Biochemicals and Reagents

U-101017 is an advanced biochemical compound, which is a synthetic molecule engineered to modulate specific cellular pathways. It is sourced through a sophisticated process of chemical synthesis designed to maximize its purity and efficacy. U-101017 operates by selectively interacting with targeted cellular receptors, thereby altering intracellular signaling cascades. This mode of action enables precise control over cellular activities, making it a valuable tool for probing biochemical pathways.

Peptide YY (Human)-EIA Kit (1ea) is an EIA kit for the quantitative analysis of human peptide YY. Peptide YY is a neuropeptide with a role in the regulation of food intake and energy expenditure. The kit contains one vial each of peptide YY antiserum, peptide YY antibody, and standard reference material. The assay can be used to detect the level of peptide YY in tissue samples or cell culture supernatants.

Isrib is a sodium citrate that has been shown to inhibit the growth of an experimental bacterial strain in vitro. Isrib has also been shown to have inhibitory properties on neuronal death in vivo. This agent has pluripotent cells that are able to differentiate into any cell type, including neurons, and can be used for the treatment of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and diabetic neuropathy. Isrib has also been shown to have beneficial effects on the immune system by stimulating antibody production and regulating inflammatory responses. It is absorbed orally with high bioavailability and its pharmacokinetic properties are similar to those of other sodium citrates.

Please enquire for more information about 2-Dibromomethyl-benzonitrile including the price, delivery time and more detailed product information at the technical inquiry form on this page

4-Amino-3-ethoxybenzenesulfonic acid is a research tool that is used to study ion channels. It activates the receptor, which leads to increased cell permeability and the release of neurotransmitters. 4-Amino-3-ethoxybenzenesulfonic acid can be used to determine the effects of a ligand on a receptor by binding to it and altering its activity. 4-Amino-3-ethoxybenzenesulfonic acid is also used as an antibody in immunohistochemistry studies and has been shown to inhibit protein interactions.

BDP FL DBCO is a synthetic peptide that binds to the GABA receptor. BDP FL DBCO is used in cell biology and research as an inhibitor of ion channels, ligand for the GABA receptor, or as a reagent to detect antibodies against GABA receptors.

NCX 1000 is a guanylate cyclase activator that has been shown to be effective in the treatment of symptoms of overactive bladder. It is a soluble guanylate cyclase activator that increases the sensitivity of the receptor site, leading to increased intracellular levels of cGMP. NCX 1000 has been shown to be an effective treatment for overactive bladder and can be used in conjunction with other drugs such as gabapentin or noradrenaline. NCX 1000 also has numerous other effects including increasing reaction time and improving muscle function. The experimental model for this drug is detrusor muscle from rats treated with carbon tetrachloride or sodium channel modulators, which are known to cause bladder dysfunction.

MD-224 is a small molecule that inhibits the function of the enzyme beta-secretase (BACE1). This protein is responsible for cleaving amyloid precursor protein (APP) to form beta-amyloid peptides. The inhibition of BACE1 has been shown to decrease the production of beta-amyloid, which may be an effective therapy for Alzheimer's Disease. MD-224 also inhibits cellular processes such as DNA repair and cell division. The compound has been validated in a xenograft tumor model and leukemia cells in vitro. A fossil sequence homologous to MD-224 has been identified in endogenous yeast, suggesting that it may have a biological function.

Rr-11a analog is a medicament that has an endopeptidase inhibitor. It is used as a pharmaceutical agent to treat various diseases such as cancer, diabetes, and Alzheimer's disease. Rr-11a analog inhibits the activity of asparagine endopeptidase, thereby preventing the breakdown of proteins. This inhibition leads to the accumulation of proteins in cells, which in turn triggers cell death by apoptosis. Rr-11a analog has been shown to be effective in treating various cancers and diabetes through experiments on mice. The drug also inhibits the production of amyloid beta protein in Alzheimer's disease patients.

6-SFX is a small molecule inhibitor of the protein interactions. It can be used as a research tool for studying protein interactions, and it has been shown to have an inhibitory effect on receptor activation. 6-SFX binds to the ligand binding site of the receptor and prevents the interaction between the ligand and receptor. This inhibits ion channel activity, which leads to decreased production of neurotransmitters such as dopamine, serotonin, and glutamate. 6-SFX also inhibits phosphorylation by inhibiting protein kinase C (PKC) signaling pathways in cells. 6-SFX has been shown to have high purity that is suitable for use in life sciences research.

WAY-151932 is a high purity, potent and selective small molecule activator of the human calcitonin receptor. WAY-151932 binds to the calcitonin receptor with high affinity and selectivity, and has been shown to stimulate calcium release from intracellular stores in vitro. WAY-151932 also inhibits the binding of peptides that mimic calcitonin to the receptor. WAY-151932 is suitable for research use only; it has not been approved by the FDA for therapeutic use in humans.

rac-Harzianolide is an analog of Harzianolide, a natural product isolated from the fungus Trichoderma sp. It has been shown to have potent anticancer activity by inhibiting kinases involved in cancer cell growth and survival. In human urine, rac-Harzianolide has been detected after oral administration of chitosan-bound rac-Harzianolide. This compound induces apoptosis in cancer cells and inhibits tumor growth in Chinese hamsters. Rac-Harzianolide acts as a kinase inhibitor, blocking the activity of the protein kinases that are essential for cancer cell proliferation and survival. It is considered a promising candidate for the development of novel anticancer agents.

Cis-atovaquone is an effective drug that inhibits the growth of Plasmodium falciparum, a parasite responsible for malaria. It works by binding to the cytochrome bc1 complex in the mitochondrial electron transport chain and disrupting the production of ATP, which is essential for DNA synthesis and protein production. Cis-atovaquone has been shown to have a strong inhibitory effect on liver mitochondria and has high catalytic efficiency. Molecular docking studies suggest that it binds to the active site of the enzyme and forms intermolecular interactions such as hydrogen bonds with amino acid residues. Crystal structures of the protein-inhibitor complex provide insights into its mechanism of action. In control mice, Cis-atovaquone has been shown to be highly effective against malaria infections, making it a promising candidate for future treatments.

Please enquire for more information about Fenitrooxon-d6 including the price, delivery time and more detailed product information at the technical inquiry form on this page

3-Cyclopentyl-2-(4-methanesulfonylphenyl)-N-thiazol-2-yl-propionamide is a medicinal compound that acts as an inhibitor of protein kinases. It has been shown to be effective in inhibiting the growth of cancer cells and tumors in humans, making it a potential anticancer agent. This compound works by selectively inhibiting specific kinases involved in cancer cell proliferation and survival, leading to apoptosis or programmed cell death. 3-Cyclopentyl-2-(4-methanesulfonylphenyl)-N-thiazol-2-yl-propionamide is an analog of Chinese urine-derived kinase inhibitors, which have been used traditionally in Chinese medicine for their anticancer properties. The potent inhibition of kinases by this compound makes it a promising candidate for the development of new cancer therapies.

Desmethyl nintedanib is an analog of the kinase inhibitor nintedanib that has potent anticancer activity. It has been shown to inhibit the growth of cancer cells by inducing apoptosis and reducing oxytocin levels in urine. Desmethyl nintedanib also inhibits calcitonin gene-related peptide release, which is associated with pain and inflammation. This drug specifically targets tumor cells and inhibits their growth by blocking the activity of certain proteins involved in cell division. Desmethyl nintedanib has been studied extensively in Chinese patients with various types of cancer, showing promising results as a potential treatment option for cancer.

Pyr-5120 is a potent, selective, and cell-permeable inhibitor of protein interactions. It has been shown to inhibit the interaction between peptides and proteins in a dose-dependent manner. Pyr-5120 inhibits the activation of certain receptors by their ligands. Pyr-5120 has also been used as research tool in studies on ion channels and antibody production.

(3S,4S)-Tofacitinib is a tyrosine kinase inhibitor that is used to treat cancer and autoimmune diseases. This drug binds to the enzyme deoxycytidine kinase, which is an important enzyme in DNA synthesis. Tofacitinib citrate is a prodrug that is converted into the active form of the drug in vivo by esterases. (3S,4S)-Tofacitinib has been shown to induce pluripotent stem cells from human bone marrow and has demonstrated efficacy in treating alopecia areata in animal models. The safety profile of this compound appears to be similar to that of other oral tyrosine kinase inhibitors, with side-effects such as diarrhea, nausea, and fatigue being most common. (3S,4S)-Tofacitinib citrate has also been found to be effective in reducing prostate hyperplasia when administered orally at dosages between 10

D-Myo-inositol 1,4-bisphosphate is a medicinal compound that acts as an inhibitor of kinases. It has been shown to have potential therapeutic applications in cancer treatment due to its ability to inhibit tumor growth and induce apoptosis in cancer cells. D-Myo-inositol 1,4-bisphosphate is an analog of inositol phosphates found in human urine and Chinese medicinal herbs. It specifically targets protein kinases involved in the regulation of cell proliferation and survival, making it a promising candidate for anticancer therapy. Its inhibitory effects on kinase activity make it a valuable tool for studying the function of these enzymes in cellular processes.

CD3 antibody (PE-CY7) was raised in mouse using the epsilon chain of CD3/T-cell antigen receptor complex as the immunogen.

Sorafenib is a drug that belongs to the class of multikinase inhibitors. It inhibits a number of kinases, including the Mcl-1 protein, which is involved in apoptosis along with blocking picolinic acid (PA), an endogenous metabolite involved in apoptosis signal transduction. Sorafenib also binds to epidermal growth factor receptor (EGFR) on the surface of cancer cells, inhibiting the production of proteins that are required for angiogenesis, thus blocking the formation of new blood vessels. Sorafenib may also inhibit P-glycoprotein (Pgp) activity. Overall, these cytotoxic effects give Sorafenib anti-tumor properties, inhibiting angiogenesis and cellular transformation, which are the two main processes of tumor growth and metastasis. Sorafenib has been shown to be effective against a range of solid tumors such as breast, prostate and lung cancers and is also used for the treatment of metastatic colorectal cancer and renal cell carcinoma. A combination therapy group found that sorafenib was more effective when used with interferon alfa-2b for the treatment of advanced renal cell carcinoma. Sorafenib also has the potential for drug interactions with other drugs that are metabolized by cytochrome P450 enzymes.

5-[4-(4-Bromoanilino)anilino]-N'-(1-hydroxypropan-2-yl)-3-oxo-1,2-thiazole-4-carboximidamide is a potent inhibitor of the human Fc receptor (FcR). The Fc receptor plays a key role in immunoregulation. It is also a pharmacological target for drugs that modulate immune responses. 5-[4-(4-Bromoanilino)anilino]-N'-(1-hydroxypropan-2-yl)-3-oxo-1,2-thiazole-4-carboximidamide has been shown to inhibit the binding of an antibody with its antigen and to inhibit the binding of an antibody with its antigen. This inhibition was dose dependent and reversible. The IC50 value for 5-[4-(4-Bromoanilino)anilino]-N'-

Glycozolinol is a research tool that belongs to the group of activators. It can be used as an activator to induce receptor-mediated signal transduction pathways. Glycozolinol has shown to activate a number of ion channels, such as Ca2+ and K+ channels, and also inhibits protein interactions with peptides and proteins. This compound also appears to have pharmacological properties, suggesting it may be useful in the treatment of diseases such as cancer, epilepsy, or diabetes.

PDE10-IN-1 is a peptide with the amino acid sequence of GGRDYGGLPPG. It is an activator of PDE10, which belongs to the family of phosphodiesterases. The inhibition of PDE10 in the brain has been shown to have antidepressant effects in mice and rats. This peptide has been shown to be a potent inhibitor of protein interactions, with IC50 values ranging from 1 μM to 10 μM for a number of proteins including TNF-α receptor (IC50 = 2 μM), CD4 receptor (IC50 = 1 μM), and CX3CR1 receptor (IC50 = 0.5 μM). In addition, PDE10-IN-1 has been shown to be a ligand for the dopamine D2 receptor and may function as an antagonist or agonist depending on its binding affinity.

Please enquire for more information about o-Ethyl chlorthalidone hydrate including the price, delivery time and more detailed product information at the technical inquiry form on this page

BY27 is an innovative synthetic derivative, designed as a specialized compound for advanced biochemical applications. This product is derived from a unique sequence of engineered organic compounds, developed through a process of targeted molecular synthesis. Its primary mode of action is the selective modulation of specific biochemical pathways, achieved through high-affinity interaction with targeted molecular structures. This allows for precise manipulations within cellular systems, facilitating the study of complex biological processes.

Gliorosein is a mixture of naturally occurring orsellinic acids that has been shown to have anticancer activity. The compounds are biosynthesized by Streptomyces sp., which is an aerobic bacterium. These orsellinic acids have been shown to inhibit the growth of cancer cells by interfering with the synthesis of DNA and RNA, as well as inhibiting protein synthesis. Gliorosein may be effective against other types of cancer cells, such as leukemia and lymphoma, due to its ability to inhibit nucleic acid synthesis.

Please enquire for more information about D-Glucopyranose 1,2,3,6-tetrabenzoate including the price, delivery time and more detailed product information at the technical inquiry form on this page