluoropentanoic Anhydride is a useful compound in silicon-based energy storage devices.<br>References Ji, L., &amp; Benjamin, Y.: U.S. Pat. Appl. Publ. (2020), US 20200203711 A1<br></p>

<p>Applications Isobutyryl chloride is a useful intermediate commonly used in synthetic chemistry. Isobutyryl chloride is also a potential inducer of pulmonary adenomas in strain A mice.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Theiss, J., et al.: Cancer Res., 39, 391 (1979)<br></p>

<p>Stability Hygroscopic<br>Applications 5-Chloro-2-Thiophenecarbonyl Chloride is a reagent in the synthesis of indolinyl-thiazole based inhibitors of cellular lipid uptake. Also used in the preparation of anticoagulants and such related promising drug candidates.<br>References Dockendorff, C. et al.: ACS Med. Chem. Lett.., 6, 375 (2015);<br></p>

<p>Applications (Z)-Ethyl 4-(2-(tert-butoxy)-2-oxoethoxy)-2-(2-chlorobenzylidene)-3-oxobutanoate is an intermediate for the synthesis of O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine (D289480), which is the metablolite of Amlodipine (A633495), a long-acting calcium channel blocker that is commonly used as an anti-hypertensive in the treatment of cardiovascular conditions.<br>References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986), Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987), Haria, M., et al.: Drugs, 50, 560 (1995)<br></p>

<p>Applications 1-Bromo-4-chlorobutane is used as a reagent in the synthesis of a novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Czopek, A., et al.: Bioorg. Med. Chem., 23, 3436 (2015)<br></p>

<p>Applications (S)-(-)-2-Chloropropionic Acid (cas# 29617-66-1) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Methyl 4-(Chloroformyl)butyrate is used in the synthesis of Leukotriene B4, a proinflammatory agent produced from leukocytes.<br>References Crooks, S. et al.: Int. J. Biochem. Cell. Biol., 30, 173 (1998); Wenkert, E. et al.: J. Org. Chem., 55, 6203 (1990);<br></p>

<p>Applications α,α,α-Trifluorotoluene, is used as a specialty solvent in organic synthesis and an intermediate in the production of pesticides and pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Skelly, P. D., et al.: Handbook for Critical Cleaning, 1, 191 (2011);<br></p>

<p>Applications 2,2,2-Trifluoroethyl Formate acts as a reagent for the preparation of HCV NS5B inhibitor MK-3281, an inhibitor of hepatitis C virus.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Colarusso, S., et al.: Synlett, 11, 1527 (2011)<br></p>

<p>Applications Ethyl 2-bromoethanesulfonate is a useful reagent for the esterification of sulfonic acids.<br>References Etienne, A., et al.: Comptes Rendus Acad. Sci., 275, 633 (1972)<br></p>