Toxicology

<p>Applications A mixture of 2 metabolites of butadiene. The isomeric ratio has been determine to be approximately 1:1 based on proton nmr integration.<br>References Barnsley, E.A., et al.: Biochem. J., 100, 362 (1966),<br></p>

<p>Applications Picolinafen-d4 is deuterium labelled Picolinafen (P436800), a pesticide. It is a molecule for selective post emergence weed control in wheat and barley.<br>References Wang, J., et al.: Anal. Bioanal. Chem., 396, 1513 (2010); Sinclair, C., et al.: Environ. Sci. Technol., 40, 7283 (2006); Magnani, D., et al.: Atti, Giornate fitopatologiche, Perugia, 2, 405 (2000)<br></p>

<p>Applications The metabolite in soil and sugar beets of Chloridazon.<br>References Smith, D.T., et al.: Weed Sci., 18, 260 (1970),<br></p>

<p>Stability Light Sensitive<br>Applications A labelled metabolite of Rifampicin.<br>References Blumenfeld,O.O., et al.: J. Biol. Chem., 236, 2472 (1961), Cowxan, R.A., et al.: Biochem. Biophys. Res. Commun, 23, 799 (1966)<br></p>

<p>Applications 1,4-Dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester has been studied as a novel influenza endonuclease inhibitor. They also function as high-affinity ligands at the benzodiazepine site of brain GABAA receptors.<br>References Baughman, B. et al.: ACS. Chem. Biol., 7, 526 (2012); Gaurav, A. et al.: Medicin. Chem. Res., 20, 192 (2011);<br></p>

<p>Applications Imazapic can be used in analytical and biological studies of residue analysis and determination of imidazolinone herbicides in sunflower and soil by GC-MS.<br>References Ozcan, C., et al.: Chromatographia, 80, 941 (2017)<br></p>

<p>Stability Sample is unstable in solution<br>Applications Erythromycin A N-oxide is a facile metabolite of erythromycin A.<br></p>

<p>Applications Thiamine (T344185) derivative used in the treatment of neurogenic bladder dysfunction. It is absorbed from the intestine and rapidly metabolized into thiamine in the blood. Studies suggest that it has stimulant action on intestinal motility.<br>References Nihira, H. et al.: Hinyok. Kiyo, 12, 823 (1966); Shiobara, Y. et al.: Bitamin, 37, 306 (1968); Kuriaki, K. et al.: Bitamin, 41, 30 (1970);<br></p>

<p>Applications Chlorethoxyfos is an organophosphorous pesticide/insecticide.<br>References Li, S., et al.: Toxicology In Vitro, 56, 93 (2019); Yi, X., et al.: Sepu, 34, 1097 (2016); Can, A., et al.: Toxicol. Lett., 230, 434 (2014)<br></p>

<p>Applications An anticholinergic. Used as an antispasmodic.<br>References Zhang, L., et al.: Pharm. Res., 25, 1902 (2008), Sanderson, H., et al.: Toxicol Lett., 187, 84 (2009),<br></p>

<p>Applications 4’-Hydroxy Pyrimethanil is a labelled metabolite of the pesticide Pyrimethanil (P997250).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Environmental Protection Agency EPA: Fed. Reg., 69, 52434 (2004);<br></p>

<p>Applications Anticonvulsant; hypnotic.Controlled substance (depressant).<br>References Rieder, et al.: Arzneim.-Forsch., 23, 212 (1973), Kangas, L., Acta Pharmacol. Toxicol., 45, 16 (1979), Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 9, 487 (1980).<br></p>

<p>Applications Herbicide, active by perturbing cell membranes<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009), Bollman, S., et al.: Weed Technol., 23, 264 (2009), Goudarzi, N., et al.: J. Agric. Food Chem., 57, 7153 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications Neuroleptic agent related structurally to thiothixene. Antipsychotic; neuroleptic agent; dopamine receptor antagonist.<br>References Nielsen, et al.: Acta Pharmacol. Toxicol., 32, 363 (1973), Post, M.L., et al.: Nature, 256, 342 (1975), Peuch, et al.: Neuropharmacology, 20, 1279 (1981),<br></p>

<p>Applications Diphenyl Phosphate is an organophosphate diester and metabolite of the flame retardant Triphenyl Phosphate (T808990) and also a metabolite of 2-Ethylhexyl diphenyl phosphate.<br>References Cooper, E.M. et al.: Anal. Bioanal. Chem., 401, 2123 (2011); Nishimaki-Mogami, T. et al.: Arch. Toxicol., 61, 259 (1988);<br></p>

<p>Applications Bis-(1-Chloro-2-propyl)phosphate is the metabolite of organic flame retardants.<br>References Schindler, B. et al.: Anal. Bioanal. Chem., 395, 1167 (2009);<br></p>

<p>Applications Cyhexatin is a derivative of tricyclohexyltin and an effective acaricide used in the control of spider mites.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jeppson, L.R. et al.: J. Econ. Entomol., 61, 1502 (1968); Rudd, J.A. et al.: Exp. Appl. Acarol., 21, 615 (1997);<br></p>

<p>Applications Labelled Bifenthrin (B383000). Third generation synthetic pyrethroid. Insecticide, acaricide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Plummer, E.L., et al.: Pestic. Sci., 14, 560 (1983), Trumble, J.T., et al.: J. Econ. Entomol., 81, 608 (1988), Ross, M., et al.: Biochem. Pharmacol., 71, 657 (2006), Hillegass, J., et al.: Toxicol. Sci., 102, 413 (2008),<br></p>

<p>Applications Labelled Spirotetramat (S683300). Spirotetramat is a synergistic insecticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Byrne, F., et al.: Crop. Prot., 25, 831 (2006), Kanrar, B., et al.: Bull Environ. Contam. Toxicol., 77, 631 (2006), Venkateswarlu, P., et al.: Food Chem., 105, 1760 (2007), Khay, S., et al.: Biomed. Chromatogr., 22, 581 (2008),<br></p>

<p>Applications Labelled Deshydroxyethoxy Ticagrelor analog of Ticagrelor (T437700) an antiplatelet agent, and preventative in the treatment of heart attacks, myocardial infarction, and other pulmonary diseases.<br>References Zhang, H. et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012);<br></p>

<p>Applications Labelled Brimonidine. It is an α2 receptor agonist. It is a drug used to treat glaucoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Katz, L.J., et al.: Am. J. Ophthalmol., 127, 20 (1999), Cantor, L. B., Expert Opin. Pharmacother., 1, 815 (2000),<br></p>

<p>Applications Boscalid is a fungicide belonging to the class of carboxamides. Boscalid acts by inhibiting spore germination, germ tube elongation and is also effective on all other stages of fungal development. Boscalid is used in the agriculture to protect crops from gray mold, powdery mildew and other fungus. Used in Pesticide detection. Boscalid is useful in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yan, F. et al.: Nongyao, 47, 132 (2008); Lozowicka, B. et al.: Prog. Plant Prot., 48, 1211 (2008); Stammler, G. et al.: Int. Plant Prot. Cong. Proc. 16th Glas. U.K., 1, 40 (2007);<br></p>

<p>Applications Diethanolamine similar to triethanolamine (T775580) is used as a surfactant. It also has the potential to be a corrosion inhibitor by means of chemisorption. This is the labelled analog.<br>References Bhajiwala, H.M et al.: Bull. Electrochem., 17, 441 (2001); Yu, J. et al.: Thin. Solid. Films., 379, 7 (2000);<br></p>

<p>Applications Pirimicarb is a pesticide which is useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Endosulfan Sulfate is a pesticide used in the control and protection of plant and vegetation. Endosulfan Sulfate is useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Weston, D. et al.: Env. Sci. Tech., 38, 2752 (2004); Antonious, G. et al.: Env. Tox. Chem., 16, 644 (1997);<br></p>

<p>Applications Triflumizole is an conazole fungicide is an imidazole fungicide used on many food and ornamental crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Haralson, J.C., et al.: Crop. Protect., 44, 1 (2013); Leroux, P., et al.: Pest. Manage. Sci., 69, 15 (2013);<br></p>

<p>Applications Antiepileptic agent with anxiolytic and antimanic properties. Anticonvulsant.This is a controlled substance (depressant).<br>References Blum, et al.: Arzneim.-Forsch., 23, 377 (1973), Winslow, W.C., et al.: Anal. Profiles Drug Subs., 6, 61 (1977)<br></p>

<p>Applications (+)-Irinotecan is a Topo I inhibitor.<br></p>

<p>Applications The active labelled metabolite of the antibacterial dye, Sulfamidochrysoidine. Inhibits folic acid synthesis in prokaryotes. Antibacterial.<br>References Colebrook, L., et al.: Lancet, 233, 1291 (1937), Dye, C., et al.: Nat. Rev. Microbiol., 7, 81 (2009), Isik, S., et al.: Bioorg. Med. Chem., 17, 1158 (2009),<br></p>

<p>Applications Bromothalonil can be used in biological study of comparison and validation of an in vitro skin sensitization strategy using a data set of 33 chemical references.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.<br>References Clouet, E., et al.: Toxicology In Vitro, (2017)<br></p>

<p>Applications A charged sulfhydryl reactive reagent.<br>References Karlin, A., et al.: J. Mol. Biol. , 61, 175 (1971)<br></p>

<p>Applications A metabolite of Imipramine (I465980).<br>References Magdalou, J., et al.: J. Biol. Chem., 257, 13624 (1982), Orzechowski, A., et al.: Carcinogenesis, 15, 1549 (1994), Hawes, E., et al.: Drug Metab. Dispos., 26, 830 (1998),<br></p>

<p>Applications β-Cypermethrin is a pyrethroid compound that is used as an insecticide to eliminate unwanted pests from crop fields. β-Cypermethrin has been advertised to be safe for humans despite the fact that considered a possible human carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chen, S., et al.: Appl. Micro. 94, 505 (2012); Li, Z., et al.: Bull. Env. Cont. Toxicol., 80, 335 (2008)<br></p>

<p>Applications Metyrapone acts as a glucocorticoid synthesis inhibitor, maintaining stress-hormone levels.<br>References Keller, C. et al.: Drug. Alc. Dep., 133, 405 (2013); Vilela, F. et al.: Neuroendocrinol., 97, 322 (2013);<br></p>

<p>Applications Main Quinfamide (Q670600) metabolite.<br>References Bailey, D., et al.: J. Med. Chem., 22, 599 (1979),<br></p>

<p>Applications Estradiol 17β-sulfate is a naturally occuring steroid in whihc can be converted into Estradiol(E888000)<br>References Takanashi, K., et al.: Steroids., 68, 383-392 (2003)<br></p>

<p>Applications Isovaleryl L-Carnitine-d3 Chloride is labelled Isovaleryl L-Carnitine Chloride (I917580) which is used to prepare carnitine benzyl esters as neuroprotectant prodrugs.<br>References Gong, X., et al.: J. Chem. Res., 6, 327 (2008)<br></p>