Toxicology

<p>Applications A deuterated metabolite of Terbinafine, an orally active, antimycotic allylamine related to naftifine.<br>References Petranyi, G., et al.: Science, 224, 1239 (1984), Petranyi, G., et al.: Antimicrob. Agents Chemother., 31, 1365 (1987), Humbert, H., et al.: Biopharm. Drug Dispos., 16, 685 (1995), Nejjam, F., et al.: Br. J. Dermatol.,132, 98 (1995),<br></p>

<p>Applications O-Benzyl Ganciclovir N-Formyl Diacetate Dimer is an intermediate used in the synthesis of Valganciclovir N3,N3'-Methylene Dimer (&gt;90%) (V092015), which is an impurity of Valganciclovir (V092000), a pro-drug of Ganciclovir (G235000) . Used in treatment of retro-virus.<br>References Acosta, E., et al.: Clin. Pharmacol. Ther., 81, 867 (2007), Nassetta, L., et al.: J. Antimicrob. Chemother., 63, 862 (2009),<br></p>

<p>Applications 4-​(1,​2-​Dimethyl-​1-​propen-​1-​yl)​-​benzoic Acid Methyl Ester is an intermediate in synthesizing 1-Desmethyl-2-methylpropyl Amorolfine (D292315), an analogue of Amorolfine Hydrochloride (A634170). Amorolfine hydrochloride is a salt of Amorolfine which is a morpholine antifungal drug. It is a topical solution for the treatment of toenail infections.<br>References Rotta, I., et al.: JAMA Dermatol., 149, 341 (2013); Espinel-Ingroff, A., et al.: Antimicrob. Agents Ch., 26, 5 (1984)<br></p>

<p>Applications Protected metabolite of Chloramphenicol (C325030).<br>References Simons, P., et al.: Xenobiotica, 22, 1267 (1992), Kaji, H., et al.: Drug Metab. Dispos., 33, 60 (2005),<br></p>

<p>Applications Process impurity of Darunavir synthesis. It is a COVID19-related research product.<br></p>

<p>Applications 6,7,8-Trifluoro-4-oxo-1-(1-oxopropan-2-yl)-1,4-dihydroquinoline-3-carboxylic Acid Ethyl Ester is an intermediate in the synthesis of Marbofloxacin (M197000), a fluorinated quinolone antibacterial agent.<br>References Gruet, P., et al.: Vet. Rec., 140, 199 (1977), Lefebvre, H.P., et al.: J. Vet. Pharmacol. Ther., 21, 453 (1998),<br></p>

<p>Applications Tolbutamide derivative.<br>References Relling, et al.: J. Pharmacol. Exp. Ther., 252, 442 (1990), Parent, et al.: J. Pharmacol. Exp. Ther., 261, 780 (1992), Ho, et al.: Life Sci., 52, 21 (1993),<br></p>

<p>Applications 12α-Deoxycholic Acid Methyl Ester 3α-Benzoate is an intermediate in the synthesis of 3α,12α-Dihydroxy-5β-chol-9(11)-enic Acid which is used in the analysis and in the structure determination of unsaturated 5β-cholanoic acids.<br>References Kuksis, A., et al.: Lipids, 15, 770 (1980)<br></p>

<p>Applications Methotrexate Disodium Salt is a folic acid antagonist which is used as a antineoplastic and antirheumatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>

<p>Applications Acetophenone-13C8 is an intermediate in synthesizing Mandelic Acid-13C8 (M162523). It is a C13 labelled Mandelic Acid which is used as an antiseptic (urinary). It is also used as a short-term exposure biomarker in urine from styrene exposed workers.<br>References Pessela, B., et al.: Enzyme Microb. Technol., 40, 310 (2007); Carrasco-Lopez, C., et al.: J. Biol. Chem., 284, 4365 (2009); Fustinoni, S., et al.: Toxicol. Lett., 192, 40 (2010)<br></p>

<p>Applications 4-Amino-6-[(1,1-dimethylethyl)amino]-1,3,5-triazin-2(1H)-one is a fungicide derivative of Terbuthylazine (T110500), a triazine herbicide.<br>References Schenck, F., et al.: Bull Environ. Contam. Toxicol., 73, 24 (2004); Coscolla, C. et al.: Atmos. Env., 95, 29 (2014);<br></p>

<p>Applications Isotope labelled intermediate in the synthesis of the metabolites of Nitazoxanide (N490100), an anthelmintic (cestodes), antiprotozoal (cryptosporidium) agent.<br></p>

<p>Applications rac-cis-Permethrinic acid is a potent insecticide used in the agricultural industry to eliminate unwanted pests from crops. rac-cis-Permethrinic acid is also metabolite of pyrethroid compounds, a group of pesticides that are relatively low toxicity (to organisms that are not intended to be targeted) and biodegradable.<br>References Kale, M., et al.: Toxicol. Lett., 105, 197 (1999); Leszczynski, J., et al.: J. Am. Chem. Soc., 115, 5891 (1993); Sodurlund, D. &amp; Bloomquist, J.: Ann. Rev. Entomol., 34, 77 (1989)<br></p>

<p>Applications (5R)-5-Hydroxy-3-oxo-6-(benzyloxy)-hexanoic Acid tert-Butyl Ester is used in the preparation of antifungal macrolide antibiotic (+)-Roxaticin, Phorboxazole B and Bryostatin 2.<br>References Evans, D. et al.: J. Am. Chem. Soc., 125, 10899 (2003); Evans, D. et al.: J. Am. Chem. Soc., 122, 10033 (2000); Evans, D. et al.: J. Am. Chem. Soc., 121, 7540 (1999)<br></p>

<p>Applications (Z)-3-Methylpent-2-en-4-yn-1-ol is used as a reagent in organic synthesis of many compounds including that of prolycopene which is a tangerine-colored tetra-Z-isomer of lycopene that is found in fruits of the tangerine tomato. Z)-3-Methylpent-2-en-4-yn-1-ol is also used in the synthesis of Leucosceptroids A and B which have potent antifungal properties.<br>References Pattenden, G., et al.: Tetrahedron Lett., 28, 5751 (1987); Guo, S., et al.: Angew. Chem. Int. Edit., 54, 1298 (2015);<br></p>

<p>Applications Dimethyl Succinate is used in the synthesis of antifungal agents and synthetic analogues.<br>References Lee, E. et al.: Ange. Chem. Int. Ed., 41, 176 (2002); Trost, B.M. et al.: J. Am. Chem. Soc., 124, 10396 (2002);<br></p>