Toxicology

<p>Applications A labelled cholinesterase inhibitor. Insecticide; acaricide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaines, T.B., et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969),<br></p>

<p>Applications rac-Clopidogrel-d3 Hydrogen Sulfate is the labeled analogue of rac-Clopidogrel Hydrogen Sulfate (C587248), which is used in the synthesis of Clopidogrel derivatives as platelet aggregation inhibitors.<br>References Chen, J., et. al.: Hecheng Huaxue, 18, 586 (2010)<br></p>

<p>Applications Selective pre-emergence herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bailey, G.W., et al.: Residue Rev., 10, 97 (1965), Chun, O., et al.: Food Chem. Toxicol., 41, 1063 (2003), Berrada, H., et al.: Food Control., 21, 36 (2010),<br></p>

<p>Applications (±)-Quizalofop-ethyl-d3 (propionate-3,3,3-d3) is the labelled version of Quizalofop-ethyl (Q826108(P)), which may have agricultural applications specifically in controlling plant diseases. (±)-Quizalofop-ethyl-d3 (propionate-3,3,3-d3) has been useful in analytical studies as well, particularly in the development of retention time interpolation scale for liquid chromatography.<br>References Watanabe, S., Jpn. Kokai Tokkyo Koho (2020) JP 2020125364 A; Celma, A., et al.: J. Chromatogr. A, 1568, 101 (2018)<br></p>

<p>Applications A labelled antipruritic. Antibacterial, antimicrobial agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Robinson, et al.: J. Pharm. Pharmacol., 18, 19 (1966); Abdel-Moety, E., et al.: Eur. J. Pharm. Sci., 5, 1 (1997); Basavaiah, K., et al.: Chem. Pharm. Bull., 47, 1351 (1999);<br></p>

<p>Applications Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>

<p>Applications Clofentezine is a mite growth regular and an tetrazine based acaricide. Clofentezine is used in agriculture for the protection of ornamentals, food and non-food crops in the field.Used as a standard for Pesticide detection. Clofentezine is used in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bakirci, G.T., et al.; Food. Chem., 135, 1901 (2012); Ay, R., et al.: Insect. Sci., 18, 503 (2011);<br></p>

<p>Applications Anti-inflammatory.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Becker, A., et al.: J. Int. Med. Res., 8, 333 (1980), Child, R.G., et al.: Arzneim.-Forsch., 30, 695 (1980), Bolte, H.F., et al.: Arzneim.-Forsch., 30, 721 (1980).<br></p>

<p>Applications (R)-Enantiomer of Bicalutamide. Used as an antiandrogen, antineoplastic (hormonal).<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990), Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993), McKillop, D., et al.: Xenobiotica, 25, 623 (1995),<br></p>

<p>Applications Tetrasul is a chlorinated diphenyl sulfide aracacide. Tetrasul is used for the control of mites and other pests in food and gardening crops.<br>References Hansen, T. et al.: Tids. Plant., 74, 618 (6970); Dittrich, V.: Zeitsch. Angew. Entomol., 61, 240 (1968);<br></p>

<p>Applications Adenosine 5'-Monophosphate is a natural occurring nucleotide and a useful ligand determinant that facilitate the binding of APS reductase inhibitors and activates adenosine receptor agonists.<br>References Hong, J.A. et al.: J. Med. Chem., 52, 5485 (2009); Korboukh I. et al.: J. Med. Chem., 55, 6467 (2012)<br></p>

<p>Applications A metabolite of Testosterone (T155000). It is a urinary metabolite of Androstenedione (A637550) in patients with Addison's disease and also used as a marker in blood plasma for detection of prostate cancer.<br>References Lokhov, P.G. et al.: Metabolomics, 6, 156 (2010); Bonnaire, Y. et al.: J. Anal. Toxicol., 19, 175 (1995); Tamm, J. et al.: Steroids, 8, 659 (1966);<br></p>

<p>Applications Imidacloprid-urea is a metabolite of Imidacloprid (I275990), a neonicotinoid; the active ingredient in certain neuro-active insecticides. Used in pest control.<br>References Chauzat, M., et al.: Env. Entomol., 38, 514 (2009), Patial, A., et al.: Env. Ecol., 27, 320 (2009), Fernandez-Bayo, J., et al.: J. Agric., Food Chem., 57, 5435 (2009); Aregahegn, K. et al.: Env. Sci. Tech., 51, 2660 (2017);<br></p>

<p>Applications Contact herbicide used also to produce desiccation and defoliation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brian, et al.: Nature, 181, 446 (1958), Gaines, T.B., et al.: Fundam. Appl. Toxicol., 7, 299 (1986),<br></p>

<p>Applications Inhibitor of Dopamine biosynthesis.<br>References Jones, D., et al.: Drug Metab. Disposition, 35, 1466 (2007), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),<br></p>

<p>Applications A labelled metabolite of Bentazon, a selective post-emergence herbicide.<br>References Klibanov, A., et al.: Science, 221, 259 (1983), Huber, R., et al.: Rev. Environ. Contam. Toxicol., 137, 111 (1994), Roper, J., et al.: Wat. Res., 29, 2720 (1995),<br></p>

<p>Applications Chlorimuron-ethyl-d5 is a labeled analogue of Chlorimuron-ethyl (C371273), which is used in weed control method as herbicide.<br>References Sada, Y., et al.: PCT Int. Appl. 45 pp. (2020)<br></p>

<p>Applications Sumatriptan Succinate is a selective 5-HT1B/1D-receptor agonist with anticonvulsant properties (1,2). Sumatriptan Succinate is used for migraine relief (2).<br>References (1) Razzaque, Z., et al.: Br J Clin Pharmacol. 47, 75 (1999) (2) Cady, R. K., et al.: J Headache Pain. 18, 17 (2017)<br></p>

<p>Applications Destriazolyl Bromo Propiconazole is an impurity of Propiconazole (P770100).<br>References Godefroi, E.F., et al.: J. Med. Chem., 12, 784 (1969), Buchel, K.H., et al.: Arzneim.-Forsch., 22, 1260 (1972),<br></p>

<p>Applications Isotope labelled flavoprotein responsible for iodide salvage in thyroid glands. A tyrosine hydroxylase inhibitor.<br>References Fitzpatrick, P.F., et al.: Biochemistry, 30, 3658 (1991), Harsing, L.G., et al.: Neuroscience, 77, 419 (1997), Haynes, C., et al.: J. Biol. Chem., 277, 11513 (2002),<br></p>

<p>Applications 4,4'-Dichlorodiphenyldichloroethane is a synthetic organochlorine insecticide. 4,4'-Dichlorodiphenyldichloroethane is a metabolite of 4,4'-Dichlorodiphenyltrichloroethane (D434195). 4,4'-Dichlorodiphenyldichloroethane is a probable carcinogen (Group B2).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tao, S. et al.: Environ. Sci. Technol., 39, 2494 (2005); Zhou, Q. et al.: J. Chrom. A, 1216, 6680 (2009); Weiderpass, E. et al.: Cancer Epidemiol. Biomark. Prev,., 9, 487 (2000);<br></p>

<p>Applications A labelled form of Etofenprox (E936400), which is a pyrethroid derivative which is used as an insecticide. Used as a standard for Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lehotay, S., et al.: J. AOAC Int., 88, 595 (2005); Paya, P., et al.: Anal. Bioanal. Chem., 389, 1697 (2007)<br></p>

<p>Applications Metazachlor Ethane Sulfonic Acid Sodium Salt is an ethanesulfonate metabolite of Metazachlor (M225855), which is a chloroacetanilide herbicide.<br>References Laue, H., et al.: Environ. Sci. Technol., 30, 1129 (1996); Matthies, M., et al.: Environ. Sci. Technol., 43, 9223 (2009); Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009); Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010); Liu, B., et al.: J. Agric. Food Chem., 58, 2673 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications Isovaleryl L-Carnitine-d9 Chloride is labelled Isovaleryl L-Carnitine Chloride (I917580) which is used to prepare carnitine benzyl esters as neuroprotectant prodrugs.<br>References Gong, X., et al.: J. Chem. Res., 6, 327 (2008)<br></p>

<p>Stability Hygroscopic<br>Applications Bis(2,3-dibromopropyl) Phosphate is a derivative of Tris(2,3-dibromopropyl) Phosphate, a widely used flame retardant in plastic and textiles.<br>References Elliott, W.C., et al.: Life. Sci., 7, 1107 (1983);<br></p>

<p>Applications 4-Dimethylaminosulfotoluidide is an intermediate in the synthesis of Tolylfluanide (T536730), a polyvalent sulfamide fungicide that is closely related to dichlofluanide.<br>References Wainwright, A. et al.: Bright. Crop Prot. Conf. Pests Dis., 1, 275 (1996)<br></p>

<p>Applications Methylstenbolone is an anabolic androgenic steroid that have been studied in respect of testosterone-receptor interaction and in the development of QSAR models.<br>References Singh, D., et al.: J. Chem. Pharma. Rsch., 3, 1 (2011); McFarland, K., et al.: Science, 245, 494 (1989); Heckert, L., et al.: Mol. Endocrinol., 12, 1499 (1998); Themmen, A., et al.: Endocr. Rev. 21, 551 (2000); Kumar, R., et al.: Biol. Reprod., 65, 710 (2001)<br></p>

<p>Applications Difluoroacetic acid<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Labelled Brimonidine. It is an α2 receptor agonist. It is a drug used to treat glaucoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Katz, L.J., et al.: Am. J. Ophthalmol., 127, 20 (1999), Cantor, L. B., Expert Opin. Pharmacother., 1, 815 (2000),<br></p>

<p>Applications Labelled Bifenthrin (B383000). Third generation synthetic pyrethroid. Insecticide, acaricide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Plummer, E.L., et al.: Pestic. Sci., 14, 560 (1983), Trumble, J.T., et al.: J. Econ. Entomol., 81, 608 (1988), Ross, M., et al.: Biochem. Pharmacol., 71, 657 (2006), Hillegass, J., et al.: Toxicol. Sci., 102, 413 (2008),<br></p>

<p>Impurity Dexamethasone Sodium Phosphate EP Impurity B<br>Stability Hygroscopic<br>Applications Betamethasone 21-Phosphate Disodium Salt (Dexamethasone Sodium Phosphate EP Impurity B) is a Betamethasone derivative. It is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties which can be used in treatment of asthma and itching.<br>References Kerns, E., et al.: J. Pharm. Sci., 90, 1838 (2001), Seidler, J., et al.: J. Med. Chem., 46, 4477 (2003), Alsenz, J., et al.: J. Pharm. Sci., 96, 1748 (2007),<br></p>

<p>Applications Misoprostol is a cytoprotective prostaglandin PGE1 analogue.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Graham, Y., et al.: Lancet, 2, 1277 (1988); Graham, D.Y., et al.: Ann. Int. Med., 119, 257 (1993); Fletcher, H., et al.: Obstet. Gynecol., 83, 244 (1994);<br></p>

<p>Applications Labelled acetylsalicylic acid impurity B.<br>References Walter, M., et al.: Eur. J. Biochem., 1996, 239, 281 (1996), Bantignies, B., et al.: Plant Mol. Biol., 42, 871 (2000), Bais, H., et al.: J. Biol. Chem., 278, 32413 ( 2003), Finkler, C., et al.: Genetica, 124, 117 (2005),<br></p>

<p>Applications 1-Cyano-6-(methylsulfonyl)-7-nitro-9H-xanthen-9-one is an impurity of Mesotrione (M225765), a herbicide that works by inhibiting 4-hydroxyphenylpyruvate dioxygenase (HPPD), a crucial enzyme for the biosynthesis of carotenoid in plants. Mesotrione is also a synthetic analog of lepospermone.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Deng, L., et al.: Indus. Crops. Prod., 39, 154 (2012); Pileggi, M., et al.: Chemosphere., 86, 1127 (2012); McElroy, J., S., Hort. Technol.,22, 627 (2012);<br></p>

<p>Applications Agricultural fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cohen, S., et al.: Crit. Rev. Toxicol., 40, 531 (2010), Wong, J., et al.: J. Agric. Food Chem., 58, 5884 (2010),<br></p>

<p>Stability Hygroscopic<br>Applications p-Cresol Sulfate Potassium Salt-d4 is the labelled analogue of p-Tolyl Sulfate Potassium Salt (T536805), the major component of urinary myelin basic protein-like material and is derived through the secondary metabolism of p-cresol (C781900).<br>References Cuoghi, A., et al.: Anal. Bioanal. Chem., 404, 2097 (2012); Wu, I.W., et al.: Nehphrol. Dial. Transplan., 27, 1169 (2012);<br></p>

<p>Applications Diuron is a phenyl urea herbicide (1,2). Pre-emergent herbicide which may find its way into aquatic environments, and consumable fruit/vegetation (3,4). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Noseworthy, J. et al.: Weed. Tech. 2010 Jul:24(1) pp64-702. Armenta, S. et al.: Anal. Bioanal. Chem. 2010 May;397(1):297-308.3. Neuwoehner, J. et al.: Aquat. Toxicol. 2010 Apr 1;97(1):58-67.4. Wong, J. et al.: J. Agric. Food. Chem. 2010 May 26;58(10):5897-9034<br></p>

<p>Applications Terbuthylazine-(ethyl-d5) is the deuterized or labeled form of Terbuthylazine (T110500), which is a triazine herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schenck, F., et al.: Bull Environ. Contam. Toxicol., 73, 24 (2004)<br></p>

<p>Applications A classical β-adrenergic agonist in retina in interlaboratory study.<br>References Horwitz, W., et al.: Anal. Chem., 54, 67 (1982), Gowik, P., et al.: Analyst, 125, 1103 (2000),<br></p>

<p>Applications Labelled Levamisole. Biological response modifier with anthelmintic activity. Anthelmintic (nematodes); immunomodulator.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Thienpoint, D., et al.: Nature, 209, 1084 (1966), Bullock, M.W., et al.: J. Med. Chem., 11, 169 (1968), Miller, M.J., et al.: Drugs, 20, 122 (1980), Stevenson, H.C., et al.: J. Clin. Oncol., 9, 2052 (1991), Amery, W.K., et al.: Int. J. Immunopharmacol., 14, 481 (1992),<br></p>

<p>Applications Controlled substance (depressant). Sedative; hypnotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Horwitz, et al.: Drug Metab. Dispos., 8, 77 (1980),<br></p>

<p>Applications Cycloprate is an insecticide with ovicidal activity.<br>References Asano, S., et al.: Apl. Entomol. Zool., 17, 67 (1982); Asano, S., et al.: Nippon Oyo Dobutsu Konchu Gakkaishi, 23, 113 (1979)<br></p>