Biochemicals and Reagents

<p>KU14R is a novel molecule that can be used as a pharmacological agent to treat diabetes. It blocks the ATP-sensitive potassium channels in the hippocampus, which leads to an increase in cytosolic calcium levels and inhibits beta-cell function. KU14R also blocks the ATP-sensitive potassium channels in the bladder, which results in increased camp levels and pge2 levels. This drug has been shown to have a beneficial effect on diabetic patients. The molecular targets of KU14R are intracellular targets including transcription-polymerase chain and protein synthesis. KU14R also inhibits potassium channel activity by blocking voltage-gated potassium channels, leading to an increase in cytosolic calcium levels and inhibition of beta-cell function.</p>

<p>Borrelia Burgdorferi Basic Membrane Protein A (BBMPA) is a protein that belongs to the Borrelia burgdorferi bacterium. It is a glycoprotein found on the surface of the bacterial cell, which has been shown to be involved in adhesion to host tissue. BBMPA is composed of two identical subunits, each containing five domains. These domains are involved in different functions and range from binding to other proteins and lipids to receptor-binding sites for host cells. This protein has been studied extensively as it is important for pathogenicity and infectivity of Borrelia Burgdorferi.</p>

<p>Parireotide diaspartate is a peptide that belongs to the group of activators and is used as a research tool. It can be used to activate different ion channels, such as calcium channels. In cell biology, it has been shown to inhibit protein interactions and receptor-ligand binding. Parireotide diaspartate has also been reported to have pharmacological properties, including the ability to inhibit protein synthesis and act as an antagonist at glutamate receptors.</p>

<p>Antagonist of CCK-A receptor</p>

<p>1-[6-Fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile is a peptide that has been used as a research tool to study protein interactions, antibody and cell biology. It can act as an inhibitor of ion channels such as sodium channels. The binding site for this peptide is located at the extracellular loop of the receptor. 1-[6-Fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine 4 carbonitrile is a ligand that binds to receptors on cells, which may be responsible for its pharmacological effects.</p>

<p>RVT 501 is a biochemical reagent, which is derived from synthetic organic compounds with high specificity. Its primary mode of action involves the modulation of cellular oxygenation pathways, impacting the activity of specific intracellular enzymes. By interacting with these molecular targets, RVT 501 effectively alters oxidative stress responses, making it invaluable for experimental protocols focused on redox biology and related fields.</p>

<p>Ce3F4 analog 1 is a protein that belongs to the class of ligands, which are organic molecules that bind to receptors. It has been shown to be an inhibitor of ion channels, such as potassium and calcium channels. Ce3F4 analog 1 is a high-purity, recombinant peptide with a purity of &gt;98% and an activity of &gt;90%. Ce3F4 analog 1 is also known as Cas No. 2141967-43-1 and can be used as a research tool in the fields of pharmacology, cell biology, and antibody production.</p>

<p>SR-318 is a synthetic, non-antigenic peptide that mimics the antigen tropomyosin. It has been shown to be effective in treating inflammatory diseases, cancer, and autoimmune diseases by binding to the sensor protein on cells that are activated by the peptide. SR-318 binds to the tropomyosin receptor on the cell surface and inhibits cellular activation by regulating kinase activity. This allows for termination of an immune response at its source, preventing inflammatory and autoimmune disorders. The high concentration of SR-318 also prevents cancer cells from dividing and spreading throughout the body.<br>SR-318 has been shown to be effective in treating pulmonary fibrosis in animal models with a body mass index (BMI) greater than 25 kg/m2.</p>

<p>Dinoterb is a potent anticancer agent that belongs to the group of kinase inhibitors. It has been shown to induce apoptosis in cancer cells, making it an effective treatment for various types of tumors. Dinoterb has been found to be particularly effective against Chinese hamster ovary cells and human leukemia cells. This drug works by inhibiting the cell cycle, which prevents cancer cells from dividing and growing. Dinoterb is excreted mainly through urine and has been used in medicinal preparations as an inhibitor of protein kinases involved in cancer development. Its anti-tumor activity makes it a promising candidate for further research into cancer treatments.</p>

<p>2-(9-((4-Chlorophenyl)thio)-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid (BETI) is a synthetic compound that has been shown to have an inhibitory effect on the inflammatory response. BETI has been shown to reduce the production of eosinophils in mice and rats. This drug has also been shown to lower blood pressure in rats by inhibiting cyclooxygenase 2 (COX2). In addition, BETI inhibits Ca2+ responses in human platelets.</p>

<p>ML336 is an antiviral agent that inhibits the replication of alphaviruses. ML336 has been shown to be effective against a variety of viruses, including those that are resistant to other antiviral agents. It binds to the viral envelope protein and inhibits virus entry into the host cell, which prevents the virus from replicating. The mechanism of action of ML336 is similar to that of the human immunodeficiency virus (HIV) inhibitor Maraviroc. Clinical trials have shown that ML336 is efficacious in inhibiting cellular and animal viruses, such as HIV-1, HIV-2, simian immunodeficiency virus (SIV), human cytomegalovirus (HCMV), and dengue fever virus (DENV).</p>

<p>Antagonist of neurokinin receptor NK1</p>

<p>GSK984 is a novel, orally bioavailable small molecule that has been shown to inhibit the growth of human primary keratinocytes and fibroblasts. GSK984 inhibits the proliferation of human cells by inducing apoptosis, which is a form of cellular suicide in response to DNA damage or stress. It is believed that GSK984 may be useful for the treatment of cancer and HIV/AIDS because it inhibits the replication of viruses such as herpes simplex virus and HIV-1. GSK984 binds to viral proteins and prevents the release of new virus particles from infected cells. The mechanism studies are ongoing to determine how GSK984 inhibits cell proliferation in human primary cells.</p>

<p>KP372-1 is a selective inhibitor that is synthetically derived. This compound functions by targeting and interfering with specific signaling pathways involved in cell growth and survival. Its inhibitory action primarily affects pathways such as PI3K/Akt, which are integral to the processes of cellular proliferation and apoptosis.</p>

<p>piperidin-1-yl)methanone is a research tool that has been shown to activate ligands and receptors, to inhibit ion channels, and to bind to antibodies. It is a white crystalline solid that is soluble in organic solvents. Piperidin-1-yl)methanone has been used in cell biology as an activator or inhibitor of protein interactions, peptides, and life science applications such as pharmacology and antibody production. This chemical can be used in the study of ion channels, including voltage gated channels, ligand-gated channels, and receptor-gated channels.</p>

<p>ICA is a diagnostic imaging technique that evaluates the carotid artery for signs of acute ischemic injury. This technique uses a radioactive isotope, such as technetium-99m, to produce signals that are visible on an image. ICA can be used to diagnose carotid artery stenosis and occlusion, which may occur as a result of atherosclerosis or trauma. The signal intensity in the carotid artery can be measured using a positron emission tomography (PET) scanner and quantified with the use of a linear model. The signal intensity in the carotid artery is also correlated with blood flow velocity and blood pressure in the neck. In order to evaluate pharmacokinetics properties, ICA can be combined with pharmacological treatment or pharmacokinetic study.</p>

<p>ITMN 4077 is an ion channel activator that belongs to the group of peptides. It is a synthetic peptide with a high purity, and has been shown to be an inhibitor of sodium channels in neuronal cells. ITMN 4077 may be used as a research tool to study protein interactions, such as those between ion channels and their ligands. This compound may also be used for pharmacological purposes or for the treatment of diseases caused by abnormal ion channel activity, such as epilepsy or chronic pain.</p>

<p>MLS000532223 is a small molecule that is potent and selective against a variety of cancer cell lines. It has been shown to inhibit the growth of cells through biochemical and morphological studies. MLS000532223 inhibits the production of bone morphogenetic protein (BMP), which is a molecule that contributes to tumor formation, by inhibiting the function of the BMP receptor. This drug also inhibits the production of other molecules, such as hematopoietic growth factor and platelet-derived growth factor. MLS000532223 can be used to treat cancer by inhibiting cell proliferation in patients with solid tumors, sarcomas, or leukemias.</p>

<p>TC-N 22a is a novel, orally active metabotropic glutamate receptor ligand that has been shown to have potent and selective pharmacological effects in rat models. TC-N 22a is a synthetic, neutralized form of the endogenous neurotransmitter glutamate. It binds to the glutamate binding site on the metabotropic glutamate receptor and inhibits glutamate activation of both ionotropic (AMPA) and metabotropic (mGluR) receptors. TC-N 22a was developed by Promega Corporation as part of a series of compounds targeting the mGluR5 receptor. In animal studies, TC-N 22a inhibited dyskinesia induced by dopamine depletion in rats with chronic Parkinson's disease.</p>

<p>ZAP 180013 is an advanced enzymatic reagent, which is derived from a recombinant source with specificity for targeted protein modification. It operates through a unique mechanism of action that involves the precise cleavage of peptide bonds at target sites identified by a specific amino acid sequence. This specificity allows for minimal off-target effects, making it a reliable tool in proteomics.</p>

<p>UU-T02 is an emergent natural compound that has been found to stabilize cancer cells. UU-T02 has been shown to prevent the degradation of β-catenin, a protein that promotes cell survival and proliferation. UU-T02 also inhibits the activation of downstream signaling pathways such as Wnt/β-catenin and PI3K/AKT, which have been implicated in cancer development. Flavonoids are thought to be the bioactive components in UU-T02, which are responsible for its anti-cancer properties. The flavonoids present in UU-T02 have been shown to inhibit cancer cell proliferation by modulating apoptosis and autophagy.</p>

<p>TAS-103 is an investigational anti-cancer drug, which is a synthetic compound with origins in advanced medicinal chemistry. It functions as a topoisomerase inhibitor with dual-action targeting both topoisomerase I and II enzymes. Topoisomerases are crucial for modulating DNA supercoiling during replication and transcription processes. By interfering with these enzymes, TAS-103 hinders the DNA replication machinery, leading to replication fork stalling and subsequent induction of DNA damage, which can trigger cell death.</p>

<p>Febrifugine is a chiral optical antiparasitic drug that is used to treat and prevent malaria. It has potent antimalarial activity against the parasite Plasmodium falciparum, which causes malaria. Febrifugine is an orally active compound that can be administered by mouth and is rapidly absorbed from the gastrointestinal tract. It binds to red blood cells and inhibits their function, leading to parasite sequestration in the erythrocytes and subsequent death of the parasites. The drug also has anti-inflammatory properties and may potentiate aminoguanidine, a drug that helps to control blood cell production.</p>

<p>DAMGO is a synthetic opioid drug that is used in scientific research to study the effects of opioids on cell membrane excitability. DAMGO binds to the δ-opioid receptor, which is found in high concentrations in the central nervous system and small intestine. It has a synergistic effect with other drugs, such as naloxone, that block the μ-opioid receptor. In vivo studies have shown that DAMGO induces significant upregulation of energy metabolism genes in squamous epithelial cells, and this upregulation is synergic with naloxone.</p>

<p>Monogalactosyldiacylglycerol (MGDG) is a component of the lipids that make up cell membranes. It is found in the cytoplasm of cells, where it is bound to proteins. MGDG plays an important role in cellular processes such as cell division and differentiation, and may be involved in the development of cancer. MGDG has been shown to inhibit the growth of cancer cells by preventing the synthesis of proteins required for cell division. The MGDG phase transition temperature is lower than that of other lipids, which suggests that it can act as a potential drug target for certain cancers with low body temperatures.</p>

<p>Inhibitor of CK1 kinase</p>

<p>SSR 69071 is a small-molecule inhibitor of the serine protease activated by covalent binding. It has been shown to inhibit the activity of the enzyme in vitro and in vivo, and is able to inhibit growth factor-induced proliferation in cells. SSR 69071 has also been shown to be effective against diabetic neuropathy and cardiac infarction, as well as other inflammatory diseases. The exact mechanism of action is not yet known, but it may be due to its ability to inhibit peptidases, which are enzymes that break down proteins into smaller peptides. SSR 69071 also inhibits reactive oxygen species (ROS), which are molecules that can cause oxidative stress and damage cells. The inhibition of ROS may be responsible for some of the drug’s anti-inflammatory effects.</p>

<p>Please enquire for more information about Axitinib-d3 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>GNRH precursor (14-26) is a peptide that is important for the regulation of reproduction and fertility. It has been shown to activate the receptor in living cells, where it signals through G-protein coupled receptors. GNRH precursor (14-26) has also been shown to have an inhibitory effect on the activity of certain ion channels and can be used as a research tool in cell biology or pharmacology, as well as an antibody production reagent.</p>

<p>Phospho-glycogen synthase (PGS) peptide-2 is a research tool that is used as an activator for phospho-glycogen synthase. It binds to PGS and activates the enzyme by stimulating its ability to bind with phosphate groups. This peptide is also used as a ligand in receptor binding studies and has been shown to be an inhibitor of ion channels. Phospho-glycogen synthase peptide-2 has been shown to have high purity, and can be used in the study of protein interactions, pharmacology, and peptides.</p>

<p>CD152 antibody (Azide free) was raised in hamster using keat-killed Staphylococcus A bacteria coated with murine CTLA-4/human IgG1 fusion protein as the immunogen.</p>

<p>MDL 19301 is a high-affinity antagonist of the nicotinic acetylcholine receptor, specifically the alpha4beta2 subtype. It has been shown to inhibit the binding of nicotine and other nicotinic agonists to receptors in cell culture. MDL 19301 has also been shown to inhibit the release of acetylcholine from nerve endings in rat ileum, suggesting that it may have therapeutic applications for treatment of neurodegenerative disorders such as Alzheimer's disease or Parkinson's disease.</p>

<p>M-89 is a monoclonal antibody that targets fatty acid binding protein 4 (FABP4) and inhibits the uptake of lipids in muscle cells. M-89 has been shown to be clinically relevant for women with atherosclerotic cardiovascular disease and also for those who are obese. M-89 has shown some promise as a diagnostic tool for polymyositis, dermatomyositis, systemic lupus erythematosus, and other inflammatory muscle diseases. The experimental model system used to assess the efficacy of M-89 was a rat model of polymyositis induced by injection of an allergen into the thigh muscle. In this study, M-89 inhibited lipid uptake by blocking FABP4, which is located on the surface of muscle cells. This inhibition led to decreased levels of proinflammatory cytokines that are responsible for causing muscle damage.</p>

<p>Ldn 212854 is a novel small molecule that has been shown to promote the regeneration of epithelial cells in a population of organoids. In addition, this drug has been shown to increase the size and number of regenerative epithelial cells in cell preparations. Ldn 212854 has also been demonstrated to have therapeutic potential for regenerative medicine. It may be used as an alternative treatment for skin damage or other epithelial-related conditions. This drug is currently being researched for its applications in the field of regenerative medicine.</p>

<p>A-278637 is a quinoline derivative that has been shown to be effective in treating acute decompensated heart failure. The mechanism of the drug is not fully understood, but it is thought to inhibit the opening of certain membrane channels in the bladder and detrusor muscle. A-278637 has also been shown to produce a significant increase in systolic pressure, which may be due to its ability to activate cardiac β 1 -adrenergic receptors.</p>

<p>CDM-NAG is a specialized biochemical substrate, which is a chemical compound derived from the structural modification of chitin. It has been engineered to act as a chromogenic or fluorescent marker due to its functional groups that undergo changes upon enzymatic action. The mode of action involves hydrolysis by N-acetylglucosaminidases, enzymes that recognize and cleave specific glycosidic bonds within the substrate. Upon enzymatic cleavage, CDM-NAG releases a measurable signal, either through colorimetric change or fluorescence, enabling precise quantification of enzyme activity.</p>

<p>Inhibitor of EGFR, HER2 and VEGFR2 tyrosine kinases</p>

<p>This is a research tool that is commonly used as an inhibitor in pharmacology and cell biology. It has been shown to inhibit ion channels and protein interactions. Dihydrocyclosporin C has a purity of &gt;98% with a CAS number of 63556-15-0.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>PROTAC ERRα Degrader-2 is an antibody that binds to the alpha subunit of the estrogen receptor, a nuclear transcription factor. It is a research tool for studying the molecular mechanisms of estrogen regulation in cells and for identifying potential therapeutic targets. The antibody has been shown to inhibit protein interactions with estrogen receptor alpha and to activate ligand-dependent signaling pathways. PROTAC ERRα Degrader-2 also has high purity, as it is made of pure recombinant proteins. This antibody can be used as a diagnostic tool for biomarker discovery in cancer and other diseases.</p>

<p>CMP3a is a small molecule that inhibits the activity of tyrosine kinase enzymes. It is used for cancer therapy and to treat hepatitis. CMP3a has been shown to inhibit the replication of various viruses, including HIV-1, herpes simplex virus 1 (HSV-1), and influenza A virus. CMP3a binds to the kinase domain of the enzyme and modifies it, which prevents the enzyme from phosphorylating downstream substrates and initiating signal transduction pathways. Target gene expression was also inhibited in cancer cells treated with CMP3a, suggesting that this drug may be useful for treating cancer.</p>

<p>AVE 0991 is a blocker of the angiotensin receptor type 1, which inhibits the binding of angiotensin II to its receptors. It has been shown to reduce infarct size and improve cardiac function in experimental models of myocardial infarction. Captopril, an orally administered ACE inhibitor, also has this property. AVE 0991 may be used for the treatment of thromboembolism and angioplasty as well as transluminal coronary artery intervention.<br>AVE 0991 is a potent and selective blocker of the AT1 receptor that binds with high affinity to this receptor without affecting other receptors or tissues. The effects on cardiovascular parameters were evaluated in patients undergoing percutaneous transluminal coronary angioplasty (PTCA). AVE 0991 significantly decreased mean arterial pressure (MAP) and heart rate (HR), with no significant change in cardiac index, stroke volume index, or ejection fraction.</p>

<p>CD90 antibody (Allophycocyanin) was raised in rat using murine T-Cell hybridoma c6/G8, produced by fusion of porl insulin-specific BALB/c T cells with the AKR thymoma line BW 5147 as the immunogen.</p>

<p>PF-04634817 is a small molecule that inhibits the activity of VEGF, which is a potent chemoattractant protein. It has been shown to be safe in clinical trials and has shown promising results for the treatment of infectious diseases. PF-04634817 inhibits the production of proteins such as chemokines, which are important in the immune system response. It also blocks the activation of receptors on cells that bind to these proteins. PF-04634817 is currently being investigated for its ability to treat eye diseases such as diabetic retinopathy and age-related macular degeneration.</p>

<p>Temarotene is an all-trans retinoic acid (ATRA) analog that binds to the IL-2 receptor with high affinity and specificity. It has been shown to inhibit the proliferation of HL-60 cells in vitro, which may be due to its ability to induce the release of colony-stimulating factor from these cells. Temarotene also enhances the uptake of ATRA by HL-60 cells and increases the expression of receptors for ATRA in humans. In vivo studies have shown that temarotene is a potent inducer of fatty acid synthesis in Sprague-Dawley rats. This agent has a long half-life and is rapidly absorbed when administered orally, with peak plasma concentrations occurring 2 hours after administration. The pharmacokinetic properties of this drug are similar to those of other synthetic retinoids, such as all-trans-retinoic acid.</p>

<p>Anti Amyloid B-Protein (1-40), human serum is a recombinant inhibitor of amyloid beta protein (Aβ) that inhibits the formation of amyloid plaques in Alzheimer's disease. This product is used as a research tool for studying the mechanism of Aβ toxicity. It is also used as a reagent for antibody detection and other research purposes.</p>

<p>Riluzole is a drug that binds to the glutamate receptor, which is a ligand-gated ion channel. It is used as a research tool in pharmacology and cell biology. Riluzole can be used to study glutamate receptors and protein interactions. This product has the CAS number 1215552-03-6, has high purity, and is an inhibitor.</p>

<p>Pacfa glccer is a peptide that is a high-affinity, selective activator of the hGLP-1 receptor. It has been shown to activate the hGLP-1 receptor in vitro and in vivo, with EC50 values of 0.17 nM and 15 nM, respectively. Pacfa glccer has no effect on the activity of other GPCRs at concentrations up to 10 μM. The peptide was also found to be an inhibitor of voltage-gated potassium channels Kv1.2 and Kv1.3 with IC50 values of 0.8 μM and 1.6 μM, respectively.</p>

<p>4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine, also known as BromoBZAT, is a peptide that can be used as a research tool and an activator. It has been shown to activate the ion channels in cells and inhibit protein interactions. This product is highly pure and is sold for research purposes only.</p>

<p>CD90.2 antibody (Azide free) was raised in rat using CD90.2/`Thy-1.2 alloantigen as the immunogen.</p>

<p>Dihydrexidine is a selective dopamine receptor agonist, which is synthesized in a laboratory setting. It primarily acts on D1-like dopamine receptors, facilitating an increase in dopaminergic signaling pathways. This increased signaling is achieved through binding and activating specific receptor subtypes that influence numerous neural pathways.</p>

<p>c-Kit-IN-3 is a peptide that is an inhibitor of protein interactions with the receptor c-kit. It has been shown to act as an activator for Ligand and a ligand for the receptor c-kit. The high purity, pharmacological potency and specificity make this compound suitable for use in research.</p>

<p>GW-406381 is a potent and selective agonist for the peroxisome proliferator-activated receptor delta (PPARδ), which is commonly employed in pharmacological research. This compound functions as a ligand that activates PPARδ, a nuclear receptor that plays a critical role in the regulation of lipid metabolism, energy homeostasis, and inflammatory responses. By binding to the PPARδ receptor, GW-406381 modulates the transcription of target genes involved in fatty acid oxidation, mitochondrial biogenesis, and muscle fiber type switching.</p>

<p>Anitgen of the fungus, Aspergillus fumigatus</p>

<p>CD28 antibody (biotin) was raised in hamster using CD28 costimulatory receptor as the immunogen.</p>

<p>Etabenzarone is a research tool that was developed for the study of ion channels and protein interactions. It is a ligand that binds to the receptor Ligand and has been used to study cell biology, antibody production, and pharmacology. Etabenzarone is also an inhibitor that prevents the activation of ion channels by binding to them. It has been shown to bind to proteins in cell culture experiments as well as inhibit their function.</p>

<p>Serotonin receptor 5-HT2B antagonist</p>

<p>SYFPEITHI MHC binding peptide</p>

<p>The IGHG1 MS Calibrator-4 is a tryptic peptide that is a product of the Ig gamma-1 chain C region. This peptide is used as a calibrator for mass spectrometry. The IGHG1 MS Calibrator-4 contains Biologically Active Peptides, which can be used to identify the presence of proteins in biological samples. The New England Peptide Company offers peptides for use in proteomics, such as the IGHG1 MS Calibrator-4.</p>

<p>Inhibitor of GSK-3 kinase</p>

<p>Combretastatin A-1 Phosphate is a peptide inhibitor that binds to the receptor of protein kinase C and inhibits its activity. This drug is a potent activator of G proteins and has been used as a research tool in cell biology. It has been shown to inhibit ion channels and activate ligand-gated ion channels, which may be beneficial in the treatment of hypertension. Combretastatin A-1 Phosphate is also an excellent reagent for labeling antibodies with radioactive iodine, which can be used for immunohistochemistry assays.</p>

<p>E3 Ligase ligand 8 is a protein that belongs to the ubiquitin ligase family. It is involved in the regulation of gene expression and metabolism. E3 Ligase ligand 8 catalyzes the attachment of ubiquitin molecules to other proteins, marking them for degradation by proteasomes. It also has been shown to be a linker between the e3 ligases and their substrates.<br>E3 Ligase ligand 8 has been shown to bind DNA in vitro, which may be due to its ability to form heterocycles with c-Myc protein, leading to increased transcriptional activity.</p>

<p>Rac 1-Nitroso-2-methylindoline is a potent anticancer agent that has been shown to induce apoptosis in cancer cells. It works by inhibiting protein kinase activity, which plays a critical role in cancer cell proliferation and survival. This compound is an analog of a Chinese medicinal herb and has been found to be effective against various types of tumors in human studies. Rac 1-Nitroso-2-methylindoline acts as a cell cycle inhibitor, preventing the growth and division of cancer cells. It is also being investigated as a potential urine biomarker for early detection of certain types of cancers. With its promising properties, rac 1-Nitroso-2-methylindoline holds great potential as a powerful weapon in the fight against cancer.</p>

<p>ML 218 hydrochloride is a calcium-channel blocker that inhibits the influx of extracellular calcium into cells. ML 218 hydrochloride has been shown to be effective in the treatment of conditions such as brain cell dysregulation and sclerosis, where there is an increased concentration of sulfate ions. This drug binds to sulfated glycosaminoglycans, which are found on the surface of cells, blocking the entry of calcium ions into cells. It also inhibits the release of calcium from intracellular stores by binding to receptors on the cell membrane. ML 218 hydrochloride has a multistep mechanism: it blocks influx from outside the cell and releases calcium from inside the cell.</p>

<p>CDK1/2 inhibitor III is an experimental drug that inhibits the activity of CDK1 and CDK2, which are cyclin-dependent kinases (CDKs) that regulate cell cycle progression. It has been shown to inhibit epidermal growth in explants from human skin. This inhibitor has anti-tumor effects, as it prevents the formation of new blood vessels in tumor cells and slows down their growth rate. CDK1/2 inhibitor III has also been shown to have a suppressive effect on virus replication by inhibiting the binding of the virus with its receptor. The drug can be used as an antiviral agent against HIV and herpes simplex virus type 1. Furthermore, CDK1/2 inhibitor III has an inhibitory effect on cellular proliferation and cancer cells.</p>

<p>Adenosine antagonist-1 is a substance that binds to the adenosine receptor. It has been shown that this substance inhibits the binding of adenosine to its receptors, which blocks the effect of endogenous adenosine and prevents the transmission of pain signals in animals. Adenosine antagonist-1 also has an effect on neurotransmission and blood pressure. In addition, it has been shown that this substance does not affect glutamate release or produce locomotor activity in animals.</p>

<p>TNF-± Antagonist III is a drug that is used to inhibit the production of TNF-α. It has been shown to regulate transcriptional activity in cells and to inhibit the growth of cancer cells. TNF-± Antagonist III has been observed to decrease the M2 phenotype, which may be due to its ability to activate ATP levels in macrophages. This drug also inhibits kidney fibrosis by reducing pro-inflammatory factors, such as tumor necrosis factor-α (TNF-α) and fatty acids. The drug also has effects on abdominal surgery, as it reduces inflammation following this type of procedure. TNF-± Antagonist III is used in fat tissue and adipose tissue, where it reduces the number of pro-inflammatory factors produced by macrophages.</p>

<p>Inhibitor of heat shock protein Hsp90</p>

<p>Hsp70, His tagged human, is a recombinant protein, which is derived from human cells and engineered with a hexahistidine (His) tag. It is part of the Heat Shock Protein 70 family, known for its crucial role in cellular stress response. The His tag facilitates purification and detection via affinity chromatography, making it a convenient tool for research applications.</p>

<p>SHR0302 is a peptide that activates the G protein-coupled receptor. It has been shown to inhibit protein interactions with the receptor and is used as a research tool to study the cell biology of ion channels. SHR0302 is a potent inhibitor of ligand binding to its receptor, which may be due to its conformational flexibility and ability to bind at different sites on the ligand.<br>SHR0302 can also be used as an antibody for immunohistochemical detection of the receptor in tissue sections. SHR0302 has a molecular weight of 2,867 g/mol and CAS number 1445987-21-2.</p>

<p>Tlr7 agonist 3 is a peptide that belongs to the class of activators. It has been shown to activate Tlr7, which is a receptor that plays an important role in the activation of immune cells. Tlr7 agonist 3 has been shown to inhibit the interaction between Tlr7 and its ligand, which is necessary for the activation of immune cells.</p>

<p>1-Deoxyfructosyl-Gly is a multifunctional inhibitor that has been shown to inhibit the activity of protein interactions, activator, ligand, and receptor. It is a research tool used to investigate the role of ion channels in cell biology. The antibody has high purity and is suitable for use in life science research.</p>

<p>E 7386 is a monoclonal antibody that targets β-catenin, which is found in the cytoplasm of cells. E 7386 binds to β-catenin and inhibits its interaction with the transcription factor LEF1, preventing it from binding to DNA. In addition, E 7386 has been shown to inhibit epidermal growth factor (EGF) signaling and potentiate tumor cell death by inducing apoptosis. E 7386 has also been shown to reduce microvessel density and increase tumor cell death in mouse xenografts. It is currently being used for treatment of colorectal carcinoma and other cancers.</p>

<p>Apadenoson-d5 is a synthetic ligand for the beta 2 adrenergic receptor, a protein that regulates the rate of cellular metabolism and the release of hormones. It has been shown to bind to both rat and human beta 2 adrenergic receptors with high affinity. Apadenoson-d5 has also been shown to inhibit the function of adenylate cyclase, an enzyme involved in the production of cAMP, which is important for many cell functions including signaling. Apadenoson-d5 may be used as a research tool or pharmacological agent.</p>

<p>CAY10566 is a novel compound that has been shown to induce apoptosis in cells. It binds to the cytosolic protein cytochrome c, which is involved in the mitochondrial electron transport chain. This binding leads to an increase of intracellular levels of hydrogen peroxide and reactive oxygen species (ROS), leading to increased cell apoptosis. CAY10566 also inhibits autophagy, a process that assists in the degradation of cellular components during starvation or other unfavorable conditions. This drug was also found to inhibit cell growth and proliferation by suppressing the MAPK/AMPK pathway, which regulates cellular metabolism and growth.</p>

<p>VAS 3947 is a peptide inhibitor of the protein interaction between the N-ethylmaleimide sensitive factor and the erythrocyte membrane. It has been used as a research tool to study protein interactions, receptor binding, ion channels, and antibody production. VAS 3947 is synthesized by solid-phase chemistry and purified by HPLC. The purity of this product is greater than 98%.</p>

<p>Endothelin receptor antagonist</p>

<p>Saikogenin A is a natural compound found in the tuberous roots of Pueraria lobata that has been shown to have a variety of biological activities. Saikogenin A inhibits protein synthesis through a number of mechanisms, including interfering with the production of growth factors, blocking the conversion of epoxyeicosatrienoic acids to prostaglandins, and inhibiting the activity of human liver cancer cells. It also has anti-inflammatory properties and has been shown to inhibit UV absorption as well as erythromycin-induced uvB damage in human skin cells. The triple-quadrupole mass spectrometry analysis reveals that saikogenin A has absorptions at 336, 338, and 340 nm in urine samples. This suggests that saikogenin A may be metabolized by cytochrome P450 enzymes into metabolites with different absorption spectra.</p>

<p>CD49d antibody (PE) was raised in mouse using human CD49d as the immunogen.</p>

<p>N2-[2-[4-[(2-Naphthalenylcarbonyl)amino]phenyl]acetyl]-L-arginyl-L-isoleucyl-L-α-aspartyl-N-[(2S)-2-methylbutyl]-L-argininamide is a synthetic peptide drug, which is a product of advanced chemical synthesis processes. It functions as a selective inhibitor, targeting specific proteolytic enzymes involved in pathological conditions. The molecular structure allows it to engage in precise interactions with target enzymes, thereby modulating biological pathways and offering therapeutic potential.</p>

<p>Meseclazone is a non-steroidal anti-inflammatory drug (NSAID) that is used to treat inflammation, pain, and stiffness caused by arthritis. Meseclazone is a prodrug that is converted in vivo to mesalazine, its active form. Mesalazine has been shown to have biological properties that are similar to acetylsalicylic acid, including ionotropic gelation. This drug also has the ability to form hydrogen bonds with acidic or basic groups, which helps it act as a cavity filler. Meseclazone also contains a carbonyl group and hydrochloric acid, which can be used for the synthesis of other drugs.</p>

<p>Hydroxypyruvic acid lithium hydrate is a research tool that can be used to study the interaction of peptides with antibodies and receptor proteins. It is also used as an activator for the production of antibodies. This product is a white powder that is soluble in water and alcohol. CAS No. 209728-15-4</p>

<p>Achyranthes bidentata polysaccharide (ABP) is a chinese herb that has been used in traditional Chinese medicine for the treatment of various diseases. ABP is a protein synthesis inhibitor, and it also inhibits the transcriptional regulation of NF-κB DNA binding. It has shown to be effective in vitro against carcinoma cells lines, cell culture, and p24 antigen levels. This drug should not be used in patients with autoimmune diseases or congestive heart failure. Achyranthes bidentata polysaccharide should not be taken by patients with collagen disease because it may lead to increased degradation of collagen.</p>

<p>Fulacimstat is a drug that is used to treat chronic kidney disease and ventricular dysfunction. Fulacimstat blocks angiotensin II, which is a potent vasoconstrictor, by inhibiting the angiotensin-converting enzyme (ACE). It has been shown to have beneficial effects on cardiac function in patients with chronic kidney disease who are undergoing hemodialysis. Fulacimstat has also been shown to reduce blood pressure in patients with renal impairment. Fulacimstat lowers potassium levels and increases serum levels of renin, which may lead to adverse events such as infarction or hyperkalemia. Fulacimstat may be an effective treatment for heart failure, but the safety profile needs to be further investigated before it can be recommended for this use.</p>

<p>Please enquire for more information about 1-Undecanoyl-2-hydroxy-sn-glycero-3-phosphocholine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Kif15-IN-2 is a chemical inhibitor that specifically targets the kinesin-12 family protein Kif15. It is derived from small molecule libraries through structure-based design and medicinal chemistry processes. The mode of action of Kif15-IN-2 involves the disruption of Kif15's motor function, which is crucial for the proper formation and function of the mitotic spindle during cell division. This inhibition disrupts microtubule dynamics, thereby affecting cell proliferation.</p>

<p>Potent inhibitor of SERCA ATPase</p>

<p>Etamicastat hydrochloride is a drug that inhibits the activity of the human liver enzyme CYP2D6. It is an inhibitor of the acetylation of dopamine to noradrenaline, which is important for the synthesis of adrenaline and dopamine. Etamicastat hydrochloride has been shown to have affinity for both human and monkey tissues. It also inhibits hydroxylation in rat plasma, liver cytosol, and liver microsomes. This drug has also been shown to inhibit dopamine hydroxylase in rat brain tissue as well as in vitro studies with human liver preparations. Etamicastat hydrochloride has been found to be effective against Parkinson's disease and other diseases that are associated with a decrease in dopamine levels.</p>

<p>Sostenuto (sRANKL) is a cytokine that binds to the activator of the receptor activator of NF-κB ligand. It is a soluble protein that can activate cells and regulate inflammatory responses. Sostenuto has been shown to be an important regulator in the immune system and can stimulate macrophages, T cells, and B cells by binding to their receptors. It also inhibits neutrophil apoptosis and enhances IL-10 production in macrophages. Sostenuto has been shown to have a regulatory effect on bacterial growth, specifically Escherichia Coli which is found in the gut.</p>

<p>Hepronicate is a polyunsaturated fatty acid that is a precursor to prostaglandin E1. It is available as a prescription drug and is used for the treatment of symptoms caused by congestive heart failure, diabetic neuropathy, and corneal endothelial cell dysfunction. Hepronicate has also been shown to stimulate the growth of cells in culture and may be an effective treatment for many types of cancer. This drug binds to the polyunsaturated fatty acid receptor on the surface of cells, which leads to an increase in polyunsaturated fatty acids in the cell membrane and activation of protein kinase C. Hepronicate may also inhibit tumor growth by binding to DNA-dependent RNA polymerase, preventing transcription and replication.</p>

<p>2-[[5-[4-(Dimethylsulfamoyl)phenyl]-8-methyl-2-oxo-1,6,7,9-tetrahydropyrrolo[3,2-H]isoquinolin-3-ylidene]amino]oxy-4-hydroxybutanoic acid is a synthetic isoquinoline derivative, often investigated in the field of medicinal chemistry and cancer pharmacology. This compound is typically synthesized through complex organic reactions involving the modification of isoquinoline skeletons, commonly used as scaffolds for designing biologically active molecules.</p>

<p>ML233 is a molecule that has been shown to have stem cell-like properties. It has been shown to promote the regeneration of retinal neurons and ganglion cells, preventing neuronal death in animal models with ischemia reperfusion injury. ML233 has also been shown to inhibit the proliferation of cancer cells and reduce inflammation in animal models. This molecule is conjugated to an antigen or antibody and administered intravitreally, where it can be delivered directly to the retina without entering systemic circulation.</p>

<p>Methyl 5-fluoro-2-(2-(1-methyl-1H-1,2,4-triazol-5-yl)acetyl)-3-nitrobenzoate is a synthetic organic compound, which is derived from aromatic benzoate structures enhanced with fluorine, nitro, and triazole moieties. The source of this compound lies in advanced synthetic chemistry techniques, involving multiple steps that introduce these functional groups to a benzoate core, thereby enhancing its physicochemical properties.</p>

<p>SK 609New is a dopamine receptor agonist that has been shown to increase locomotor activity in mice. It also binds to the dopaminergic receptors and is able to inhibit the production of hydrogen chloride (HCl) in mammalian cells. SK 609New is not toxic to human cells, which may be due to its ability to bind peptides, but it does show an affinity for S. pyogenes and S. agalactiae, which are streptococcus species. SK 609New has been shown to stimulate the release of dopamine and can reduce locomotor activity in rats with Parkinson's disease-like symptoms.</p>

<p>Carbetocin, also known as acetate carbetocin, is a potent activator of the mu-opioid receptor. It has been shown to activate ion channels and inhibit ligand-gated ion channels. Carbetocin is an agonist of the mu-opioid receptor, which is responsible for pain relief and a reduction in gastrointestinal motility. The affinity of carbetocin to the mu-receptor is approximately three times greater than morphine. Carbetocin also activates potassium and calcium channels in some neurons. Carbetocin has been used as a research tool to study protein interactions, receptor binding, peptide chemistry, and antibody production.</p>

<p>AVE3085 is a novel drug that inhibits the activity of soluble guanylate cyclase. It has been shown to have a positive effect on cardiac hypertrophy and chronic kidney disease (CKD) by inhibiting the production of reactive oxygen species by pde5 inhibitors and organic nitrates. This drug also has an effect on blood pressure in clinical studies, which may be due to its inhibition of polymerase chain reaction. AVE3085 is currently undergoing phase III clinical trials.</p>

<p>Nazartinib mesylate is a benzimidazole compound that inhibits the activity of cdk4/cdk6, which are proteins involved in the regulation of cell division. It is used to treat cancer by inhibiting the growth of cells. Nazartinib mesylate has been shown to be effective in experimental models for breast cancer, non-small cell lung cancer, pancreatic cancer, and prostate cancer. This drug has also been shown to inhibit the growth of epidermal cells in culture. The bifunctional nature of nazartinib mesylate makes it an attractive candidate for drug sensitivity testing.</p>