Biochemicals and Reagents

IL-1α is a cytokine protein that has been shown to be involved in the immune system. IL-1α is an activator of the receptor and is also a ligand for it. The protein has been shown to activate ion channels, which are proteins that allow ions to pass through either by diffusion or by facilitated transport. This activation causes cells to produce more hydrogen ions, which leads to an increase in the acidity of the cell. IL-1α has also been shown to inhibit cell proliferation and induce apoptosis.

PAR1 antibody is a Polyclonal Antibody used in Life Sciences research. It is designed to target the PAR1 receptor, which plays a crucial role in various physiological processes including coagulation, chemotherapy, and mineralocorticoid signaling. This antibody specifically binds to the extracellular domain of the PAR1 receptor, neutralizing its activity and preventing downstream signaling events. It has been extensively used as a tool in studying the function of PAR1 and its involvement in disease processes. The high specificity and affinity of this antibody make it an ideal choice for researchers looking to investigate the role of PAR1 in different biological systems.

Selatogrel is a peptide that can activate the receptor, which is known as selatoprotein. Selatogrel binds to the receptor and inhibits ion channels, which are the proteins that selectively permit the passage of ions across a cell membrane. It is used in research as a tool for studying protein interactions and has been shown to inhibit ligand-receptor binding with high purity. Selatogrel also inhibits receptors on cells, and has been shown to block the enzyme phosphodiesterase 4 (PDE4). Selatogrel can be used in pharmacology to study protein interactions and has shown potential as an inhibitor of PDE4.

Delcasertib is a synthetic peptide inhibitor that is derived from biochemical research on protein kinase C (PKC) signaling pathways. This compound specifically targets the delta isoform of protein kinase C (PKCδ), playing a crucial role in modulating signaling pathways involved in cellular responses to stress and injury.

Lys-Ala-AMC is an activator of ion channels and a ligand for receptors. It is used in research as a tool to study protein interactions, receptor pharmacology, and ion channel pharmacology. Lys-Ala-AMC binds to the α-subunit of voltage gated calcium channels and can activate these channels by increasing the rate of opening. This peptide also inhibits receptor binding by competing with the natural ligand. It has been shown to be an antagonist at the NMDA receptor and can inhibit the binding of glycine to this receptor.

The CNS 5161A is a device for the measurement of cerebral blood flow and pressure. It is used in anesthetized animals to measure changes in cerebral blood flow, cerebral perfusion pressure and regional cerebral blood flow. The device consists of a probe that contains a thermistor that measures the temperature change when it passes through the brain tissue. The thermistor is connected to a computer that records the data. The CNS 5161A is used in clinical practice for the assessment of neuroprotective drugs and for EEG-guided surgery. This device has been shown to be useful in measuring changes in c-fos protein expression after spinal cord injury.