Organic Halides

<p>Applications Used for preparation of an inhibitor of the NLS-derived BC peptides.<br>References Byk, G., et al.: J. Med. Chem., 39, 3174 (1996), Gallay, P., et al.: J. Virol., 70, 1027 (1996), Nigg, E., et al.: Nature, 386, 779 (1997), Friedler, A., et al.: Biochemistry, 37, 5616 (1998),<br></p>

<p>Applications 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol (cas# 355-80-6) is a useful research chemical.<br></p>

<p>Applications 7-(2-Chloroethyl)theophylline (cas# 5878-61-5) is a useful research chemical.<br></p>

<p>Applications Furoyl Chloride is used in the preparation of novel dibenzothiepins that show antibiofilm activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stecoza, C. et al.: Curr. Org. Chem., 17, 113 (2013);<br></p>

<p>Applications Heptafluorobutyranilide (cas# 336-61-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Bis(2-chloroethoxy)methane is an chloroether used to manufacture polysulfide polymers.<br>References Didier, M., et al.: Indust. Engineer. Chem Res., 52, 9317 (2013);<br></p>

<p>Applications 2,3,4,5-Tetrachlorophenol is a halogenated phenol found in textiles and leather products.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhu, Feng.: Pige Kexue Yu Gongcheng, 24(4), 65-72 (2014)<br></p>

<p>Stability Hygroscopic<br>Applications Used in nucleophilic substitution.<br>References Genicot, C., et al.: Bioorg. Med. Chem. Lett., 13, 437 (2003),<br></p>

<p>Applications A reagent used in the preparation of prodrugs of diacidic nonpeptide angiotensin II antagonist as well as pyrrolothiazole platelet activating factor antagonist.<br>References Aungst, B.J. et al.: Pharmac. Res., 12, 763 (1996); Davidsen, S.K. et al.: J. Med. Chem., 37, 4423 (1994);<br></p>

<p>Applications p-Trifluoromethylphenyl is used in the synthesis of P2Y1 antagonists and antithrombotic agents. Also, used in the synthesis of potent myeloid cell leukemia inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chao, H. et al.: J. Med. Chem., 56, 1704, 2013; Friberg, A. et al.: J. Med. Chem., 56, 15 (2013);<br></p>

<p>Applications α-Chloroethyl Chloroformate (cas# 50893-53-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,4,5-trichlorobenzoic acid (cas# 50-82-8) is a useful research chemical.<br></p>

<p>Applications Methyl 5-Aminopentanoate Hydrochloride is used as a reactant to synthesize several compounds with therapeutic potential.<br>References Larson, Peter, et al.: ACS Med. Chem. Let, 8(11), 1148-1152 (2017);Li, Yongtao, et al.: J. of Med. Chem., 61(7), 3166-3192 (2018);Lu, Yuzhi, et al.: ACS Med. Chem. Let., 7(12), 1185-1190 (2016)<br></p>

<p>Applications 2,6-Dichlorobenzoic Acid is an di-halogenated benzoic acid derivative and is used in the synthesis of Lux-S enzyme inhibitor.<br>References Dhimitruka, I., et al.: Organic. Lett., 8, 47 (2006);<br></p>

<p>Applications 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]-ethanol, is used in the preparation of hydroxy(aminomethyl)pyridine derivatives.<br>References Elworthy, T.R., et al.: J. Med. Chem., 40, 2674 (1997)<br></p>

<p>Stability Unstable in DMSO solution<br>Applications Chlorimuron-ethyl is used in weed control method as herbicide.<br>References Sada, Y., et al.: PCT Int. Appl. 45 pp. (2020)<br></p>

<p>Applications 3-[3-(trifluoromethyl)phenyl]propan-1-amine (cas# 104774-87-0) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 3-[[[2-[(Diaminomethylene)amino]-4-thiazolyl]methyl]thio]propanimidamide hydrochloride (cas# 76833-47-1) is a useful research chemical.<br></p>

<p>Applications 7H-Dodecafluoroheptanoic Acid is a derivative of Heptanoic Acid (H998455) which can be used as an organic building blocks for the synthesis of variety of chemical compounds. Heptanoic Acid is used in the synthesis of 17-epi-Testosterone Enanthate (T155095). It is used in the preparation of esters, such as ethyl heptanoate, which are used in fragrances and as artificial flavors. It is also one of many additives in cigarettes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anneken, D. et al.: Fatty Acids, Ullmann's Encyclopedia of Industrial Chemistry (2006); Wudy, S., et al.: Steroids, 66, 759 (2001); Kootstra, P., et al.: Anal. Chim. Acta., 586, 82 (2007); Sten, T., et al.: Drug Metab. Dispos., 37, 417 (2009)<br></p>

<p>Applications 4-Chlorobenzenesulfonic acid is an aromatic compound that is used to synthesize a variety of sulfonyl azides. 4-Chlorobenzenesulfonic acid is also used for its effectivenes in promoting para-selective reactions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bovonsombat, P., et al.: Tetrahedron, 66, 6928 (2010); Kiani, A., et al.: J. Sulf. Chem., 35, 119 (2014)<br></p>

<p>Stability Moisture sensitive<br>Applications Diisopropyl Phosphorochloridate is a phosphorylating agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sartori: Chem. Rev., 48, (1951), Nachmansohn, et al.: Adv. Enzymology, 12, 259 (1951)<br></p>

<p>Applications 2-Amino-3-(2-chlorobenzoyl)thiophene is a useful compound for the synthetic process of Brotizolam (B689280(M)), which is a hypnotic and a sedative.<br>References Du, D. P., et al.: Zhongguo Yaowu Huaxue Zazhi, 25, 280 (2015); Sato, T., et al.: J. Med. Chem., 51, 7705 (2008); Nishino, T., et al.: J. Pharmacol. Sci., 107, 349 (2008); Yamashiro, T., et al.: J. Clin. Pharm, Ther., 33, 273 (2008); Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008)<br></p>

<p>Applications (((9H-Fluorene-9,9-diyl)bis(4,1-phenylene))bis(oxy))bis(ethane-2,1-diyl) diacrylate (CAS# 161182-73-6) is a photosensitive compound often found in film curing resins and solutions.<br>References Tanigaki, Y.; et al.: WO 2018181311 (2018).<br></p>

<p>Applications 4-(2-Chlorophenyl)-cyclohexanone is used in the synthetic preparation of cyclohexyl pyridylpiperazines as Δ8-Δ7 sterol isomerase ligands with antiproliferative activity.<br>References Berardi, F., et al.: J. Med. Chem., 51, 7523 (2008)<br></p>

<p>Applications A reagent used in the preparation of hepatitis C virus NS3 protease inhibitors and PMPA prodrugs with antiretroviral activity.<br>References Sheng, X. et al.: Bioorg, Med. Chem. Lett., 169, 3453 (2009); Arimilli, M.N. et al.: Antiviral Chem. Chemother., 8, 557 (1997);<br></p>

<p>Applications 1-(Bromomethyl)pyrene (cas# 2595-90-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Tryptamine hydrochloride (cas# 343-94-2) is a useful research chemical.<br></p>

<p>Applications Isotope labelled Trifluoroacetic Acid used as a solvent in a variety of organic synthesis and chemical processes. Used in the synthesis of anticancer agents as well as phospholipase D inhibitors.<br> E0<br>References Scott, S. et al.: Nat. Chem. Biol., 5, 108 (2009); Minko, T. et al.: Cancer. Chemother. Pharmacol., 50, 143 (2002);<br></p>

<p>Applications Ethenesulfonyl chloride is a useful reactant for the preparation of oral quinoline-based ALDH1A1 inhibitors as potential antitumor agents.<br>References Yang, SM., et al.: J. Med. Chem., 61, 4883-4903 (2018);<br></p>

<p>Stability Light Sensitive<br>Applications p-(2-Bromo)vinyl Anisole (cas# 6303-59-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Fluorinert FC 40 is a colorless, thermally stable, fully- fluorinated liquid. A useful modifier for the design of soft porous polymers.<br>References Turani-i-Belloto, A., et al.: Polymers (Basel, Switzerland), 12, 1008 (2020)<br></p>

<p>Applications 1H,1H,2H,2H-Perfluorohexyl iodide has been used for the study for fluorinated phosphonium ionic liquids as a reagent, and in general is used as a reactant in organic reactions.<br>References Rauber. D., et al.: Phys. Chem. Chem. Phys., 19, 27251-58 (2017); Hawker,R.R., et al.: ChemComm., 54, 2296-99 (2018);<br></p>

<p>Applications 2-Bromo-2-phenylacetic acid<br></p>

<p>Applications Bromothalonil can be used in biological study of comparison and validation of an in vitro skin sensitization strategy using a data set of 33 chemical references.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.<br>References Clouet, E., et al.: Toxicology In Vitro, (2017)<br></p>

<p>Applications 2-Fluorobenzamide (cas# 445-28-3) is a useful research chemical.<br></p>

<p>Applications 4'-(Trifluoromethyl)-3-biphenylcarboxylic Acid functions as a reagent in the scalable development of GPR40 receptor agonist AMG 837. A potential antidiabetic agent.<br>References Houze, J. B., et al.; Bioorg. Med. Chem. Lett., 22, 1267 (2012); Walker, S. D., et al.: Org. Process Res. Dev., 15, 570 (2011)<br></p>

<p>Applications 1,2,5,6,9,10-Hexabromocyclododecane is a flame retardant used in foamed polystyrene. One of the new POPs under the Stockholm Convention<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Larsen, E.R. et al.: J. Fire Sci., 4, 261 (1986);<br></p>

<p>Applications Dibromoformaldoxime is a reagent that undergoes cycloaddition with alkynes to prepare substituted 3-bromo-isoxazoles in high yield.<br>References Chiarino, D., et al.: J. Heterocyclic Chem., 24, 43 (1987); De Amici, M., et al.: J. Org. Chem., 54, 2646 (1989); Castelhano, A., et al.: 16, 335 (1988).<br></p>

<p>Applications 1,3-Bis(bromomethyl)benzene is a reagent used in the synthesis of germanosilicates to construct large pore zeolites. As well use to synthesize 2,4,5-triethylimidazolium scaffolds in photoactive anthracene rings.<br> E0<br>References Sabater, P. et al.: J. Org. Chem., 81, 3790 (2016); Boal, B. et al.: Chem. Mat., 28, 2158 (2016);<br></p>

<p>Applications 5-Amino-2-chlorobenzotrifluoride is a compound useful in organic synthesis. It also performs a radioprotective activity against ionizing radiations.<br>References Blickenstaff, R. T., et al.: J. Pharm. Sci., 83, 219 (1994); Kumari, P., et al.: Org. Biomol. Chem., 16, 2049 (2018)<br></p>

<p>Applications 3-Pyridylacetic Acid is a metabolite of Nicotine (N412420). 3-Pyridylacetic Acid is an antilipemic.<br>References Baer, T.A., et al.: J. Med. Chem., 16, 85 (1973); Kyerematen, G. A., et al.: Drug Metab. Dispos., 16, 125 (1988);<br></p>

<p>Applications Used for preparation of substituted indazole amides as glucokinase activators.<br>References Perles, J., et al.: J. Mater. Chem., 14, 2683 (2004),<br></p>

<p>Applications Tetrachlorohydroquinone is a chlorinated hydroquinone compound used as an analytical standard.<br></p>

<p>Applications 4-Fluorobenzoic acid<br></p>

<p>Impurity Fluorouracil EP Impurity E<br>Applications Used for the experimental and clinical treatment of neoplastic and viral diseases. Fluorouracil EP Impurity E.<br>References Yu, H., et al.: J. Biol. Chem., 268, 15935 (1993), Staleva, L., et al.: Mutat. Res., 370, 81(1996), Harris, V., et al.: J. Mol. Biol., 326, 1389 (2003)<br></p>

<p>Applications α,α-Dichlorotoluene is a chemical reagent used in organic synthesis through activation of the chlorinated methyl group. Pesticide component.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Siwek, A. et al. ChemCatChem., 9, 839 (2017);<br></p>

<p>Applications Bromocyclopropane (cas# 4333-56-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2,2-DICHLOROACETAMIDE (cas# 683-72-7) is a useful research chemical.<br></p>

<p>Applications 4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzoic Acid is a photoreactive aromatic diazirine.<br>References Wiedmann, M .; J. Cell biol.; 104, 201 (1987).<br></p>

<p>Applications 2-​Amino-​3-​chloro-​5-​trifluoromethylpyrid​ine acts as a reactant in the synthesis of novel imidazo[1,2-a]pyridine-coumarin hybrid molecules as inhibitors of NS5B in potential treatment of Hepititis C.<br>References vManvar, P. et al.: Tetrahedron 72, 1293 (2016);<br></p>