Chiral Organic Compounds

Impurity Tadalafil EP Impurity A
Applications The (6R)-cis-enantiomer of Tadalafil (T004500). Tadalafil Impurity (6R,12aS)
References Aldridge, J., et al.: Br. Med. J., 318, 669 (1999), Daugan, A., et al.: J. Med. Chem., 46, 4533 (2003), Vredenbregt, M., et al.: J. Pharm. Biomed. Anal., 40, 840 (2006),

Stability Very Hygroscopic
Applications 2-O-α-D-Glucosylglycerol is used to prepare glycoglycerolipid analogs active as antitumor-promoters the influence of the anomeric configuration.
References Colombo, D., et al.: Eur. J. Med. Chem., 35, 1109 (2000);

Applications Di(α-tocopherol) Phosphate is used as a vitamin E supplement.
References Libinaki, R., et al.: Food Chem. Toxicol., 44, 916 (2006)

Applications GDC 0152 is a peptidomimetic small molecule antagonist of inhibitor of apoptosis (IAP) proteins with antitumor activity.
References Yue, Q., et. al.: Drug Metab. Dispos., 41, 508 (2013)

Applications A potent novel activators of large-conductance Ca2+-activated K+ channel.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Imaizumei, Y. et al.: Mol. Pharmacol., 62, 836 (2002); Chang, S. et al.: AM. J. Physiol., 298, F1416 (2010);

Applications A new calcium sensing receptor ligand demonstrating potent calcilytic activity.
References Ray, N., et al.: J. Bone Miner. Res., 12, 24 (1997), Sato, M., et al.: J. Med. Chem., 42, 1 (1999),Rodan, G., et al.: Science, 289, 1508 (2000), Goltzman, D., et al.: Nat. Rev. Drug Discov., 1, 784 (2002), Petrel, C., et al.: J. Biol. Chem., 279, 18990 (2004),

Stability Hygroscopic
Applications Deoxypyridinoline Chloride Trihydrochloride Salt a collagen cross-links agent. A primary reference material for the monitoring of bone metabolism.
References Heaney, R., et al.: J. Bone Miner. Res., 5, 1135 (1990), Hannon, R., et al.: J. Bone Miner. Res., 13, 1124 (1998), Coudray, C., et al.: Eur. J. Nutr., 42, 91 (2003), Abrams, S., et al.: Am. J. Clin. Nutr., 82, 471 (2005),

Applications Bisabolene is a sesquiterpene and can be extracted from oregano and other aromatic plants. It may be a potential anticancer agent that can induce apoptosis in A549 cancer cell line.
References Grosso, N. R., et al.: Argent., Pat. Appl. AR 90961 A1 20141217 (2014); Yfanti, P., et al.: Am J Plant Sci. 6, 2092 (2015)

Stability Hygroscopic
Applications 4-Desacetamido-4-chloro Andarine is a Selective Androgen Receptor Modulator (SARM) that has potential use for treatment of androgen related diseases such as muscle wasting and osteoporosis. 4-Desacetamido-4-chloro Andarine also a derivative of Andarine (A637470), a non-steroidal SARM that is used by athletes to enhance performance.
References Jones, A., et al.: Endocrinology, 150, 385 (2009); Marhefka, C., et al.: J. Med. Chem., 47, 993 (2004); Thomas, A., et al.: Rapid Comm. Mass Spec., 24, 1124 (2010)

Applications N-Jasmonyl-L-Isoleucine (Mixture of Diastereomers) is a plant horomone.
References Chen, Y., Chen, Z.: J. Separation Sci., 36, 892 (2013)

Applications Desacetyl Forskolin is an analogue of Forskolin (F701800). Desacetyl Forskolin was tested for its ability to activate rat brain adenylate cyclase, activate detergent-solubilized rat brain adenylate cyclase, increase cyclic AMP in intact S49 wild-type cells, and inhibit the binding of 3H-forskolin to rat brain membranes.
References Desouza, N., et al.: Med. Res. Rev., 3, 201 (1983); Seamon, K., et al.: J. Med. Chem., 26, 436 (1983); Seguin, E., et al.: Planta Medica, 54, 4 (1988);

Impurity Rac-Vildagliptin Impurity F
Applications Vildagliptin Lactam is an impurity of Vildagliptin (V305000). Glyptins are class of oral anti-hyperglycemic agents that inhibit dipeptidyl peptidase 4 (DPP-4), which can act as a serine exopeptidase. ASide from there use in type 2 diabetes, gliptins have positive cardiovascular and anti-inflammtatory effects. Antidiabetic.
References Ahren, B., et al.: J. Clin. Endocrinol. Metab., 89, 2078 (2004), Ahren, B., et al.: Diabetes Care, 27, 2874 (2004), Barlocco, D., et al.: Curr. Opin. Invest. Drugs, 5, 1094 (2004),

Stability Hygroscopic
Applications 10-O-2,2-Dichloroethoxycarbonyl Docetaxel is an impurity of Docetaxel (D494420); an antineoplastic and antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin.Docetaxel Impurity 1.
References Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991); Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)

Impurity Orlistat USP Related Compound D
Applications N-Formyl-L-leucine (3S,4R,6S)-3-Hexyltetrahydro-2-oxo-6-undecyl-2H-pyran-4-yl ester is an impurity of Orlistat (O686500). Orlistat USP Related Compound D.
References Stalder, H., et al.: Helv. Chim. Acta , 75, 1593 (1992),

Impurity Simvastatin EP Impurity C
Applications Dehydro Simvastatin (Simvastatin EP Impurity C) is a Simvastatin (S485000) impurity.
References Carlucci, G., et al.: J. Pharm. Biomed. Anal., 10, 693 (1992), Nagarajan, R., et al.: Langmuir, 16, 6400 (2000), Wang, L., et al.: J. Pharm. Biomed. Anal., 21, 1243 (2000),

Applications Rivaroxaban Pseudodimer is an impurity of Rivaroxaban (R538000), a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.
References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),