Biochemicals and Reagents
Subcategories of "Biochemicals and Reagents"
- Biomolecules(98,575 products)
- By Biological Target(100,728 products)
- By Pharmacological Effects(6,938 products)
- Cryopreservatives(21 products)
- Desinfectants and Related Compounds(28 products)
- Hormones(440 products)
- Plant Biology(6,906 products)
- Secondary Metabolites(14,368 products)
Found 130509 products of "Biochemicals and Reagents"
4-Bromoestrone
CAS:Controlled Product4-Bromoestrone is a synthetic estrogen that has been shown to be useful in the treatment of breast cancer. It has been used as an antineoplastic drug, which is a substance that slows the growth of abnormal cells. 4-Bromoestrone can be acetylated by a nitro group and then converted into 4-bromotamoxifen (4-BT), which is a potent anti-tumor agent. The structure of 4-bromoestrone resembles that of estrogens, but it lacks the C2 methyl group found on estradiol and other estrogens, which makes it more difficult for enzymes to convert it into other estrogens. 4-Bromoestrone binds with high affinity to estrogen receptors and can activate them without requiring any cofactors or cofactors. This means that the drug has no effect on tissues that do not contain these receptors.Formula:C18H21BrO2Purity:Min. 95%Molecular weight:349.3 g/molCPTH2 hydrochloride
CAS:CPTH2 is a small molecule that is able to inhibit the activity of histone deacetylases (HDACs), which are enzymes that remove acetyl groups from the lysine residues of proteins. CPTH2 inhibits HDAC activity by binding to and inactivating it. This inhibition prevents the removal of acetyl groups from lysines on histones, which helps maintain their structure. CPTH2 has been shown to have therapeutic potential for cancer, as it can enhance tumor cell response to treatment with chemotherapy drugs or radiation therapy by reducing DNA damage. The molecule may also be used to treat bladder cancer and other cancers where HDACs are overexpressed, such as breast cancer. CPTH2 has also been shown to target cells with high levels of sirtuins, such as bladder cells and cho-k1 cells. It is also possible that this compound may affect mammalian cells, but more research is needed before conclusions can be made.
Formula:C14H15Cl2N3SPurity:Min. 95%Molecular weight:328.3 g/molResminostat
CAS:Resminostat is a small molecule that inhibits the transcriptional co-activator, pd-l1. It has been shown to be very effective at reducing the growth of squamous cell carcinoma cells in vitro and in vivo. Resminostat also reduces liver fat content and steatosis by inhibiting fatty acid synthesis. Resminostat has been shown to induce apoptosis in cancer cells through inhibition of nuclear DNA replication, which leads to decreased production of proteins required for cell division. This drug has not been tested on humans but is being investigated as a potential treatment for hepatic steatosis, a condition characterized by excess fat accumulation in the liver.Formula:C16H19N3O4SPurity:Min. 95%Molecular weight:349.41 g/molStafia-1-dipivaloyloxymethyl ester
CAS:Stafia-1-dipivaloyloxymethyl ester is a research tool that may be used to study protein interactions. It can also be used in the development of new drugs for treating diseases such as Parkinson's, Alzheimer's, and schizophrenia. Stafia-1-dipivaloyloxymethyl ester is an activator of the G protein coupled receptors (GPCRs) and ion channels. Stafia-1-dipivaloyloxymethyl ester has been shown to be a specific ligand for the human GPCR receptor called the metabotropic glutamate receptor 2 (mGlu2). It binds to this receptor and activates it by increasing calcium ion influx. This process leads to the opening of ion channels, which causes an increase in neurotransmitter release from nerve cells.
Formula:C37H48FO13PPurity:Min. 95%Molecular weight:750.7 g/mol(1'RS,2'S)-nicotine 1,1'-di-N-oxide [ ethanol]
CAS:(1'RS,2'S)-nicotine 1,1'-di-N-oxide is a research tool that is used in cell biology and pharmacology. It has been shown to activate ion channels and bind to receptors. This molecule interacts with proteins and the antibody response. (1'RS,2'S)-nicotine 1,1'-di-N-oxide is used as a ligand for receptor binding studies because of its high purity and availability.Formula:C10H14N2O2Purity:Min. 95%Molecular weight:194.23 g/molPD 0332991 Isethionate
CAS:Selective and potent inhibitor of cyclin-dependent kinases CDK4 and CDK6. It blocks cell cycle progression from phase G1 into S by inhibiting CDK4/6-dependent retinoblastoma (RB) phosphorylation. It has been used for the treatment of HER2 negative, estrogen receptor (ER) positive metastatic breast cancer.
Formula:C24H29N7O2·C2H6O4SPurity:Min. 95%Color and Shape:SolidMolecular weight:573.67 g/molBavisant
CAS:Bavisant is a serotonin receptor antagonist. This drug has been used in the diagnosis of serotonin-related disorders, such as depression and anxiety. Bavisant has also been used to treat hyperactivity and attention deficit hyperactivity disorder (ADHD) in children. The drug is administered orally, with a dose of 0.5 mg/kg per day for up to 5 days. Bavisant interacts with h2-receptor antagonists, which may lead to decreased gastric acidity and increased absorption of other drugs, such as warfarin or cimetidine. In clinical trials, the drug has shown statistically significant improvements in treatment effect on ADHD symptoms in children when compared to placebo groups. It is hypothesized that Bavisant's pharmacological effects are due to its ability to block serotonin receptors and reduce the synthesis of dopamine by inhibiting the enzyme tyrosine hydroxylase.Formula:C19H27N3O2Purity:Min. 95%Molecular weight:329.4 g/molHGF Human CHO
HGF is a cytokine that is thought to play an important role in the development of cancer. HGF stimulates the proliferation, differentiation, and survival of cells and acts as a chemoattractant for cells. It is also known to inhibit apoptosis and promote angiogenesis. HGF has been found in many human tissues, including liver, lung, kidney, heart, muscle, pancreas and brain. HGF is a member of the platelet-derived growth factor family and can be used as a marker for certain types of cancer.Purity:Min. 95%10-Cholesteryloxy decylphosphocholine
CAS:10-Cholesteryloxy decylphosphocholine is a phospholipid that is used as a research tool. It has been shown to activate the muscarinic receptor, which is found in the central and peripheral nervous systems. 10-Cholesteryloxy decylphosphocholine has also been shown to inhibit ion channels by binding to them and preventing ion flow. 10-Cholesteryloxy decylphosphocholine is purified and of high quality, with a CAS number of 1389265-82-0.Formula:C42H78NO5PPurity:Min. 95%Molecular weight:708.05 g/molAvatrombopag maleate
CAS:Avatrombopag maleate is a small molecule that activates platelets by binding to the beta-granule protein receptor. This drug has been shown to improve blood clotting and lower the need for blood transfusions in patients with thrombocytopenia, which is a condition where there are fewer than normal numbers of platelets in the blood. Avatrombopag maleate has also been shown to reduce brain infarct volume after stroke, suggesting that it may be useful for treating ischemic stroke.Formula:C33H38Cl2N6O7S2Purity:Min. 95%Molecular weight:765.7 g/molHyaluronidase
Hyaluronidase is a glycosaminoglycan that is synthesized by the cells of the synovial membrane, and is used in the treatment of osteoarthritis. It has been shown to be potent inducers of apoptosis in cancer cell lines, with a high percentage of caspase-3 activation. Hyaluronidase also inhibits angiogenesis and induces cell death through an unknown mechanism. This enzyme functions as an extracellular matrix-degrading enzyme and has been shown to have anti-inflammatory properties.Purity:Min. 95%Adrenomedullin 2, human
Adrenomedullin 2, a peptide hormone product with a disulfide bond between Cys10-Cys15. Adrenomedullin 2 can be applied as a potent cardiovascular and renal regulator as well as a suppressor for food intake and gastric emptying. This product is available as a 0.1mg vial.Formula:C219H349N69O66S3Purity:Min. 95%Molecular weight:5,100.7 g/mol18:0-Phodag
CAS:18:0-Phodag is a synthetic ligand that binds to the extracellular domain of the human β2-adrenergic receptor. It is a potent full agonist at this receptor. 18:0-Phodag has been shown to be an antagonist at other G protein-coupled receptors, including the α1A and α1B subtypes of the adrenergic receptor and the δ1, δ2, and δ3 subtypes of dopamine receptors. The binding of 18:0-phodag to these receptors leads to inhibition of adenylyl cyclase and reduces intracellular cAMP levels. 18:0-Phodag has also been shown to inhibit phospholipase C (PLC) activity by blocking activation of PLCβ2 with phosphatidylinositol 4,5-bisphosphate (PIP2).Formula:C41H64N2O5Purity:Min. 95%Molecular weight:664.96 g/molLeptin (Rat)-ELISA Kit (1ea)
Leptin ELISA Kit is a sandwich ELISA for the quantitative measurement of mouse leptin in rat serum. Leptin is a 16-kDa peptide hormone that regulates energy balance and body weight. It is produced by adipose tissue, and circulates in the blood as a protein complex with high-density lipoprotein (HDL). The assay employs monoclonal antibodies (MAbs) to measure mouse leptin in rat serum. The Mabs are specific for the mouse leptin sequence, which allows them to selectively bind to the mouse leptin in rat serum. Quantitative measurements of mouse leptin can be made using standard colorimetric procedures.Purity:Min. 95%16:0-09:0 (Aldo) pc
CAS:16:0-09:0 (Aldo) pc is a metabolite of hexadecanoyl. It is produced from the oxidation of hexadecanoic acid and can be found in human urine. Hexadecanoyl is a fatty acid that can be found in various animal fats, including butter and cheese. 16:0-09:0 (Aldo) pc has been shown to have antioxidant properties, which may be due to its ability to inhibit lipid peroxidation by binding reactive oxygen species.
Formula:C33H64NO9PPurity:Min. 95%Molecular weight:649.84 g/molNiraparib hydrochloride
CAS:Niraparib hydrochloride is an inhibitor of poly (ADP-ribose) polymerase, which is a key enzyme in the repair of DNA. It also inhibits the phosphorylation of histone H2AX at serine 139, which leads to cell cycle arrest and apoptosis. Niraparib hydrochloride has been shown to be effective against inflammatory lesions caused by radiation and platinum-resistant ovarian cancer. This drug has a synergistic effect with cisplatin in preclinical models for platinum-resistant ovarian cancer. Niraparib hydrochloride has also been evaluated as a potential biomarker for primary breast cancers by measuring its serum concentration in vivo using fluorescence imaging.
Formula:C19H21ClN4OPurity:Min. 95%Molecular weight:356.85 g/molBimoclomol
CAS:Heat shock protein (HSP) co-inducerFormula:C14H20ClN3O2Purity:Min. 95%Molecular weight:297.78 g/molF16
CAS:F16 is a natural product extracted from the leaves of the Acacia senegal tree. It has been shown to be effective in treating bowel disease, solid tumours and endometriosis. The acetate extract of F16 has been shown to have therapeutic effects on human serum, including maintaining physiological function in healthy cells. F16 also inhibits bacterial growth and is used as a diagnostic tool for bacterial strains. Research has also shown that F16 can inhibit xenograft tumor growth and the development of autoimmune diseases such as inflammatory bowel disease. F16 has been shown to inhibit the mitochondrial membrane potential in cancer cells.Formula:C16H15IN2Purity:Min. 95%Molecular weight:362.21 g/molWAY 127039-A-1 Sodium
CAS:WAY 127039-A-1 Sodium Salt is a phosphodiesterase 4 (PDE4) inhibitor, which is a synthetically derived compound designed for biochemical research. Its primary source is laboratory synthesis, which allows for precise structural modifications, crucial for scientific studies. The mode of action of WAY 127039-A-1 Sodium Salt involves the inhibition of PDE4, an enzyme that breaks down cyclic adenosine monophosphate (cAMP). By preventing this breakdown, the compound effectively increases levels of cAMP within cells, thereby modulating inflammatory responses and reducing the release of pro-inflammatory cytokines.Formula:C15H10BrNO4•NaPurity:Min. 95%Molecular weight:371.14 g/mol
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