Heterocycles with Nitrogen (N)

<p>Applications PIPERONYL ACETONE (cas# 55418-52-5) is a useful research chemical.<br></p>

<p>Applications A labelled Voriconazole (V760000) impurity.<br>References Rieke, R., et al.: Science, 246, 1260 (1989), Dickinson, R., et al.: Bioorg. Med. Chem. Lett., 6, 2031 (1996),<br></p>

<p>Applications 2-Benzotriazol-1-yl-propionic acid is used in the synthesis of N-substituted benzotriazole/morpholine derivatives which has antiinflammatory anthelmintics properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Upadhyay, R. K., et al.: J. In. Coun. Chem., 9, 36 (1993);<br></p>

<p>Stability Hygroscopic<br>Applications 2-Fluoro-6-(trifluoromethyl)pyridine-3-boronic acid<br></p>

<p>Applications (1-Ethyl-piperidin-3-yl)-carbamic Acid tert-Butyl Ester is an intermediate in the synthesis of 4-Amino-N-(1-ethyl-3-piperidinyl)-5-(ethylsulfonyl)-2-methoxybenzamide (A609495), which is an impurity of Amisulpride (A633250). Amisulpride EP Impurity G.<br>References Elslager, E.F., et al.: J. Med. Chem., 24, 127 (1981)<br></p>

<p>Applications 2-Isopropylthio-5-trifluoromethylpyridine-3-boronic acid<br></p>

<p>Applications 5-Aminomethyl-2-bromopyridine<br></p>

<p>Applications 3,5-Diphenylpyrazole (cas# 1145-01-3) is a useful research chemical.<br></p>

<p>Applications 1H-pyrrolo[2,3-b]pyridin-1-amine (cas# 161264-46-6) is a useful research chemical.<br></p>

<p>Applications 1-[(2-Nitrophenyl)sulfonyl]-1H-pyrrole is used in the preparation of various 2-​substituted N-​nosylpyrroles.<br>References Shibata, M. et al. Tetrahedron. 71, 4495 (2015);<br></p>

<p>Applications 2,2,2-trifluoro-1-(3-hydroxypiperidin-1-yl)ethan-1-one (cas# 73193-62-1) is a useful research chemical.<br></p>

<p>Applications 2-(1H-pyrazol-4-yl)aniline (cas# 1342757-33-8) is a useful research chemical.<br></p>

<p>Applications 3-tert-Butylthio-2-carboxypyridine (cas# 178811-41-1) is a compound useful in organic synthesis.<br></p>

<p>Applications N-2-Pyridinyl-1,2-ethanediamine is a reactant used in the synthesis of dual histamine H1 and H2 receptor antagonists based on cyanoguanidine. Also used in the synthesis of 2-thiohydantoins as somatostatin receptor ligands,<br>References Sadek, B. et al.: Molecules, 18, 14186 (2013); Wang, X. et al.: Lett. Drug Design. DIsc., 9, 655 (2012);<br></p>

<p>Applications 3,4-Dimethyl-5-pyrazolone (cas# 6628-22-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,4-Di(tert-butoxy)pyrimidine-5-boronic acid<br></p>

<p>Applications 5-Ethylpyridine-2-carboxylic Acid (cas# 770-08-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Hydroxy-6-methylpicolinic Acid is used as a reactant in the preparation of spiro[3,4-dihydro-2H-pyrrolo[1,2-a]pyrazine-1,4'-piperidine] derivatives as modulators of sodium ion channels.<br>References Hadida Ruah, Sara S., et al.: U.S. Pat. Appl. Publ., US 20120196869 A1 20120802 (2012)<br></p>

<p>Applications 3-Chloro-4-cyanopyridine (cas# 68325-15-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Pyrrolidinyl-3-pyridineacetic Acid is a reagent that is used in the synthesis of phenylalanine cyanomethylamides as cathepsin B inhibitors.<br>References Roy, P., et al.: PCT Int. Appl., 2010:777979 (2010);<br></p>

<p>Applications Pyridine-4-d1 (CAS# 10259-15-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,4,6-Trimethylpyridine-d11 (CAS# 1219805-54-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-(2,4-Dichlorophenylamino)-4-trifluoromethylpyrimidine-5-carboxylic Acid is used to prepare a selective CB2 receptor agonist for the treatment of inflammatory pain.<br>References Giblin, G., et al.: J. Med. Chem., 50, 2597 (2007)<br></p>

<p>Applications Chlorotripyrrolidinophosphonium Hexafluorophosphate acts as a peptide coupling reagent or condensing agent for phosphinate ester formation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prasad, K. et al.: Int. J. Pharm. Sci. Rev. Res., 8, 108 (2011); Winqvist, A. et al.: Eur. J. Org. Chem. 10, 1705 (2008);<br></p>

<p>Applications Used as a heterocyclic scaffold<br>References Matysiak, J., et al.: Bioorg. Med. Chem., 11, 2285 (2003), Das, J., et al.: Bioorg. Med. Chem. Lett., 18, 2652 (2008),<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-Acetylimidazole (cas# 2466-76-4) is a useful research chemical.<br></p>

<p>Applications Guanine (G836000) analog.<br>References Kini, G., et al.: J. Med. Chem., 34, 3006 (1991),<br></p>

<p>Stability Light Sensitive, Moisture Sensitive, Temperature Sensitive<br>Applications 7,9-Dimethoxycarbonyl-2-ethoxycarbonyl-1H-pyrrolo-[2,3-f]quinoline-4,5-dione (cas# 80721-47-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-(4-aminophenoxy)-N,N-dimethylpyridine-2-carboxamide (cas# 284462-86-8) is a useful research chemical.<br></p>

<p>Applications N-Boc-4-(hydroxymethyl)-pyrrolidin-2-ol is a chemical reagent used in organic synthesis for pharmaceutically active compounds.<br>References Yohannes, D. et al.: Org. Lett., 10, 5353 (2008);<br></p>

<p>Applications Methyl Dl-2-(1-Boc-Piperidin-4-Yl)-Beta-Glycinate (cas# 362703-57-9) is a useful research chemical.<br></p>

<p>Applications 5,6-Diamino-2-hydroxybenzimidazole (cas# 55621-49-3) is a compound useful in organic synthesis.<br></p>

<p>Applications (αE)-α-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-β-oxo-1-piperidinepropanenitrile is an impurity of Entacapone (E558500), a peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.<br>References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992), Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992), Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993),<br></p>

<p>Stability Hygroscopic<br>Applications Methyl 4-Oxopiperidine-3-carboxylate Hydrochloride (cas# 71486-53-8) is a useful research chemical.<br></p>

<p>Applications 9-(Acetyloxy)-3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one can be synthesized from 3-(2-Chloroethyl)-2-methyl-9-(benzyloxy)-4H-pyrido[1,2a]pyrimidin-4-one (C366140).<br></p>

<p>Applications 2-ethoxy-3-ethylpyrazine (cas# 35243-43-7) is a useful research chemical.<br></p>

<p>Applications Methyl 6-aminopyridazine-3-carboxylate<br></p>

<p>Applications 2-Chloromethyl-3,5-dimethylpyridin-4-one (cas# 1114596-75-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(2-Thienyl)pyrrolidine is used in the preparation of imidazopyridine derivatives for treating viral infections.<br>References Serradeil-Le Gal, C., et al.: J. Pharmacol. Exp. Ther., 300, 1122 (2002), Hodgson, R., et al.: Pharmacol. Biochem. Behav., 3, 431 (2007),<br></p>

<p>Applications 5-(BROMOMETHYL)-2-NITROPYRIDINE (cas# 448968-52-3) is a useful research chemical.<br></p>

<p>Applications 5-benzoyl-2H-1,2,3,4-tetrazole (cas# 14506-41-3) is a useful research chemical.<br></p>

<p>Applications 2-Mercapto-5-nitrobenzimidazole is useful for treating giardiasis. Antigiardial drug.<br>References Hernandez-Ochoa, B., et al.: Molecules, 25, 3979 (2020)<br></p>

<p>Applications 3-(2,5-dimethyl-1H-pyrrol-1-yl)-2-thiophenecarboxylic Acid (cas# 477888-48-5) is a useful research chemical.<br></p>

<p>Applications 1-(4-Chlorophenyl)-1,2-dihydro-3H-pyrazol-3-one is also used in the synthesis of antifungal, oxazolidinon-based strobilurin analogues. Also used in the preparation of heterologous haptens for the synthesis of high-affinity anti-pyraclostrobin antibody generation.<br>References Li, Y. et al.: Bull. Kor. Chem. Soc., 31, 3341 (2010); Mercader, J. et al.: Org. Biomol. Chem., 9, 1443 (2011);<br></p>

<p>Applications 6-(4-Aminophenoxy)-N-methyl-4-pyrimidinamine is an intermediate in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.<br>References Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);<br></p>

<p>Applications 1-Phenyl-pyrazole 4-pyruvic Acid is a derivative of N-Phenylpyrazole, a reactant in the synthesis of candesartan cilexetil(C175580), an ester prodrug; hydrolized in vivo to the active carboxylic acid. Used in treatment of congestive heart failure. Antihypertensive.<br>References Seki, M. et. al: ACS Catalysis, 4, 4047 (2014); Shibouta, Y., et al.: J. Pharmacol. Exp. Ther., 266, 114 (1993; Ogihara, T., et al.: Clin. Ther., 16, 74 (1994)<br></p>

<p>Applications 3-Benzylpiperazine-2,5-dione (cas# 5037-75-2) is a useful research chemical.<br></p>

<p>Applications Pyrrolidine-2,2,5,5-d4 Hydrochloride is the salt, labeled analogue of Pyrrolidine (P997950), a heterocyclic compound used as a building block in the synthesis of wide range of pharmaceutical compounds, namely matrix metalloprotein inhibitors (MMPIs) and aminopeptidase N inhibitors (APNIs).<br>References Li, X. et al.: Mini-Rev. Med. Chem., 10, 794 (2010); Gragutan, I. et al.: Beil. J. Org. Chem., 7, 699 (2011)<br></p>

<p>Applications 2-Chloro-6-ethyl-N,N-dimethylthieno[2,3-d]pyrimidin-4-amine-d6 is the isotope labelled analog of 2-Chloro-6-ethyl-N,N-dimethylthieno[2,3-d]pyrimidin-4-amine (C367635); a useful synthetic intermediate.<br></p>

<p>Applications 1-ACETYL-2-PIPERIDINEACETIC ACID (cas# 25393-20-8) is a useful research chemical.<br></p>

<p>Applications 4-amino-1-propylpyrrolidin-2-one hydrochloride (cas# 1255717-37-3) is a useful research chemical.<br></p>

<p>Applications 3-Fluoro-6-bromopyridine is used in the synthesis of mGluR5 antagonist for the treatment of neuropathic pain.<br>References Son, M.H., et al.: Bioorg. Med. Chem. Lett., 23, 1472 (2013);<br></p>

<p>Applications 2-(4,5-dihydro-1H-imidazol-2-yl)pyridine (cas# 7471-05-8) is a useful research chemical.<br></p>