Toxicology

Applications Reagent used in the synthesis of herbicides.
References Mekenyan, O., et al.: Chem. Res. Toxicol., 10, 994 (1997), Brown, T., et al.: Environ. Sci. Technol., 42, 5202 (2008),

Applications 3-(Dichloroacetyl)-2,2,5-trimethyloxazolidine is used in the synthesis of herbicidal compositions containing methiozolin.
References Kraus, H., et al.: PCT Int. Appl., 75 (2019)

Applications A deuterated 4-chloro Bupropion (B689625) analogue used in the preparation of compounds for indirect dopamine agonist pharmacotherapy for treating cocaine, methamphetamine, nicotine, and other drugs of abuse addiction.
References Carroll, F.I. et al.: J. Med. Chem., 52, 6768 (2009);

Stability Hygroscopic
Applications 4-(Trifluoromethoxy)aniline is used in the synthesis of anticancer agents and antitumor medicaments. Also, its an intermediate in the production of labelled Riluzole (R510000), a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cilibrizzi, A., et al.: J. Med. Chem., 52, 5044 (2009), Verhaeghe, P., et al.: Bioorg. Med. Chem., 17, 4313 (2009), Chandregowda, V., et al.: Eur. J. Med. Chem., 44, 3046 (2009), Wahl, F., et al.: Eur. J. Pharmacol., 230, 209 (1993) Bensimon, G., et al.: N. Engl. J. Med., 330, 585 (1994); Piras, S. et al.: Eur. j. Med. Chem., 75, 169 (2014); Vyas, V. et al.: Eur. J. Med. Chem., 82, 385 (2014);

Applications Spasmoxale is an analgesic.
References Deeb, O., et al.: Chem. Biol. Drug. Des., 76, 255 (2010); Mathur, K.C., et al.: Bioorg. Med. Chem., 11, 1915 (2003)

Stability Moisture Sensitive
Applications Quinalphos is an organothiophosphate pesticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lehotay, S., et al.: J. AOAC Int., 88, 595 (2005); Paya, P., et al.: Anal. Bioanal. Chem., 389, 197 (2007)

Applications CMPD101 is a potent and selective GRK2/3 inhibitor.
References Lowe, J.D., et al.: Mol. Pharmacol., 88, 347 (2015); Ikeda, S., et al.: PCT Int. Appl. WO 2007034846 A1 20070329. Mar 29, 2007

Applications Simetyrn is an methylthiotriazine based herbicide used in rice paddy.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Inoue, T. et al.: J. Agri. Food. Chem., 59, 3857 (2011); Wang, S., et al.: Environ, Sci. Technol., 47, 4768 (2013);

Applications Desamino Chloro Carbamazepine-d2 is an intermediate in the synthesis of Carbamazepine-d2,15N (C175841), the labeled analogue of Carbamazepine (C175840), used in treatment of pain associated with trigeminal neuralgia. Anticonvulsant.
References Stenger, E.G., et al.: Med. Exp., 11, 191 (1964), Pynnonen, S., et al.: Ther. Drug Monit., 1, 409 (1979), Sidebottom, A., et al.: J. Clin. Pharm. Ther., 20, 31 (1995)

Applications O-Desmethyl-N-deschlorobenzoyl Indomethacin-d3, is the labeled analogue of O-Desmethyl-N-deschlorobenzoyl Indomethacin (D291620), a metabolite of Indomethacin (I641000).
References O'Brien, W., et al.: Clin. Pharmacol. Ther., 9, 94 (1968), Duggan, D., et al.: J. Pharmacol. Exp. Ther., 181, 563 (1972), Abourashed, E., et al.: Curr. Med. Chem., 6, 359 (1999), Chatterjee, P., et al.: J. Nat. Prod., 62, 761 (1999);

Applications 4-Benzyloxyacetophenone is used in preparation of inhibitors of various proteins such as hepatitis C virus polymerase, glucosylceramide synthase and protein tyrosine phosphatase 1B.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Deng, Y., et al.: Bioorg. Med. Chem. Lett., 19, 5363 (2009); Lee, L., et al.: J. Biol. Chem., 274, 14662 (2009); Liu, Z., et al.: Bioorg. Med. Chem. Lett., 21, 3755 (2011)

Applications Propionyl-L-carnitine (CAS# 20064-19-1) is a useful research chemical compound.

Applications Diphenyl Sulfide is an aromatic organosulfur compound. Diphenyl Sulfide is metabolite of the fungicide Edifenphos as well as a potential impurity of Fenticonazole Nitrate (F279250).
References Ueyama, I. et al.: Agric. Biol. Chem., 42, 885 (1978); Tajana, A. Arzneim.-Forsch., 31, 2127 (1981);

Applications Chloroethylnitrosourea derivative with antitumor activity. Similar to carmustine, chlorozotocin, nimustine, ranimustine. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Johnston, T.P., et al.: J. Med. Chem., 9, 892 (1966), Oliverio, V.T., et al.: Cancer Res., 30, 1330 (1970), Thompson, G.R., et al.: Toxicol. Appl. Pharmacol., 21, 405 (1972), Al-Shammary, F.J., et al.: Anal. Profiles Drug Subs., 19, 315 (1990),

Applications Inhibitor of Dopamine biosynthesis.
References Jones, D., et al.: Drug Metab. Disposition, 35, 1466 (2007), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),

Stability Hygroscopic
Applications Mycophenolic Acid β-D-Glucuronide Disodium Salt is A metabolite of Mycophenolic Acid (M831500), an antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleotides.
References Senda, M., et al.: Transplantation, 60, 1143 (1995); Nimmesgern, E., et al.: J. Biol. Chem., 271, 19421 (1996); Gummert, J.F., et al.: J. Pharmacol. Exp. Ther., 291, 1100 (1999)

Applications 2,5,7,8-Tetrahydroxy-1,4-Naphthalenedione have been synthesized and studied for antimicrobial and antifungal activities.
References Yakubovskaya, A. et al.: Pharma. Chem. J., 43, 396 (2009)

Applications Dihydro Normorphine is a metabolite of Normorphine (N740300).
References Hug, C.C, et al.: J. Pharmacol. Exp. Therap., 149, 446 (1965),

Applications Naftalofos

Applications 2,4-Dimethylphenol is used both as a pesticide to ward of insects or other common pests from crops from crops as well as in the synthesis of anti-oxidant compounds due to the phenol moiety in the structure. This is a labelled analog.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Liu, B. et al.: J. Agri. Chem., 58, 2673 (2010); Guillen, M. et al.: J. Agri. Chem., 47, 3016 (1999); J. Agri. Chem., 46, 1276 (1999); Kim, S. et al.: J. Agri. Chem., 59, 4570 (2011);

Applications Acetophos is used as an insecticide.
References Saito, T., et al.: Bochu Kagaku. 31, 77 (1966)

Stability Hygroscopic
Applications Isovaleryl L-Carnitine-d9 Chloride is labelled Isovaleryl L-Carnitine Chloride (I917580) which is used to prepare carnitine benzyl esters as neuroprotectant prodrugs.
References Gong, X., et al.: J. Chem. Res., 6, 327 (2008)

Applications Isotope labelled (R,R,S,R)-Nebivolol Hydrochloride is a stereoisomer of rac Nebivolol (N387900) which is a β1-Adrenergic blocker. Nebivolol is used as an antihypertensive.
References Van de Water, A., et al.: J. Cardiovasc. Pharmacol., 11, 552 (1988); De Cree, J., et al.: Angiology, 41, 95 (1990)

Stability Air Sensitive, Light Sensitive
Applications Isotope labelled Phenserine is inhibitor of amyloid precursor protein (APP). Used in Alzheimer’s treatments.
References Nordberg, A. et al.: J. Alz. DIsease., 47, 691 (2015); Reale, M. et al.: Curr. Alzheimer. Treatments., 11, 608 (2014);

Applications Testosterone 17-Hexahydrobenzoate-d11 is the isotope analog of Testosterone 17-Hexahydrobenzoate. Testosterone 17-Hexahydrobenzoate is a metabolite of testosterone (T155000), which is used in biological studies to determine the hemolytic and lipophilic activity of this anabolic steroid.
References Biagi, G.L., et al.: J. Med. Chem., 13, 944 (1970); Biagi, G. L., et al.: J. Med. Chem., 18, 873 (1975)

Applications 3,5,6-Trichloro-8-quinolinecarboxylic Acid is an impurity of Quinclorac (Q670300), which is a disubstituted quinolinecarboxylic acid that is part of a new class of highly selective auxin herbicides. Quinclorac is used in rice to control dicotyledonous and monocotyledonous weeds, particularly barnyardgrass (Echinochloa crus-galli). Quinclorac is also used for weed control in turfgrasses.
References Haden, E. et al.: Proc. Br. Corp. Prot. Conf. Weeds, 1, 77 (1985); Chism, W.J. et al.: Weed Sci., 39, 62 (1991); Grossmann, K. et al.: Weed Sci., 46, 707 (1998);

Applications Methyl (2E)-[2-(chloromethyl)phenyl)](methoxyimino)acetate is an impurity from the pesticide active ingredient, Trifloxystrobin, a broad-spectrum foliar fungicide used in plant pritection.
References Margot, P. et al.: Bright. Crop Prot. Conf. Pest Dis., 2, 375 (1998); Karadimos, D.A. et al.: Crop Prot., 24, 23 (2005); Prom, L.K. et al.: Plant Dis., 87, 252 (2003);

Applications tert-Butyl 3-Cyanomorpholine-4-carboxylate is used as a reactant for the synthesis of HIV integrase inhibitors.
References Gardelli, C., et. al.: J. Med. Chem., 50, 4953 (2007); Pace, P., et. al.: J. Med. Chem., 50, 2225 (2007); Summa, V., et. al.: J. Med. Chem., 49, 6646 (2006)

Applications N-Boc Gatifloxacin N-Oxide is an intermediate used in the synthesis of Gatifloxacin N-Oxide (G250005), which is an impurity of Gatifloxacin (G250000), an antibacterial agent.
References Bauernfeind, A.: J. Antimicro. Chemother., 40, 639 (1997), Fukuda, H., et al.: Antimicrob. Ag. Chemother., 42, 1917 (1998),

Applications 3-trans-Hydroxy Norcotinine (cas# 1292911-83-1) is a compound useful in organic synthesis.

Stability Hygroscopic
Applications A labelled related drug of Clenbuterol (C569998), a β-agonist which can be used as a growth promoter in farm animals.
References Mosbach, K., et al.: Biotechnology, 14, 163 (1996), Rashid, B., et al.: J. Pharm. Biomed. Anal., 21, 635 (1999), Brambilla, G., et al.: Toxicol. Lett., 114, 47 (2000),

Applications An enantiomer of Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),

Applications di-Val-L-dC Trihydrochloride is a β-L-2'-Deoxynucleoside for treatment of resistant hepatitis B virus strains, and combination therapies.
References Standring, D. et al.: PCT Int. Appl. (2004)

Applications Picloram is used as a herbicide. Studies show that Picloram can reduce seed germination rate and vigor as well as seedling growth in Bidens pilosa L.
References Freitas, M.R., et al.: RSC Adv., 5, 7547 (2015); Tian, X., et al.: Nongyao, 53, 485 (2014)

Applications Tenofovir Disoproxil is a therapeutic option for nucleos(t)ide analog (NA)-experienced chronic hepatitis B (CHB) patients infected with hepatitis B virus (HBV). Also, it is an intermediate used in the synthesis of Tenofovir Disoproxil Dimer (T018515), which is a Tenofovir Disoproxil impurity.
References Huang, M., et al.: Clin. Drug Investig., 36, 471-478 (2016); Cheng, G., et al.: Chem. Res. Toxicol., 16, 145 (2003)

Applications Phenamacril is a fungicide.
References Tang, L., et al.: Synthesis, 46, 1621-1629 (2014);

Applications Fenticonazole nitrate (F279250) impurity, with antimycotic and antibacterial activity.
References Nardi, D., et al.: Arzneim.-Forsch., 31, 2123 (1981),

Applications Clindamycin 3-Palmitate Hydrochloride, is an impurity in the synthesis of Clindamycin Palmitate Hydrochloride (C580035), a semi-synthetic antibiotic with high bioavailability. Clindamycin Palmitate is an antibacterial.
References Bharathi, Ch. et al.: J. Pharm. Biomed. Anal., 48, 1211 (2008); Platzer, D., et al.: J. Pharm. Biomed. Anal., 41, 84 (2006);

Applications 4'-[(4,5-Dimethyl-3-isoxazolyl)sulfamoyl]acetanilide is an renal metabolite of Sulfatroxazole (S699265), is an component present in various veterinary drugs.
References Nouws, J. F. M., et al.: J. Vet. Pharmacol. Ther., 12, 50 (1989);

Applications 1-Chloro-2-(α-chlorophenylmethyl)benzene-d5 is the isotope labelled analog of 1-Chloro-2-(α-chlorophenylmethyl)benzene (C427570); a reagent in the synthesis of bifonazole analogs which have antibacterial and antifungal activities. It is also used in the preparation of diphenylpiperazine N-type calcium channel inhibitors.
References El Hage, S., et al.: Arch. Pharm., 344, 402 (2011); Pajouhesh, H., et al.: Bioorg. Med. Chem. Lett., 20, 1378 (2010)

Applications A degradation product of labelled Cefuroxime, and an intermediate for the synthesis of labelled Cephalosporin antibiotics
References Nomura, H., et al.: J. Med. Chem., 17, 12 (1974), Takaya, T., et al.: J. Antibiotics, 34, 1300 (1981), Wang, D., et al.: J. Pharm. Sci., 83, 577 (1994), Okamoto, Y., et al.: J. Pharm. Sci., 85, 985 (1996),

Applications Azadiradione is an extract from Neem (Azadirachta indica) plant and may contain antifungal properties. It has also been shown to restore protein quality control and ameliorate disease pathogenesis in Huntington’s disease.
References Singh, T. et al.: Am. J. PharmTech. Res., 6, 323 (2016); Singh, B. et al.: Mol. Neurobiol., 55, 6337 (2018);

Applications Testosterone (T155000) derivative. Inhibits estrogen biosynthesis. A steroid ligand for the cytosol androgen receptor (AR) of rat prostate.
References Ojasoo, T. et al.; J. Steroid Biochem. 27, 255 (1987); Schwarzel, W. et al.; Endrocrinology 92, 866 (1973);

Applications Nodakenin (CAS# 495-31-8) is a useful research chemical compound.