Toxicology

<p>Applications (S)-2-Benzyl-N,N-dimethylaziridine-1-sulfonamide is a reagent for the synthesis of N-alkylsulfamic acid derivatives. It also has utility for preparing pharmaceutical peptide analog agents.<br>References Sherman, E. S., et al. Science of Synthesis 40b, 1285 (2008); Polniaszek, R., et al.: PCT Int. Appl. WO 2010115000 A2 20101007 (2010)<br></p>

<p>Applications 2-Iodo-4-(1-methylethyl)-6-(trifluoromethyl)pyrimidine is a pyrimidine compound, generally used in the synthesis of pharmaceutical compounds, it may be used in the synthesis of cycloindoles for the treatment of hepatitis C.<br></p>

<p>Applications 2-(Bromomethyl)-5-(trifluoromethyl)furan is an intermediate used to prepare tertiary sulfonamides as liver X receptor antagonists. It is also used to synthesize hydantoin based inhibitors of MMP13 with potential use in osteoarthritis.<br>References Zuercher, W., et al.: J. Med. Chem., 53, 3412 (2010); De Savi, C., et al.: Bioorg. Med. Chem. Lett., 23, 4705 (2013)<br></p>

<p>Applications Sofosbuvir 3',5'-Bis-(S)-phosphate is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.<br>References Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)<br></p>

<p>Applications Used in the preparation of triazole antifungal agents.<br></p>

<p>Stability Hygroscopic<br>Applications 5R,6R-Benzylpenicilloic Acid is the β-lactamase cleavage product/metabolite of antibiotic Penicillin G (P223400).<br>References Dryjanski, M., Pratt, R.: Biochem., 34, 3561 (1995); Ho, H., et al.: Rapid Commun. Mass Spectrom., 25, 25 (2011);<br></p>

<p>Applications Zinc salicylate trihydrate (CAS# 16283-36-6) is a useful research chemical compound.<br></p>

<p>Applications β-Amyrin is used as a protein tyrosine phosphatase 1B inhibitor with potential treatment towards diabetes. Also used in the synthesis of HIV-1 integrase inhibitory compounds based upon plant extracts.<br>References Zhang, Y. et al.: Bioorg, Med. Chem., 16, 8697 (2008); Tewtrakul, S. et al.: Phytother. Res., 17, 232 (2003);<br></p>

<p>Applications (rac)AIB-Precursor is used as a reagent in the preparation of cyclized sulfamoylarylamide derivatives for treatment of hepatitis B.<br>References Vendeville, S. M. H., et al.: PCT Int. Appl. 244pp. (2017)<br></p>

<p>Applications 4-[4-(4-Aminophenyl)-1-piperazinyl]phendiamineol is an intermediate of Posaconazole (P689600), which is orally active antifungal triazole.<br>References Cacciapuoti, A., et al.: Antimicrob. Agents Chemother., 44, 2017 (2000); Herbrecht, R., et al.: Int. J. Clin. Pract., 58, 612 (2004); Panackal, A., et al.: J. Clin. Microbiol., 44, 1740 (2006); Yan, X., et al.: Guangzhou Huagong, 41, 107 (2013);<br></p>

<p>Applications Methyl (1R,4S)-4-Amino-2-cyclopentene-1-carboxylate (2S,3S)-2,3-Dihydroxybutanedioic Acid is an intermediate used in the synthesis of ent-Abacavir (A105015), which is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br></p>

<p>Applications N-Boc Gatifloxacin is an intermediate used in the synthesis of Gatifloxacin N-Oxide (G250005), which is an impurity of Gatifloxacin (G250000), an antibacterial agent.<br>References Bauernfeind, A.: J. Antimicro. Chemother., 40, 639 (1997), Fukuda, H., et al.: Antimicrob. Ag. Chemother., 42, 1917 (1998),<br></p>

<p>Applications Lomefloxacin is a fluorinated quinolone antibacterial. Lomefloxacin is a DNA gyrase antagonist.<br>References Hirose, T., et al.: Antimicrob. Agents Chemother., 31, 854 (1987), Sanzgiri, Y.D.. et al.: Anal. Profiles Drug Subs. Excip. 23, 321 (1994),<br></p>

<p>Applications (5R)-Flucloxacillin N4-Acetyl Penilloic Acid is an impurity of Flucloxacillin (F419200), a new semisynthetic penicillin.<br>References Markovich, M., et al.: Antibiot. Med. Biotekhnol., 31, 603 (1986); Rahman, M., et al.: Biochem. Pharmacol., 46, 1721 (1993); Silva, D., et al.: Med. Biol. Res., 37, 963 (2004);<br></p>

<p>Applications Fenticonazole nitrate (F279250) impurity, with antimycotic and antibacterial activity.<br>References Nardi, D., et al.: Arzneim.-Forsch., 31, 2123 (1981),<br></p>

<p>Applications Benoxaprofen (B165300) derivative. A 5-benzoxazolealkanoic acid with antiinflammatory activity.<br>References Dunwell, D. W. et al.: J. Med. Chem. 18, 53 (1975)<br></p>

<p>Applications Sulforaphene is an extract from the seeds of Raphanus sativus and displays anti-inflammatory and anti-cancer activity.<br>References Kim, K. et al.: J. Ethnopharmacol., 151, 503 (2014);<br></p>

<p>Applications 2-Methylphenyl Diethylcarbamate is an intermediate in the synthesis of o-Cresol (C781910), which is a compound used as a disinfectant and have also been used as antiseptic in surgery.<br>References Razavi, S.M., et al.: Nat. Prod. Res., 26, 2148 (2012); Asadollahi-B. M., et al.: Environ. Toxicol. Pharmacol., 34, 826 (2012);<br></p>