Toxicology

Applications A metabolite of new designer drug α-Pyrrolidinopropiophenone (PPP). α-Pyrrolidinophenones like 4'-Methyl-α-pyrrolidinopropiophenone (MPPP), 4'-Methoxy-α-pyrrolidinopropiophenone (MOPPP), 3',4'-Methylenedioxy-α-pyrrolidinopropiophenone (MDPPP) and 4'-Methyl-α-pyrrolidinohexanophenone (MPHP) are new designer drugs which have appeared on the illicit drug market. Controlled substance.
References Bryant, S., et al.: Clin. Pharm., 1983, 2, 525 (1983), Kalix, P., et al.: Biochem. Pharmacol., 35, 3015 (1986), Maurer, H., et al.: J. Anal. Toxicol., 24, 340 (2000), Kraemer, T., et al.: Drug Metab. Dispos., 2000, 28, 339 (2000),

Applications Pyrametostrobin is a novel fungicide. Also, it is derived from 1-Methyl-2-nitrobenzene (N572306), which is a toxic pollutant of the environment because of its large scale use in the production of explosives. It is a useful synthetic intermediate. It shows carcinogenic activity in rats.
References Huang, C., et al.: J. Sep., 40, 2335-2343 (2017)

Applications N-(3-((2-Chlorothiazol-5-yl)methyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene)benzenesulfonamide is an impurity of Thiamethoxam (T344180) which is a neonicotinoid insecticide.
References Oliver, J., et al.: J. Environ. Horticult., 28, 135 (2010), Ghosh, A., et al.: J. Entomol. Res., 34, 35 (2010), Chem. and Eng. News 90: 10 (2012)

Applications 5-Methyl-N-[2-(4-sulfamoylphenyl)ethyl]-1,2-oxazole-3-carboxamide is a reagent used for the synthesis of glisoxepid (G410600). Glisoxepid is used as an antidiabetic drug. Glisoxepid is a sulfonylurea derivative used in the treatment of diabetes mellitus type 2.
References Schulz, M., et al.: Pharmazie, 58, 447 (2003), Viswanathan, C., et al.: Pharm. Res., 24, 1962 (2007), Drees, J., et al.: Clin. Chem., 55, 126 (2009),

Applications Milbemycin D (~90% purity) is a macrocyclic lactones that can be used as a nematocide and insecticide.
References Arena, J. P., et al.: J. Parasitol 81, 286 (1995); Takiguchi, Y., et al.: J. Antibiot 36, 502 (1983)

Applications 3-sec-Amylphenyl N-Methylcarbamate is a component of the carbamate insecticide Bufencarb (B689385).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kmellar, B., et al.: Food Addit. Contam., 27, 1415 (2010); Kaufmann, A., et al.: Anal. Bioanal. Chem., 403, 1233 (2012);

Applications Isotope labelled 1’-Hydroxy Midazolam (H948424), metabolite of Midazolam (M343000).
References Dundee, J., et al.: Drugs, 28, 519 (1984), Galetin, A., et al.: Drug Metab. Dispos., 30, 1512 (2002), Uchaipichat, V., et al.: Drug Metab. Dispos., 34, 449 (2006), Lewis, B., et al.: Biochem. Pharmacol., 73, 1463 (2007),

Applications N-Lignoceroyl Taurine facilitate skin wound healing in mouse skin where it was observed that margins of a freshly inflicted wound decreases with increasing dosage of N-Lignoceroyl Taurine.
References Sasso, O., et al.: Proc. Natl. Acad. Sci. U. S. A., 113, E4397-E4406 (2016)

Stability Hygroscopic, Light Sensitive
Applications Intermediate for the synthesis of Furosemide Acyl-β-D-glucuronide.

Applications A tricyclic carbamate compound for inhibition of Cell proliferation.
References Villani, et al.: J. Med. Chem., 15, 750 (1972), Anon, et al.: J. Biol. Chem., 266, 15575 (1991),

Stability Moisture sensitive
Applications Deethylphosphamidon is an insecticide used in the protection of crops.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ferreira, J. et al.: Pest. Sci., 14, 167 (1983); Hung, L. et al.: Bull. Env. Cont. Toxicol., 8, 297 (1972);

Applications BMS 833923 is an antagonist of smoothened, a key hedgehog (Hh) pathway regulator.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Brechbiel, J., et. al.: Cancer Treat. Rev., 40, 750 (2014); Cortes, J., et. al.: J. Natl. Compr. Cancer Netw., 11, 10 (2013)

Stability Hygroscopic
Applications 4-Hydroxybutyryl-L-carnitine Chloride, is an aryl carnitine, which is an important metabolite used as a diagnostic tool for detecting inherited metabolic disorders. Antibodies can be raised against L-carnitine and other carnitine-related compounds to measure the quantity of L-carnitine in biological samples and serum.

Applications Labelled Diltiazem (D460620). A calcium channel blocher with vasodilating activity. Antianginal; antihypertensive; antiarrhythmic (class IV).
References Sato, et al.: Arzneim.-Forsch., 21, 1338 (1971), Smirnov, S.R.: Eur. J. Pharmacol., 360, 81 (1998), Hansson, L., et al.: Lancet, 356, 359 (2000),

Applications Astragaloside IV has cardiovascular protective effects, protecting the vascular endothelial cells. In addition it is attributed to have anti0inflammatory and anti-virus effects as well. This is due to its scavenging ability of oxygen free radicals, regulation of mineral homeostasis and antioxidative effects.
References Liu, S. et al.: J. Chinese Pharm. Sci., 22, 222 (2013);

Applications (Z)-Hexadec-11-en-1-ol is a pheromone antagonist that regulates optimal mating time in moth Helicoverpa armigera.
References Chang, H., et al.: Curr. Biol., 27, 1610 (2017); Du, M., et al.: Insect Biochem. Mol. Biol., 87, 154 (2017)

Applications Trimethyl-tetradecylammonium chloride,99% (cas# 4574-04-3) is a useful research chemical.

Applications An additive which contributes spiciness to foods. This compound is also often used as a regent in the preparation of its reduced alcohol, a compound commonly used in perfumery.
References Hardcastle, I., et al.: Biochem. Pharmacol., 57, 801 (1999), Mookdasanit, J., et al.: Food Sci. Technol. Res., 8, 367 (2002), Jang, Y., et al.: J. Agric. Food Chem., 53, 7892 (2005),

Applications 2-Phenoxypropionic Acid is used in organic chemistry reduction reactions. Used in the synthesis of PPAR (peroxisome proliferator-activated receptor (PPAR) ligands.
References Brown, P. et al.: Synthesis., 7, 778 (1997);

Applications 3,4-Dimethyl-N-(1-methylpropyl)-2,6-dinitrobenzenamine is a herbicide.
References Victoria F. R., et al.: Planta Daninha, 4, 11 (1981); Stoller, E. W., et al.: J. Environ. Qual., 6, 124 (1977); Van Yahres, R. D., et al.: Proceedings of the Annual Meeting of the Northeastern Weed Science Society, 36, 292 (1982)

Applications Mepronil is an benzanilide based fungicide found in the raw materials of herbal medicine.
References Inoue, T., et al.: J. Agr. Food. Chem., 59, 3857 (2011);

Applications Spasmoxale is an analgesic.
References Deeb, O., et al.: Chem. Biol. Drug. Des., 76, 255 (2010); Mathur, K.C., et al.: Bioorg. Med. Chem., 11, 1915 (2003)

Stability Hygroscopic
Applications 3-[N-(2-Carboxyethyl)methylamino]-7-[N-ethyl(3-sulfonatopropyl)amino]phenoxazin-5-ium sodium is a fluorescent dye for covalent labeling.

Applications Chlorflurenol-methyl is an auxin polar transport inhibitor that effects elongation growth of the excised fourth internode of tulips. Chlorflurenol-methyl is a pesticide.
References Wegrzynowicz-Lesiak, E., et al.: J. Hort. Res., 21, 31-39 (2013);

Impurity Atazanavir Impurity 1
Applications An epimeric impurity of Atazanavir, novel azapeptide HIV protease inhibitor. Atazanavir Impurity 1
References Chitturi, S.R. et al.: J. Pharmac. Biomed. Anal., 55, 31 (2011);

Applications A novel, potent, and highly selective SGLT2 inhibitor that has been shown to improve glycemic control in diabetic mice and rats.