Organic Halides

Applications 3-Bromoanisole is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.
References Hura, N., et al.: ACS Omega, 3, 1955 (2018); Srinivas L. K., et al.: Bioorg. Med. Chem. Lett., 28, 778 (2018); Yoon, D., et al.: ACS Med. Chem. Letters, 8, 1336 (2017)

Applications PV8 (Hydrochloride), is similar to alpha-pyrrolidinophenone (alpha-PVP) which is an analog of pyrovalerone (psychoactive compound). PV8 (hydrochloride) differs from alpha-PVP as it has hexaphenone in place of the pentiophenone portion of the compound.
References Staack, R.F., et al.: Curr. Durg Metab., 6, 259 (2005); Meyer, M.R., et al.: Curr. Drug Metab. 11, 468 (2010)

Applications (+/-)-tert-Butyl 6-Chloro-5-hydroxy-3-oxohexanoate is an impurity in the synthesis of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor. Antilipemic.
References Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997), Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005), Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006);

Applications 4-(Chloromethyl)-2,4'-difluoro-1,1'-biphenyl, is a building block used in chemical synthesis of more complex compounds.

Stability Moisture Sensitive
Applications 2,3-Dichloropropionyl Chloride is used as a reagent in the synthesis of 6-chloro-5-cyclohexyl-1-indancarboxylic acid, a potent analgesic, antipyretic, and antiinflammatory agent, and its related compounds.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sawa, Y., et al.: Yakugaku Zasshi, 96, 653 (1976)

Applications (2-Chloroethoxy)methyl Chloride (cas# 1462-33-5) is a compound useful in organic synthesis.

Applications 1-Chloro-4-(chlorophenylmethyl)benzene is used in the synthesis of novel benzhydrylpiperazine derivatives as cytotoxic compounds in the treatment of various cancers.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gurdal, E. et al.: Drug Res., 63, 121 (2013); Yarim, M. et al.: Int. J. Mol. Sci., 13, 8071 (2013);

Applications Alpha-(trifluoromethyl)styrene
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Carboxymethoxyamine Hemihydrochloride (cas# 2921-14-4) is a compound useful in organic synthesis.

Applications o-Iodochlorobenzene is a building block that has been used as a reactant for the synthesis of biaryl derivatives of seasamol used for their antioxidant activity against DPPH radical.
References Rodriguez, S.A., et. al.: Australian J. Chem., 66, 1334 (2013)

Applications 1-Bromo-2,3-dimethyl-2-butene is used as a reagent in the synthesis of (+)-virantmycin (CAS#: 104871-14-9).
References Morimoto, Y., et al.: Tetrahedron, 52, 10631 (1996)

Applications 2,6-Diiodophenol is a useful reactant in organic synthesis.
References Gebara, Karimi S., et al.: Tetrahedron Let., 52(22), 2849-2852 (2011);Lv, Chunjie, et al.: Org. Let., 20(7), 1919-1923 (2018)

Applications 3-Bromo-benzenebutanoic Acid is a reactant used in the preparation of pyrrolo-(di)-benzazocinones via an intramolecular cyclization of N-acyliminium ions formed from 4,4-diethyoxybutyl amides (Erratum)
References King, F.D., et al.: Org. Biomol. Chem., 7, 5271 (2009); King, F.D., et al.: Org. Biomol. Chem., 7, 167 (2009)

Stability Moisture Sensitive
Applications Trifluoromethanesulfonic Anhydride is a strong electrophile used in chemical synthesis for introducing the triflyl group.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cai, D. et al.: Org. Synth., 10, 112 (2004);

Applications Oxydiethylene Bis(chloroformate) is a useful research intermediate for organic synthesis.
References Qian, W., et al.: Zhejiang Yike Daxue Xuebao, 25, 252 (1996); Alekseev, N. N., et al.: Kinetika i Kataliz, 29, 471 (1988); Alekseev, N. N., et al.: Plast. Massy, 5, 52 (1984)

Applications Ethyl 2-fluoropropionate is used as a solvent for lithium secondary batteries. Ethyl-2-fluoropropionate is also used as a reagent to synthesize a series of potent Nicotinic Acid (N429250) receptor agonists for the treatment of dyslipidemia, a health condition characterized by high triglyceride levels.
References Grundy, S., et al.: Arch. Intern. Med., 162, 1568 (2002); Nambu, N., et al.: Electrochemistry, 80, 746 (2012); Qin, J., et al.: ACS Med. Chem. Lett., 2, 171 (2011)

Stability Moisture Sensitive
Applications Chlorocarbonylsulfenyl chloride is a useful research chemical for organic synthesis and other chemical processes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sorra, K., et al.: Int. J. Mol. Sci., 15, 16500 (2014); Gurjar, A. S., et al.: Bioorg. Chem., 57, 90 (2014); Enache, L., et al.: e-EROS Encyclopedia of Reagents for Organic Synthesis, 1 (2005)

Applications (S)-4-Chlorostyrene oxide is used in the biosynthetic preparation though epoxidation of styrene and substituted styrenes by whole cells of Mycobacterium.
References Rigby, S. R., et al.: Bioorg. Med. Chem. 2, 553 (1994);

Applications 4,5-Dichloro-phenylenediamine (cas# 5348-42-5) is a compound useful in organic synthesis.

Applications 2,4-Dimethylbenzenesulfonyl Chloride is used as a reagent in the synthesis of dimethyl benzimidazolones as potent and selective inhibitors of BRPF1 bromodomain. 2,4-Dimethylbenzenesulfonyl Chloride is also used as a reagent in the synthesis of quinazoline analogs as glucocerebrosidase inhibitors with chaperone activity for the treatment of Gaucher disease.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Demont, E.H., et al.: ACS Med. Chem. Lett., 5, 1190 (2014); Marugan, J.J., et al.: J. Med. Chem., 54, 1033 (2011)

Stability Moisture Sensitive
Applications 1,5-Dichlorohexamethyltrisiloxane is a useful chemical in organic synthesis.
E0
References Tagne Kuate, Alain C., et al.: J. of Organometallic Chem., 751, 628-637 (2014);Basenko, S. V., et al.: Doklady Chem., 450(1), 135-138 (2013);Gao, Fei, et al.: Polymer Journal, 43(2), 136-140 (2011)

Stability Moisture Sensitive
Applications Dichloromethanesulfonyl Chloride is a useful reactant in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Opitz, Guenter, et al.: Liebigs Annalen, (12), 2151-63 (1995);Serrano, Pedro, et al.: J. of Combi. Chem., 9(1), 43-52 (2007)

Applications 3,4-Difluoro-1-nitrobenzene was used in the synthesis of nitrogen-carbon-linked (azolylphenyl)oxazolidinones with antibacterial activities. It was also used in the preparation of (homo)piperazinylphenyl- and piperidinylphenyl-substituted oxazolidinones with antibacterial activities.
References Genin, M., et al.: J. Med. Chem., 43, 953 (2000); Das, B., et al.: Bioorg. Med. Chem. Lett., 15, 4261 (2005)

Applications A metabolite of halogenated aniline.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cnubben, N.H.P., et al.: Biochem. Pharmacol., 49, 1235 (1995),

Applications 4-(4-Chlorophenyl)but-3-en-2-one (cas# 3160-40-5) is a useful research chemical.

Applications 4-Bromophenyl disulfide
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 4-Bromotoluene is used as a reagent in the preparation of aromatic diselenides which are useful for generating anticancer lead compounds.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rizvi, M.A., et al.: Bioorg. Med. Chem. Lett., 24, 3440 (2014); Leung, C., et al.: Angew Chem., Int. Ed., 52, 766 (2013)

Stability Moisture Sensitive
Applications 3,5-Dinitrobenzoyl Chloride was used as a derivatization agent for high performance liquid chromatographic analysis of several compounds including polyamines and acteylated derivatives, taurine and hypotaurine and biogenic amines in fermented foods. It was also used in the synthesis of several organic compounds including that of a novel starch derivative which has adsorption property for creatinine and may therefore be useful in treatment of renal failure.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kirschbaum, J., et al.: J. Chromatogr A., 881, 517 (2000); Wongyai, S., et al.: Biomed. Chromatogr., 2, 254 (1988); Masuoka, N., et al.: J. Chromatogr B., 660, 31 (1994); Jiu-gao, Y., et al.: Acta Pharm. Sin., 38, 191 (2003);

Applications 2-Bromo-4-nitrotoluene

Applications 2,4-Dichloroquinazoline has been used as a reactant for the preparation of 1-methyl-1H-imidazole derivatives as Jak2 inhibitors.
References Su, Q., et. al.: J. Med. Chem., 57, 144 (2014)

Applications 4-Chlorodifluoromethoxyaniline has been used as a reactant for the preparation of arylphthalazines as a potent and orally bioavailable inhibitor of VEGFR-2.
References Duncton, M. A. J., et. al.: Bioorg. Med. Chem., 17, 731 (2009)

Applications 2-Fluoro-5-(trifluoromethyl)benzoic acid

Applications 4-Bromo-2-fluorobenzamide is used as a reagent to synthesize tricyclic dihydroquinazolinones, compounds that act as anti-obesity agents. 4-Bromo-2-fluorobenzamide is also used as a reagent to synthesize imidazole pyrimidine amides, compounds that act as cyclin-dependent kinase inhibitors.
References Ahmad, S., et al.: Bioorg. Med. Chem. Lett., 20, 1128 (2010); Jones, C., et al.: Biororg. Med. Chem. Lett., 18, 6486 (2008)

Applications 7-Bromoheptanoic Acid is a reagent that is used in the synthesis of N-Heptanoic Acid Tianeptine Disodium Salt (H281500) which are metabolite of Tianeptine (T436800), having psychostimulant, anti-ulcer and anti-emetic properties.
References Malen, C., et al.: Experientia, 28, 811 (1972), Safa, A., et al.: J. Biol. Chem., 262, 7884 (1987), Ford, J.M., et al.: Pharmacol. Rev., 42, 155, (1990), Pierre, A., et a.: Cancer Res., 51, 2312 (1991),

Applications Methoxyacetyl chloride
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications ETHYL 4-AMINO-2-FLUOROBENZOATE (cas# 73792-06-0) is a useful research chemical.

Applications 2-Amino-3-bromo-5-chlorobenzoic Acid is used as a starting material in the synthesis of a series of 3-(2-(2-methoxyphenyl)-2-oxoethyl) quinazolinone derivatives, which showed anticoccidial activity against Eimeria tenella in chicken.
References Ye, Changwen., et al.: Pestic. Biochem. Phys., 97(3), 194-198 (2010)

Stability Moisture Sensitive
Applications Oleyl Chloride is used as a chemical reagent in the preparation of Vitamin E analogs as well as antiviral nucleoside phosphoramidate prodrugs used in the treatment of HIV and HBV.
References Cho, J. et al.: Bioorg. Med. Chem., 22, 6665 (2014); Iwata, R. et al.: Bioorg. Med. CHem. Lett., 25, 815 (2015);

Applications 4-Chloro-N'-hydroxybenzimidamide

Applications N-[(4-fluorophenyl)methyl]prop-2-enamide (cas# 1046471-60-6) is a useful research chemical.

Applications 2-[(2-fluorophenyl)sulfanyl]acetic acid (cas# 705-02-2) is used in the preparation of phenylsulfanylalkylcarboxylic acid compositions, useful for the delivery of active agents.
References Wang, N. F., et al.: PCT Int. Appl. 118 pp. (2008)

Applications o-Chloramine T (cas# 110076-44-3) is a useful research chemical.

Applications Dibromoisocyanuric acid is a bromine compound with a superior bactericidal activity.
References Gottardi, W., et al.: J. Appl. Microbiol., 116, 1427 (2014)

Applications 5-​Bromopentyl Acetate is used to model the toxicity of haloesters on marine bacterium such as Vibrio fischeri.
References Cornin, M.T.D, et. al.: SAR QSAR Environ. Res., 11, 301 (2000)

Applications 2-[[[(9H-Fluoren-9-ylmethoxy)Carbonyl]Amino]Methoxy]-Acetic acid is a useful reagent in organic synthesis.

Stability Hygroscopic
Applications 4-Aminophenylboronic Acid Hydrochloride is a reagent used for the synthesis of colorimetric and fluorescent nanosensor based on B, N, S-codoped carbon dots (BNS-CDs).
References Liu, Y., et al.: ACS Appl. Mater. Interfaces, 9, 12663-12672 (2017)

Applications 2-chloro-2-phenylacetamide (cas# 7462-76-2) is a useful research chemical.

Applications 4-Bromo-1,2-dimethoxybenzene is a metabolite of bromobenzene, with a catechol moiety in the substructure. It also has use as a redox shuttle additive, essentially a component in lithium batteries that consumes excess current during overcharge.
References Billings, R.E. et al.: Drugs. Metab. Disp., 13, 287 (1985); Adachi, M. et al.: J. Electrochem. Soc., 146, 1256 (1999);

Applications 3-(Cbz-Amino)-5-fluorophenylboronic acid

Applications 2,4-Dibromobenzoic acid

Applications 5-Bromopentyltrimethylammonium Bromide (cas# 15008-33-0) is a compound useful in organic synthesis.

Applications 2-Bromo-4-chloro-6-nitroanisole

Applications 2-Bromo-1,4-dichlorobenzene is a reactant used in the synthesis of C-13 and C-14-labeled versions of the investigational proteasome inhibitor MLN9708.
References Plesescu, M., et. al.: J. Labelled Compd. Rad., 56, 464 (2013)

Applications 3,3,3-trifluoro-2-oxopropanoic acid (cas# 431-72-1) is a useful reagent in the biotransformation of pentafluoropropane in rat and humans.
References Bayer, T., et al.: Chem. Res. Toxicol., 15, 723 (2002)

Applications 3-Bromothioanisole (cas# 33733-73-2) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Ethyl (Z)-3-(Dimethylcarbamoylamino)-4,4,4-trifluoro-but-2-enoate is an intermediate in the synthesis of Tiafenacil (T436300), which is a uracil herbicide used as a pesticide for the prevention and control of plants.
References Peng, X., et al. Faming Zhuanli Shenqing, 68pp Patent 2018 CODEN:CNXXEV

Applications 1-Bromo-3,4-dichlorobenzene