Heterocycles with Nitrogen (N)

<p>Applications [3-(2-Amino-6-methoxy-4-pyrimidinyl)phenyl](3,6-dihydro-4-methyl-1(2H)-pyridinyl)-methanone is a useful chemical for cancer immunotherapy research.<br></p>

<p>Applications 6-Bromo-5-methyl-3h-imidazo[4,5-b]pyridine<br></p>

<p>Applications 2-(2-Thienyl)pyrrolidine is used in the preparation of imidazopyridine derivatives for treating viral infections.<br>References Serradeil-Le Gal, C., et al.: J. Pharmacol. Exp. Ther., 300, 1122 (2002), Hodgson, R., et al.: Pharmacol. Biochem. Behav., 3, 431 (2007),<br></p>

<p>Applications Intermediate in the preparation of Omeprazole metabolites<br></p>

<p>Applications 4-ethylpyrimidine-5-carboxylic acid (cas# 1147710-24-4) is a useful research chemical.<br></p>

<p>Applications 3-(Trifluoromethyl)-1H-1,2,4-triazole, is a fluorinated building block used in various chemical synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-Bromo-2,4,6-trimethylpyridine<br></p>

<p>Applications 3-Bromopyridine N-Oxide (cas# 2402-97-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-(BROMOMETHYL)-2-NITROPYRIDINE (cas# 448968-52-3) is a useful research chemical.<br></p>

<p>Applications 5-methyl-1H-pyrazole hydrochloride (cas# 119760-62-2) is a useful research chemical.<br></p>

<p>Applications 5-benzoyl-2H-1,2,3,4-tetrazole (cas# 14506-41-3) is a useful research chemical.<br></p>

<p>Applications [3-(Trifluoromethyl)-1H-pyrazol-4-yl]boronic Acid Pinacol Ester is a chemical reagent used in the synthesis of carboxamides used in the treatment of lymphomas, psoriasis and endometriosis.<br></p>

<p>Applications Used in the preparation of azaindazole compounds as CCR1 antagonists.<br></p>

<p>Applications 2-Pyrazinecarboxylic Acid 4-Oxide (cas# 874-54-4) is a compound useful in organic synthesis.<br>References Ambrogi, V., et al.: Eur. J. Med. Chem., 15, 157 (1980),<br></p>

<p>Applications 3-(Pyridin-2-yl)propiolic Acid is a useful reagent in the regioselective Pd-catalyzed carbopalladation/decarboxylative allylic alkynylation of ortho-iodoallenamides.<br>References Hedouin, J., et al.: J. Org. Chem., 84, 10535 (2019)<br></p>

<p>Applications 2-chloro-N-[2-(pyrrolidin-1-yl)pyridin-3-yl]acetamide (cas# 1156200-84-8) is a useful research chemical.<br></p>

<p>Applications 4-Hydroxypiperidine-d9 is labelled 4-Hydroxypiperidine (H950845) which is used as a reagent for the synthesis of acridine (A190900) derivatives and fibrinogen receptor antagonists.<br>References Yang, D. et al.: Macromol., 35, 5304 (2002); Harrison, R.J. et al.: Bioorg. Med. Chem. Lett., 9, 2463 (1999)<br></p>

<p>Applications {2-[(Pyridin-4-ylmethyl)thio]-1,3-thiazol-4-yl}acetic acid (cas# 1040631-48-8) is a useful research chemical.<br></p>

<p>Applications 2-Mercapto-5-nitrobenzimidazole is useful for treating giardiasis. Antigiardial drug.<br>References Hernandez-Ochoa, B., et al.: Molecules, 25, 3979 (2020)<br></p>

<p>Applications Imidazo[1,2-a]pyridine-6-boronic acid is a useful intermediate for organic synthesis and other pharmaceutical processes.<br>References Gonzalez C., et al.: J. Med. Chem., 55, 11022 (2012); Cooper, A. B., et al.: Bioorg. Med. Chem. Lett., 27, 4471 (2017)<br></p>

<p>Stability Hygroscopic<br>Applications 5-Benzyl-1H-imidazole (cas# 4238-72-6) is a useful research chemical.<br></p>

<p>Applications 2-Fluoropyridine-5-carbonyl chloride<br></p>

<p>Applications 2,4-Diamino-6-hydroxypyrimidine-15N4 is an intermediate in the synthesis of 2’-Deoxyguanosine-5N5 which is a nucleoside.<br>References Krenitsky, T.A., et al.: Biochemistry, 20, 3615 (1981), Chapeau, M.-C., et al.: Chem. Res. Toxicol., 4, 636 (1991),<br></p>

<p>Applications 2-oxo-2,3-dihydrobenzo[d]oxazol-6-ylboronic acid pinacol ester (cas# 1105710-32-4) is a useful research chemical.<br></p>

<p>Applications 4,6-Diamino-2-(dimethylamino)pyrimidine-5-carbonitrile is a useful chemical reagent.<br></p>

<p>Applications 2,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine is used in the synthesis of morpholinothiazoles as alpha 7 position allosteric modulators.<br>References MacDonald, G., et al.: PCT Int. Appl. (2011), WO 2011064288 A1 20110603<br></p>

<p>Applications 6-Fluoro-4-methyl-2-pyridinamine can be synthesized from 2,6-Dichloro-4-methylpyridine (39621-00-6).<br></p>

<p>Applications N-[1-[1-(4-Methoxyphenyl)-1H-tetrazol-5-yl]-1-methylpropyl]-1H-indole-3-ethanamine,<br></p>

<p>Stability Hygroscopic<br>Applications 2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride (cas# 1187830-76-7) is a useful research chemical.<br></p>

<p>Applications 1-[4-(5-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethanone is used as a reagent in the synthesis of a series of 3-(1-substituted-4-piperidinyl)-1,2-benzisoxazoles which exhibit neuroleptic activity.<br>References Strupczewski, J.T., et al.: J. Med. Chem., 28, 761 (1985)<br></p>

<p>Applications 2,4-Dichloro-5-bromopyrimidine (cas# 36082-50-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-(4-Bromophenyl)-4,6-dichloropyrimidine is a reactant used in the synthesis of Macitentan, an orally active dual endothelin receptor antagonist.<br>References Bolli, M. et al.: J. Med. Chem., 55, 7849 (2012);<br></p>

<p>Applications 2,6-di-tert-Butylpyridine is used in the preparation of polymers with n-type nitroxide side groups to be used in organic radical batteries.<br>References Jaehnert, T., et. al.: Eur. Polymer J., 61, 105 (2014)<br></p>

<p>Applications N-Boc-3-(1-cyano-2-ethoxy-2-oxoethylidene)-1-piperidine is a useful synthetic intermediate.<br></p>

<p>Applications 4-Benzoyl-1H-pyrrole-2-carboxylic Acid (cas# 15372-84-6) is a useful research chemical.<br></p>

<p>Applications 2-(5-Ethylpyridin-2-yl)prop-2-en-1-ol is a key intermediate in the synthesis of pioglitazone hydrochloride.<br>References Mohanty, S., et al.: Org. Process Res. Dev., 18, 168 (2014)<br></p>

<p>Applications 2-(3-Aminophenyl)pyridine Dihydrochloride<br></p>

<p>Applications Ethyl 2-pyrimidinecarboxylate<br></p>

<p>Applications H-Pro-Ala-OH (cas# 6422-36-2) is a useful research chemical.<br></p>

<p>Applications 6-(Ethylamino)pyridine-3-carbonitrile<br></p>

<p>Applications 6-Nitropyrido[2,3-d]pyrimidin-4(3H)-one is a useful research chemical for organic synthesis and other chemical processes.<br></p>

<p>Applications 3-aminoisoxazole-4-carbonitrile (cas# 258518-65-9) is a useful research chemical.<br></p>

<p>Applications 1-(4-Chlorophenyl)-1,2-dihydro-3H-pyrazol-3-one is also used in the synthesis of antifungal, oxazolidinon-based strobilurin analogues. Also used in the preparation of heterologous haptens for the synthesis of high-affinity anti-pyraclostrobin antibody generation.<br>References Li, Y. et al.: Bull. Kor. Chem. Soc., 31, 3341 (2010); Mercader, J. et al.: Org. Biomol. Chem., 9, 1443 (2011);<br></p>

<p>Applications 4-hydroxy-1H,2H-pyrrolo[1,2-d][1,2,4]triazin-1-one (cas# 50269-88-0) is a useful research chemical.<br></p>

<p>Applications 2,4,4-Trimethyl-2-oxazoline is a useful building block and has been used in the preparation of imides by ring opening of heterocycles by reactions of acyl palladium species.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Perrone, S.; et al.: Tetrahedron, 70, 6938 (2014).<br></p>

<p>Applications 7-Chloro-N-[1-(methylsulfonyl)-4-piperidinyl]-4-quinazolinamine, is a building block used in chemical synthesis.<br></p>

<p>Applications 6-(4-Aminophenoxy)-N-methyl-4-pyrimidinamine is an intermediate in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.<br>References Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);<br></p>

<p>Applications 1-(2-chloro-5-nitrophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione (cas# 313069-92-0) is a useful research chemical.<br></p>

<p>Applications A boc-protected cyclic amine used in the preparation of heterocyclic boronic acid compounds.<br></p>

<p>Applications 2,2,6,6-Tetramethylpiperidine-1,4-diol is related to 4-Hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy (H956500), which is a free radical scavenger. 2,2,6,6-Tetramethylpiperidine-1,4-diol has also been shown to be an in vitro and in vivo radioprotector. It is used as a reagent in stereoselective preparation of tetrasubstituted triarylated olefins via Pd-catalyzed sequential oxidative Heck arylation of alkenes with arylboronic acids using nitroxides as oxidants.<br>References Flather, M., et al.: Lancet, 355, 1575 (2000); Sasso, F., et al.: Metabolism, 52, 675 (2003); Kass, D., et al.: Circ. Res., 94, 1533 (2004); Murdoch, C., et al.: Cardiovasc Res., 71, 208 (2006); Hahn, M., et al.: Free Radic. Biol. Med., 28, 953 (2000); He, Z., et al.: Angew. Chem. Int. Ed., 51, 3699 (2012);<br></p>

<p>Applications 1-Phenyl-pyrazole 4-pyruvic Acid is a derivative of N-Phenylpyrazole, a reactant in the synthesis of candesartan cilexetil(C175580), an ester prodrug; hydrolized in vivo to the active carboxylic acid. Used in treatment of congestive heart failure. Antihypertensive.<br>References Seki, M. et. al: ACS Catalysis, 4, 4047 (2014); Shibouta, Y., et al.: J. Pharmacol. Exp. Ther., 266, 114 (1993; Ogihara, T., et al.: Clin. Ther., 16, 74 (1994)<br></p>

<p>Applications 1,3,5-Tris(3-chloro-2-hydroxypropyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione-d15 is an intermediate for the synthesis of Triglycidyl Isocyanurate-d15 (T793817). Isotope labelled Triglycidyl isocyanurate is a reagent used in the synthesis of N-Benzyl Metaxalone (B285000), which is a muscle relaxant used to relax muscles and relieve pain.<br>References Toth, P.E., et al.: Clin. Ther., 26, 1355 (2004)<br></p>

<p>Applications ethyl (3-bromo-1H-pyrazol-1-yl)acetate (cas# 1427022-51-2) is a useful research chemical.<br></p>

<p>Applications 2-(2-Aminophenyl)-1H-benzimidazole is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins. Also used in the synthesis of pharmaceutical agents targeting leishmania related parasites.<br>References Keurulainen, L. et al.: Bioorg. Med. Chem. Lett., 25, 1933 (2015); He, Y. et al.: Bioorg. Med. Chem., 23, 2798 (2015);<br></p>

<p>Applications 1-(3-Bromopropyl)-4-(4-chlorophenyl)piperazine is an intermediate in the synthesis of 2-​[3-​[4-​(4-​Chlorophenyl)​-​1-​piperazinyl]​propyl]​-1,​2,​4-triazolo[4,​3-​a]​pyridin-​3(2H)​-​one Hydrochloride (C433100), which is a related compound of Trazodone (T718500), which is an antidepressant.<br>References Silvestrini, B., et al.: Eur. J. Pharmacol., 12, 231 (1970), Brogden, R.N., et al.: Drugs, 21, 401 (1981), Gorecki, D., et al.: Anal. Profiles Drug Subs., 16, 693 (1986),<br></p>