Organic Halides

Applications 2-t-Butyl-3-hydroxy-4-trifluoromethylisoindolin-1-one

Applications 3-chloro-5-fluoro-4-hydroxybenzoic acid (cas# 455-57-2) is a useful research chemical.

Applications 4-(Dimethylphosphinyl)benzenamine Hydrochloride is the salt form of 4-(Dimethylphosphinyl)benzenamine, a reactant in the preparation of 9-(arenethenyl)purines as dual Src/Abl kinase inhibitors.
References Huang, Wei-Sheng, et al.: J. of Med. Chem., 52(15), 4743-4756 (2009)

Applications 1,​1,​1,​2-​Tetrachloroethane is a chlorinated hydrocarbon and used as a solvent for cellulose, acetate, fat, waxes, greases, rubber, and sulfur. It is a contaminant in groundwater. 1,​1,​1,​2-​Tetrachloroethane can also induce heptotoxicity.Environmental contaminants; food contaminants.
References Lorah, M. M., and Olsen, L. D. Environ. Sci. Technol. 33, 227 (1999); Zheng, R. D., et al.: J Dig Dis. 13, 321 (2012)

Applications Bis[2-(2-chloroethoxy)ethyl] Ether, is an impurity in the synthesis of 2-[2-[2-(2-Chloroethoxy)ethoxy]ethoxy]ethanol (C365875), which is a polyethylene glycol used in the synthesis of novel glycolipids that bind HIV-1 cell surface glycoprotein Gp120 with potential application to pharmaceutical HIV-1 drugs. Also used in the synthesis of PET imaging agents targeting brain β-amyloid.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References LaBell, R. et al.: Bioconj. Chem., 13, 143 (2002); Zhang, W. et al.: Nucl. Med. Biol., 32, 799 (2005);

Applications 1-Iodo-3-nitrobenzene is a reactant used int he synthesis of Vismodegib (V674700), an, antineoplastic drug that targets the Hedgehog (Hh) pathway. Inhibition of the Hh signaling may be effective in the treatment and prevention of many types of human cancers.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cao, M., et. al.: Chem. Papers, 68, 1408 (2014); Gupta, S. et al.: Ther. Advances in Med. Oncology 2,237(2010)

Applications 6-Chloro-7-deazaguanine (cas# 84955-31-7) is a compound useful in organic synthesis.

Applications N-Phenyl 2-Bromo-5-Fluorobenzamide (cas# 949443-48-5) is a useful research chemical.

Applications Dichloramine B (cas# 473-29-0) is a useful research chemical.
E0

Applications 3-Fluoropyruvic Acid is a useful building block and has been proposed to have a mechanistic effect on the inactivation of mandelate racemase.
References Nagar, M.; et al.: Biochemistry, 54, 2747 (2015).

Applications 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is used in the analysis of Watson-Crick and Hoogstein base pairing in nucleotides. Also used in the formation of ribavirin chemical delivery systems.
References Schlitt, K. et al.: Org. Biomol. Chem., 9, 1565 (2011); Deyrup, M. et al.: Antivir. Chem. Chemo., 2, 337 (1991);

Applications 4-Borono-2-(trifluoromethyl)benzoic acid

Applications 1,3,6,8-Tetrabromopyrene is used as a reactant in the synthesis of pyrene-centered starburst oligofluorenes which display good film forming ability and sky blue fluroescence and used in electroluminescent devices.
References Liu, F., et al.: Macromol. Rapid Comm., 29, 659 (2008);

Applications 2-Bromo-6-morpholinobenzonitrile (cas# 1129540-65-3) is a useful research chemical.

Applications 1,2-Dichloro-4-nitrobenzene is an intermediate in the synthesis of agrochemicals. Studies have been conducted to use 1,2-Dichloro-4-nitrobenzene as an organic intermediate for the synthetic preparation of ciprofloxacin (C482500).
References Lu, C.S., et al.: Adv. Mater. Res., 396, 2379 (2012); Suzuki, H., et al.: Synthesis., 841 (1994); Wang, P.C., et al.: Cataly. Commun., 14, 42 (2011);

Applications Phenylsulfenyl Chloride is an intermediate used in the synthesis of Tabanone (T003450), which is found in oils of Trifolium pratense L. and is a potential natural anti-oxidant.
References Vlaisavljevic, S., et. al.: Molecules, 19, 713 (2014)

Applications 2-(2,2,2-Trifluoroethoxy)phenol is a reactant used for the preparation of phenyl acetate compounds with short sedative and hypnotic effect.

Applications N-Fluorobenzenesulfonimide is a mild electrophilic fluorinating reagent

Applications 2-(Diethylamino)ethyl 3-Nitro-4-propoxybenzoate Hydrochloride is a useful intermediate used in the preparation of proxymetacaine.
References Monguzzi, R., et al.: Eur. J. Med. Chem., 9, 214 (1974)

Applications 9-chloro-1,2,3,4-tetrahydroacridine (cas# 5396-30-5) is a useful research chemical.

Applications 2,6-Dichloro-α-(4-chlorophenyl)(cyano)methylbenzenediazonium Chloride is an intermediate used in the synthesis of Diclazuril-13C3,15N2 (D436202), which is the labelled analogue of Diclazuril (D436200). Diclazuril is a nucleotide analogue with broad-spectrum anticoccidial activity and a coccidiostat.
References Maes, L., et al.: J. Parasitol., 74, 931 (1988)

Stability Hygroscopic, Water Sensitive
Applications A useful synthetic intermediate.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 4-(Trifluoromethyl)benzonitrile is used in the synthesis of quinazolines for amidines. Also used in the synthesis of s-transferase p1-1 and cancer cell proliferation.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lv, Y. et al.: Chem. Comm., 49, 6349 (2013); Yang, X. et al.: J. Med. Chem., 53, 1015 (2010);

Applications Ammonium 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonate (CAS# 29081-56-9) is a fluorosurfactant used as an additive to increase heat stability and resistance of materials.
References Gloeckner, V.; et al.: Tenside, Surfactants, Detergents, 26, 376 (1989).

Applications 4-​Morpholinocyclohex-​1-​en-​1-​yl Trifluoromethanesulf​onate is a reagent used in the preparation of inhibitors of c-Jun N-terminal kinase in the treatment of neurodegenerative disorders and autoimmune diseases.
References Graczyk, P. et al.: PCT Int. Appl. (2010), WO 2010015803 A1 20100211.

Applications A reagent used in the preparation of prodrugs of diacidic nonpeptide angiotensin II antagonist as well as pyrrolothiazole platelet activating factor antagonist.
References Aungst, B.J. et al.: Pharmac. Res., 12, 763 (1996); Davidsen, S.K. et al.: J. Med. Chem., 37, 4423 (1994);

Applications 2,2,2-Trifluoroethyl trifluoroacetate is a reagent that is used in the synthesis of Dimethyl Diazomethylphosphonate (D470900).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 4,5-Dichlorothiophene-2-carboxylic Acid is used in the preparation of compounds that have therapeutic BACE1 and BACE2 inhibitors which are used for the treatment of Alzheimer’s disease, type 2 diabetes and other metabolic disorders.
References Banner, D., et al.: PCT Int. Appl., 2011:1438553 (2013)

Applications Intermeidate in the preparation of many GABA modulators
References Stafford, J., et al.: Bioorg. Med. Chem. Lett., 12, 3215 (2002), Fadeyi, O., et al.: Bioorg. Med. Chem. Lett., 18, 4172 (2008),

Applications 1-Bromo-2-fluorobenzene is used as a reagent in the synthesis of organic compounds inlcuding that of brominated N-arylated carbazoles which are widely useful in organic chemistry.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, L., Synthesis, pages ahead of print, (2015);

Applications 2-​Bromo-4-​thiazolesulfonyl chloride is a useful chemical for research.

Applications 5-Aminopentanenitrile Hydrochloride is a useful research chemical.

Applications Ethyl 2-bromoethanesulfonate is a useful reagent for the esterification of sulfonic acids.
References Etienne, A., et al.: Comptes Rendus Acad. Sci., 275, 633 (1972)

Applications α,α,α-Trifluorotoluene, is used as a specialty solvent in organic synthesis and an intermediate in the production of pesticides and pharmaceuticals.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Skelly, P. D., et al.: Handbook for Critical Cleaning, 1, 191 (2011);