Toxicology

<p>Applications Clindamycin B (C580040) derivative.<br></p>

<p>Applications A receptor antagonist for the treatment of respiratory diseases.<br>References Morgenstern, R., et al.: Biochem. J., 260, 577 (1989), Armstrong, R., et al.: Chem. Res. Toxicol., 10, 2 (1997), Larsen, J., et al.: Ann. Allergy, 71, 103 (1993),<br></p>

<p>Applications Intermediate in the preparation of Mifepristone derivatives.<br>References Jiang, W., et al.: Bioorg. Med. Chem. Lett., 17, 1471 (2007),<br></p>

<p>Applications The labelled aglucon of apiin and of apigenin-7-glucoside.<br>References Chaumontet, C., et al.: Carcinogenesis, 15, 2325 (1994), Sato, F., et al.: Biochem. Biophys. Res. Commun., 204, 578 (1994), Kuo, M.L. et al.: Biochem. Biophys. Res. Commun., 212, 767 (1995)<br></p>

<p>Applications 1,1'-Oxybis[2-chloro-ethane] is a carcinogen. It is an intermediate used to prepare 2,2'-[Oxybis(2,1-ethanediylimino)]bis-ethanol which is patented as one of the antibacterial oral compositions in mouthwash.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Norpoth, K., et al.: J. Cancer Res. Clin. Oncol., 112, 125 (1986); Weisburger, E., et al.: J. Nat. Cancer. Inst., 67, 75 (1981); Gaffar, A., et al.: U.S. (1980), US 4224309 A 19800923.<br></p>

<p>Applications Protected 17α-Estradiol.<br>References Bernstein, S., et al.: Biochem., 10, 2941 (1971),<br></p>

<p>Applications (1S,2R,6R)-6-Acetoxy-2-((bis(benzyloxy)phosphoryl)oxy)-4-(ethoxycarbonyl)cyclohex-3-en-1-yl benzoate is an intermediate in the synthesis of Shikimate-3-phosphate (S357026), an substrate for 5-Enolpyruvoyl-shikimate-3-phosphate synthase (EPSPS), the target for the board-spectrum herbicide N-(phosphonomethyl)glycine(glyphosate).<br>References Mooney, C.A., et al.: J. Med. Chem., 57, 3154 (2014);<br></p>

<p>Applications 2,3,7,8-Tetrachloro-[1,4]dioxino[2,3-b:5,6-b']dipyridine is used in analytical studies for the presence and formation of dioxin-like compounds in heat-treated chlorpyrifos herbicide, a potential precursor of pyridine analog of 2,3,7,8-Tetrachloro-p-dioxin (T291370).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sakiyaama, T., et al.: Organohalogen Compounds, 73, 146 (2011);<br></p>

<p>Applications 4-Hydroxyestradiol 3-O-β-D-Glucuronide is a glucuronide derivative of 4-Hydroxy-17β-estradiol (H941895); a metabolite of Estradiol (E888000) which is the major estrogen secreted by the premenopausal ovary.<br>References Bucala, R., et al.: J. Clin. Endocrinol. Metab., 60, 841 (1985); Telang, N., et al.: Anticancer Res., et al.: 11, 1021 (1991); Seeger, H., et al.: Med. Sci. Res., 26, 481 (1998); Bolton, J., et al.: Chem. Res. Toxicol., 13, 135 (2000); Salole, E.G., et al.: Anal. Profiles Drug Subs., 15, 283 (1986); Lievertz, R.W., et al.: Am. J. Obstet. Gynecol., 156, 1289 (1987)<br></p>

<p>Applications Labelled Ethyl Alcohol, used in alcoholic beverages in suitable dilutions. Other uses are as solvent in laboratory and industry , in the manufacture of denatured alcohol, pharmaceuticals, in perfumery, in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, R. et al.: Green Chem., 15, 1155 (2013); Zhao, D. et al.: Chem. Eng. J., 221, 99 (2013); Huang, C. et al.: J. Agri. Food Chem., 61, 4326 (2013); Joichi, A. et al.: Aroma Res., 11, 256 (2010); Wiberg, G.S., et al.: Toxicol. Appl. Pharmacol., 16, 718 (1970), Brown, N.A., et al.: Science, 206, 573 (1979),<br></p>

<p>Applications Labelled 7-{[(2,2,2,-Trichloroethyl)oxy]carbonyl} Paclitaxel is used in the semi-synthesis of Taxol (P132500) and Docetaxel (D494420).<br>References Commercon, A., et al.: Tetrahedr. Lett., 33, 5185 (1992),<br></p>

<p>Applications A highly reactive thiol-specific spin-label. A specific conformational probe of thiol site structure by virtue of its minimal rotational freedom and distance from the covalent disulfide linkage to the macromolecule under study.<br></p>