Toxicology

<p>Applications 20(3'-Oxo-caspofungin) Triflate Salt is derived from Pneumocandin B0 (P645300), which is the major analogue of a family of lipopeptides isolated from several species of several different genera, such as Cryptosporiopsis, Glarea and Pezicula. Pneumocandin B0 is a potent antifungal and acts by inhibition of the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi.<br>References Schwartz, R., et al.: J. Antibiot., 45, 1853 (1992); Petersen, L., et al.: Appl. Microbiol. Biotechnol., 62, 263 (2003), Petersen, L., et al.: Appl. Microbiol. Biotechnol., 62, 263 (2003)<br></p>

<p>Applications 3,4-Dimethoxybenzenesulfonyl Chloride is used in the synthesis of aryl sulfonamides as selective carbonic anhydrase IX and XII inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rosatelli, E., et. al.: Bioorg. Med. Chem. Lett., 24, 3422 (2014)<br></p>

<p>Applications 3'-Deoxyadenosine 5’-(2,2,2-Trifluoroacetic Phosphoric Anhydride) is an intermediate in the synthesis of 3'-Deoxyadenosine 5’-Triphosphate Triethylamine Salt (D232070), a salt form of 3'-Deoxyadenosine 5’-Triphosphate(D232070). 3'-Deoxyadenosine 5’-Triphosphate is a nucleotide and was shown to inhibit the replication of hepatitis C virus in human hepatoma cells.<br>References Arnold, Jamie J., et al.: PLoS Pathogens, 8(11), e1003030 (2012)<br></p>

<p>Applications Heterocyclic inhibitor of the RNA-dependent RNA polymerase enzyme transcribed by the Hepatitis C virus.<br>References Dhanak, D., et al.: J. Biol. Chem., 277, 38322 (2002), Liu, Y., et al.: Biochem., 45, 11312 (2006), Tedesco, R., et al.: J. Med. Chem., 49, 971 (2006),<br></p>

<p>Applications Methyl 3-(Hydroxymethyl)benzoate is used in the synthetic preparation of N-acylhydrazone derivatives as lactate dehydrogenase A inhibitors.<br>References Rupiani, S., et al.: J. Med. Chem., 101, 70 (2015)<br></p>

<p>Applications Avibactam Butylammonium Salt is a novel β-lactamase inhibitor with a non-lactam structural scaffold. Avibactam irreversibly inhibits lactamase from Mycobacterium tuberculosis.<br>References Iland, C., et al.: J. Pathol. Bacteriol., 58, 495 (1946); Flores, A., et al.: Microbiology, 151, 521 (2005); Livermore, D., et al.: J. Antimicrob. Chemother., 62, 1053 (2008); Tremblay, L., et al.: Biochemistry, 49, 9685 (2010)<br></p>

<p>Applications Itraconazole Desethylene-seco-piperazine Di-N-formyl Impurity is a by-product in the synthesis of Itraconazole Desethylene-seco-piperazine Mono-N-formyl Impurity (I937520), which is an impurity of Itraconazole (I937500). Itraconazole is an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.<br>References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),<br></p>

<p>Applications Vidarabine, is an antiviral drug which is active against herpes simplex and varicella zoster viruses.<br>References Sneader, W., et al.: Drug Discovery, 258 (2005); Lee, W. W., et al.: J. Am. Chem. Soc., 82, 2648 (1960);<br></p>

<p>Stability Hygroscopic<br>Applications Nicotine-N-(4-deoxy-4,5-didehydro)-β-D-glucuronide is a possible metabolite of Nicotine (N412420).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Ethychlozate<br></p>

<p>Applications Labelled analogue of Fenthion Sulfoxide, the sulfoxide anlogue and metabolite of the organothiophosphate insecticide Fenthion (F278000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wallnoefer, P. et al.: Pflanzensch.-Nach., 29, 236 (1976); Minelli, E.V. et al.: J. Agric. Food. Chem., 44, 936 (1996);<br></p>

<p>Applications A Nicorandil (N398500) derivative<br></p>

<p>Applications An amine reactive trifunctional cross linker.<br></p>

<p>Applications (6R,7S)-Cefoperazone Sodium Salt is the enantiomer of Cefoperazone (C242900) as an impurity.<br>References Fabre, H., et al.: J. Pharm. Sci., 73, 611 (1984), Strasters, J., et al.: Anal. Chem., 63, 2503 (1991), Chen, Z., et al.: World Notes Antibiot., 25, 249 (2004),<br></p>

<p>Applications Terbufos is used as an organophosphorus insecticide and nematicide (1,2). May induce apoptosis with reactive oxygen species present.Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Fillion J. et al.: J AOAC Int. 2000 May-Jun;83(3):698-713. 2. Kojima H. et al.: Environ Health Perspect. 2004 Apr;112(5):524-31.<br></p>

<p>Applications An intermediate for insecticide.<br>References Cole, L., et al.: Pestic. Biochem. Physiol., 46, 47 (1993), Cole, L., et al.: Life Sci., 56, 757 (1995), Hosie, A., et al.: Br. J. Pharmacol., 115, 909 (1995),<br></p>

<p>Applications Analgesic.<br>References Viaud, et al.: J. Pharm. and Pharmacol., 6, 361 (1954),<br></p>

<p>Applications Linezolid Dimer is an impurity of the antibacterial agent Linezolid (L466500).<br></p>

<p>Applications Pitavastatin 1-Phenylethylamide is an impurity of Pitavastatin (P531000), which is a competitive inhibitor of HMG-CoA reductase. Antilipemic.<br>References Aoki, T., et al.: Arzneim.-Forsch., 47, 904 (1997), Yamada, I., et al.: Xenobiotica, 33, 789 (2003), Park, S., et al.: Clin. Ther., 27, 1074 (2005),<br></p>

<p>Applications N-Acetyl-S-(4-hydroxy-2-methyl-2-trans-buten-1-yl)-L-cysteine is a metabolite of Isoprene.<br>References Pecivova, P. et al.: J. Sci. Food Agric., 90, 1681 (2010); Hui, N. et al.: Meat Sci. Appl., 74 (2001); Kiviharju, K. et al.: J. Biotechnol., 117, 299 (2005);<br></p>

<p>Applications (S)-Benzylphenobarbital is a derivative of Phenobarbital (P316760), which is an Anticonvulsant; sedative; hypnotic.<br>References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Chao, M.K.C., et al.: Anal. Profiles Drug Subs., 7, 359 (1978),<br></p>

<p>Applications Imiprothrin is an analytical standard that is also used in insect neurotoxin research.<br></p>

<p>Applications Protected metabolite of Mycophenolic Acid.<br>References Nelson, P., et al.: J. Med. Chem., 39, 4181 (1996), Ubukata, M., et al.: Bioorg. Med. Chem. Lett., 17, 4767 (2007),<br></p>

<p>Applications 2,6-Dibromo-4-cyanophenyl Octanoate-d15 is a useful isotopically labeled compound of Bromoxynil Octanoate (B694345)<br></p>

<p>Applications Nabam-d4 Hexahydrate is a labeled fungicide used to synthesize zinc ethylenebis(dithiocarbamate):amine complexes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Clifford, D.P., Carson, C.: Pesticide Sci., 23, 93 (1988)<br></p>

<p>Applications Lomitapide is a drug used in the treatment of obesity and aids in lowering LDL cholesterol and overall cholesterol levels in subjects.<br>References Cuchel, M. et al.: Lancet., 381, 40 (2013); Stefanutti, C. et al.: Atherosclero. Suppl., 14, 19 (2013);<br></p>

<p>Applications Dehydronaproxen is an analog of Naproxen (N377520), an anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory.<br>References Harrison, I.T., et al.: J. Med. Chem., 13, 203 (1970);<br></p>

<p>Stability Hygroscopic<br>Applications Profenofos-D3 is the labeled form of Profenofos(P755880). Profenofos is a broad-spectrum organophosphorous pesticide that is used widely in cotton fields for insect control (1). Acetylcholinesterase inhibiting organophosphoric pesticide (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br></p>

<p>Applications Labelled Triazolam (T767380(M)). Triazolam in an hypnotic drug used in the short term treatment of insomnia.<br>References Lomen, P., et al.: J. Int. Med. Res., 4, 55 (1976), Allens, G.S., et al.: J. Int. Med. Res., 6, 343 (1978), Pakes, G.E., et al.: Drugs, 22, 81 (1981).<br></p>

<p>Applications Isothiazol-3(2H)-one (cas# 1003-07-2) is a useful research chemical.<br></p>

<p>Stability Unstable in Solution<br>Applications Profoxydim Lithium Salt is a salt of Profoxydim (139001-49-3) and an herbicide.<br>References Kaczynski, P., et al.: Food Chemistry, 230, 411-422 (2017);<br></p>

<p>Applications Labelled (6R,7S)-Cefoperazone (C242890). (6R,7S)-Cefoperazone is the enantiomer of Cefoperazone (C242900) as an impurity.<br>References Fabre, H., et al.: J. Pharm. Sci., 73, 611 (1984), Strasters, J., et al.: Anal. Chem., 63, 2503 (1991), Chen, Z., et al.: World Notes Antibiot., 25, 249 (2004),<br></p>

<p>Applications (±)-Miconazole-d5 Nitrate (2,4-dichlorobenzyloxy-d5) (CAS# 1398065-80-9) is the labelled version of Miconazole Nitrate (M342500(P)), which is an anti-fungal. Miconazole Nitrate’s corrosion inhibition performance has been studied with 5083 aluminum alloy.<br>References Godefroi, E.F., et al.: J. Med. Chem., 12, 784 (1969); Brugmans, et al.: Arch. Dermatol., 102, 428 (1970); Heel, R.C., et al.: Drugs, 19, 7 (1980); Zhang, T., et al.: Corros. Sci., 176, 108930 (2020)<br></p>

<p>Applications Estradiol Acetate-d3 is the labelled version of estradiol acetate(H454140); a reactant in the preparation of a modifier conjugate through a physiologically cleavable bond for enhanced drug transport across membranes.<br>References Hale, R., et al.: PCT Int. Appl. (1993), WO 9325197 A1 19931223.<br></p>

<p>Applications Pyr-Gln-OHis a dipeptide that is found in fruits, has a role as a human metabolite.<br>References Dallmann, Robert. et al., P. NATL. ACAD. SCI. USA. 109, 2625-2629(2012);<br></p>

<p>Applications 2,4'-Dibromobenzophenone (CAS# 78281-59-1) is a useful research chemical compound.<br></p>

<p>Applications Tetrabromobisphenol S Dimethyl Ether-d6 is the isotope labelled analog of Tetrabromobisphenol S Dimethyl Ether (T291115); a useful insecticide against house flies and sugar beet aphids. Also found in coating mixtures used for fireproofing of polyester fibers.<br>References Pisanenko, D. A., et al.: Vestn. Kievskogo Politekhnicheskogo Instituta Khimicheskoe Mashinostroenie i Tekhnologiya, 25, 79 (1988); Tomita, M., et al. Fireproofing of polyester fibers and their blends. Jpn. Kokai Tokkyo Koho. JP 54006996 A 19790119. Jan 19, 1979<br></p>

<p>Applications A labelled metabolite of Dapsone (D193250).A representative lot is 73% d8, 23% d7 and 3% d6 with no d0.<br>References Shin, I., et al.: J. App. Pharmacol., 10, 193 (2002), Bhaiya, P., et al.: Toxicol. App. Pharmacol., 215, 158 (2006), Paixao, P., et al.: Eur. J. Pharm. Sci., 36, 544 (2009),<br></p>

<p>Applications A metabolite of Cevimeline (C283500).<br></p>

<p>Applications Micafungin-d11 Sodium is the isotope labelled analog of Micafungin Sodium (M342350); an echinocandin antifungal drug which inhibits the synthesis of 1,3-β-D-glucan, an essential component of the fungal cell wall. Micafungin Sodium also represents a valuable treatment option for fungal infections.<br>References Chen, S.C. et al.: Drugs, 71, 11 (2011); Groll, A.H. et al.: Opin. Anti-Infect. Invest. Drugs, 2, 405 (2000); Tomishima, M. et al.: J. Antibiot., 52, 674 (1999)<br></p>

<p>Applications A metabolite of Midazolam (M343000).<br></p>

<p>Applications 3-(Ethylsulfonyl)pyridine-2-sulfonamide (cas# 117671-01-9) is a useful research chemical.<br></p>

<p>Applications Phenobarbital Sodium is a barbital drug that can be used to synthesize antiepileptic pharmaceutical compounds.<br>References An, L., et al.: Faming Zhuanli Shenqing, CN 105250316 A, 20160120 (2016)<br></p>

<p>Applications Digoxin O-Tetra-acetate is an intermediate used in the synthesis of (3β,5β,12β)-3-[2-[[6-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]amino]-2-oxoethoxy]-12,14-dihydroxycard-20(22)-enolide (D486968), which is a digoxin (D446575) cross-linking reagent.<br></p>

<p>Applications Chlorflurenol-methyl is an auxin polar transport inhibitor that effects elongation growth of the excised fourth internode of tulips. As well as a pesticide.<br>References Wegrzynowicz-Lesiak, E., et al.: J. Hort. Res., 21, 31-39 (2013);<br></p>

<p>Applications Gatifloxacin derivative; a new antimycobacterial.<br>References Sanchez, J., et al.: J. Med. Chem., 35, 361 (1992), Cecchetti, V., et al.: Bioorg. Med. Chem., 7, 2465 (1999), Alovero, F., et al.: Antimicrob. Agents Chemother., 44, 320 (2000),<br></p>

<p>Applications Chlorhexidine Digluconate Impurity N-d4 Hydrochloride, is labelled Chlorhexidine Digluconate Impurity N (C377660), which is a degradation product found in chlorhexidine digluconate solution.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Revelle, L., et. al.: Pharmaceut. Res., 10, 1777 (1993)<br></p>