Biochemicals and Reagents

<p>Anti-Human CD3ExCD20 Bispecific Antibody</p>

<p>A humanized anti-CD74 monoclonal antibody.</p>

<p>A recombinant humanized anti-CD19 monoclonal antibody.</p>

<p>Anti-EPHA3 human monoclonal antibody</p>

<p>Anti-TNFRSF10B (TRAIL-R2) humanized monoclonal antibody, cancer treatment</p>

<p>Humanized anti-CD44 v6 monoclonal antibody; used in radiotherapy when linked to radioisotopes</p>

<p>Silybin B is a natural compound that has been shown to have antioxidative properties and inhibit the growth of cancer cells. It has been shown to inhibit the angiogenic process, which is the formation of new blood vessels from existing ones. Silybin B also inhibits metabolic disorders and heart tissue damage. Silybin B may be able to treat autoimmune diseases by inhibiting the inflammatory response and suppressing immune cell proliferation. It may also be able to improve mitochondrial membrane potential in primary cells and suppress mitochondrial dysfunction in cancer cells.</p>

<p>A murine anti-IFNA1 IgG1 mouse monoclonal antibody</p>

<p>Anti-Human IL-20 Monoclonal Antibody</p>

<p>Ac-His-D-Phe(p-Iodo)-Arg-Trp-NH2 is a peptide that binds to the melanocortin receptor. It is a potent antagonist of MSH and related peptides and has been shown to be effective in the treatment of cancer, including melanoma.</p>

<p>Anti-Human IL-23α Monoclonal Antibody</p>

<p>Anti-Human CD20 Monoclonal Antibody</p>

<p>Humanized anti-CD40LG, CD154 monoclonal antibody</p>

<p>Pdgfrb active human is an antibody that blocks the receptor tyrosine kinase of the platelet-derived growth factor family. It can be used for research in cell biology, pharmacology, and life science. The Pdgfrb active human antibody has been shown to inhibit PDGFRB phosphorylation and activation by a number of ligands, including PDGF-BB, PDGF-AB, and platelet-derived growth factor (PDGF). This antibody also inhibits the binding of PDGF to its receptor and can be used as a research tool to study protein interactions.</p>

<p>MERS-CoV Spike Antigen, Recombinant is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about MERS-CoV Spike Antigen, Recombinant including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Anti-EGFR antibody</p>

<p>(5S)-N-(5-Amino-1-carboxypentyl) iminodiacetic acid hydrate is a sophisticated chelating agent, designed for precise control in various biochemical applications. The reactive moieties of this compound are particularly useful in affinity chromatography and surface functionalization, making it a valuable tool in both protein purification and the development of biosensors or other biotechnological applications. Affinity chromatography: As a metal-chelator, it is particularly adept at binding divalent metal cations such as Ni²⁺, Co²⁺, and Cu²⁺, which are instrumental in stabilizing protein structures or facilitating enzyme activity. When complexed with Ni²⁺ (nickel) ions (5S)-N-(5-Amino-1-carboxypentyl) iminodiacetic acid forms a surface that can specifically capture proteins engineered with a polyhistidine tag (His-tag). Such interactions facilitate the purification and isolation of target proteins with high specificity, allowing immobilization in a controlled orientation without compromising functional integrity.Surface functionalization: The free amine group allows for conjugation via strong covalent bonds to surfaces such as glass, silica, gold (e.g., electrodes), polymers, hydrogels and magnetic beads. This creates metal-functionalized surfaces for biospecific interactions with His-tagged proteins. Examples of potential applications of this include Surface Plasmon Resonance (SPR), fluorescence microscopy and use in artificial cell systems with hydrogel-based cell-mimicking environments. Thus giving (5S)-N-(5-Amino-1-carboxypentyl) iminodiacetic acid a broad scope in its application in advanced biochemical assays and materials science.</p>

<p>Anti-Human IGF1RxHer3 Bispecific Antibody</p>

<p>Anti-Human CSF2 Monoclonal Antibody</p>

<p>Fmoc-Met-Wang Resin (100-200 mesh) 1% DVB is a resin that has been synthesized by the Fmoc group. The resin is used to attach peptides, proteins and other organic molecules to a solid support for use in research. The resin is also an activator of ligands and can be used as a receptor for the binding of antibodies. The resin has high purity and is made from methacrylate polymer. It contains no detectable levels of hydroquinone and 4-Vinylpyridine.<br>Fmoc-Met-Wang Resin (100-200 mesh) 1% DVB can be used as a research tool in cell biology, immunology, pharmacology, protein interactions, receptor binding, ion channel activation and more. CAS No.: 58897-27-6</p>

<p>Anti-canine CD20 antibody; used in Canine B-cell lymphoma research</p>

<p>Anti-CD26 monoclonal antibody</p>

<p>Humanized anti-PTK7 monoclonal antibody</p>

<p>Anti-Human CCR4 Monoclonal Antibody</p>

<p>Anti-IL13 humanized monoclonal antibody; asthma treatment</p>

<p>Human anti-IL21 monoclonal antibody</p>

<p>H-Arg-Glu(Edans)-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(Dabcyl)-Arg-OH is a peptide that is a substrate for the enzyme beta secretase. It has been observed to inhibit γ secretase activity in cell culture. This product can be used as an enzyme substrate or biochemicals, such as memapsin.</p>

<p>Anti-fibrin II beta chain monoclonal antibody</p>

<p>Olopatadine is a histamine H1 antagonist that is used to treat allergic conjunctivitis and rhinitis. This drug is also a mast cell stabilizer. Upon binding, Olopatadine blocks the H1 receptor signaling pathway, inhibiting the release of inflammatory mediators, such as tryptase, prostaglandin D2, TNF-alpha, as well as pro-inflammatory cytokines.</p>

<p>A recombinant monoclonal antibody to HIV-1 gp120</p>

<p>Anti-idiotypic mouse IgG2b monoclonal antibody that mimics the ganglioside GD3.</p>

<p>A fully humanized monoclonal antibody (from mouse) against human 1-42 β-amyloid (Aβ).</p>

<p>Selective 5-HT2C receptor agonist</p>

<p>A recombinant mouse monoclonal antibody to interleukin-6.</p>

<p>Anti-CD19 monoclonal antibody with enhanced antibody-dependent cell-mediated cytotoxicity against B cell.</p>

<p>Anti-Human CEACAM5 Monoclonal Antibody</p>

<p>Fmoc-Thr(tBu)-Rink-Amide MBHA Resin is a resin that can be used for the synthesis of peptides. It is an inhibitor of Protein interactions, Activator, Ligand, and Receptor. This resin can be used in research to study ion channels and antibodies. Fmoc-Thr(tBu)-Rink-Amide MBHA Resin is also a high purity product with CAS No.</p>

<p>Humanized whole monoclonal antibody targeting CD11 and CD18; designed to treat haemorrhagic shock</p>

<p>A humanized IgG1 kappa anti-PcrV/Psl monoclonal antibody.</p>

<p>A human monoclonal antibody to target tyrosinase-related protein 1 (TYRP1).</p>

<p>A IgG1-type recombinant human hepatitis B Immunoglobulin.</p>

<p>H-AHESAAMAETLQHVPS-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-AHESAAMAETLQHVPS-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-AHESAAMAETLQHVPS-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-AHESAAMAETLQHVPS-OH at the technical inquiry form on this page</p>

<p>H-Pro-Val-OH is an amide that is used to treat renal disorders by inhibiting leukocyte elastase. It has been shown to be a potent inhibitor of serine proteases, including chymotrypsin and trypsin. H-Pro-Val-OH binds to the active site on serine proteases and blocks the release of peptides from the enzyme. The binding constant for H-Pro-Val-OH with chymotrypsin was found to be in the range of 3 x 10 M, which is significantly higher than that for other amides. In addition, H-Pro-Val-OH inhibits cytolysis by lysosomal enzymes and protects against liver injury caused by chronic liver disease. This drug also shows low molecular weight and high water solubility, making it effective in treating acute hepatitis.</p>

<p>D-(-)-Norgestrel is a progestin having similar effects to those of the hormone progesterone</p>

<p>Ac-Gly-Lys-OMe acetate salt is a reactive chemical compound that is used in the synthesis of peptides. This salt is synthesized by reacting glycine with lysine and formaldehyde. Ac-Gly-Lys-OMe acetate salt has been shown to have hemolytic activity and can be used as a synthetic substrate for kinetic studies. It has also been found to activate complement, which may be due to its disulfide bond formation. Ac-Gly-Lys-OMe acetate salt has been shown to inhibit fibrinogen and nitrosylation, which may result in thrombotic disorders.</p>

<p>GSK3008348 is a quinoline derivative that inhibits the production of collagen by binding to and inhibiting the activity of TGF-β receptors. GSK3008348 has been shown to inhibit the proliferation of lung fibroblasts and reduce chronic cough in animal models. It was also successful in clinical studies for treatment of cancer, but not for treatment of kidney fibrosis. GSK3008348 is structurally related to nintedanib, which was approved by FDA in 2011 as a treatment for idiopathic pulmonary fibrosis (IPF) and other severe chronic obstructive pulmonary diseases. Although GSK3008348 has been shown to be an effective inhibitor of collagen production, it is not yet known whether this drug will have similar beneficial effects on IPF or other chronic obstructive pulmonary diseases.</p>

<p>Fmoc-Phe-Ser(Psi(Me,Me)Pro)-OH is a diastereomer of Fmoc-Phe-Ser. It is used as a substrate for peptide synthesis and can be used to synthesize oxytocin receptor antagonists. It has been shown to have high affinity for the oxytocin receptor and inhibits the binding of oxytocin to the receptor by competing with it for the same site on the receptor. This inhibition leads to decreased levels of oxytocin that are responsible for uterine contractions during labour and milk ejection from the breast during breastfeeding. Fmoc-Phe-Ser(Psi(Me,Me)Pro)-OH also has been shown to be useful in filtration techniques such as chlorides, propargylamines, and divalent cyclopentenones.</p>

<p>Loxoprofen is a non-steroidal anti-inflammatory drug that belongs to the group of propionic acid derivatives. It can be used for the treatment of pain and inflammation associated with osteoarthritis, rheumatoid arthritis and other musculoskeletal disorders. Its therapeutic effects are attributed to inhibition of cyclooxygenases 1 and 2 (COX-1 and COX-2) enzymes.</p>

<p>High control human Serum</p>

<p>Follicle Stimulating Hormone (FSH), Highly Purified is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Follicle Stimulating Hormone (FSH), Highly Purified including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>