Organic Halides

Stability Air Sensitive, Moisture Sensitive
Applications 2,4,6-Trimethylbenzyl Chloride (cas# 1585-16-6) is a compound useful in organic synthesis.

Impurity Bupropion (S)-Hydroxy Propanone Impurity
Applications Bupropion intermediate.
References Kelley, J., et al.: J. Med. Chem., 39, 347 (1996), Musso, D., et al.: Bioorg. Med. Chem. Lett ., 7, 1 (1997)

Stability Moisture Sensitive
Applications Tert-Butyldimethylsilyl Trifluoromethanesulfonate is a highly reactive silylating agent and lewis acid capable of converting primary, secondary and tertiary alcohols to their respectctive TBDMS. Tert-Butyldimethylsilyl Trifluoromethanesulfonate is also used to covert ketones and lactones into their enol silyl ethers.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hua, D.H. et al.: e-ROS Encyc. Reag. Org. Synth., No pp. given (2001); Suzuki, T. et al.: Synthesis, 4, 555 (2001);

Applications 2-(4-Chlorophenyl)ethylamine has been used as a reactant in the preparation of isoalloxazine derivatives as cholinesterase inhibitors with a potential use in Alzheimer therapy.
References Kanhed, A.M., et. al.: Bioorg. Chem., 61, 7 (2015)

Applications 1-Bromo-2,4-difluorobenzene is a reactant used in the preparation of azole derivatives as highly-selective fungal CYP51 inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hoekstra, W.J., et. al.: Bioorg. Med. Chem. Lett., 24, 3455 (2014)

Applications (4-Bromobutyl)triphenylphosphonium Bromide is used in the synthesis of cell-penetrating peptoids with cationic side chains.
References Koelmel, D. K., et al.: Eur. J. Med. Chem., 79, 231(2014)

Applications 1-​Bromododecane (n-Lauryl Bromide) is a reagent used in the synthesis of porous organic polymers.
References Zhao, Y. et al.: ACS Macro. Lett., 7, 300 (2018);

Applications Used in the preparation of phenyloxadiazolyl pyridines as immunomodulating agents.
References Iwakubo, M., et al.: Bioorg. Med. Chem., 15, 350 (2007), Schaafsma, D., et al.: Eur. J. Pharmacol., 585, 398 (2008),

Applications Used for preparation of substituted heteroaryl- and phenylsulfamoyl compounds as peroxisome proliferator activator receptor (PPAR) agonists.
References Yao, Z., et al.: Bioorg. Med. Chem., 6, 1799 (1998), Fischer, E., et al.: Science, 253, 401 (1991), Andersen, H., et al.: J. Biol. Chem., 275, 7101 (2000),

Applications N-(2-Chloroethyl)benzenesulfonamide is an intermediate for the synthesis of Bensulide (B166000), which is an organophosphate acetylcholinesterase inhibitor used as an herbicide (1) in the protection of crops through pesticides (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.

Applications 3-Fluorophenylacetone is used in the preparation of optically active cyanohydrins.
References Roberge, C. et al.: Tetrahed. Asym., 18, 208 (2007); Roberge, C. et al.: Prac. Meth. Biocat. Biotrans., 259 (2010);

Applications 2,4,6-Trimethyliodobenzene (cas# 4028-63-1) is a useful research chemical.

Applications rac-Trifluorolactic Acid is a derivative of DL-Lactic Acid (L113490) which occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity.
References He, W. et al.: Comp. Biochem. Phys. Part A: Mol. Int. Phys., 166, 308 (2013)

Applications Diphenyl Chlorophosphonate, is a building block used for the synthesis of various chemical compounds. It can be used for the synthesis of phosphate esters of polyhedral hydroxyboranes, showing enhanced tumor uptake.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bechtold, R., et al.: J. Med. Chem., 18, 371 (1975);

Applications 2-Bromo-6-chloroaniline is an intermediate in the synthesis of Diclofenac Monobromo Sodium Salt (D436490), which is a bromide impurity of Diclofenac (D436450).
References Moser, P., et al.: J. Med. Chem., 33, 2358 (1990),

Applications ISOPROPYL TRIFLUOROACETATE (cas# 400-38-4) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2-Chloro-5-(hydrazinocarbonyl)benzenesulfonamide is an intermediate in the synthesis of Besulpamide (B319750) which is an antihypertensive agent. It also exhibits diuretic activity in rats and dogs.
References Bojarska, J., et al.: J. Mol. Struct. 1116, 22 (2016); Colombo, M., et al.: Methods Find Exp Clin Pharmacol. 9, 101 (1987); Esteve, J., et al.: Methods Find Exp Clin Pharmacol.9, 121 (1987)

Applications 2-Chloro-1,3-benzothiazole-6-carboxylic acid

Stability Moisture Sensitive
Applications Cyclopropanecarbonyl Chloride is a reagent used in the synthesis of orally bioavailable HCV NS5A inhibitor for the treatment of Hepatitis C virus.
References Kang, IJ. Med. Chem., 60, 228 (2017);

Applications 5-Amino-2-chloro-4-fluorobenzoic Acid is an intermediate in the synthesis of Saflufenacil-d7 (S081802). Saflufenacil-d7 is the labeled version of Saflufenacil (S081800), which is a herbicide of the pyrimidinedione chemical class used for the preplant burndown and selective preemergence dicot weed control in different field crops. It was found to inhibit protoporphyrinogen IX oxidase (PPO) enzyme.
References Knezevic, S., et al.: Crop Prot., 29, 148 (2010); Grossmann, K., et al.: Weed Sci., 58, 1 (2010)

Applications Formamidine is an intermediate used to prepare Formiminoglycine which is used in biological studies for the metabolism by purinolytic clostridia. It was also used in the synthesis of 5-methyl-4,6-dihydroxypyrimidine.
References Duerre, P., et al.: J. Bacteriology, 154, 192 (1983); Novais, H., et al.: J. Phys. Chem., 91, 426 (1987)

Applications 2,6-Dichlorobenzonitrile (DCBN or dichlobenil) is a herbicide and is slightly toxic for humans. It is metabolized in the liver by the enzyme CYP2A6.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Li, H., et al.: Soil Sci. Soc. Am. J., 67, 122 (2003); Shedletzky, E., et al.: Plant Physiol., 94, 980 (1990)

Applications 2-Amino-3-chloro-1,4-benzenedicarboxylic Acid 1,4-Dimethyl Ester is a ueful synthetic interemediate.

Stability Moisture Sensitive
Applications 4-Chlorobenzyl Chloride is a benzylchloride derivative used in the preparation of various biologically active compounds such as bronchodilators and antibacterial agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Adams, M. et al.: Synth. Comm., 29, 2419 (1999); Foroumadi, A. et al.: Arch. Pharm. Res., 30, 138 (2007);

Applications 2-(Acetylamino)-2-[2-(4-bromo-2-chlorophenyl)ethyl]propanedioic Acid 1,3-Diethyl Ester (cas# 1346604-54-3) is a compound useful in organic synthesis.

Applications A useful synthetic intermediate. It is used as a reactant in synthetic preparation of chiral 2-carboxy cyclic ethers.
References Zhu, S., et al.: J. Am. Chem. Soc., 132, 16374 (2010);

Applications 3-​Chloroiodobenzene is used in the synthesis of is a common organic reagent used i the synthesis of a prostacyclin agonist actin in the treatment of pulmonary hypertension.
References Tran, T. et al.: J. Med. Chem., 60, 913 (2017);

Applications N-(3-Chloro-4-fluorophenyl)-2-cyanoacetamide (cas# 219529-31-4) is a compound useful in organic synthesis.

Applications 2-bromo-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4h)-one (cas# 10513-26-5) is a useful research chemical.

Applications 2,4,6-Trichloroaniline

Applications 1-Bromo-4-(t-butyldimethylsilyloxy)butane

Applications Methyl 5-(2,2-Dibromoacetyl)-2-hydroxybenzoate is a by-product in the synthesis of Labetalol-1-carboxylic Acid (L096510), an impurity of the α-and β-adrenergic, Labetalol (L096500).

Applications Methyl Pentadecafluoroheptyl Ketone 754-85-8 (cas# 754-85-8) is a useful research chemical.

Applications Trichloroacetic Anhydride is used in organometallic reactions as well as oxadiazole containing 5-lipoxygenase activating protein inhibitors.
References Takahashi, H. et al.: J. Med. Chem., 58, 1669 (2015);

Applications α-Chlorophenylacetyl Chloride is a reagent used for dehydrohalogenation of ketones.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Brady, W.T., et al.: J. Org. Chem., 45, 3525 (1980); Brady, W.T., et al.: J. Org. Chem., 45, 2025 (1980);

Applications 2-Chloro-5-nitrotoluene (cas# 13290-74-9) is a useful research chemical.
References Mi, Z., et al.: J. Polym. Sci. A Polym. Chem., 55, 3253 (2017); Zhang, Y., et al.: Org. Process Res. Dev., 20, 799 (2016)

Applications tert-Butyl 2-Bromopropanoate is a reactant used in the synthesis 3-(1-Aryl-1H-indol-5-yl)propanoic Acids as cytosolic phospholipase A2α inhibitors.
References Tomoo, T., et. al.: J. Med. Chem., 57, 7244 (2014)

Applications 2-Bromo-5-nitroanisole

Applications 2-(4-Chlorophenyl)-1-phenylethanone is an intermediate in the synthesis of pyrrobutamine which is antihistaminic. Also used as a reagent on the synthesis of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines which display antileukemic annd antiplatelet properties.
References Casy, A.F., et al.: J. Pharm. Pharmacol., 22, 270 (1970); Ramajayam, R., et al.: Eur, J. Med. Chem., 43, 2004 (2008);

Applications Hydrofluoric Acid is a common chemical reagent used as a precursor to most pharmaceutical and high volume fluoride compounds as well as in the oil refinery process. Hydrofluoric acid causes skin burns if contact with skin.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yamashita M. et al.; Crit. Care. Med., 29, 1575 (2001); Stahl, K. et al.: Ind. Eng. Chem., 7, 56 (1915);

Applications 3-Bromo-4,6-difluorobenzoic Acid (cas# 28314-83-2) is a compound useful in organic synthesis.

Applications SUCCINYL CHLORIDE (cas# 543-20-4) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications cis-3-(2-Chloro-3,3,3-trifluoro-1-propen-1-yl)-2,2-dimethyl-cyclopropanemethanol is a reactant used in the preparation of pyrethroid compounds as pesticides.

Applications 5-δ-Bromobutylhydantoin (cas# 28484-49-3) is a compound useful in organic synthesis.
References Can. J. Res., 26B, 387 (1948)

Applications 2-CHLOROSTYRENE (cas# 2039-87-4) is a useful research chemical.

Applications Impurity produced during the synthesis of antiarrhythmic N-(Piperidylalkyl)trifluoroethoxybenzamides

Applications 2,3,4-Trichloronitrobenzene is a useful synthetic intermediate that is mainly used as the starting material in the synthesis of third generation quinolone antibacterial drugs, such as Lomefloxacin (L469415, HCl) and Ofloxacin (O245750). 2,3,4-Trichloronitrobenzene is also used as the starting material in the synthesis of Aclonifen (A190200); a compound used as a pesticide and herbicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lu, Y., et al.: Guangdong Huagong, 36, 20 (2009); Laini, A., et al.: Sci. Total Environ., 438, 312 (2012); Fantke, P., et al.: Enviorn. Int., 49, 9 (2012)

Applications 2,4-Difluorophenyl Isothiocyanate (cas# 141106-52-7) is a compound useful in organic synthesis.

Applications Methyl 3-(4-chlorophenyl)-3-oxopropanoate (cas# 22027-53-8) is a useful research chemical.

Applications 3,5-Dichloro-2,6-dimethoxybenzoic Acid is an intermediate in the synthesis of doapmine D2 receptor antagonists.
References Fei, X.S., et al.: Syn. Commun., 34, 1897 (2004); Karimi, F., et al.: J. Chem. Soc. 20, 2256 (2002); Ehrin, E., et al.: J. Labelled Comp. Radiopharm., 24, 931 (1987);