Toxicology

<p>Applications A reactive metabolite of Lapatinib (L175800) which is associated with various drug toxicities. Lapatinib is metabolized mainly by P450 3A4 to form O- and N-dealkylated metabolites.<br>References He, K., et al.: Chem. Res. Toxicol., 11, 252 (1998), Rusnuk, D., et al.: Cancer Res., 61, 7196 (2001), Li, X., et al.: Drug Metab. Dispos., 37, 1242 (2009),<br></p>

<p>Applications Spasmoxale is an analgesic.<br>References Deeb, O., et al.: Chem. Biol. Drug. Des., 76, 255 (2010); Mathur, K.C., et al.: Bioorg. Med. Chem., 11, 1915 (2003)<br></p>

<p>Applications Methiozolin is commonly used in herbicidal mixtures. it is a bluegrass selective herbicide.<br>References Auler, T., et al.: PCT Int. Appl., 51 (2020); Kim, J., et al.: J. Agric. Food. Chem., 67, 13534-13543 (2019)<br></p>

<p>Applications Isotope labelled 1’-Hydroxy Midazolam (H948424), metabolite of Midazolam (M343000).<br>References Dundee, J., et al.: Drugs, 28, 519 (1984), Galetin, A., et al.: Drug Metab. Dispos., 30, 1512 (2002), Uchaipichat, V., et al.: Drug Metab. Dispos., 34, 449 (2006), Lewis, B., et al.: Biochem. Pharmacol., 73, 1463 (2007),<br></p>

<p>Applications Malathion (Diethyl-d10) is used as one of the substances for the clean-up step in post-harvest pesticide residue analysis.<br>References Ucles, A., et al.: Talanta, 144, 51 (2015)<br></p>

<p>Applications (S,2E,6E)-Dehydroxy Pitavastatin is an impurity of Pitavastatin (P531000), a competitive inhibitor of HMG-CoA reductase and antilipemic agent.<br>References Aoki, T., et al.: Arzneim.-Forsch., 47, 904 (1997), Yamada, I., et al.: Xenobiotica, 33, 789 (2003), Park, S., et al.: Clin. Ther., 27, 1074 (2005),<br></p>

<p>Applications 4,6-Dinitro-2-methyl-d3-phenol (CAS# 1219804-69-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,3-Dichloropropanoic acid is an organochlorine herbicide<br>References Okochi, Yumiko, et al.: Kankyo Gijutsu, 26(4), 225-228 (1997)<br></p>

<p>Applications Reagent used in the synthesis of herbicides.<br>References Mekenyan, O., et al.: Chem. Res. Toxicol., 10, 994 (1997), Brown, T., et al.: Environ. Sci. Technol., 42, 5202 (2008),<br></p>

<p>Applications Labelled Nabumetone. Anti-inflammatory. Antibacterial.<br>References Kumpulainen, H., et al.: J. Med. Chem., 49, 1207 (2006),<br></p>

<p>Applications Estradiol 4-Carboxymethyl, is a metabolite of 17β-Estradiol (E888000). Estradiol is the major estrogen secreted by the premenopausal ovary.<br>References Bucala, R., et al.: J. Clin. Endocrinol. Metab., 60, 841 (1985), Telang, N., et al.: Anticancer Res., et al.: 11, 1021 (1991), Seeger, H., et al.: Med. Sci. Res., 26, 481 (1998), Bolton, J., et al.: Chem. Res. Toxicol., 13, 135 (2000),<br></p>

<p>Impurity Tenofovir Impurity<br>Stability Light Sensitive<br>Applications An impurity of Tenofovir (T018500). Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent.<br>References Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>

<p>Applications Triadimefon is an triazole fungicide is used for the management of mango powdery mildew in South Gujarat.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, S., et al.: Environ. Sci. Technol., 47, 4768 (2013); Sharma, H., et al.: J. Mycol. Plant. Pathnol., 42, 494 (2012);<br></p>

<p>Stability Moisture Sensitive<br>Applications Fensulfothion is a highly toxic insecticide used for agriculture purposes. Fensulfothion is used in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wong, J.W., et al.: J. Agri. Food. Chem., 58, 5884 (2010); Inoue, T., et al.: J. Agri. Food. Chem., 59, 3857 (2011); Kojima, H., et al.: Toxicol., 280, 77 (2011);<br></p>

<p>Applications Didodecyldimethylammonium Bromide<br></p>

<p>Impurity Esomeprazole Impurity 16<br>Applications Omeprazole (O635000) impurity. Esomeprazole Impurity 16.<br></p>

<p>Applications N-Methylperfluorooctanesulfonamide is a derivative of Perfluorooctanesulfo​namide (FOSA) (P286245), which represents an important subgroup of the environmental contaminants known as perfluorinated compounds (PFCs).<br>References Hradkova, P., et al.: Czech J. Food Sci., 28, 333 (2010); Del Gobbo, L., et al.: J. Agr. Food Chem., 56, 7551 (2008)<br></p>

<p>Stability Hygroscopic, Light Sensitive<br>Applications Intermediate for the synthesis of Furosemide Acyl-β-D-glucuronide.<br></p>

<p>Applications Anesthetic.<br>References DesJarlais, R., et al.: J. Med. Chem ., 31, 722 (1988), Woo, Y., et al.: Toxicol. Lett., 79, 219 (1995), Blundell, T., et al.: Nature, 384, 23 (1996),<br></p>

<p>Applications 2-Hydroxy Estradiol 1-N7-Guanine was shown to induce mutations in the mammary glands of ACI rats which correlated with formation of depurinating DNA adducts.<br>References Mailander, Paula C., et al.: J. of Steroid Biochem. and Mol. Bio., 101(4-5), 204-215 (2006)<br></p>

<p>Applications Estropipate is used in post-menopausal women for hormonal replacement therapy, with benefits to improved cognition and prevention of osteoporosis.<br>References Klaiber, E. et al.: Psychoneuroendocrinol., 22, 549 (1999); McCombs, J. et al.: Maturitas., 48, 271 (2004); Burkhardt, M. et al.: J. Alz. Dis., 6, 221 (2004);<br></p>

<p>Applications Dichlofenthion is used as a pesticide and nematicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ragnarsdottir, K.: J. Geo. Soc., 157, 859 (2000)<br></p>

<p>Applications Phorate is a non-biocumulative organophosphate used as an insecticide and acaricide. Phorate is an inhibitor of acetylcholinesterase and pseudocholinesterase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pandey, G.C. et al.: Ind. J. Comp. Anim. Physiol., 6, 1 (1988); Henderson, M.C. et al.: Biochem. Pharmacol., 68, 959 (2004); Peter, J.V. et al.: NeuroToxicology, 29, 335 (2008);<br></p>

<p>Applications Testosterone Methanesulfonate is an intermediate in the synthesis of Androstadienone (A637340), a prominent androstene present on male human axillary hair and on the male axillary skin surface.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 7-Ketolithocholic Acid-taurine Conjugate is a bile acid conjugate and metabolite of Taurolithocholic Acid (T009100) with antiinflammatory activity. Taurochenodeoxycholic Acid has been shown to inhibit hepatocyte apoptosis through suppression of Bid translocation to mitochondria.<br>References Emerman, S. et al.: J. Biol. Chem., 242, 661 (1967); Takikawa, Y. et al.: Falk Symp., 120, 249 (2001); Li, P. et al.: Zhong. Shour. Xue., 28, 1317 (2008);<br></p>

<p>Applications Labelled Acetohexamide, a sulfonylurea derivative. Acetohexamide is a hyopglycemic agent with moderate uricosuric activity. Acetohexamide is a first generation medication used in the treatment of diabetes metilus type 2.<br>References Yu, T-F. et al.: Metab. Clin. Exp., 17, 309 (1968); Harrower, A.D.B. et al.: Clin. Pharmacokin., 31, 111 (1996); Hirota, Y. et al.: Diab. Med., 26, 948 (2009);<br></p>

<p>Applications 6-Chloropyridine-2-carboxylic Acid is an intermediate of Sorafenib b(S676850), a multiple kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis. Antineoplastic.<br>References Richly, H., et al.: Int. J. Clin. Pharmacol. Ther., 41, 620 (2003); Khire, U.R., et al.: Bioorg. Med. Chem. Lett., 14, 783 (2004); Wilhelm, S.M., et al.: Cancer Res., 64, 7099 (2004); Rini, B.I., et al.: Expert Opin. Pharmacother., 7, 453 (2006)<br></p>

<p>Applications Monosodium Acid Methane Arsonate Sesquihydrate is an environmental toxic compound. It also functions as a commonly used herbicide for weed control in grass.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Matteson, A. R., et al.: J. Environ. Qual., 43, 379 (2014); Lee, J. S., et al.: Hamilton &amp; Hardy's Industrial Toxicology (6th Edition), 45 (2015); Rosen, B. P., et al.: Proceedings of the International Congress on Arsenic in the Environment, 5th, Buenos Aires, Argentina, 309 (2014);<br></p>