Toxicology

Stability Very Hygroscopic
Applications Mildronate-d3 is the labeled analogue of Mildronate (M344450), a novel pharmaceutical composition based on a reverse transcriptase inhibitor and meldonium. May contain a significant amount of water.

Applications Fosthiazate is a pesticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lehotay, S., et al.: J. AOAC Int., 88, 595 (2005); Hiemstra, M., et al.: J. Chromat. A, 1154, 3 (2007)

Applications Isotope labelled Digitoxin (D445950), is used as a cardiotonic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Foerster, et al.: Arch. Int. Pharmacodyn. Ther., 159, 1 (1966), Jakovljevic, I.M., Anal. Profiles Drug Subs., 3, 149 (1974)

Applications Fumagillol is an analog of Fumagillin (F862650), a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis. Fumagillin shows promise as both an an anti-infective and antiangiogenic agent.
References Molina, J.M. et al.: N. Eng. J. Med., 346, 1963 (2002); Hou, L. et al.: Pathol. Int., 59, 448 (2009); Ingber, D. et al.: Nature, 348, 555 (1990);

Applications Pyflubumide is an acaricide used in the control of phytophagous mites.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zhang, Y.: Shijie Nongyao, 38, 15 (2016), Furuya, T., et al.: J. Pest. Sci. , 40, 38 (2015), Van L., et al.: Pest. Biochem. Physiol., 121, 12 (2015)

Applications Bendiocarb is a benzodioxolyl carbamate derivative. Bendiocarb is commonly used as an insecticide in agriculture against a wide range of pests and insects. Bendiocarb is one of the insecticides recommended by world health organization (WHO) for use in malaria control.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sadasivaiah, S. et al.: Am. J. Trop. Med. Hyg., 77, 249 (2007); Brooker, P. J. et al.: Pest. Sci., 3, 735 (1972);

Applications Foramsulfuron is used in weed control practises in reduced tillage production. It also functions as a new herbicide with ALS-inhibiting active ingredient for the control of troublesome weeds in sugar beet.
References Wendt, M. J., et al.: Weed Res., 57, 267 (2017); Isik, D., et al.: Phytoparasitica, PagesAhead of Print (2017)

Stability Hygroscopic
Applications A labelled serotonin 5-HT2A receptor antagonist. Used as potential controls in various biological studies.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wong, D.F., et al.: Science, 226, 1393 (1984), Blin, J., et al.: Eur. J. Pharmacol., 147, 73 (1988), Kehne, J.H., et al.: J. Pharmacol. Exp. Ther., 277, 968 (1996),

Applications Chlorphentermine is an anorectic agent. Chlorphentermine is the 4-chloro derivative of the better known appetite suppressant Phentermine (P318830). Chlorphentermine is structurally related to amphetamine but is a relatively weak stimulant with little abuse potential.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gylys, J.A. et al.: J. Pharmacol. Exp. Therap., 137, 365 (1962); Jun, H.W. et al.: Can. J. Pharmac. Sci., 4, 27 (1969); Luellmann, H. et al.: J. Pharm. Pharmacol., 25, 239 (1973);

Applications Mezlocillin Sodium is an antibacterial agent. Penicillin antibiotic effective against gram negative and gram positive bacteria.
References Sanders, C. et al.: J. Antimicrob. Chemother., 9, 15 (1982); Gasca, M. et al.: Am. J. Hosp. Pharm., 44, 574 (1987);

Applications Flurprimidol is a plant growth regulator used to control stem elongation.
References Lee, J., et al.: Horttechnology, 25, 480-486 (2015)

Applications Carboxyformamido Metazachlor Benzoic Acid is a metabolite of Metazachlor (M225855) which is a chloroacetanilide herbicide used on vegetable crops.
References Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009); Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010); Liu, B., et al.: J. Agric. Food Chem., 58, 2673 (2010);

Applications 4-Amino-6-[(1,1-dimethylethyl)amino]-1,3,5-triazin-2(1H)-one is a fungicide derivative of Terbuthylazine (T110500), a triazine herbicide.
References Schenck, F., et al.: Bull Environ. Contam. Toxicol., 73, 24 (2004); Coscolla, C. et al.: Atmos. Env., 95, 29 (2014);

Applications N-Nitrosodiethylamine-d10 is a labelled form of N-Nitrosodiethylamine (N525465) which is a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver.NDMA and NDEA were found as an impurity in generic versions of valsartan, losartan and irbesartan.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Oda, Y., et al.: Mutation Research, Genetic Toxicology and Environmental Mutagenesis, 584, 1 (2005); Yamazaki, H., et al.: Carcinogenesis, 13, 1789 (1992);Chem. and Eng. News, p.5, Feb. 25, 2019

Applications Lindane-d6 is very toxic. It was an effective insecticide on mosquitoes, house flies, and on German and American cockroaches.
References Tanaka, K., et al.: Pestic. Biochem. Physiol., 6, 386-391 (1976)

Applications Phosphfolan-methyl is an insecticide used in the treatment of crops and protection from pests.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chen, H. et al.: Sepu, 29, 409 (2011);

Applications Labelled selective COX-2 inhibitor
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kulmacz, R.J., et al.: J. Biol. Chem., 264, 14136 (1989), Kalgutkar, A.S., et al.: J. Med. Chem., 43, 2860 (2000), Hata, A.N., et al.: Mol. Pharmacol., 67, 640 (2005), Tuccinardi, T., et al.: J. Med. Chem., 49, 984 (2006),

Applications Analgesic; sedative; anesthetic.Controlled substance (opiate).
References DeRossi, R., et al.: Vet. J., 178, 294 (2008), Hoecker, J., et al.: Anesthesiol., 109, 95 (2008), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009),

Applications An alkylated dipeptide reported to be 6000 to 10000 times sweeter than sucrose; structurally related to Aspartame. A non-nutritive sweetener.
References Ranney, R., et al.: J. Toxicol. Environ. Health, 2, 441 (1976), Padden, B.E., et al.: Anal. Chem., 71, 3325 (1999), Arai, H., et al.: Metabolism, 56, 115 (2007),

Stability Moisture Sensitive
Applications Fensulfothion Oxon Sulfone is a metabolite of the insecticide fensulfonthion (F265490), an inhibitor of cholinesterase activity.
References Solly, S.R.B., et al.: New. Zea. J. Agri. Res., 14, 88 (1971); Hansch, C., et al.: Biochem. Toxicol. Insectic. Proc., 33 (1970);

Applications Neuroleptic agent related structurally to thiothixene. Antipsychotic; neuroleptic agent; dopamine receptor antagonist.
References Nielsen, et al.: Acta Pharmacol. Toxicol., 32, 363 (1973), Post, M.L., et al.: Nature, 256, 342 (1975), Peuch, et al.: Neuropharmacology, 20, 1279 (1981),

Stability Moisture Sensitive
Applications Fosthietan is used as a nematicide, to protect soils and crops from nematodes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Choudhari, K. & Koli, S.: Pesticides, 12, 29 (1978); King, P., et al.: Anim. Prod. Sci., 22, 209 (1982); Murthy, M., et al.: Pesticides, 19, 40 (1985)

Applications Sedative, hypnotic.Controlled substance (depressant).
References Lomen, P., et al.: J. Int. Med. Res., 4, 55 (1976), Allens, G.S., et al.: J. Int. Med. Res., 6, 343 (1978), Pakes, G.E., et al.: Drugs, 22, 81 (1981).

Applications Fenpropidin-d10 is the labeled analogue of Fenpropidin (F249470), a fungicide.
References Leroux, P. Walker, A.: Eur. J. Plant Path., 135, 683 (2013); Zhao, H., et. al.: Ecotox. Environ. Safe., 77, 52 (2012)

Stability Hygroscopic
Applications A labelled metabolite of Estradiol (E888000).
References Agasan, A., et al.: J. Immunol. Methods., 177, 251 (1994), Stone, R., et al.: Science, 265, 308 (1994), Tacey, R., et al.: J. Pharm. Biomed. Anal., 2, 1303 (1994),

Applications (S)-2-(4-CHLOROPHENYL)-3-METHYLBUTANOIC Acid (cas# 55332-38-2) is a useful research chemical.

Stability Hygroscopic
Applications Sodium 17beta-Estradiol-2,4,16,16-d4 3-Sulfate (Stabilized with TRIS, 50% w/w) (CAS# 352431-50-6) is a useful isotopically labeled research compound.

Applications Labelled analogue of Indeno[1,2,3-cd]pyrene, a polycyclic aromatic hydrocarbon (PAH) and a known carcinogen. Indeno[ 1,2,3-cd]pyrene is listed as a priority pollutant by the Environmental Protection Agency (EPA). Indeno[1,2,3-cd]pyrene has been detected in automobile engine exhaust, charcoal broiled foods, ground water, river sediments as well as cigarette smoke condensate.
References Rice, J.E. et al.: J. Org. Chem., 51, 2428 (1986); Smith, C.J. et al.: Food Clin. Toxicol., 38, 637 (2000); Panalaks, T.: J. Environ. Sci. Health. Part B Pest. Food Cont. Agric. Wastes, B11, 299 (1976);

Applications Used as an antiandrogen, antineoplastic (hormonal). (94%d4; 5.7%d3, 0.1%d1, no d0)
References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990), Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993), McKillop, D., et al.: Xenobiotica, 25, 623 (1995),

Applications rel-(4R,5R)-5-(4-Chlorophenyl)-4-methyl-2-thiazolidinone is a useful building block and has been used in the synthesis of hexythiazox (H298500).
References Lou, J.; et al.: Nongyao, 47, 328 (2008).

Applications L-Norcarnitine is a butyric acid derivative used in the preparation of L-Carnitine (C184110).
References Jain, R.P. et al.: Tetrahed. Lett., 42, 4437 (2001);

Applications Acyclovir (A192400) impurity. The L-Valine ester prodrug of Acyclovir.
References Beauchamp, L.M., et al.: Antiviral Chem. Chemother., 3, 157 (1992), Weller, S., et al.: Clin. Pharmacol. Ther., 54, 595 (1996), Lowance, D., et al.: N. Engl. J. Med., 340, 1462 (1999),

Applications Tetrabromobisphenol S is a brominated flame retardant (BFR) and a derivative of Bisphenol-S. It can be used as a herbicide to control weeds such as Digitaria, Cyperus microiria, and Echinochloa crusgalli in cucumbers, tomatoes, and white radish.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, X.M., et al.: Anal. Chim. Acta, 753, 1 (2012); Liaw, D.-J., et al.: Angew. Makromol. Chem., 199, 171 (2003); Takamatsu, H., et al. Sulfones as herbicides. Jpn. Kokai Tokkyo Koho. JP 53109942 A 19780926. Sep 26, 1978

Impurity Prilocaine USP Related Compound A
Applications o-Toluidine Chloride is a carcinogenic and toxic aromatic amine contained in hair dye, henna and dyed hair samples. Prilocaine USP Related Compound A
References El-Bayoumy, K., et al.: Cancer Res., 46, 6064 (1986), Turesky, R., et al.: Chem. Res. Toxicol., 16, 1162 (2003), Andrew, A., et al.: Int. J. Cancer, 109, 581 (2004), Pinheiro, H., et al.: Dyes Pigments, 61, 121 (2004), Kirkland, D., et al.: Mutat. Res., 588, 88 (2005),

Applications Pre-emergence herbicide for use in rice and other food crops.
References Jurney, W., et al.: J. Neurosci., 22, 6019 (2002), Yap, C., et al.: J. Cell Biol., 180, 827 (2008),

Stability Hygroscopic
Applications Clencyclohexerol-d10 is a labelled analog of Clenbuterol, a β-agonist which can be used as a growth promoter in farm animals.
References Maistro, S., et al.: Lancet, 346, 180 (1995); Vanoosthuyze, K., et al.: J. Agric. Food Chem., 45, 3129 (1997); Fiori, M., et al.: Anal. Chim. Acta, 529, 207 (2005); Salquebre, G., et al.: J. Anal. Toxicol., 31, 114 (2007);

Applications Antimicrobial agent used as a substitute for chlorophenols in industrial applications.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Martin, I.D., et al.: Arch. Environ. Contam. Toxicol., 24, 381 (1993), Reemtsma, T., et al.: Environ. Sci. Technol., 29, 478 (1995),

Applications Labelled Pholedrine (P352000). An α-adrenergic agonist. Antihypotensive.
References Glennon, R., et al.: J. Med. Chem., 23, 294 (1980), de Letter, E., et al.: J. Anal. Toxicol., 26, 113 (2002), Lin, D., et al.: J. Anal. Toxicol., 31, 109 (2007),

Applications Chrysanthemic Acid is an intermediate in the synthesis of Chrysanthemic Acid (C903440); Dimethrin is a pesticide, a pyrethroid insecticide. An acaricide for agricultural purposes.
References Ford, M G.: Pestic. Sci., 10, 39 (1979); Gan, W., et al.: Zhonghua Yufang Yixue Zazhi, 35, 13 (2001); Wright, F. C.: Southwestern Entomol., 5, 222 (1980);

Applications Procaine is a sodium channel blocker and inhibitor of a variety of processes.