Biochemicals and Reagents

<p>Applications Useful as a substrate for UDP-GlcNAc:Gal1-beta-3GalNAc(GlcNAc-GalNAc)-6-beta-GlcNAc transferase and sialytransferase.<br>References Hoh, C., et al.: Bioorg. Med. Chem. Lett., 12, 1031 (2002), Li, M., et al.: Biochem., 47, 11590 (2008),<br></p>

<p>Stability Hygroscopic<br>Applications α-Glycosidase inhibitor.<br>References van de Water, F., et al.: Drug Metab. Rev., 37, 443 (2005), Koepsell, H., et al.: Pharm. Res., 24, 1227 (2007), Jappar, D., et al.: Pharm. Res., 26, 172 (2009),<br></p>

<p>Applications Alkylated Diphenylamines are a derivative of aniline, a common chemical reagent. Good antioxidant agent.<br></p>

<p>Applications 2-Phenylbenzothiazole is an organic compound that was detected in water and sediment from sedimentation ponds as a contaminant.<br>References Grung, M., et al.: Sci. Total Environ., 751, 141808 (2021)<br></p>

<p>Applications Chocolate Brown HT (CAS# 4553-89-3) is a synthetic organic food colourant, and a long-term carcinogen.<br>References Amchova, P.; et al.: Regul. Toxicol. Pharm., 73, 914 (2015); Aguilar, F.; et al.: EFSA Journal, 8, 1536 (2010).<br></p>

<p>Applications A labelled marker for peroxynitrite. Oxidant and cytotoxic agent.<br>References Sekiguchi, M., et al.: Brain Res., 978, 228 (2003), van den Tweel, E., et al.: J. Neurobiol., 167, 64 (2005), Shirakura, T., et al.: Biol. Pharm. Bull., 28, 1658 (2005),<br></p>

<p>Stability Light Sensitive<br>Applications γ-Linolenic Acid is a fatty acid found mainly in vegetable oil. Studies suggest that γ-Linolenic Acid may have immune regulating and anti-inflammatory effects. γ-Linolenic Acid has also been used in the treatment of atopic eczeme although its efficacy is disputed.<br>References Ziboh, V. et al.: Fatty Acids Food Health Implic., 791 (2008); Kapoor, R. et al.: Curr. Phar, Biotechnol., 7, 531 (2006); Horrobin, D. et al.: Am. J. Nutrit., 71, 367S (2000);<br></p>

<p>Applications A common additive for peptide coupling.<br> E0<br></p>

<p>Applications 13(S)-HODE is an inhibitor of tumor cell adhesion in endothelium tissue. 13(S)-HODE is also used to activate GPR132 which may affect autoimmune function and lymph organ size.<br>References Le, L. et al.: Immunity., 14, 561 (2001);<br></p>

<p>Stability Temperature Sensitive<br>Applications A cofactor of microbial quinoprotein enzyme, and imidazopyrroline. A redox/cofactor found in a a class of enzymes called quinoproteins.<br></p>

<p>Applications 4-Vinylphenol, 10 wt.% In propylene glycol (cas# 2628-17-3) is a useful research chemical.<br></p>

<p>Applications Plastic additive 21 is a plasticizer; used in preparation of natural mineral modified degradable polymer flame-retardant composite material.<br>References Xu, H., et al.: Faming Zhuanli Shenqing, (2021);<br></p>

<p>Applications Danofloxacin is a broad spectrum fluoroquinolone antibacterial compound.<br>References Golet, E., et al.: Anal. Chem., 73, 3632 (2001); Golet, E., et al.: Environ. Sci. Technol., 36, 3645 (2002); Huet, A., et al.: J. Agric. Food Chem., 54, 2822 (2006);<br></p>

<p>Applications 3-Hydroxydodecanoic Acid Methyl Ester is a 3-hydroxyl fatty acid Me ester as methionine regulator.<br>References Akamatsu, Y., et al.: J. Biol. Chem., 245, 709 (1970); Alvarez, L., et al.: Biochem. J., 301, 557 (1994), Varbanova, M., et al.: Plant Cell, 19, 32 (2007), Atsumi, S., et al.: Nature, 451, 86 (2008),<br></p>

<p>Stability Light Sensitive<br>Applications Ostruthin imperatorin (cas# 148-83-4) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Poly(ethylene Glycol) molecules of an average molecular mass of 1000. Poly(ethylene Glycol) is used in various applications from industrial chemistry to biological chemistry. Recent research has shown PEG maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals. In rats, it has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery. It is industrially produced as a lubricating substance for various surfaces to reduce friction. PEG is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.<br>References Borgens, R. et al.: J. Neurosci. Res., 66, 1179 (2001); Stavisky, R. et al.: Neurosci. Lett., 376, 98 (2005); Nalam, P. et al.: Tribiol. Lett., 37, 541 (2010); Steinmetz, N. et al.: J. Am. Chem. Soc., 131, 17093 (2009); Li, X. et al.: J. Am. Chem. Soc., 133, 11147 (2011); Li, L. et al.: Int. J. Pharm., 447, 192 (2013);<br></p>

<p>Applications (E)-2-Octenoyl-L-carnitine Inner Salt is an L-carnitine metobolite which are often used to diagnose specific inherited metabolic diseases especially glucose related ones.<br>References Yang, S. et l.: J. Chrom. B., Anal. Tech. Biomed. Life Sci., 857, 251 (2007); Anderson, K. et al.: Mol. Endocrinol., 26, 281 (2012);<br></p>

<p>Applications Glyceryl Triheptadecanoate is used in cosmetics that stimulates the growth of hair and skin.<br>References Adachi, K., et al.: Eur. Pat. Appl. (1985), EP 129778 A2 19850102.; Jpn. Kokai Tokkyo Koho (1984), JP 59027809 A 19840214<br></p>

<p>Applications Cocamidopropyl Betaine is a medium strength surfactant.<br></p>

<p>Applications Oxalic Acid Ethyl Ester is a useful synthetic intermediate. It is used to synthesize 2-substituted 3-aryl-4(3H)-quinazolinones with anticonvulsant activities. It is also used to prepare nonbenzamidine tetrazole derivatives as factor Xa inhibitors.<br>References Wolfe, J., et al.: J. Med. Chem., 33, 161 (1009); Quan, M., et al.: bioorg. Med. Chem. Lett., 13, 369 (2003)<br></p>

<p>Applications 1-O-Dodecylglycerol is a antibacterial agent which stimulates autolysin activity in Streptococcus faecium ATCC 9790. It is also found to be synergistic with amphotericin B against fungi.<br>References Ved, H., et al.: J. Biol. Chem., 259, 8115 (1984); Haynes, M., et al.: Antimicro. Agents Chemother., 38, 1523 (1994)<br></p>

<p>Applications Isomaltotetraose, can be used for immunizication of hybridoma antibodies. the use of synthetic glycolipids as antigens enables one to study the gene control of antibody responses to glycolipids and to investigate the combining-site specificities of antibodies to a single antigenic determinant.<br>References Lai, E., et al.: Mol. Immunology, 22(9), 1021 (1985); Chen, H. T., et al.: Mol. Immunology, 24(4), 333 (1987);<br></p>

<p>Stability Hygroscopic<br>Applications D-(+)-Cellotriose (cas# 33404-34-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic Acid is a bifunctional fluorescent probe for proteins.<br>References Hawe, A., et al.: Anal. Biochem., 378, 115 (2008), Hawe, A., et al.: Eur. J. Pharm. Sci., 38, 79 (2009), Hawe, A., et al.: Pharm. Res., 27, 314 (2010),<br></p>

<p>Applications Polyunsaturaded fatty acid.<br></p>

<p>Applications Carboxymethylcellulose Sodium (cas# 9004-32-4) is a useful research chemical.<br></p>

<p>Applications A fluorescent analog of Nicotinamide Adenine Dinucleotide as a coenzyme for glutamate dehydrogenase.<br>References Gafni, A., et al.: Biochemistry, 20, 6041 (1981), Creedon, K., et al.: J. Biol. Chem., 269, 16364 (1994), Seley, K., et al.: Bioorg. Med. Chem., 6, 797 (1998),<br></p>

<p>Stability Hygroscopic<br>Applications 4-Methylumbelliferyl β-D-N,N’,N”-Triacetylchitotrioside is a fluorogenic substrate of uniform, characterized structure for assays of lysozyme.<br>References Yang, Y., et al.: J. Biochem., 87, 1003 (1980)<br></p>

<p>Applications 5-Ethynyl-2’-deoxyuridine is an extensively used nucleoside analog used as a probe for DNA synthesis. 5-Ethynyl-2’-deoxyuridine is known as an toxic anti-metabolite, which potentially causes DNA instabiliy, necrosis and cell-cycle arrest, therefore it is often used for short-term DNA synthesis in tissue culture and living organisms where prolonged cell survival is not required.<br>References Neef, A.B., et al.: P. Natl. Acad. Sci.., 108, 20404 (2011); Gristwood, T., et al.: Nucleic. Acids. Rsch., 40, 5487 (2012);<br></p>

<p>Applications 2'-Deoxy-N-methyladenosine plays role in catalytic activity and may promote proper folding of A730 loop.<br>References Lafontaine, D. A., et al.: J. Mol. Biol., 323, 23-34 (2002)<br></p>

<p>Applications N1,N3-Bis(2-ethylhexyl)-2-methyl-1,2,3-propanetriamine is a hydrolysis product usually found in preparations of the antimicrobial drug hexetidine.<br>References Mende, P.; Food and Chem. Tox. 31(1), 53-58 (1993)<br></p>

<p>Applications 17α-Dydrogesterone is an isomer of Dydrogesterone (D826000), a synthetic progestin largely used in hormone therapy, on the central nervous system by studying two markers of the neuroendocrine function: the neurosteroid allopregnanolone and the opioid .beta.-endorphin. Progestogen.<br>References Bernardi, F., et al.: Eur. J. Endocrinol., 138, 316 (1998); Rupprecht, R., et al.: Steroids, 64, 83 (1999); Uzunova, V., et al.: Brain Res., 976, 1 (2003); Pluchino, N., et al.: J. Steroid Biochem. Mol. Biol., 102, 205 (2006)<br></p>

<p>Applications 2,5-Diaminotoluene is an aromatic compound that is commonly used in permanent hair-dye formulations. 2,5-Diaminotoluene is weakly mutagenic and is also partially responsible for causing allergic contact dermatitis in humans.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chung, K., et al.: Mutat. Res./Rev. Mutat. Res., 387, 1 (1997); Inouye, M. &amp; Murakami, U.: Food Cosm. Toxicol., 15, 447 (1977); Yazer, K., et al.: Cont. Derm., 66, 27 (2012)<br></p>

<p>Stability Hygroscopic, Temperature Sensitive<br>Applications A metabolite of Adenosine (A280400), a multifunctional nucleoside triphosphate used in cells as a coenzyme of intracellular energy transfer. It transports chemical energy within cells for metabolism.<br>References Knowles, J., et al.: Annu. Rev. Biochem., 49, 877 (1980),<br></p>

<p>Applications N2-Acetyl Acyclovir Methyl Acetate is an intermediate in the synthesis of Acyclovir (A192400), an orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. Antiviral.<br>References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992)<br></p>

<p>Stability Hygroscopic<br>Applications Reacts with NO forming anadduct which is a potent and stable vasodilator. Its actions are very similar to those of NG-Hydroxy-L-arginine on the potentiation and stabilization of NO.<br>References Zembowicz, A., et al.: Br. J.Pharmacol., 107, 1001 (1992)<br></p>

<p>Applications Direct Brown 95, Techincal Grade is an azo dye used in PET/cotton blended fabrics as well as other textiles. Environmental reproductive toxin.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list. Dyes and metabolites, Environmental Testing<br>References Pielesz, A., et al.: J. Mol. Struct., 511, 337 (1999); Galloway, S., et al.: Env. Mol. Mutagen., 10, 1 (1987)<br></p>

<p>Applications Labelled Pantothenic Acid. A member of the B complex vitamins; essential vitamin for the biosynthesis of coenzyme A in mammalian cells. Occurs ubiquitously in all animal and plant tissue. The richest common source is liver, but jelly of the queen bee contains 6 times as much as liver. Rice bran and molasses are other good sources.<br>References Gardner, P., et al.: Food Chem., 68, 471 (2000), Ou, B., et al.: J. Agric. Food Chem., 50, 2772 (2002), Bahorun, T., et al.: J. Sci. Food Agric., 84, 1553 (2004),<br></p>

<p>Impurity Rabeprazole EP Impurity I<br>Applications Rabeprazole Sulfone N-Oxide (Rabeprazole EP Impurity I) is a potential impurity of Rabeprazole (R070500) sodium.<br>References Fujisaki, H., et al.: Biochem. Pharmacol., 42, 321 (1991), Morri, M., et al.: J. Biol. Chem., 268, 21553 (1993)<br></p>