Toxicology

<p>Applications Labelled Tamoxifen (T006000). A nonsteroidal estrogen antagonist of interest in the treatment of some forms of breast cancer. Tamoxifen is a protein kinase C inhibitor, and induces apoptosis in human malignant glioma cell lines.<br>References Sutherland, R., et al.: Nature, 267, 434 (1977), Lerner, L., et al.: Cancer Res., 50, 4177 (1990), Love, R., et al.: J. Clin. Oncol., 20 2559 (2002),<br></p>

<p>Applications Mancozeb is a mixture of Maneb (M163500) and Zineb, a manganese and zinc (1:1) complex mixture with the ethylene bis(dithiocarbamate) anionic ligand. Mancozeb is a foliate fungicide used to protect crops in agriculture. Mancozeb has a broader and more effective fungacidal activity than either of its component on their own. Mancozeb also significantly enhances the copper activity against several bacteriosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tang, M. et al.: Turang Tong., 41, 1365 (2010); Navneet; M. et al.: J. Ind. Botan. Soc., 74, 19 (1995); Lecigne, P. et al.: Phytoma, 531, 13 (2000);<br></p>

<p>Stability Hygroscopic<br>Applications Empagliflozin is a novel, potent and selective SGLT-2 inhibitor. It improves glycaemic control syndrome in diabetic rats.<br>References Thomas, L., et al.: Diabetes. Obesity. Metabol. 14, 94 (2012); Grempler, R., et al.: Diabetes. Obesity. Metabol., 14, 83 (2012);<br></p>

<p>Applications Movento is a synergistic insecticide. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Byrne, F., et al.: Crop. Prot., 25, 831 (2006), Kanrar, B., et al.: Bull Environ. Contam. Toxicol., 77, 631 (2006), Venkateswarlu, P., et al.: Food Chem., 105, 1760 (2007), Khay, S., et al.: Biomed. Chromatogr., 22, 581 (2008),<br></p>

<p>Applications Chloroxuron<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Daidzein-3',5',8-d3 is labelled Daidzein (D103500) which is an inactive analog of Genistein (Cat. #G350000). It blocks the G1 phase of the cell cycle in Swiss 3T3 cells by inhibiting casein kinase II activity.<br>References Jones, P., et al.: J. Biol. Chem., 274, 32008 (1999), Hassan, M., et al.: Anticancer Res., 19, 5657 (1999), Salti, G., et al.: Eur. J . Cancer, 36, 796 (2000).<br></p>

<p>Applications Carbetamide-D5 is the labelled analogue of Carbetamide (C178028). Carbetamide is used in the determination of pesticides.<br>References Jia, W., et al.: Journal of Chromatogr. A., 1395, 160-166 (2015)<br></p>

<p>Applications Dichlorobenzenamine is used in the synthesis of effective inhibitors of plant δ1-pyrroline-4-carboxylate reductase. Also used in the preparation of anti-tumor agents based upon diaryl urea derivatives.<br>References Forlani, G. et al.: J. Agri. Food Chem., 61, 6792 (2013); Zhai, X. et al.: Molecules, 18, 2904 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Pirlimycin Hydrochloride (Mixture of Diastereomers) is a semi-synthetic lincosaminide antibiotic; structural analog of Clindamycin. Antibacterial.<br>References Ahonkhai, V.I., et al.: Antimicrob. Agents Chemother., 21, 902 (1982); Qadri, S.M.H., et al.: J. Antibiot., 36, 42 (1983); Birkenmeyer, R.D., et al.: J. Med. Chem., 27, 216 (1984);<br></p>

<p>Applications Fluoxetine (F597100) derivative.<br>References Cashman, J. et al.: Bioorgan Med. Chem. 17, 337 (2009)<br></p>

<p>Applications Fosetyl Aluminum is a fungicide. It is highly inhibitory in vitro against several species of Phytophthora.<br>References Fenn, M., et al.: Phytopathology, 74, 606 (1984); Matheron, M., et al.: Plant Disease, 84, 454 (2000)<br></p>

<p>Applications Zinc Thiozole is a fungicide.<br>References Domagalina, E., et al.: Fresenius' Zeitschrift fuer Analytische Chemie, 207, 411-14 (1965);<br></p>

<p>Applications Isotope labelled intermediate in the synthesis of Desloratadine (D290250), an nonsedating-type histamine H1-receptor antagonist.<br>References Kreutner, W., et al.: Arzneimittel-Forsch., 50, 345 (2000), Salmun, L.M., et al.: Clin. Ther., 22, 613 (2000), Agrawal, D.K., et al.: Expert Opin. Invest. Drugs, 10, 547 (2001),<br></p>

<p>Applications 1-Naphthylacetyl Spermine Trihydrochloride is a poliamine amide as potent Spermidine uptake inhibitor.<br>References Li, Y., et al.: Cancer Res., 57, 234 (1997), Muller, T., et al.: Science, 256, 1563 (1992), Hironaka, K., et al.: J. Biol. Chem., 275, 16167 (2000),<br></p>

<p>Applications: Used as agricultural fungicide.<br>Dangerous Goods Info: Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Levinskas, G.J., et al.: Toxicol. Appl. Pharmacol., 3, 127 (1961), Ross, R.G., et al.: Can. J. Plant Sci., 49, 655 (1969),<br></p>

<p>Applications Ophthalmic anticholinergic. Mydriatic.<br>References Blessel, K.W., et al.: Anal. Profiles Drug Subs., 3, 565 (1974), Krapivinsky, G., et al.: J. Biol. Chem., 270, 29059 (1995), Bedingfield, J., et al.: Eur. J. Pharmacol., 309, 71 (1996), Jin, W., et al.: Biochemistry, 38, 14294 (1999), Kew, J., et al.: Pharmacol. Ther., 104, 233 ( 2004), Bertaso, F., et al.: J. Neurochem., 99, 288 (2006),<br></p>

<p>Applications 2,6-Dichlorobenzoic Acid is an di-halogenated benzoic acid derivative and is used in the synthesis of Lux-S enzyme inhibitor.<br>References Dhimitruka, I., et al.: Organic. Lett., 8, 47 (2006);<br></p>

<p>Applications 3-Ketocarbofuran is a metabolite of Carbofuran (C176590). A pesticide residue found in fruits and vegetables. 3-Ketocarbofuran causes cell migration in cell gel electrophoresis (SCGE) test.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abass, K., et al.: Chem-Biol. Interact., 18, 210 (2009); Ambrus, A., et al.: J. Environ. Sci. Heal. B., B40, 297 (2005); Usmani, K., et al.: Chem-Biol. Interact., 150, 221 (2004)<br></p>

<p>Stability Moisture Sensitive<br>Applications A cholinesterase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pickering, W.R., et al.: Biochem. Pharmacol., 16, 1183 (1967)<br></p>

<p>Applications Cuprolinic Blue, has been shown to be able to form a particularly stable blue chromophore with single-stranded RNA in neuronal Nissl substance and nucleoli, and thus can be used for counterstaining of enteric neurons for peroxidase immunocytochemistry<br>References Holst, M., et al.: J. Neurosci., Meth., 62, 121 (1995);<br></p>

<p>Applications Procaine Penicillin G is a composed of the β-lactam antibiotic of Penicillin G and the sodium channel blocker Procaine. As an antibiotic, Penicillin G is noted to posses effectiveness mainly against gram-positive organisms. Procaine Penicillin G is used a growth stimulant for poultry.<br>References Galal, E.E. et al.: J Drug Res., 3, 179 (1971); Coates, M.E. et al.: J. Sci. Food Agric., 20, 182 (1969);<br></p>

<p>Applications Herbicide used to control the spread of weedgrass.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Haith, D., et al.: Environ. Sci. Technol., 44, 6496 (2010), Jabran, K., et al.: Int. J. Agric. Biol., 12, 335 (2010), Rahaman, S., et al.: Environ. Ecol., 28, 1 (2010),<br></p>

<p>Applications A labelled metabolite of Nabumetone (N200500). A competitive, non-selective COX inhibitor.<br>References Turpeinen et. al.: Drug Metabolism and Dispositoin, 37: 1017 (2009); Daniels, F., et al.: J. Invest. Dermatol., 44, 259 (1965), Bosca, F., et al.: Photochem. Photobiol., 71, 173 (2000),<br></p>

<p>Applications Ciprofibrate is a hypolipemic agent, related structurally to Clofibrate (C586910). Ciprofibrate is used as an antilipemic.<br>References Davison, C., et al.: Drug. Metab. Dispos., 3, 520 (1975), Arnold, A., et al.: J. Pharm. Sci., et al.: 68, 1557 (1979), Tuchman-Duplessis, H., et al.: Toxicology, 12, 1 (1979),<br></p>

<p>Applications Brompheniramine (cas# 86-22-6) is a useful research chemical.<br></p>

<p>Applications Trimethyl Thiophosphate is one of the impurities of Diphos [3383-96-8]; Also, it is a reactant used in the synthesis of O,O-Dimethyl 5-[2,2,2-trichloro-1-(β,β,β-trichloro-α-hydroxyethylthio)ethyl]thiophosphate, which is used as an acaricides and fungicides.<br>References Perlova, T. G., et al.: Khimiya v Sel’skom Khozyaistve, 14, 24-25 (1976); Sohr, J., et al.: Ger. (East) (1976), DD 118884 A1 19760320<br></p>

<p>Applications Metformin (cas# 657-24-9) is a useful research chemical.<br></p>

<p>Applications Carfentanil Citrate is a Fentanyl (F275000) analogue, an opioid receptor agonist. Analgesic agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zernig, G., et al.: Life Sci., 57, 2113 (1995), Bot, G., et al.: J. Pharmacol. Exper. Therap., 285, 1207 (1998), Gear, et al.: Neuroscience, 66, 5 (1995), Boronat, et al.: Br. J. Pharmacol., 125, 175 ( 1998), Ozdogan., et al.: Eur. J. Pharmacol., 460, 127 (2003),<br></p>

<p>Applications A labelled metabolite of Theophylline.<br>References ottrup, A., et al.: Pharmacol. Toxicol., 67, 340 (1990), El-Kadi, A., et al.: Drug Metab. Dispos., 28, 1112 (2000), Kim, S., et al.: J. Med. Chem., 45, 2131 ( 2002), Hansel, T., et al.: Drugs Today, 40, 55 (2004),<br></p>

<p>Applications R(-)-Methamphetamine is an intermediate in the synthesis of (R)-Benzphetamine Hydrochloride (B209870), the R-enantiomer of Benzphetamine (B209880). Controlled substance (stimulant). Anorexic.<br>References Stewart, J.T., et al.: J. Pharma. Sci., 60, 461 (1971),<br></p>

<p>Applications A labelled anticholinergic drug used in the treatment parkinson’s disease. It is also used to treat patients suffering from drug-induced parkinsonism, akathisia and acute dystonia.<br>References Salako, L.A.: Arch. Int. Pharmacodyn, Ther., 184, 233 (1970); Vas, C.J. et al.: Neurol., 19, 234 (1969);<br></p>

<p>Applications A metabolite of Duloxetine.<br>References Lantz, R.J., et al.: Drug Dispos. Metab., 31, 1142 (2003), Detke, M., et al.: J. Clin Psy., 63, 308 (2002), Bymaster, F.P., et al.: Bioorg. Med., Chem. Lett., 13, 4477 (2003),<br></p>

<p>Stability Hygroscopic<br>Applications Ractopamine-d5 Hydrochloride is the isotope labelled analog of Ractopamine Hydrochloride (R071400); a β-adrenergic agonist and repartitioning agent.<br>References Eisemann, J.H., et al.: J. Nutr., 128, 504 (1998); Shelver, W.L., et al.: J. Agric. Food Chem., 48, 4020 (2000); Apple, J.K., et al.: J. Anim. Sci., 86, 2711 (2008)<br></p>

<p>Applications Labelled Nizatidine. Histamine H2-receptor antagonist related to Ranitidine (R120000). Antiulcerative.<br>References Callaghan, J.T., et al.: Clin. Pharmacol. Ther., 37, 162 (1985), Secor, J.W., et al.: Br. J. Clin. Pharmacol., 20, 710 (1985), Knadler, M.P., et al.: Drug Metab. Dispos., 14, 175 (1986), Wozniak, T.J., et al.: Anal. Profiles Drug Subs., 19, 397(1990)<br></p>

<p>Applications Tetrachloro-1,4-benzoquinone is a potential intermediate in the process of pentachlorophenol-induced carcinogenicity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhu, B. et al.: Cham. Res. Toxicol., 22, 969 (2009);<br></p>

<p>Applications Cyadox is an antibiotic drug and has the potential to be used as a feedstuff additive in promoting the growth of animals.<br>References Huang, C., et al.: J. Proteome, Res. 4, 537 (2013); Wu, H.X., et al.: J. Pharma. Biomed. Anal., 67, 175 (2012);<br></p>

<p>Applications Labelled Octopamine (O239750). A biogenic amine that is the phenol analog of Noradrenaline. It is a neurosecretory product found in several vertebrates and invertebrates. Adrenergic.<br>References Pisano, et al.: Biochim. Biophys. Acta., 43, 566 (1960), Breen, C.A., et al.: Nature, 303, 716 (1983)<br></p>

<p>Applications Pyribambenz-Propyl is used in methods and formulations for preventing downward migration of agricultural materials.<br>References Essig, Kenneth J., et al.:PCT Int. Appl., (2020);<br></p>

<p>Applications Coumatetralyl is used as an anticoagulant rodenticide. Coumatetralyl is widely used to control rodent populations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jones, A., et al.: Bull Environ. Contain Toxicol., 56, 8 (1996), Brakes, C., et al.: J. Appl. Ecol., 42, 118 (2005), Giraudoux, P., et al.: Environ. Res., 102, 291 (2006),<br></p>

<p>Applications Diclosulam is used as a broadleaf herbicide that is used to control weeds in soybean and peanut crops. Diclosulam is applied either preplant or preemergence in order to maintain maximum control of weed growth.<br>References Grichar, W., et al.: Crop Protect., 23, 1145 (2004); Lancaster, S., et al.: Proc. Am. Peanut Res. Ed. Soc., No vol. given, No pp. given, (2006); Sheppard, B., et al.: Proc. South. Weed Sci. Soc., 50, 161 (1997)<br></p>

<p>Applications Labelled trichloroethylene metabolite<br>References Werner, M., et al.: Chem. Res. Toxicol., 9, 41 (1996), Bruning, T., et al.: Toxicol. Sci., 41, 157 (1998), Newman, D., et al.: Drug Metab. Disposition, 35, 43 (2007),<br></p>

<p>Applications Methyclothiazid, is derivative of Hydrochlorothiazide (H714560), which is a diuretic used in the hospital or for personal use to promote excess fluid associated with congestive heart failure. It is also used as an antihypertensive.<br>References Piala, J.J., et al.: J. Pharmacol. Exp. Ther., 134, 273 (1961), Deppeler, H.P., et al.: Anal. Profiles Drug Subs., 10, 405 (1981),<br></p>