Toxicology

Applications Efavirenz (E425000) potential synthetic impurity and degradation product.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Phelan, P., et al.: J. Chromatogr. Sci., 19, 13 (1981), Mangia, A., et al.: Anal. Chim. Acta., 149, 349 (1983), Careri, M., et al.: J. Chromatogr., 647, 79 (1993), van Beek, T., et al.: Phytochem. Anal., 6, 1 (1995),

Applications Stearoyl Ethanolamide-d4 is the labelled analogue of Stearoyl Ethanolamide (S686608), which is a prolific fatty acid ethanolamide produced by PLD hydrolysis of membrane phospholipids.
References Kasatkina, L. A., et al.: Biochem. Pharmacol. 174, 113783 (2020)

Applications Labelled analogue of (R)-Linezolid, an enatiomeric impurity of Linezolid (L466500).
References Bednarek, E. et al.: J. Chrom. A, 1193, 164 (2008); Nirogi, R. et al.: J. Chrom. Sci., 46, 764 (2008);

Applications 1-Chloro-3-fluoro-2-propanol is a component of Gliftor (G410000) which is a rodenticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Menon, K., et al.: J. Biochem. Mol. Toxicol., 15, 47 (2001); Xie, W., et al.: J. Hygiene Res. 31, 316 (2002)

Applications Rilpivirine Glycosamine Product II is an impurity of Rilpivirine(R509800) which is a novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. An anti-HIV agent.
References Sun, et al.: J. Med. Chem., 41, 4648

Applications Filipin III is a cholesterol-binding, fluorescing antibiotic. Also, it is a pentaene macrolide produced by Streptomyces filipinensis, widely used for the detection and quantitation of cholesterol in biological membranes and as a tool for the diagnosis of Niemann-Pick type C disease;Polyene antibiotic, most extensively used tool for the specific detection of fluorescently labeled 3-β-hydroxysterols.
References Payero, T. D., et al.: Microb. Cell Fact., 14, 1-14 (2015); Stanislas, T., et al.: Methods Mol. Biol., 1209, 13-29 (2014)

Applications Labelled Olsalazine (O586000). Dimer of Mesalazine (M258100), an anti-inflammatory drug used in the treatment of inflammatory bowel disease and ulcerative colitis.
References Willoughby, C.P., Gut, 23. 1081 (1982), Scand, J., et al.: Gastroenterol, 20, 607 (1985), Wadworth, A.N., et al.: Drugs, 41, 647 (1991)

Applications A phosphocholine ester metabolite of the immunosuppressant macrolide SDZ RAD (also known as Everolimus E945400) which is an analog of the parent drug Rapamycin (R124000).
References Zollinger, M. et al.: Drug. Metab. Disp., 36, 1457 (2008); Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001);

Applications 4-Chlorosalicylic Acid is a metabolite of the herbicide Benthiocarb. 4-Chlorosalicylic Acid shows antifungal activity.
References Nakamura, Y. et al.: Agric. Biol. Chem., 41, 1613 (1977); Patel, H.S. et al.: J. Macromol. Sci. Chem., A20, 453 (1983); Amborabe, B.-E. et al.: Plant Physiol. Biochem., 40, 1051 (2002);

Applications Protected, labelled Ambrisentan.

Applications N-Desmethyl rac-14-epi-Dextromethorphan is an intermediate in the synthesis of rac-14-epi-Dextromethorphan (D299440), which is an analog of Dextromethorphan (D299445) which is an antitussive compound showing analgesic properties. Dextromethorphan is used in cough medication formulations.
References Church J. et al.: Can J Physiol Pharmacol., 67, 561 (1989); Carliss, R. et al.: Neurotoxicology., 28, 813 (2007)

Applications 1,4-Diaminobutane is an amino acid degradation product. Used in the preparation of hexahydropyrimidines as novel hepatitis C virus inhibitors. Also a reagent in the synthesis of antibacterial castor oil-based polyurethane membranes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hwang, J. et al.: Eur. J. Med. Chem., 70, 315 (2013); Yari, A. et al.: J. Biomed. Mat. Res., 102A, 84 (2014);

Applications Marbofloxacin N-oxide is a metabolite of Marbofloxacin (M197000); a fluorinated quinolone antibacterial.
References Gruet, P., et al.: Vet. Rec., 140, 199 (1977); Lefebvre, H.P., et al.: J. Vet. Pharmacol. Ther., 21, 453 (1998); Schneider, M., et al.: J. Diary Sci., 87, 202 (2004)

Applications Serotonin-13C215N Hydrochloride, is a labelled Serotonin (S274980). Serotonin is a monoamine neurotransmitter.

Stability Hygroscopic
Applications Piperacilloic Acid-Piperacillin Dimer Disodium Salt is Piperacillin (P479950) impurity and can be obtained from it. Piperacillin (P479950) is broad spectrum semi-synthetic antibiotic related to Penicillin. Antibacterial.
References Takai, A., et al.: Chemotherapy, 25, 816 (1977); Bodey, G.P., et al.: Antimicrob. Agents Chemother., 14, 78 (1978); Kuck, N.A., et al.: J. Antibiot., 31, 1175 (1978);

Applications N-[[2'-(1H-Tetrazol-5-Yl)[1,1'-Biphenyl]-4-Yl]Methyl]Amine (cas# 147225-68-1) is a useful research chemical.

Stability Very Hygroscopic
Applications A benzoquidine diimine derivative useful as animal growth substance.
References Clark, R., et al.: J. Agric. Food Chem., 44, 3643 (1996), Sadowski, J., et al.: J. Med. Chem., 41, 332 (1998), Estrada, E., et al.: J. Med. Chem., 43, 1975 (2000),

Applications p-Hydroxy-(D)-phenylglycyl Amoxicillin is a labeled derivative of Amoxicillin (A634235) a semi-synthetic antibiotic related to Penicillin.
References Brogden, R.N., et al.: Drugs, 18, 169 (1979), Bird, A.E., et al.: Anal. Profiles Drug Subs. Excip., 23, 1 (1994),

Applications Bis-clindamycinyl-(2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran) Phosphate is an intermediate used in the synthesis of Bis-clindamycinyl Phosphate (B419135), which is an impurity of Clindamycin (C580000), an antibiotic prepared from Lincomycin (L466200), used to treat various infections.
References Birkenmeyer, R.D., et al.: J. Med. Chem., 13, 616 (1970); Oesterling, et al.: J. Pharm. Sci., 59, 63 (1970); Gray, J.E., et al.: Toxicol. Appl. Pharmacol., 21, 516 (1972); Brown, L.W., et al.: Anal. Profiles Drug Subs., 10, 75 (1981);

Applications A phenylpyridine derivative used in the preparation of HIV protease inhibitors I and other pharmaceutical agents.
References De Goey, D.A. et al.: J. Med. Chem., 52, 2571 (2009); Engstrom, K. et al.: J. Org. Chem., 71, 5369 (2006);

Applications Nafcillin Penilloic Acid Ester is derived from Sodium Nafcillin Monohydrate (S645800), which is used as an antibiotic, and for the treatment of gram-positive bacteria.
References Taboada, P. et al.: Langmuir. 16, 3175 (2000)

Applications 6-​Fluoro-​3-​[(trimethylsilyl)​oxy]​-2-​pyrazinecarboxamide is an intermediate in synthesizing T-705RTP (T003210), a derivative of T-705 (F103350) which has activity against the lethal H5N1 influenza A viruses. T-705RTP which has the triphosphate group, gets strongly inhibited by the influenza virus RNA polymerase activity in comparison with T-705RMP (T003202).
References Yousuke, F., et al.: Antimicrob Agent Chemother., 49, 981 (2005); Kiso, M., et al.: Proc. Natl. Acad. Sci. U.S.A., 107, 882 (2010);

Applications N'-Boc,N,N'-Desethylene Iso Gatifloxacin Anhydride with Diacetyl Borate is an impurity of Gatifloxacin (G250000), an antibacterial agent.
References Bauernfeind, A.: J. Antimicro. Chemother., 40, 639 (1997), Fukuda, H., et al.: Antimicrob. Ag. Chemother., 42, 1917 (1998),

Applications Sodium Benzoate-d5 (CAS# 62790-26-5) is a useful isotopically labeled research compound.

Applications N-Oxacilloilyl (+)-6-Aminopenicillanic Acid Disodium Salt is a derivative of Oxacillin which is used as an antibiotic related to Penicillin. Antibacterial.
References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971);

Applications 6-Hydroxy Albaconazole, is a metabolite of Albaconazole (H761395), an antifungal agent as neuroprotectant.
References Pujol, I., et al.: J. Antimicrob. Chemother., 39, 163 (1997), Gilgado, F., et al.: J. Clin. Microbiol., 43, 4930 (2005), Raad, I., et al.: Clin. Infect. Dis., 42, 1398 (2006), Nucci, M., et al.: Clin. Microbiol. Rev., 20, 695 (2007),

Applications: Imidazole derivative with antifungal properties.
References Walker, K.A.M., et al.: J. Med. Chem., 21, 840 (1978), Odds, F.C., et al.: J. Antimicrob. Chemother., 14, 105 (1984),

Applications A hydrated form of trisodium glycyrrhizinate, a bioactive compound used in conjunction with glutamyl-​tryptophan to treat acute infections caused by influenza (H3H2) virus.
References Smirnov, V. S.; Voprosy Virusologii, 57, 23 (2012).

Applications b-Phenylethyl Furoate (cas# 7149-32-8) is a useful research chemical.

Applications A metabolite of Triazolam (T767380).
References Gygi, S., et al.: Drug Metab. Dispos., 24, 282 (1996), Slawson, M., et al.: J. Anal. Toxicol., 20, 350 (1996), Mei, Z., et al.: Ther. Drug Monit., 19, 92 (1997), Nakahara, Y., et al.: Life Sci., 63, 88392 (1998),

Impurity Nevirapine EP Impurity D
Applications Nevirapine Dimer (Nevirapine EP Impurity D) is a dimeric impurity of the antiviral Nevirapine (N391275).

Applications (2E)-3-(2-Thiazolyl)-2-propenoic Acid is a useful synthetic intermediate. It is used as an intermediate for HIV-1 protease inhibitor.
References Baloglu, E., et al.: PCT Int. Appl. (2014), WO 2014085607 A1 20140605

Applications (2S,4R)-Itraconazole is an enantiomer of Itraconazole (I937500), an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.
References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),

Applications Methyl 5-Methyl-3-phenyl-4-isoxazolecarboxylate-d5 is an intermediate in the synthesis of Oxacillin Sodium-d5 Salt (O758502); Isotope labelled Oxacillin Sodium Salt is a semi-synthetic antibiotic related to Penicillin. Antibacterial.
References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971),

Applications 2-Hydroxy Carbamazepine β-D-Glucuronide is a metabolite of 2-Hydroxy Carbamazepine (H884100).

Stability Hygroscopic
Applications A labelled metabolite from endophytes of the medicinal plant Erythrina crista-galli.
References Stadler, M., et al.: Planta Med., 60, 128 (1994), Kopcke, B., et al.: Phytochemistry, 60, 709 (2002), Chu, M., et al.: J. Nat. Prod., 66, 1527 (2003), Weber, D., et al.: J. Antibiot., 57, 559 (2004),