Toxicology

<p>Applications 2,2',3,3',4,4',5,5',6,6'-Decachlorobiphenyl is a polychlorinated biphenyl (PCB) congeners. A halogenated organic contaminant and a pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ballschmiter, K., et al.: Fresenius J Anal Chem., 302, 20 (1980); Hawker, Darryl W., et al.: Environ Sci Technol., 22, 382 (1988); Souza, A. C., et al.: Mar. Pollut. Bull., 133, 436 (2018); Siddiqi, H. A., et al.: J. Chem.Soc. Pakistan, 39, 851 (2017)<br></p>

<p>Applications A metabolite of halopropanes.<br>References Barnsley, E.A.: Biochem. J., 100, 362 (1966)<br></p>

<p>Applications Dimethyldimyristylammonium Chloride is used as a surfactant.<br>References Cipiciani, A., et al.: Austr. J. Chem., 44, 1505 (1991); Hueck, H., et al.: Appl. Microbiol., 14, 308 (1966)<br></p>

<p>Applications A metabolite of Cortisol (H714615).<br>References Aguilera, R., et al.: Clin. Chem., 47, 292 (2001), Pujos, E., et al.: Anal. Bioanal. Chem., 381, 244 (2005), Flenker, U., et al.: Steroids, 73, 408 (2008),<br></p>

<p>Applications Isotope labelled Ammelide (A633650), which is a metabolite of Melamine (1) (M208700), which acts as a non-protein nitrogen food additive (2). Also present in pet foods as well (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br>References 1. Mast R. et al.: Food Chem Toxicol. 1983 Dec;21(6):807-10. 2. Ehling S. et al.: Food Addit. Contam. 2007 Dec;24(12):1319-25.3. Vail T. et al.: J Anal Toxicol. 2007 Jul-Aug;31(6):304-12.<br></p>

<p>Applications An isotopically labelled metabolite of halopropanes; also the metabolite of 2 glycosylnitrosoureas (RFCNU and RPCNU).<br>References Madelmont, J.C., et al.: Drug Metab. Dispos., 10, 662 (1982), Barr, D.B., et al.: J. Anal. Toxicol., 22, 96 (1998),<br></p>

<p>Applications Pyrasulfotole (P847008) is a 4-hydroxyphenylppvate dioxygenase (HPPD) inhibitor herbicide, used in controlling post-emergence weeds in small grains cultures.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Isotope Labelled Triphenyltin Hydroxide (T809350), an organotin compound. Triphenyltin Hydroxide is used as a fungicide and antifeeding compound for insect control (1,2). Recent studies show that Triphenyltin Hydroxide may have adverse effects on the reproductive and immune systems and may disrupt the endocrine system (3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Sarpa M. et al.: J Toxicol Environ Health A. 2010;73(13-14):965-712. Soderquist, J. et al.: J. Agric. Food. Chem. Jan:28(1);111-1173. 3. Golub, M. et al.: J. Toxicol. Environ. Health B. Crit. Rev. 2004 Jul-Aug;7(4):281-95<br></p>

<p>Applications A labelled metabolite of Diethylstilbestrol.<br>References Liehr, J.G., et al.: Steroids, 40, 713 (1982),<br></p>

<p>Applications Spinetoram belongs to spinosyn family of insecticides and shows potential of natural products research.<br>References Kirst H. A.: J. Antibiot., 63, 101-111 (2010)<br></p>

<p>Applications Iprovalicarb-d8 is the deuterated form of Iprovalicarb (I747500), which is a systematic fungicide. Iprovalicarb is used for the control of pathogenic fungi from the oomycetes class in grapes, potatoes, tomatoes and other crops.<br>References Stubler, D., et al.: Pflanzensch.-Nach. Bay., 52, 33 (1999); Stenzel, K., et al.: Bright. Crop Prot. Conf. Pests Dis., 2, 367 (1998);<br></p>

<p>Applications Sulfobromophthalein (BSP) is an organic dye used a for liver diagnostics in vitro. Reagent for the quantitative determination of proteins.<br>References 1. McGuire, J., et al. 1977. Anal. Biochem. 83: 75-81. PMID: 920954<br></p>

<p>Applications A novel labelled HIV reverse transcriptase inhibitor useful in treatment of HIV infection.<br>References Scholler-Gyure, M., et al.: J. Clin. Pharmacol., 48, 322 (2008), Thakur, A., et al.: Eur. J. Med. Chem., 43, 471 (2008),<br></p>

<p>Applications Dexketoprofen Trometamol is an non-steroidal anti-inflammatory drug used for the treatment of mild to moderate pain.<br>References Gokce, B., et al.: J. Enzyme. Inhibit. Med. Chem., 27, 37 (2012); Sagiroglu, G., et al.: Eurosian. J. Med., 43, 23 (2011);<br></p>

<p>Applications An inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells.<br>References Park, J.M., et al.: J. Urol., 162, 1110 (1999), Watson, M., et al.: Brit. J. Pharmacol., 127, 590 (1999)<br></p>

<p>Applications Propafenone-d5 Hydrochloride is labelled Propafenone which is a sodium channel blocker.<br>References Hollmann, M., et al.: Arzneim.-Forsch., 33, 763 (1983), Bryson, H. M., et al.:Drugs, 45, 85 (1993), Rae, A. P., et al.: Am. J. Cardiol., 82, 59N (1998),<br></p>

<p>Stability Hygroscopic<br>Applications Methyl Isofenphos is an organophosphorus compound, that according to biological studies, can cause acute toxicity to animals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, S.: Huanjing Wuran Yu Fangzhi, 20, 13 (1998); Yin, Y., et al.: Huanjing Yu Jiankang Zazhi, 28, 583 (2011)<br></p>

<p>Stability Hygroscopic<br>Applications Chromone complex which blocks mast cell degranulation.<br>References Ashton, M.J., et al.: Toxicol. Appl. Pharmacol., 26, 319 (1973), Friday, G.A., et al.: Am. J. Ophthalmol., 95, 169 (1983)<br></p>

<p>Applications The major metabolite of Norflurazon (N684500) in soil.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mazzola, E.P. , et al.: J. Agric. Food Chem., 32, 1102 (1984),<br></p>

<p>Applications Diphenylamine is an aromatic amine that was shown to exhibit antioxidant activities and is now used as an anti-scald agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sugihara, T., et al.: Free. Radic. Biol. Med., 14, 381 (1993); Hanthorn, J.J., et al.: J. Am. Chem. Soc., 134, 8306 (2012);<br></p>

<p>Applications Triethyl Phosphorothioate, is a widely used organophosphorus insecticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhou, Q., et al.: Atmospheric Environ., 43, 4163 (2009);<br></p>

<p>Applications Antibacterial.<br>References Taha, M., et al.: Bioorg. Med. Chem., 16, 1218 (2008), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),<br></p>

<p>Stability Hygroscopic<br>Applications A major metabolite of Nicotine in humans. Carcinogen.<br>References Benowitz, N., et al.: Clin. Pharmacol. Ther., 56, 483 (1994), Nakajima, M., et al.: Drug Metab. Dispos., 24, 1212 (1996), Messina, E., et al.: J. Pharmacol. Exp. Ther., 282, 1608 (1997), Oscarson, M., et al.: Hum. Mutat., 20, 275 (2002),<br></p>

<p>Applications An aromatase inhibitor.<br>References Aello, A., et al.: J. Nat. Prod., 54, 281 (1991), Salaja, B.A., et al.: Steroids, 59, 330 (1994), Hunter, A.C., et al.: J. Steroid Biochem. Mol. Biol., 87, 301 (2003),<br></p>

<p>Applications A cell division factor found in various plant parts and in yeast. A plant growth regulator. Augments growth of microbial cultures.<br>References Fry, D.W., et al.: Science, 265, 1093 (1994), Vesely, J., et al.: Eur. J. Biochem., 224, 771 (1994),<br></p>

<p>Applications (9α,13α,14α)-3-(Methoxy-d3)-17-methyl-morphinan Hydrobromide is the labeled analogue of Dextromethorphan Hydrobromide Monohydrate (D299455), an antitussive drug. Orally active synthetic morphine analog. Analgesic (narcotic). Racemethorphan and levomethorpham are controlled substances (opiates).<br>References Hafliger, et al.: Helv. Chim. Acta, 39, 2053 (1956); Cox, B.M., et al.: Br. J. Pharmacol. Chemother., 27, 81 (1966); Hou, Chia-Hui; Tzeng, J., et al.: Eur. J. Pharmacol., 544, 10 (2006)<br></p>

<p>Stability Very Hygroscopic<br>Applications 3-Methylglutarylcarnitine Chloride is the chloride salt of M226345, which is derived from DL-Carnitine Benzyl Ester Chloride (C184135), which is an intermediate in the synthesis of 3-Hydroxybutyrylcarnitine Hydrochloride (H830900), a reagent used to study acylcarnitine profile in thyroid disease.<br>References Hintze, U., et al.: Lipids., 10, 20 (1975)<br></p>

<p>Applications 2-[4-(2,4-Dichloro-5-hydroxyphenoxy)phenoxy]propanoic Acid Methyl Ester, is the metabolite of Diclofop-methyl, used as a herbicide.<br>References Tanaka, F. S., et al.: J. Agri. Food Chem., 38, 553 (1990);<br></p>

<p>Applications O,O-Dimethyl-d6 Dithiophosphate is the isotope labelled analog of O,O-Dimethyl Dithiophosphate (3, an dimethyl phosphorodithiolate derivatives used as insecticides.<br></p>

<p>Stability Moisture Sensitive<br>Applications Phosphoric Acid Tributyl Ester is used as a solvent in the solvent-detergent method for production of immunoglobulin for inactivation of viruses with lipid envelope on the model of duck hepatitis B virus. It is also used as a ligand in the extraction of lanthanide ions from solid and liquid materials by supercritical CO2.This compound is a contaminant of emerging concern (CECs).<br>References Zubkova, N., et al.: Bull. Exp. Biol. Med., 155, 821 (2013); Lin, Y., et al.: Anal. Chem., 66, 1971(1994)<br></p>

<p>Applications Labelled ester analog of Rapamycin.<br>References Raymond, E., et al.: J. Clin. Oncol., 22, 2336 (2004), Galanis, E., et al.: J. Clin. Oncol., 23, 5294 (2005)<br></p>

<p>Applications Labelled Tolperisone, a muscle relaxant.<br></p>

<p>Stability Air Sensitive<br>Applications Used for detecting the presence of hydrolytic analytes, such as leukocytes, esterase, and protease. The detection of leukocytes is especially important in medical diagnostics.<br>References Jackson, D.S., et al.: Arch. Biochem. Biophys., 20, 323(1), 108 (1995)<br></p>

<p>Applications Bedaquiline is a diarylquinoline derivative that acts as a mycobacterial inhibitor. Bedaquiline shows promise as potential drug in the treatment of tuberculosis.<br>References de Jonge M.R. et al.: Proteins, 67, 971 (2007); Diacon A.H. et al.: N. Eng. J. Med., 360, 2397 (2009);<br></p>

<p>Applications Trimethadione is an anticonvulsant and antiepileptic agent used in the treatment of pregnant women. Prenatal exposure to anti-epileptic drugs (AEDs) has indicated increased risk of major or minor congenital malformation.<br>References Ahir, B. et al.: Toxicol. Vitro., 28, 948 (2014); Pastore, V. et al.: Bioorg. Med. Chem., 21, 841 (2013);<br></p>