Biochemicals and Reagents

<p>POLDIP3 is preferentially associated with CBC-bound spliced mRNA-protein complexes during the initial round of mRNA translation. POLDIP3 is deposited at the exon junction during pre-mRNA splicing. It becomes part of the exon junction complex (EJC), which then facilitates the recruitment of S6K1 to the spliced RNA to boost the translation efficiency of the spliced mRNA. In addition, POLDIP3 is involved in nuclear mRNA export mediated by association with the TREX complex._x000D_<br>_x000D_<br>POLDIP3 interacts with DNA polymerase Pol Ύ and PCNA depending on its modifications. This creates a distinct regulatory role for POLDIP3 during DNA synthesis.</p>

<p>Serotonin (5-HT7) receptor antagonist; anti-psychotic</p>

<p>Peptide Ac-FQRKTLQRRNLKGLNLNL-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Dixin</p>

<p>Donkey anti-rabbit IgG (H + L) (Fab'2) (Alk Phos) was raised in donkey using rabbit IgG (H&amp;L) as the immunogen.</p>

<p>GLAST/ EAAT-1 (Glutamate-Aspartate Transporter/ Excitatory Amino Acid transporter 1) (rodent/human nomenclature) is a sodium-dependent plasma membrane glutamate transporter expressed exclusively by astrocytes in the cerebellum and present at high densities near excitatory synapses. Glutamate transporters regulate glutamate receptors and limit glutamate accumulation to prevent neurotoxicity whilst ensuring accurate synaptic communication. GLAST is the major transporter expressed during development.</p>

<p>Please enquire for more information about Cy3 Acid(tri SO3) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>The Morphine antibody is a highly specialized monoclonal antibody used in the field of Life Sciences. It is designed to target and bind to morphine, an opioid analgesic drug commonly used for pain management. The antibody is activated when it comes into contact with morphine, allowing for precise detection and measurement.</p>

<p>Nisoldipine is a calcium channel blocker that is used to treat hypertension. It acts on vascular smooth muscle cells by blocking voltage-gated L-type calcium channels. By inhibiting the influx of calcium in smooth muscle cells, Nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction.</p>

<p>CKMM antibody was raised in goat using highly purified human CK-MM isoenzyme as the immunogen.</p>

<p>Interleukin-13 human is a recombinant cytokine, which is derived from the expression of the human IL-13 gene in suitable host systems, such as E. coli or mammalian cells. This cytokine belongs to the interleukin family and plays a pivotal role in the immune response by modulating inflammatory pathways. The mode of action of interleukin-13 involves binding to specific cell surface receptors, IL-13Rα1 and IL-13Rα2, which facilitates the activation of various intracellular signaling cascades, including the JAK/STAT pathway. This promotes the differentiation and proliferation of certain immune cells, influencing the production of IgE and contributing to the regulation of inflammatory responses.</p>

<p>Anti-MINK1 antibody</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>LAMP3 antibody was raised in Rabbit using Human LAMP3 as the immunogen</p>

<p>EDDP BSA Hapten Conjugate</p>

<p>Progesterone 11 antibody was raised in rabbit using progesterone 11 as the immunogen.</p>

<p>H-ENFAGEATLQR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-ENFAGEATLQR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-ENFAGEATLQR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-ENFAGEATLQR-OH at the technical inquiry form on this page</p>

<p>Bovine Serum Albumin (BSA) is widely used in biochemical and laboratory applications. It is used as a blocking agent in Western blotting, ELISA, and immunohistochemistry to prevent non-specific binding. As well as being a protein standard in protein quantification assays (e.g., Bradford and Lowry assays), this widely used reagent can be used in enzyme reactions to stabilize proteins and prevent denaturation. It can also be used as a nutrient supplement in cell culture media.<br>Cymit Quimica now offers an animal-free BSA product, called StabolyTM. Visit our product page today.</p>

<p>Anti-GFP antibody</p>

<p>Anti-TRPA1 antibody</p>

<p>Glimepiride is a sulfonylurea drug that is used in the treatment of type 2 diabetes mellitus. This drug works by inhibiting ATP-sensitive potassium channels by binding non-specifically to the B sites of both sulfonylurea receptor-1 (SUR1) and sulfonylurea receptor-2A (SUR2A) subunits. As a result, this promotes insulin secretion from beta cells.</p>

<p>HBsAg antibody was raised in mouse using hepatitis B Virus as the immunogen.</p>

<p>Dopamine reuptake inhibitor; ligand of sigma receptors</p>

<p>Peptide Z-GFFL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-THLAPYSDELR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Antagonist of NMDA glutamate receptor at glycine binding site</p>

<p>H-STQAAIDQINGK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-STQAAIDQINGK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-STQAAIDQINGK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-STQAAIDQINGK-OH at the technical inquiry form on this page</p>

<p>H3K27me3 antibody was raised in rabbit using a synthetic Histone H3 peptide with Lys27 tri-methylated and conjugated to KLH as the immunogen</p>

<p>Rabbit polyclonal XPR1 antibody</p>

<p>Anti-DYRK3 antibody</p>

<p>Together with IL12B, IL23A forms part of the heterodimeric cytokine IL-23 which functions in innate and adaptive immunity. IL-23 is a member of the IL-12 family of cytokines that includes IL-12, IL-35, IL-27, and IL-39. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R and activates the Jak-Stat signaling cascade. IL-23 is a key driver of Th17-mediated immune response during infection and inflammation and its over production is involved in several cancers._x000D_<br>_x000D_<br>IL23A expression is induced by several mechanisms including Tumour necrosis factor (TNF)/NF-kB, mitogen-activated protein kinase (MAPK) signalling and the formation of a transcriptional enhancer complex consisting of proto-oncogene c-Jun (c-Jun), RELA proto-oncogene NF-kB subunit (RelA), RUNX family transcription factor 1 (RUNX1), and RUNX3. Collectively, these proteins induced IL23A secretion._x000D_<br>_x000D_<br>IL-23 is produced by dendritic cells and macrophages as well as keratinocytes and gastric; intestinal; lung and ovarian epithelial cells.</p>

<p>Apo E</p>

<p>H-FYYIDDPK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-FYYIDDPK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-FYYIDDPK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-FYYIDDPK-OH at the technical inquiry form on this page</p>

<p>H-PGHPLAPG-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-PGHPLAPG-OH is provided at greater that &gt;98% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-PGHPLAPG-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-PGHPLAPG-OH at the technical inquiry form on this page</p>

<p>Vegfb</p>

<p>PDEs are a family of phosphohydrolyases, used to catalyse hydrolysis of 3 €™ cyclic phosphate bonds in the second messengers adenosine and guanine 3 €™, 5 €™ cyclic monophosphates (cAMP and cGMP). Physiologically, Pde2a is a locus for communication between cAMP and cGMP signalling pathways, regulating this process through degradation of cAMP and cGMP. This is particularly noteworthy in cells where cAMP and cGMP regulate opposing cell functions.Pde2a is expressed both in the periphery and central nervous system, but is found in highest concentration in the brain; implying that Pde2a is necessary in regulation of interneuronal cAMP and cGMP involved in emotion, sensory perception and memory. Alteration in cyclic nucleotide signalling is shown cause depression, bipolar disorder and schizophrenia; hence Pde2a, a molecule used to break down cyclic nucleotides, has the potential to be a novel biomarker or therapeutic target for such psychiatric conditions.</p>

<p>H-VGTQFTR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-VGTQFTR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-VGTQFTR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-VGTQFTR-OH at the technical inquiry form on this page</p>

<p>Ca2+ ATPase antibody was raised in rabbit using N-terminal sequence-specific peptide of the human pump epitope as the immunogen.</p>

<p>mGluR5 antagonist</p>

<p>ICOS</p>

<p>H-MREGVELCPGNKYEMRRHGT-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-MREGVELCPGNKYEMRRHGT-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-MREGVELCPGNKYEMRRHGT-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-MREGVELCPGNKYEMRRHGT-OH at the technical inquiry form on this page</p>

<p>Glycogen Synthase Kinase 3 beta (GSK3β) is a multifunctional serine/threonine kinase widely expressed in most mammalian cells. GSK3β is highly active under basal conditions and acts downstream of phosphoinositide 3-kinase (PI3K) signalling. PI3K activation results in Akt phosphorylation and the subsequent phosphorylation of GSK3β at serine-9 and its inactivation. GSK3β in turn activates the production of pro-inflammatory cytokines including IL-1β, IL-6, IL-12, IL-17, TNFα and IFNγ, and supresses the production of IL-10, IL-1Ra, and IFNβ by immune cells.</p>

<p>Glut-4</p>

<p>The Osteocalcin antibody is a highly specific monoclonal antibody that targets human chorionic gonadotropin (HCG). It is widely used in various research fields, including Life Sciences and nuclear medicine. This antibody is designed to specifically recognize and bind to the antigen, allowing for accurate detection and quantification of HCG levels in biological samples.</p>

<p>Reactive red 66 is a reactive dye that is used for wastewater treatment. The high resistance to hydrochloric acid, photo-oxidation, and protease activity make it an ideal candidate for this application. Reactive red 66 has been shown to have the ability to react with proteins and other compounds in the water to form covalent bonds. These bonds are then broken down by reductive mechanisms such as photocatalytic activity, which results in the formation of radicals. Functional groups on the molecule are responsible for its color, while transfer mechanisms between molecules allow it to be soluble in water at low concentrations.</p>

<p>H-PDGKKLASGCKNGQILLWDP-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-PDGKKLASGCKNGQILLWDP-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-PDGKKLASGCKNGQILLWDP-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-PDGKKLASGCKNGQILLWDP-OH at the technical inquiry form on this page</p>

<p>H-GFYPSDIAVEWESNGQPE-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-GFYPSDIAVEWESNGQPE-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-GFYPSDIAVEWESNGQPE-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-GFYPSDIAVEWESNGQPE-OH at the technical inquiry form on this page</p>

<p>Peptide H-AVLTIDKK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>H-VPMNSLRFLFE-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-VPMNSLRFLFE-OH is provided at greater that &gt;98% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-VPMNSLRFLFE-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-VPMNSLRFLFE-OH at the technical inquiry form on this page</p>

<p>Naftopidil is an alpha adrenergic antagonist drug that is used to treat urinary symptoms and conditions related to benign prostatic hypertrophy. This drug works to relax smooth muscles by inhibiting alpha adrenergic receptors, thus allowing an improvement in urine flow.</p>