Organic Halides

Applications Tetramethylammonium Bromide (cas# 64-20-0) is a useful research chemical.

Applications 2,2’-Bs(trifluoromethyl)-10H-3,10'-biphenothiazine is an impurity in the synthesis of 2-(4-(3-(2',8-Bis(trifluoromethyl)-10H-[3,10'-biphenothiazin]-10-yl)propyl)piperazin-1-yl)ethanol (B586700), an impurity of Fluphenazine Decanoate (F598350) which is used in psychotropic drug treatments like those relating to schizophrenia.
References Frasch, K. et al.: Pharmacopay., 45, 138 (2012); Aggarwal, N. et al.: J. Clin. Psychopharmacol., 32, 323 (2012)

Applications 2-Acetylfluorene (cas# 781-73-7) is a useful research chemical.

Applications 2-Bromopropane is a compound that induces hemapoietic and reproductive effects on humans. It is known to cause male infertility and primary ovarian failure in humans as well. In the industry, 2-bromopropane is used as an alternative solvent to ozone depleting chlorofluorocarbons (e.g. 1,1,1-Trichlorotrifluoroethane [T774305]).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Park, J., et al.: J. Occup. Health, 39, 138 (1997); Takeuchi, Y., et al.: Occup. Heal. Ind. Med., 38, No pp given (1998)

Applications Crotonoyl chloride is an unsaturated acid chloride that is used as an acylation agent in synthetic chemistry. Crotonoyl chloride is also used as a reagent in the synthesis of (-)-Exiguolide, a 16-membered macrolide that is used as a fertilization inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Arumugam, V., et al.: Tetrahedron Lett., 38, 6473 (1997); Han, X., et al.: Eur. J. Org. Chem., 2013 (1193 (2013); Rathke, M. & Sullivan, D.: Tetrahedron Lett., 14, 1297 (1973)

Applications Diethyl Chlorothiophosphate is used in the preparation of various organophosporus insecticide including Flupyrazofos (F598620) and Chlorpyrifos (C425300).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Fujioka, K., et al.: Chem. Res. Toxicol. 20, 1211 (2007); Segall, Y., et al.: Chem. Res. Toxicol., 16, 350 (2003);

Applications 3-Amino-4-chlorobenzoic acid (cas# 2840-28-0) is a useful research chemical.

Applications 2’,8-Bis(trifluoromethyl)-10H-3,10'-biphenothiazine is an intermediate for the synthesis of 2-(4-(3-(2',8-Bis(trifluoromethyl)-10H-[3,10'-biphenothiazin]-10-yl)propyl)piperazin-1-yl)ethanol (B586700), an impurity of Fluphenazine Decanoate (F598350) which is used in psychotropic drug treatments like those relating to schizophrenia.
References Frasch, K. et al.: Pharmacopay., 45, 138 (2012); Aggarwal, N. et al.: J. Clin. Psychopharmacol., 32, 323 (2012)

Applications 1-Bromo-2,4-difluorobenzene is a reactant used in the preparation of azole derivatives as highly-selective fungal CYP51 inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hoekstra, W.J., et. al.: Bioorg. Med. Chem. Lett., 24, 3455 (2014)

Applications tert-Butyl 2-Bromopropanoate is a reactant used in the synthesis 3-(1-Aryl-1H-indol-5-yl)propanoic Acids as cytosolic phospholipase A2α inhibitors.
References Tomoo, T., et. al.: J. Med. Chem., 57, 7244 (2014)

Applications 2-Bromo-N-[4-chloro-2-(trifluoroacetyl)phenyl]acetamide is an intermediate in the synthesis of novel quinolinones as HIV-1 reverse transcriptase inhibitors.
References Patel, M., et al.: Bioorg. Med. Chem. Lett., 11, 1943 (2001);

Applications Acetamidine Hydrochloride (cas# 124-42-5) is a compound useful in organic synthesis.

Applications 3-Iodobenzonitrile

Applications 4-(Chloromethyl)benzoyl Chloride is used in the synthetic preparation of various compounds and pharmaceuticals. 4-(Chloromethyl)benzoyl Chloride was used in the synthesis of several imidazo[2,1-b]thiazoles.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bratulescu, G., et al.: Asian. J. Chem., 24, 350 (2012);

Applications 4-Benzyloxy-2-bromonitrobenzene (cas# 165190-62-5) is a compound useful in organic synthesis.

Applications Decanoyl Chloride is used in the synthesis of an effective metalloproteinase inhibitor. Also acts as a reagent in the synthesis of reversible α-ketoheterocycle inhibitors of fatty acid amide hydrolase as potnetial analgesics.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Levy, D. et al.: J. Med. Chem., 41m 199 (1998); Boger, D. et al.: J. Med. Chem., 48, 1849 (2005);

Applications 4-CHLORO-2-NITRODIPHENYLAMINE (cas# 16611-15-7) is a useful research chemical.

Applications 4-(Hydroxymethyl)-2-iodophenol is a reagent that is used in the synthesis of 3,3’,5-Triiodo-D-thyronine (T795375), which has been shown to reduce cholesterol in blood serum.
References Mintz, D.O., et. al.: New Engl. J. Med., 266, 808 (1962)

Applications 5-Bromo-1-(2-fluorophenyl)-2-pentanone is an intermediate in the synthesis of Prasugrel (P701150). Prasugrel is a novel antiplatelet agent; it is a third-generation thienopyridine. Antiplatelet agent Prasugrel showed greater platelet inhibition and decreased incidence of ischemic events than Clopidogrel but may induce increased incidence of bleeding in patient with acute coronary syndrome.
References Von Beckerath, N., et al.: Circulation, 112, 2946 (2005), Jernberg, T., et al.: Eur. Heart J., 27, 1166 (2006), Farid, N., et al.: Drug Metab. Dispos., 35, 1096 (2007), Farid, N., et al.: Clin. Pharmacol. Ther., 81, 735 (2007), Jakubowski, J., et al.: J. Cardiovasc. Pharmacol., 49, 167 (2007), Wiviott, S., et al.: N. Engl. J. Med., 357, 2001 (2007),

Applications 1-(2-chlorophenyl)propan-1-one (cas# 6323-18-8) is a useful research chemical.

Applications 1,3-Dihydro-5,6-dichlorobenzo(c)thiophene-S,S-dioxide1,3-dihydro-5,6-dichlorobenzo(c)thiophene-S,S-dioxide is an intermediate in the synthesis of 2,3,6,7-Tetrachloronaphthalene which is a polychlorinated naphthalene (PCN) with dioxin-like toxic properties that can lead to increased risk of liver disease. It is a potential carcinogen.
References McKinney, J.D. et al.: Safe Handl. Chem. Carcinog., Mutagens, Teratog. Highly Toxic Subst., 2, 421 (1980); Blankenship, A.L. et al.: Env. Sci. Technol., 34, 3153 (2000);
Chemical Name: McKinney, J.D. et al.: Safe Handl. Chem. Carcinog., Mutagens, Teratog. Highly Toxic Subst., 2, 421 (1980); Blankenship, A.L. et al.: Env. Sci. Technol., 34, 3153 (2000);

Applications Manganese Chloride Tetrahydrate is an inorganic chemical reagent used in oxidation studies and reactions.
References Huynh, M. et al.: J. Am. Chem. Soc., 136, 6002 (2014); Gupta, Y. et al.: Res. J. Chem. Env., 16, 48 (2012);

Applications 3,4,5-Trimethoxybenzoyl Chloride is used as a reagent in the synthesis of 2-methyl-8-(3,4,5-trimethoxybenzamido)-1,2,3,4-tetrahydroisoquinoline and its analogs which display great antihypertensive activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mathison, I.W., et al.: J. Med. Chem., 16, 332 (1973)

Applications Norflurazon (N684500) intermediate.
References Mazzola, E.P., et al.: J. Agric. Food Chem., 32, 1102 (1984),

Applications 3-​Chloroiodobenzene is used in the synthesis of is a common organic reagent used i the synthesis of a prostacyclin agonist actin in the treatment of pulmonary hypertension.
References Tran, T. et al.: J. Med. Chem., 60, 913 (2017);

Applications 1-Bromo-4-isobutylbenzene

Applications rac 1-O-Trimethylsilyl 3-Chloro-1,2-propanediol (cas# 1246820-26-7) is a compound useful in organic synthesis.

Applications Formamidine is an intermediate used to prepare Formiminoglycine which is used in biological studies for the metabolism by purinolytic clostridia. It was also used in the synthesis of 5-methyl-4,6-dihydroxypyrimidine.
References Duerre, P., et al.: J. Bacteriology, 154, 192 (1983); Novais, H., et al.: J. Phys. Chem., 91, 426 (1987)

Applications 2,6-Dichlorobenzonitrile (DCBN or dichlobenil) is a herbicide and is slightly toxic for humans. It is metabolized in the liver by the enzyme CYP2A6.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Li, H., et al.: Soil Sci. Soc. Am. J., 67, 122 (2003); Shedletzky, E., et al.: Plant Physiol., 94, 980 (1990)

Applications Dichloroacetyl Chloride is a reagent used in the synthesis of substituted benzothiazoles exhibiting antitumor and anticancer activity.
References Chua, M. et al.: J. Med. Chem., 42, 381 (1999);

Applications (±)-2-(2,4-Dichlorophenyl)-2-hydroxyethylamine is an intermediate in the synthesis of Aminoazabenzimidazoles, a novel class of orally active antimalarial agent.
References Hameed, P., et al.: J. Med. Chem., 57, 5702 (2014);

Applications 3-Fluorophenylacetone is used in the preparation of optically active cyanohydrins.
References Roberge, C. et al.: Tetrahed. Asym., 18, 208 (2007); Roberge, C. et al.: Prac. Meth. Biocat. Biotrans., 259 (2010);

Applications Methyl Pentadecafluoroheptyl Ketone 754-85-8 (cas# 754-85-8) is a useful research chemical.

Applications Ethyl 4-Iodobenzoate (cas# 51934-41-9) is a compound useful in organic synthesis.

Stability Hygroscopic
Applications A phosphonic acid derivative for development of biologically active compounds.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ma, Q.F., et al.: Biochemistry, 29, 1412 (1990), Soti, C., et al.: Eur. J. Biochem., 270, 2421 (2003), Barabas, O., et al.: J. Biol. Chem., 279, 42907 (2004),

Applications 6-Chloro-1-hexanol is used as a reagent in the synthesis of 3-(4-Chloro butyl)-1H-indole-5-carbonitrile; a key intermediate of the antidepressant drug Vilazodone (V265000).
References Anitha, N., et al.: Synthetic Commun., 44, 3563 (2014)

Applications 4-[2,2,2-Trifluoro-1-[4-(phenylmethoxy)phenyl]-1-(trifluoromethyl)ethyl]-phenol is an intermediate used in the synthesis of 4,4'-[2,2,2-Trifluoro-1-(trifluoromethyl)ethylidene]bisphenol Mono-β-D-glucuronide (T792735), which is a metabolite of 2,2-Bis-(4-hydroxyphenyl)hexafluoropropane (B447290), which acts as an endocrine-disrupting chemical (EDC), activating estrogen through the estrogen receptor ERα. It is a full agonist for the estrogen receptor.
References Matsushima, A. et al.: Environ. Health, Perspect. 118, 1267 (2010);

Applications An intermediate for the synthesis of Tamoxifen.
References Ruenitz, P.C., et al.: Biochem. Pharmacol., 34, 2807 (1985), Gilbert, J., et al.: J. Med. Chem., 40, 1104 (1997), Lashley, M.R., et al.: Bioorg. Med. Chem., 10, 4075 (2002),

Applications 2-bromo-N,N-dimethylpropanamide (cas# 54537-47-2) is a useful research chemical.

Applications 1,1'-Oxybis[2-chloro-ethane] is a carcinogen. It is an intermediate used to prepare 2,2'-[Oxybis(2,1-ethanediylimino)]bis-ethanol which is patented as one of the antibacterial oral compositions in mouthwash.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Norpoth, K., et al.: J. Cancer Res. Clin. Oncol., 112, 125 (1986); Weisburger, E., et al.: J. Nat. Cancer. Inst., 67, 75 (1981); Gaffar, A., et al.: U.S. (1980), US 4224309 A 19800923.

Applications 2,4,6-Trichloroaniline

Applications 4-Nitrobenzamidine, Hydrochloride (cas# 15723-90-7) is a compound useful in organic synthesis.

Applications Dichloromethyl Methyl Ether is a common chemical reagent used in the preparation of isothioureas focusing on the inhibition of human nitric oxide synthases. Also used in the preparation of fluorescent sensore for nerve agent mimics pharmaceutical studies.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Garvey, E. et al.: J. biol. Chem., 269, 43 (1994); Dale, T. et al.: J. Am. Chem. Soc., 128, 4500 (2006);

Applications Methyl 5-(2,2-Dibromoacetyl)-2-hydroxybenzoate is a by-product in the synthesis of Labetalol-1-carboxylic Acid (L096510), an impurity of the α-and β-adrenergic, Labetalol (L096500).

Applications Intermediate in the preparation of photolabeling and cross-linking reagent.

Applications 1-Chloro-2-propanol Phosphorochloridate is an intermediate in the synthesis of metabolite of organic flame retardants.
References Schindler, B. et al.: Anal. Bioanal. Chem., 395, 1167 (2009);

Stability Moisture Sensitive
Applications 10-Bromodecanol can be used to synthesize rotaxane dendrimers. It can also be used to synthesize J2326, a molecule that induces neurite outgrowth in neuronal cells.
References Wei, W., et al.: Proc. Natl. Acad. Sci. USA 112, 5597 (2015); Chang, P., et al.: Neuropharmacology 92, 146 (2015)

Applications Ethyl 2-bromobutyrate is used in synthetic chemistry as a polymerization initiator. Ethyl 2-bromobutyrate is also used as a reagent to synthesize Efaroxan, an imidazoline α 2-antagonist that stimulated insulin secretion in rat pancreatic cells.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ball, A., et al.: Pharm. Res., 42, 575 (2000); Bibiao. J. et al.: Eur. Polym. J., 42, 179 (2006); Chan, S. & Morgan, N.: Eur. J. Pharm., 176, 97 (1990); Xu, W., et al.: Eur. Polym. J., 39, 1349 (2003)

Applications Bupropion intermediate.
References Kelley, J., et al.: J. Med. Chem., 39, 347 (1996), Musso, D., et al.: Bioorg. Med. Chem. Lett ., 7, 1 (1997)