Toxicology

<p>Applications Phenobarbital 1,3-Diethyl Butyrate is a byproduct in the synthesis of Phenobarbital 1-Butyric Acid (P316750) which is a Phenobarbital derivative.<br>References Deleide, G., et al.: Clin. Chimica Acta, 99, 195 (1979),<br></p>

<p>Applications Labelled 7-{[(2,2,2,-Trichloroethyl)oxy]carbonyl} Paclitaxel is used in the semi-synthesis of Taxol (P132500) and Docetaxel (D494420).<br>References Commercon, A., et al.: Tetrahedr. Lett., 33, 5185 (1992),<br></p>

<p>Applications The labelled epimer of Medroxyprogesterone acetate (M203560). Progesterone impurity.<br>References Tang, M., et al.: Endocrinol., 151, 1320 (2010), Lee, K., et al.: Mol. Cell. Endocrinol., 319, 109 (2010), Rodgers, A., et al.: Chem., Res. Toxicol., 23, 724 (2010), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),<br></p>

<p>Applications A labelled degradation product of Desloratadine. Desloratadine impurity.<br>References ,Billah., et al.: Lipids, 26, 1172 (1991), Piwinski., et al.: J. Med. Chem., 34(1), 457 (1991)<br></p>

<p>Applications 4-Chlororesorcinol-d3 is a labeled analogue of 4-Chlororesorcinol (C427755), which can be used as hair dye formulation, and in the synthesis of series of six coumarin compounds carrying halogen and trifluoromethyl, having antifungal activities.<br>References Hui-juan, Zh., et al.: Huanjing Yu Jiankang Zazhi, 27, 513 (2010); Hai-yun, Xh., et al.: Baoji Wenli Xueyuan Xuebao, Ziran Kexueban, 31, 12 (2011)<br></p>

<p>Applications 10-O-Acetyl SN-38-d3 is the isotope labelled protected metabolite of Irinotecan (I767500), an DNA topoisomerase inhibitor.<br>References Kunimoto, T., et al.: Cancer Res., 47, 5944 (1987), Shimada, Y., et al.: J. Clin. Oncol., 11, 909 (1993)<br></p>

<p>Applications Protected Estradiol.<br>References Lokind, K., et al.: Int. J. Pharm., 127, 155 (1996), Bubert, C., et al.: J. Med. Chem., 50, 4431 (2007), Prokai-Tatrai, K., et al.: Steroids, 73, 280 (2008),<br></p>

<p>Applications Protected 17α-Estradiol.<br>References Bernstein, S., et al.: Biochem., 10, 2941 (1971),<br></p>

<p>Applications 1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid-13C,d3 is an intermediate in synthesizing Moxifloxacin Hydrochloride-13CD3 (M745003), a fluorinated quinolone antibacterial.<br>References Woodcock, J.M., et al.: Antimicrob. Ag. Chemother., 41, 101 (1997); Stass, H., et al.: Antimicrob. Ag. Chemother., 42, 2060 (1998)<br></p>

<p>Applications 2,​4,​6-​Trifluorobenzenemethanamine-d4,15N Deuterium Chloride is an intermediate in the synthesis of Bictegravir-15N, d2 (B382096), which is the labeled version of Bictegravir, which is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.<br>References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;<br></p>

<p>Stability Hygroscopic<br>Applications Isotope labelled analogue of Phenethicillin is a semisynthetic penicillin based β-lactam antibiotic and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive bacteria.<br>References Lucien, C., et al.: Can. med. Assoc. J., 84, 535 (1961); Timmers, G.J., et al.: Clin. Microbiol. Infect., 13, 497 (2007);<br></p>

<p>Applications Process impurity of Darunavir synthesis. It is a COVID19-related research product.<br></p>

<p>Applications 2-Chloro-5-(trifluoromethyl)pyridine is a starting material for the preparation of novel herbicide fluazifop-butyi. 2-Chloro-5-(trifluoromethyl)pyridine is a mutagenic compound.<br>References Lu, Y., et al.: Shijie Nongyao, 31, 32 (2009); Dearfield, K. L., et al.: Mutat. Res. Lett., 301, 57 (1993)<br></p>

<p>Applications 1,3-Dithiolan-2-imine is one of the metabolites of Cyolane, a systemic organophosphate insecticide that is effective in larvae of all stages and is also persistent for a long period of time. Cyolane is toxic and also known to cause an asthmatic inflammatory reaction in the lungs of juvenile rats.<br>References Bahig, M. &amp; Wafa, D.: Isot. Rad. Res., 13, 153 (1981); Mistric, J. &amp; Pittard, W.: J. Econ. Entomol., 66, 232 (1973); Pasarela, N. &amp; Orloski, E.: Anal. Method. Pestic. Plant Growth Reg., No vol. given, No pp. given (1973)<br></p>