Heterocycles with Nitrogen (N)

<p>Applications 2-Pyrazinecarboxylic Acid 4-Oxide (cas# 874-54-4) is a compound useful in organic synthesis.<br>References Ambrogi, V., et al.: Eur. J. Med. Chem., 15, 157 (1980),<br></p>

<p>Applications Urazole derivative.<br></p>

<p>Applications 1-Cbz-piperazine is used in the synthesis of serotonin 5-HT6 and dopamine D2 receptor ligands (1,2). It can also be used for the synthesis of a 11-C labelled ligands for imaging vesicular acetylcholine transporter.<br>References (1) Kindahl, T. et al.: Org. Biomol. Chem., 12, 4461 (2014) (2) Krogsgaard-Larsen, N., et al.: J. Med. Chem., 57, 5823 (2014)<br></p>

<p>Applications 4-Amino-2,2,6,6-tetramethylpiperidine-d17; 1-15N-1-oxyl (CAS# 97461-87-5) is a useful isotopically labeled research compound that is used in various experiments, such as, synthesis of two cysteine-specific spin labels.<br>References Wu,G. J. Label. Compd.Radiopharm., 12,1173-1181,(1995);<br></p>

<p>Applications 2-Chloro-5-nitropyrimidin-4-ol is an intermediate used in the synthesis of 4-Chloro-5-nitro-2-(propylthio)pyrimidine (C374095), which is an impurity of the drug Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>

<p>Stability Moisture Sensitive<br>Applications 1,3-dimethyl-2,4-dioxo-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-6-sulfonyl chloride (cas# 1240529-56-9) is a useful research chemical.<br></p>

<p>Applications 6-Methylpyridine-3-amine, is a heterocyclic building block used in the manufacture of various pharmaceutical compounds. It can be used for the synthesis of 2-aminoquinazoline derivatives, as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators (mGluR5), leading toward a drug candidate for the treatment of l-DOPA induced dyskinesia.<br>References Kubas, H., et al.: Bioorg. Med. Chem. Lett., 23 (16), 4493 (2013);<br></p>

<p>Applications 3-(Triethoxysilyl)propyl 2-((4-amino-5-hydrazinyl-4H-1,2,4-triazol-3-yl)thio)propanoate is a useful reagent for organic reactions.<br></p>

<p>Applications 1,2-Dimethylpiperazine (cas# 25057-77-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Miyamoto, T., et al.: J. Med. Chem., 33, 1645 (1990),<br></p>

<p>Applications 4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine-2-thiol (cas# 5498-17-9) is a useful research chemical.<br></p>

<p>Applications 5-Aminopyrazine-2-boronic acid pinacol ester is a reagent for the synthesis of amino-pyrido-indol-carboxamides that acts as a JAK2 inhibitor used in the treatment of myeloproliferative disorder.<br>References Lim, J., et al.: J. Med. Chem., 54, 7334 (2011)<br></p>

<p>Applications 5-fluoro-4-hydrazino-2-methoxypyrimidine (cas# 166524-64-7) is a useful research chemical.<br></p>

<p>Applications 6-Fluoro-4-methyl-2-pyridinamine can be synthesized from 2,6-Dichloro-4-methylpyridine (39621-00-6).<br></p>

<p>Applications 4-Benzyloxazolidine-2,5-dione (cas# 583-47-1) is a useful research chemical.<br></p>

<p>Applications 5,5-Diphenyl-2-thiohydantoin is a reactant for synthesis of imidazole derivatives.<br></p>

<p>Applications Ethyl 6-(chloromethyl)pyridine-2-carboxylate<br></p>

<p>Applications 2-propylpiperidine (cas# 3238-60-6) is a useful research chemical.<br></p>

<p>Applications Isotope labelled 1-Ethyl-5-hydroxy-2-pyrrolidinone (E919175), an important organic solvent used in varnishing. Industrial solvent.<br>References Koch, H. et al. Arch. Toxicol., 88, 893 (2014); Koslitz, S. et al.: Toxicol. Lett., 231, 142 (2014);<br></p>

<p>Applications 5-(4-Bromophenyl)-4,6-dichloropyrimidine is a reactant used in the synthesis of Macitentan, an orally active dual endothelin receptor antagonist.<br>References Bolli, M. et al.: J. Med. Chem., 55, 7849 (2012);<br></p>

<p>Applications: 2,7-Dimethyl-[1,4]dioxino[2,3-b:5,6-b']dipyridine is intermediate in the synthesis of compounds used in analytical studies for the presence and formation of dioxin-like compounds in heat-treated chlorpyrifos herbicide, a potential precursor of pyridine analog of 2,3,7,8-Tetrachloro-p-dioxin (T291370).<br>References Sakiyaama, T., et al.: Organohalogen Compounds, 73, 146 (2011);<br></p>

<p>Applications A useful synthetic intermediate.<br></p>

<p>Applications 2-(1-Adamantyl)-4,5-dihydro-1H-imidazole (cas# 52725-79-8) is a useful research chemical.<br></p>

<p>Applications 6-Chloro-3-Fluoro-2-Iodopyridine (cas# 1211590-36-1) is a useful research chemical.<br></p>

<p>Applications 1-(2-Ethoxyphenyl)piperazine monohydrochloride 99 (cas# 83081-75-8) is a useful research chemical.<br></p>

<p>Applications Bimodal effect of the picolinic acid derivatives on the rate of wheat and pea germination.<br>References Hamaker, J., et al.: Science, 141, 363 (1963),<br></p>

<p>Applications 6-Nitropyrido[2,3-d]pyrimidin-4(3H)-one is a useful research chemical for organic synthesis and other chemical processes.<br></p>

<p>Applications 4,4'-Dicyano-2,2'-bipyridine is a photosensitizers for solar fuel generation<br>References Mills, I. N., et al.: Polyhedron, 82, 104 (2014)<br></p>

<p>Applications 3-Piperidinesulfonic Acid is an isomer of piperidine-4-sulfonic acid, a new specific GABA agonist.<br>References Krogsgaard-Larsen, P., et al.: J. Neurochem., 34, 756 (1980)<br></p>

<p>Applications 2,2-Dimethylpiperazine is a chemical reagent used in the preparation of non-covalent NAAA inhibitors used as a protective agent for the development of multiple sclerosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Migliore, M. et al.: Angew. Chem. Int. Ed., 55, 11193 (2016);<br></p>

<p>Applications 6-Bromopiperonal is a disubstituted 1,3-benzodioxole that displayed synergistic activity with carbaryl on houseflies. 6-Bromopiperonal is used as an intermediate in the preparation of GPR30-selective agonist G-1.<br>References Wilkinson, C.F. et al.: J. Agric. Food Chem., 15, 139 (1967): Hewlett, P.S. et al.: J. Sci. Food Agric., 18, 279 (1967); Burai, R. et al.: Org. Biomol. Chem., 8, 2252 (2010);<br></p>

<p>Applications Pyridine-15N, is the labeled analogue of Pyridine (P991280), a basic six-membered heterocyclic ring. Pyridine is a base structure present in many biologically active compounds like the vitamins niacin and pyridoxal. Pyridine is used in dehalogenation reactions and can be used as a base in condensation reactions.<br>References Egyed, J. et al.: Bull. Soc. Chim. Fra., 11, 3014 (1973); Li, Y. et al.: Wuli HUa. Xueb., 14, 1048 (1998);<br></p>

<p>Applications 5,7-Dichloroimidazo[1,2-a]pyrimidine (cas# 57473-32-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Chloro-3-nitropyridine (cas# 5470-18-8) is a useful research chemical.<br></p>

<p>Applications 2,5-Diacetamido-2,3-dihydrothiazolo[4,5-d]pyrimidine-7-(6H)-one (cas# 22365-29-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Bromo-N-[4-bromo-2-(2-pyridinylcarbonyl)phenyl]-acetamide is a derivative of 2-(2-Amino-5-bromobenzoyl)pyridine (A601785); an intermediate in the preparation of Bromazepam (B678500).<br>References Panderi, I., et al.: J. Pharm. Biomed. Anal., 17, 327 (1998); El-Haj, B., et al.: J. Anal. Toxicol., 25, 316 (2001); Hansen, S., et al.: J. Pharm. Biomed. Anal., 39, 322 (2005)<br></p>

<p>Applications Imidazole rings are found in numberous natural compounds such as enzymes, nucleic acid, and alkaloids that play a role in biological processes.<br></p>

<p>Applications (3E)-4-(5-Ethoxy-3-pyridinyl)-3-buten-1-ol is an intermediate in the synthesis of TC 2559 Fumarate (T012005), which is a partial agonist for AChR α4β2.<br></p>

<p>Applications α-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-4-hydroxybenzeneacetic acid is used in the preparation of Cefoperazone an antibiotic.<br>References Xu, Y., et al.: Zhongguo Yaoke Daxue Xuebao, 28, 264 (1997);<br></p>

<p>Applications 3-Bromo-6,7-dihydro-5H-cyclopenta[b]pyridin-5-one is a useful synthetic intermediate.<br></p>

<p>Applications 2-Hydrazino-1H-1,3-benzimidazole<br></p>

<p>Applications N-(3-{[2-chloro-5-(trifluoromethyl)pyrimidin-4-yl]amino}phenyl)prop-2-enamide (cas# 1374507-25-1) is a useful research chemical.<br></p>

<p>Applications 3-Bromo-2-hydroxypyridine is used in the synthesis of pyrazolopyridines as γ-secratase modulators.<br>References Qin, J. et al.: ACS Med. Chem. Lett., 2, 471 (2011);<br></p>

<p>Applications Isoxazolo[5,4-b]pyridin-3-amine<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-Cyano-4-(trifluoromethyl)pyridine<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Intermediate for heterocyclic compounds as tyrosine kinase inhibitors and anticancer agents.<br>References McLean, A., et al.: J. Chem. Phys., 72, 5639 (1980), Watts, J., et al.: J. Biol. Chem., 276, 43197 (2001),<br></p>

<p>Applications Used in the preparation of labelled indolizine compounds for use in antifungal combination therapy.<br></p>

<p>Applications 5-(N,N-Diethylcarboxamide)-1-phenylpyridin-2(1H)-one (cas# 1076199-97-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Boronic acid derivatives and their binding affinities with diols.<br>References Yang, W., et al.: Bioorg. Med. Chem. Lett., 12, 2175 (2002), Yang, W., et al.: Med. Res. Rev., 23, 346 (2003),<br></p>

<p>Applications rac-α-N-Boc-Amino-4-pyridineaceic Acid is a reagent used in the preparation of lactam-containing diaminoalkanes, β/α-amino acids and derivatives of Xa inhibitors.<br></p>

<p>Applications 5-(Aminosulphonyl)-1-methyl-1H-pyrrole-2-carboxylic acid (cas# 306936-62-9) is a useful research chemical.<br></p>

<p>Applications 5-(4-methylphenyl)imidazolidine-2,4-dione (cas# 69489-37-8) is a useful research chemical.<br></p>

<p>Applications 5-(2-Methyl-1,3-dioxolan-2-yl)-2-pyridineethanol (cas# 184766-50-5) is a compound useful in organic synthesis.<br></p>