Toxicology

<p>Applications 4-Amino-6-[(1,1-dimethylethyl)amino]-1,3,5-triazin-2(1H)-one is a fungicide derivative of Terbuthylazine (T110500), a triazine herbicide.<br>References Schenck, F., et al.: Bull Environ. Contam. Toxicol., 73, 24 (2004); Coscolla, C. et al.: Atmos. Env., 95, 29 (2014);<br></p>

<p>Applications Dimethyl Succinate is used in the synthesis of antifungal agents and synthetic analogues.<br>References Lee, E. et al.: Ange. Chem. Int. Ed., 41, 176 (2002); Trost, B.M. et al.: J. Am. Chem. Soc., 124, 10396 (2002);<br></p>

<p>Applications A labelled degradation product of Desloratadine. Desloratadine impurity.<br>References ,Billah., et al.: Lipids, 26, 1172 (1991), Piwinski., et al.: J. Med. Chem., 34(1), 457 (1991)<br></p>

<p>Applications 2-Chlorobenzhydrol is used as a reagent in the synthesis of bifonazole analogs which have antibacterial and antifungal activities. 2-Chlorobenzhydrol is also a reagent in the preparation of cinnamyl piperazine derivatives which have anticonvulsant activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References El Hage, S., et al.: Arch. Pharm., 344, 402 (2011); Hu, C., et al.: Lett. Drug Des. Discov., 7, 661 (2010)<br></p>

<p>Applications N-[(1S,2S)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamic acid 1,1-dimethylethyl ester is an impurity of Darunavir (D193500), a human immunodeficiency virus (HIV) protease inhibitor that is used to treat patients with drug-resistant HIV.<br>References Babu, K., et al.: Pharm. Chem., 3, 389 (2011); Back, D., et al.: Antivir. Ther., 13, 1 (2007); Ghosh, A., et al.: Bioorg. Med. Chem., 15, 7576 (2007)<br></p>

<p>Applications (R)-3-(2-Chloro-4-nitro-1H-imidazol-1-yl)-2-(4-trifluoromethoxybenzyl-d2-oxy)propyl-3,3-d2 Benzoate is an intermediate used in the synthesis of (S)-PA 824-d4 (P122502), which is a labelled novel anti-tuberculosis drug.<br>References Diacon, A.H. et al.: Antimicrob. Anents Chemother., 54, 3402 (2010); Dogra, M. et al.: Br. J. Pharmacol., 162, 226 (2010); Ginsberg, A.M. et al.: Antimicrob. Agents Chemother., 53, 3720 (2009);<br></p>

<p>Applications Isomer of (3R)-3-Hydroxy Quinine<br></p>

<p>Applications O-Benzyl Ganciclovir N-Formamide is an intermediate used in the synthesis of Valganciclovir N3,N3'-Methylene Dimer (&gt;90%) (V092015), which is an impurity of Valganciclovir (V092000), a pro-drug of Ganciclovir (G235000) . Used in treatment of retro-virus.<br>References Acosta, E., et al.: Clin. Pharmacol. Ther., 81, 867 (2007), Nassetta, L., et al.: J. Antimicrob. Chemother., 63, 862 (2009),<br></p>

<p>Applications Δ2-Cefuroxime Methyl Ester is a potentially related compound in cephalosporin antibacterial compounds.<br>References Miyouchi, M., et al.: J. Chem. Pharm. Bull., 38, 1906 (1990), Sugioka, T., et al.: Chem. Pharm. Bull., 38, 1998 (1990),<br></p>

<p>Applications 6-Quinoxalinecarboxylic Acid is an intermediate used in the production of antiprotozoal agents.<br>References Kim, D., et al.: Eur. J. Med. Chem., 44, 568 (2009), Lyne, P., et al.: Bioorg. Med. Chem. Lett., 19, 1026 (2009),<br></p>

<p>Applications Clindamycin Cyclomonophosphate is a by-product during the synthesis of Clindamycin Phosphatidyl Anhydride (C580110), an impurity of Clindamycin (C580000), which is an antibiotic prepared from Lincomycin (L466200), used to treat various infections.<br>References Birkenmeyer, R.D., et al.: J. Med. Chem., 13, 616 (1970); Oesterling, et al.: J. Pharm. Sci., 59, 63 (1970); Gray, J.E., et al.: Toxicol. Appl. Pharmacol., 21, 516 (1972); Brown, L.W., et al.: Anal. Profiles Drug Subs., 10, 75 (1981)<br></p>

<p>Applications 3-Phenyl-3-hydroxypropanenitrile (cas# 17190-29-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Protected metabolite of Chloramphenicol (C325030).<br>References Simons, P., et al.: Xenobiotica, 22, 1267 (1992), Kaji, H., et al.: Drug Metab. Dispos., 33, 60 (2005),<br></p>

<p>Applications Intermediate in the preparation of photolabeling and cross-linking reagent.<br></p>

<p>Applications 4-​(1,​2-​Dimethyl-​1-​propen-​1-​yl)​-​benzoic Acid Methyl Ester is an intermediate in synthesizing 1-Desmethyl-2-methylpropyl Amorolfine (D292315), an analogue of Amorolfine Hydrochloride (A634170). Amorolfine hydrochloride is a salt of Amorolfine which is a morpholine antifungal drug. It is a topical solution for the treatment of toenail infections.<br>References Rotta, I., et al.: JAMA Dermatol., 149, 341 (2013); Espinel-Ingroff, A., et al.: Antimicrob. Agents Ch., 26, 5 (1984)<br></p>