Heterocycles with Nitrogen (N)

<p>Applications Ethyl 2-(1H-Pyrrol-2-yl)acetate is an intermediate in the synthesis of rac Ketorolac 6-Benzoyl Isomer (K235620). rac Ketorolac 6-Benzoyl Isomer (Ketorolac EP Impurity C) is an isomeric impurity of Ketorolac (K235620).<br></p>

<p>Applications Dimethyl 2,6-Pyridinedicarboxylate (cas# 5453-67-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Amino-2,6-dichloropyridine (cas# 2587-02-2) is a compound useful in organic synthesis.<br>References Altenbach, R., et al.: J. Med. Chem., 51, 6571 (2008), Namba, K., et al.: Bioorg. Med. Chem., 16, 6131 (2008),<br></p>

<p>Applications 1-Piperidine-d10-carbonyl Chloride (CAS# 1219803-31-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Isopropyl-d7-piperazine (CAS# 2089679-76-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Iodosuccinimide is a iodo substituted succinimide that is used as an iodinating agent in chemical synthesis.<br>References Castanet, A.-S. et al.: Tetrahed. Lett., 43, 5047 (2002);<br></p>

<p>Applications 2,6-Dimethyl-3,5-dicarboxy-4-(2-nitrophenyl)-1,4-dihydropyridine is used as a reactant in the preparation of hydroxyindolecarboxylate and hydroxycarbolinecarboxylate from nifedipine analogous cyanoethyl ester.<br>References Gorlitzer, K., et al.: Pharmazie, 55, 35 (2000)<br></p>

<p>Applications α-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-4-hydroxybenzeneacetic acid is used in the preparation of Cefoperazone an antibiotic.<br>References Xu, Y., et al.: Zhongguo Yaoke Daxue Xuebao, 28, 264 (1997);<br></p>

<p>Applications 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride is a key intermediate in the synthesis of Riociguat, a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension.<br>References Arava, V., et al.: Pharma Chemica, 5, 232 (2013)<br></p>

<p>Applications 1-(4-Hydroxyphenyl)piperidin-2-one (cas# 79557-03-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Hydrazino-1H-1,3-benzimidazole<br></p>

<p>Applications 4-Bromo-2-(trifluoromethyl)pyridine is used in the synthesis of a potent and selective Class IIa histone deacetylase inhibitors as a potential therapy for Huntington’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Burli, R.W., et al.: J. Med. Chem., 56, 9934 (2013)<br></p>

<p>Applications 5-Phenyl-1H-tetrazole (cas# 18039-42-4) is a useful research chemical.<br></p>

<p>Applications 2-Chloro-4-piperidinopyrimidine<br></p>

<p>Applications 6-(Piperidin-1-yl)pyridin-3-ylboronic Acid Hydrochloride Salt is a useful research chemical.<br></p>

<p>Applications N-(3-{[2-chloro-5-(trifluoromethyl)pyrimidin-4-yl]amino}phenyl)prop-2-enamide (cas# 1374507-25-1) is a useful research chemical.<br></p>

<p>Applications 3-Bromo-2-hydroxypyridine is used in the synthesis of pyrazolopyridines as γ-secratase modulators.<br>References Qin, J. et al.: ACS Med. Chem. Lett., 2, 471 (2011);<br></p>

<p>Applications 5-Ethyl-2-vinylpyridine (cas# 5408-74-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Pyridineacetic Acid Hydrochloride is used in the preparation of a highly tumor-selective organometallic ruthenium(II)-Arene complex.<br>References Clavel, C.M., et. al.: J. Med. Chem., 57, 3546 (2014)<br></p>

<p>Applications 1-Butylpyrrolidine (cas# 767-10-2) is a useful research chemical.<br></p>

<p>Applications N-(5-Aminopentyl)maleimide Trifluoroacetic Acid Salt is used in the preparation of site directed maleimide bifunctional chelators for technetium and rhenium.<br>References Banerjee, S. et al.: Dalton Trans., 24, 3886 (2005);<br></p>

<p>Applications 2,2,6,6-tetramethylpiperidin-4-one hydrochloride (cas# 33973-59-0) is a useful research chemical.<br></p>

<p>Applications 1-cyclopropyl-3-phenylpiperazine (cas# 1248907-49-4) is a useful research chemical.<br></p>

<p>Applications 2-(DIMETHYLAMINOMETHYL)-PYRIDINE (cas# 43071-19-8) is a useful research chemical.<br></p>

<p>Applications An intermediate in the preparation of Pipradrol Hydrochloride<br></p>

<p>Applications 3-Hydroxypyrrolidine, HCl<br></p>

<p>Applications 4-Amino-3,5-dichloro-6-fluoropyridin-2-ol Potassium Salt is an intermediate for the synthesis of Fluroxypyr-d2,13C2 (F598782), which is the labeled analogue of Fluroxypyr (F598780), a systemic and selective herbicide. Fluroxypyr is used for the control of broad-leaved weeds in small grain cereals, maize, pastures, range land and turf. Fluroxypyr is also a synthetic auxin.<br>References Radivojevic, L. et al.: Pesticidi, 16, 181 (2001); Roberts, H.A. et al.: Tests Agrochem. Cult., 6, 96 (1985); Sanders, G.E. et al.: Ann. Appl. Biol., 111, 385 (1987)<br></p>

<p>Applications 2-Cyano-3-hydroxypyridine<br></p>

<p>Applications 2,4,6-trimethyl-5-pyrimidinol (cas# 71267-12-4) is a useful research chemical.<br></p>

<p>Applications 1,2-Diphenyl-3,5-pyrazolidinedione is a reactant used in organic synthesis such as in the preparation of inhibitors of UDP-N-acetylenolpyruvyl glucosamine reductase.<br>References Gilbert, A. et al.: J. Med. Chem., 49, 6027 (2006); Fernandez, Is. et al.: J. Am. Chem. Soc., 131, 11875 (2009);<br></p>

<p>Applications 2-Amino-3-pyridinecarbonitrile is used as a reagent in the synthesis of novel imidazo[1,2-a]pyridine derivatives as potent c-Met inhibitors and antimycobacterials.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, C., et al.: ACS Med. Chem. Lett., 6, 507 (2015); Ramachandran, S., et al.: Bioorg. Med. Chem. Lett., 23, 4996 (2013)<br></p>

<p>Applications 6-Methyl-3-pyridinol is a reagent in the preparation of anilino(pyridyl)quinolinecarbonitriles which has Src kinase inhibitiion and antitumor properties.<br>References Zhang, N., et al.: Bioorg. Med. Chem. Lett., 19, 5071 (2009); Blume-Jensen, P., et al.: Nature, 411, 355 (2001)<br></p>

<p>Applications 5-Nitropyridin-2(1H)-one can be used for molecular crystal optical materials.<br>References Uemya, T., et.al., Jpn. Kokai Tokkyo Koho, 22, (1995);<br></p>

<p>Applications 2-Pyridin-4-ylmethyl-morpholine is a useful intermediate.<br></p>

<p>Applications 1-(4-formylphenyl)-4-piperidinecarboxylic acid (cas# 727396-60-3) is a useful research chemical.<br></p>

<p>Applications Contains up to 5 % Sodium Acetate by weight.<br></p>

<p>Applications 6-ACETYL-PICOLINIC ACID ETHYL ESTER (cas# 114578-70-0) is a useful research chemical.<br></p>

<p>Applications 3-Cyano-4-(trifluoromethyl)pyridine<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2,2,5,5-Tetramethyl-2,5-dihydro-1H-pyrrolo-3-acetic Acid (cas# 76194-00-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Phenyl 4-Bromo-2-(ethyl-d3)pyridine-1(2H)-carboxylate is an intermediate in the synthesis of Ethionamide-d3 (E890422), a labelled antibacterial (tuberculostatic) agent.<br>References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),<br></p>

<p>Applications N-(3-(2-Methylpiperidin-1-yl)propyl)-2-(p-tolyl)benzo[d]imidazo[2,1-b]thiazole-7-carboxamide is a useful synthetic intermediate in organic synthesis and pharmaceuticals.<br></p>

<p>Applications A labelled impurity of Cefoperazone.<br>References Kitson, T., et al.: Biochem. J., 175, 83 (1978), Elenbaas, R., et al.: Clin. Pharmacol. Ther., 32, 347 (1982),<br></p>

<p>Applications 2,3-Dimethyl-5H,6H,7H,8H-imidazo[1,2-a]pyrazine is used in the preparation of a pluripotent stem cell inhibitor.<br>References Furukawa, Yusuke. et al., Jichi Medical University(2019);<br></p>

<p>Applications 5-Bromo-6-chloropyridine-3-sulfonyl Chloride (cas# 216394-05-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-(2-Ethoxy-2-oxoethyl)pyridin-1-ium-d5 Chloride is an intermediate used in the synthesis of Girard’s Reagent P-d5 (G388502), which is a labeled girard’s reagent used in the identification and quantification of protein carbonylation as well as in the modification of nucleosides and nucleotides. Used in the preparation of potent photoactive agents.<br>References Mirzaei, H. et al.: J. Chrom. A, 1134, 122 (2007); Kanofsky, J.R. et al.: Photochem. Photobiol., 73, 349 (2001);<br></p>

<p>Applications 4-[5-(4-Pentyloxyphenyl)isoxazol-3-yl]benzoic Acidis used to optimize the side chain of the natural product FR901379.<br>References Tomishima, M., et al.: Bioorg. Med. Chem. Lett., 18, 2886 (2008)<br></p>

<p>Applications A pyrazole derivative used as an intermediate in the preparation of herbicides.<br></p>

<p>Applications N-[1-(6-Benzothiazolyl)-2-methyl-1H-benzimidazol-5-yl]acetamideis used in the synthesis of 6-N-aryl and heteroaryl benzthiazoles as potential anthelmintics.<br></p>

<p>Applications 3-Hydroxymethyl-(1-oxy-2,2,5,5-tetramethylpyrroline)-15N is an isotope labelled spin-labelling compound.<br></p>

<p>Applications 6-​Fluoro-​3-​[(trimethylsilyl)​oxy]​-2-​pyrazinecarboxamide is an intermediate in synthesizing T-705RTP (T003210), a derivative of T-705 (F103350) which has activity against the lethal H5N1 influenza A viruses. T-705RTP which has the triphosphate group, gets strongly inhibited by the influenza virus RNA polymerase activity in comparison with T-705RMP (T003202).<br>References Yousuke, F., et al.: Antimicrob Agent Chemother., 49, 981 (2005); Kiso, M., et al.: Proc. Natl. Acad. Sci. U.S.A., 107, 882 (2010);<br></p>

<p>Applications 3-amino-6-cyanopyridazine (cas# 340759-46-8) is a useful research chemical.<br></p>

<p>Applications 2-(Tributylstannyl)oxazole is a useful reactant in preparation of potent, selective and efficacious reversible α-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boger, D., et al.: J. Med. Chem., 48, 1849 (2005);<br></p>

<p>Applications 4-Chloro-N-(methyl-d3)pyridine-2-carboxamide (cas# 1189858-48-7) is a compound useful in organic synthesis.<br></p>