Heterocycles with Nitrogen (N)

<p>Applications N-2-Pyridinyl-1,2-ethanediamine is a reactant used in the synthesis of dual histamine H1 and H2 receptor antagonists based on cyanoguanidine. Also used in the synthesis of 2-thiohydantoins as somatostatin receptor ligands,<br>References Sadek, B. et al.: Molecules, 18, 14186 (2013); Wang, X. et al.: Lett. Drug Design. DIsc., 9, 655 (2012);<br></p>

<p>Applications N-BOC-Piperidin-4-ylmethyleneboronic acid pinacol ester is a useful research chemical.<br></p>

<p>Applications 2,4,6-Trimethylpyridine-d11 (CAS# 1219805-54-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Ethyl-2,3-dioxo-1-piperazinecarbonyl Chloride-D5 is an intermediate in the synthesis of Piperacillin-d5 (P479952), which is the labeled analogue of Piperacillin (P479950), an antibacterial agent.<br>References Takai, A., et al.: Chemotherapy, 25, 816 (1977), Bodey, G.P., et al.: Antimicrob. Agents Chemother., 14, 78 (1978), Kuck, N.A., et al.: J. Antibiot., 31, 1175 (1978),<br></p>

<p>Applications Succinimidyl Nervonate (cas# 191354-88-8) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-Acetylimidazole (cas# 2466-76-4) is a useful research chemical.<br></p>

<p>Applications 1-[(1-Acetyl-4-piperidinyl)carbonyl]-4-piperidinecarboxylic Acid is a useful synthetic intermediate.<br></p>

<p>Applications 2-(3-Aminophenyl)-1H-benzo[d]imidazol-6-amine (cas# 13676-49-8) is a useful research chemical.<br></p>

<p>Applications A labelled impurity of Cefoperazone.<br>References Kitson, T., et al.: Biochem. J., 175, 83 (1978), Elenbaas, R., et al.: Clin. Pharmacol. Ther., 32, 347 (1982),<br></p>

<p>Applications 5-Phenyl-4h-1,2,4-triazol-3-amine, is an intermediate in the synthesis of WP155. 5-Phenyl-4h-1,2,4-triazol-3-amine is also used in biological studies to evaluate its pharmacological activity as it can be applied to a method for reducing susceptibility to tumor formation induced by 3-deoxyglucosone and precursors thereof.<br>References Truman, B., et al.: U.S. Pat. Appl. Publ.<br></p>

<p>Applications 4-Butylpiperidine Hydrochloride is an intermediate in the synthesis of AC 42 (A115600), an allosteric agonist of acetylcholine orthosteric site.<br>References Jacobson, M.A., et al: Mol. Pharmacol., 78, 648 (2010);<br></p>

<p>Applications (S)-tert-butyl 4-aminoazepane-1-carboxylate (cas# 878630-84-3) is a useful research chemical.<br></p>

<p>Applications 3-(N-1-Trityl-imidazol-4-yl)propionic Acid is an intermediate used to prepare imidazole-containing tetrahydrobenzodiazepine inhibitors of farnesyltransferase. It is also used in the synthesis of nonracemic arylpiperazinone analogs of the carboxyl-terminal CAAL sequence of protein geranylgeranyltransferase-I (PGGTase-I) as selective inhibitors of PGGTase-I and of protein farnesyltransferase.<br>References Ding, C., et al.: J. Med. Chem., 42, 5241 (1999); Peng, H., et al.: Org. BIomol. Chem., 4, 1768 (2006)<br></p>

<p>Applications B-(2-Cyclopropyl-4-pyridinyl)-boronic Acid Hydrochloride, can be used in synthesis of isoindole carboxamides, pyrrolopyridine carboxamides, and similar compounds as inhibitors of phosphodiesterase type 10A for treating neurological and psychiatric disorders.<br>References Geneste, H., et al.: PCT Int. Appl. (2013), WO 2013000994 A1 20130103<br></p>

<p>Applications 2,3-Dichloro-5-fluoropyridine is a reagent that is used in the synthesis of 3-Chloro-5-fluoro Clodinafop Propargyl (C368645), which is an impurity of Clodinafop Propargyl (C584515).<br>References Aliverdi, A., et al.: Weed Biol. Management, 9, 292 (2009), Hochberg, O., et al.: Weed Res., 49, 37 (2009), Liu, B., et al.: J. Agric. Food Chem., 58, 2673 (2010),<br></p>

<p>Applications 5-Fluoro-2-pyridinesulfonyl Chloride acts as a reagent for the synthesis of potential TK inhibitors with improved pharmacokinectics for resistant CML.<br>References Ali, Ahmed M., et al.: ChemMedChem, 11, 850 (2016)<br></p>

<p>Applications 1-(Tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (cas# 903550-26-5) is a useful research chemical.<br></p>

<p>Applications 2-(2-Thienyl)pyrrolidine is used in the preparation of imidazopyridine derivatives for treating viral infections.<br>References Serradeil-Le Gal, C., et al.: J. Pharmacol. Exp. Ther., 300, 1122 (2002), Hodgson, R., et al.: Pharmacol. Biochem. Behav., 3, 431 (2007),<br></p>

<p>Applications 1-isobutyl-1H-pyrazole-3-carboxylic acid (cas# 1006493-64-6) is a useful research chemical.<br></p>

<p>Applications [1,2,4]Triazolo[1,5-a]pyridin-8-ol can be used to prepare aminopyridine derivatives as glucokinase activators useful to treat diseases.<br>References Aicher, T. D., et al.: PCT Int. Appl., 145, (2008);<br></p>

<p>Applications A useful synthetic intermediate.<br></p>

<p>Applications 4-Hydroxypiperidine-3,3,4,5,5-d5-N-t-BOC (CAS# 1523606-18-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Hydroxy-2,2,6,6-tetramethylpiperidine-d17-1-oxyl (CAS# 100326-46-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications A pyrolopyrimidine derivative used in the preparation of the antibiotic tubercidin (7-deazadenosine).<br>References Ektova, L.V. et al.: Bioorg. Khim., 4, 1250 (1978);<br></p>

<p>Applications {2-[(Pyridin-4-ylmethyl)thio]-1,3-thiazol-4-yl}acetic acid (cas# 1040631-48-8) is a useful research chemical.<br></p>

<p>Applications 6-METHYL-5-PROPYL-4(1H)-PYRIMIDINONE (cas# 103980-68-3) is a useful research chemical.<br></p>

<p>Applications 1-Acetoacetyl-2,2,5,5-tetramethyl-3-pyrroline-3-carboxamide (cas# 1391054-79-7) is a compound useful in organic synthesis.<br></p>

<p>Applications (2R,4S)-4-Aminopyrrolidine-2-carboxylic acid dihydrochloride (cas# 263407-17-6) is a useful research chemical.<br></p>

<p>Applications 2,4-difluoro-5-(2-oxoimidazolidin-1-yl)benzoic acid (cas# 1178351-23-9) is a useful research chemical.<br></p>

<p>Applications α,α,1,6-Tetramethyl-3-piperidinemethanol, has shown to be able to facilitate new modes of reactivity via constrictive binding in a supramol.-assembly-catalyzed aza-Prins cyclization.<br>References Kaphan, D. M., et al.: Journal of the American Chemical Society, Vol. 137, P: 9202-9205 (2015);<br></p>

<p>Stability Shock sensitive, temperature sensitive, light sensitive<br>Applications 4-Bromopyridazine Hydrobromide is a mono-substituted pyridazine derivative used in the preparation of γ-secretase modulators.<br>References Luebbers, T. et al.: Bioorg. Med. Chem. Lett., 21, 6554 (2011);<br></p>

<p>Applications B-(5-Formyl-2-pyridinyl)boronic Acid is used as a reagent in the preparation of (hetero)biarylsulfonamides as κ opioid antagonists with selectivity over the μ receptor.<br>References Verhoest, P. R., et al.: J. Med. Chem., 54, 5868 (2011);<br></p>

<p>Applications 2-((5-Chloropyridin-2-yl)amino)-2-oxoacetic Acid is a reactant or reagent used in the synthesis of the blood coagulating enzyme factor Xa (FXa) inhibitor.<br>References Xue, T., et al.: J. Med. Chem., 57, 7770 (2014);<br></p>

<p>Applications 2-Amino-6-bromopyridine is a disubstituted pyridine used as a building block in the preparation of nitrogen containing bicyclic and polycylic compounds.<br>References Da Settimo, A. et al.: Farm. Ed. Sci., 33, 770 (1978); Cai, L. et al.: Synthesis, 1, 133 (2006);<br></p>

<p>Applications Piperophos is a pesticide used in agriculture for prevention of fungal diseases and insect infestation.<br>References Li, K. et al.: Fenxi Shi., 34, 236 (2015);<br></p>

<p>Applications N-[1-[1-(4-Methoxyphenyl)-1H-tetrazol-5-yl]-1-methylpropyl]-1H-indole-3-ethanamine,<br></p>

<p>Applications 5-Hydroxy-6-methyl-3,4-pyridinedicarboxylic Acid is used in studies to identify 4-pyridoxic acid dehydrogenase gene in pyridoxine catabolism of Mesorhizobium loti MAFF303099.<br>References Mukherjee, T., et al.: Bioorg. Chem., 35, 458 (2007)<br></p>

<p>Applications 1-[4-(4-Fluorophenyl)-2-thiazolyl]-3,5-dimethyl-1H-pyrazole-4-propanoic Acid (cas# 1172940-17-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzonitrile (cas# 31489-18-6) is a useful research chemical.<br></p>

<p>Applications 2,6-di-tert-Butylpyridine is used in the preparation of polymers with n-type nitroxide side groups to be used in organic radical batteries.<br>References Jaehnert, T., et. al.: Eur. Polymer J., 61, 105 (2014)<br></p>

<p>Applications 4-Formylpyrazole is a reactant in the preparation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors.<br>References Yao, Y., et. al.: Eur. J. Med. Chem., 86, 639 (2014)<br></p>

<p>Applications rac-α-N-Boc-Amino-4-pyridineaceic Acid is a reagent used in the preparation of lactam-containing diaminoalkanes, β/α-amino acids and derivatives of Xa inhibitors.<br></p>

<p>Applications 5-(Aminosulphonyl)-1-methyl-1H-pyrrole-2-carboxylic acid (cas# 306936-62-9) is a useful research chemical.<br></p>

<p>Applications 5-(2-Methyl-1,3-dioxolan-2-yl)-2-pyridineethanol (cas# 184766-50-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is used as the starting material in the preparation of pyrazine derivatives that are AxI and c-Met receptor enzyme inhibitors. These inhibitors are useful in the treatment of tumors. 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is also used in the preparation of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.<br>References Rushton, L.; et al.: PCT Int. Appl. 119 pp. Patent 2009 CODEN:PIXXD2; Charrier, J-D.; et al.: J. Med. Chem, 54, 2320 (2011)<br></p>

<p>Applications 1-(4-aminophenyl)imidazolidin-2-one (cas# 89518-99-0) is a useful research chemical.<br></p>

<p>Applications (2S,4R)-4-Aminopyrrolidine-2-carboxylic Acid Dihydrochloride (cas# 16257-89-9) is a useful research chemical.<br></p>

<p>Applications 2-(1-Piperazinyl)-phenol Dihydrochloride, is used to prepare nonpeptidic biaryl inhibitors of human cathepsin K in relation to treatment of osteoporosis. It is also used to synthesize serotonin transporters/histamine H3 receptors.<br>References Robichaud, J., et al.: J. Med. Chem., 46, 3709 (2003); Keith, J., et al.: Bioorg. Med. Chem. Lett., 17, 702 (2007)<br></p>

<p>Applications 4-ethylpyrimidine-5-carboxylic acid (cas# 1147710-24-4) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 1,3-Dibenzyl-1H-benzo[d]imidazol-3-ium Chloride is a useful reagent in the preparation of the antimicrobial benzimidazolium compounds via N-alkylation of benzimidazoles with benzyl chloride.<br>References Meng, J. P., et al.: Adv. Mat. Res., 554, 1686 (2012)<br></p>

<p>Applications 2,3-Dimethyl-5H,6H,7H,8H-imidazo[1,2-a]pyrazine is used in the preparation of a pluripotent stem cell inhibitor.<br>References Furukawa, Yusuke. et al., Jichi Medical University(2019);<br></p>

<p>Applications Pyrrole-ND (CAS# 10162-82-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications tert-butyl 4-(5-bromo-1H-indazol-3-yl)piperidine-1-carboxylate (cas# 1198284-77-3) is a useful research chemical.<br></p>

<p>Applications 1-Cbz-piperazine is used in the synthesis of serotonin 5-HT6 and dopamine D2 receptor ligands (1,2). It can also be used for the synthesis of a 11-C labelled ligands for imaging vesicular acetylcholine transporter.<br>References (1) Kindahl, T. et al.: Org. Biomol. Chem., 12, 4461 (2014) (2) Krogsgaard-Larsen, N., et al.: J. Med. Chem., 57, 5823 (2014)<br></p>

<p>Applications 4-Cyclohexyl-2-piperidinecarboxylic Acid is a compound useful in organic synthesis.<br></p>