Heterocycles with Nitrogen (N)

<p>Applications 2-Oxo-2-(1-phenyl-1H-pyrazol-4-yl)acetic Acid is a derivative of N-Phenylpyrazole, a reactant in the synthesis of candesartan cilexetil(C175580), an ester prodrug; hydrolized in vivo to the active carboxylic acid. Used in treatment of congestive heart failure. Antihypertensive.<br>References Seki, M. et. al: ACS Catalysis, 4, 4047 (2014); Shibouta, Y., et al.: J. Pharmacol. Exp. Ther., 266, 114 (1993; Ogihara, T., et al.: Clin. Ther., 16, 74 (1994)<br></p>

<p>Applications 5-benzoyl-2H-1,2,3,4-tetrazole (cas# 14506-41-3) is a useful research chemical.<br></p>

<p>Applications 2-Mercapto-5-nitrobenzimidazole is useful for treating giardiasis. Antigiardial drug.<br>References Hernandez-Ochoa, B., et al.: Molecules, 25, 3979 (2020)<br></p>

<p>Stability Hygroscopic<br>Applications 5-Benzyl-1H-imidazole (cas# 4238-72-6) is a useful research chemical.<br></p>

<p>Applications 2,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine is used in the synthesis of morpholinothiazoles as alpha 7 position allosteric modulators.<br>References MacDonald, G., et al.: PCT Int. Appl. (2011), WO 2011064288 A1 20110603<br></p>

<p>Applications 1-[4-(5-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethanone is used as a reagent in the synthesis of a series of 3-(1-substituted-4-piperidinyl)-1,2-benzisoxazoles which exhibit neuroleptic activity.<br>References Strupczewski, J.T., et al.: J. Med. Chem., 28, 761 (1985)<br></p>

<p>Applications 4-Benzoyl-1H-pyrrole-2-carboxylic Acid (cas# 15372-84-6) is a useful research chemical.<br></p>

<p>Applications H-Pro-Ala-OH (cas# 6422-36-2) is a useful research chemical.<br></p>

<p>Applications 1-(4-Chlorophenyl)-1,2-dihydro-3H-pyrazol-3-one is also used in the synthesis of antifungal, oxazolidinon-based strobilurin analogues. Also used in the preparation of heterologous haptens for the synthesis of high-affinity anti-pyraclostrobin antibody generation.<br>References Li, Y. et al.: Bull. Kor. Chem. Soc., 31, 3341 (2010); Mercader, J. et al.: Org. Biomol. Chem., 9, 1443 (2011);<br></p>

<p>Applications 7-Chloro-N-[1-(methylsulfonyl)-4-piperidinyl]-4-quinazolinamine, is a building block used in chemical synthesis.<br></p>

<p>Applications 2-(Difluoromethoxy)pyridin-4-amine (cas# 1211587-46-0) is a useful research chemical.<br></p>

<p>Applications {2-[(Pyridin-4-ylmethyl)thio]-1,3-thiazol-4-yl}acetic acid (cas# 1040631-48-8) is a useful research chemical.<br></p>

<p>Applications 1-ACETYL-2-PIPERIDINEACETIC ACID (cas# 25393-20-8) is a useful research chemical.<br></p>

<p>Applications 5-Nitro-2-(propylthio)pyrimidin-4-ol is an intermediate used in the synthesis of 4-Chloro-5-nitro-2-(propylthio)pyrimidine (C374095), which is an impurity of the drug Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>

<p>Applications 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is used as the starting material in the preparation of pyrazine derivatives that are AxI and c-Met receptor enzyme inhibitors. These inhibitors are useful in the treatment of tumors. 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is also used in the preparation of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.<br>References Rushton, L.; et al.: PCT Int. Appl. 119 pp. Patent 2009 CODEN:PIXXD2; Charrier, J-D.; et al.: J. Med. Chem, 54, 2320 (2011)<br></p>

<p>Applications 5-Cyano-1-methylbenzoimidazole<br></p>

<p>Applications 1H-1,2,4-Triazole-3-carboxylic acid, 1-ethyl-, methyl ester (cas# 1034197-43-7) is a useful research chemical.<br></p>

<p>Applications 2,3-Diamino-4-chloropyridine<br></p>

<p>Applications 5-(Difluoromethyl)-1h-pyrazol-3-amine<br></p>

<p>Applications N-(Benzoyl)piperazine-2,2,3,3,5,5,6,6-d8 (CAS# 1219805-49-8) is a useful isotopically labeled research compound.<br></p>

<p>Stability N/A<br>Applications (R)-(-)-4-Phenyl-2-oxazolidinone (cas# 90319-52-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-methylimidazo[1,2-a]pyridin-2-amine (cas# 39588-33-5) is a useful research chemical.<br></p>

<p>Applications Phenyl 4-Bromo-2-(ethyl-d3)pyridine-1(2H)-carboxylate is an intermediate in the synthesis of Ethionamide-d3 (E890422), a labelled antibacterial (tuberculostatic) agent.<br>References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),<br></p>

<p>Applications 1,2-Dimethylpiperazine (cas# 25057-77-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Miyamoto, T., et al.: J. Med. Chem., 33, 1645 (1990),<br></p>

<p>Applications Ethyl 7-aminothieno[2,3-b]pyrazine-6-carboxylate<br></p>

<p>Applications 4-Chloro-6-phenylpyrimidine (cas# 3435-26-5) is a useful research chemical.<br></p>

<p>Applications 2-Chloro-4-ethylpyridine (cas# 40325-11-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 4,5,6,7-Tetrahydro-3H-imidazo[4,5-c]pyridine dihydrochloride (cas# 62002-31-7) is a useful research chemical.<br></p>

<p>Applications 4-amino-1,2,4-triazolidine-3,5-dione (cas# 21531-96-4) is a useful research chemical.<br></p>

<p>Applications 2-Chloro-4-piperidinopyrimidine<br></p>

<p>Applications 1,3-dimethyl-1H-pyrazole-4-sulfonyl chloride (cas# 89501-93-9) is a useful research chemical.<br></p>

<p>Applications 1-[(2-Nitrophenyl)sulfonyl]-1H-pyrrole is used in the preparation of various 2-​substituted N-​nosylpyrroles.<br>References Shibata, M. et al. Tetrahedron. 71, 4495 (2015);<br></p>

<p>Applications 2-[4-(3-Trifluoromethylphenyl)-1-piperazinyl]propanol is an intermediate in the synthesis of Antrafenine (A697800), a phenylpiperazine derivative drug used as an analgesic and anti-inflammatory.<br>References Meguro, K., et al.: Chem. Pharma. Bull., 33, 3787 (1985);<br></p>

<p>Applications 2,4-Di(tert-butoxy)pyrimidine-5-boronic acid<br></p>

<p>Applications Fmoc-(4-carboxymethyl)piperazine<br></p>

<p>Applications 2-(3,5-Dichlorophenyl)-imidazo[1,2-a]pyridine is derived from Ethyl Bromoacetate (E900140), which is used in the synthesis of metabolites of carcinogenic PAHs. Also it is used in the preparation of steroidal antiestrogens through cyclic condensation. A reactant in the preparation of antimicrobial and antioxidant coumarinyloxymethyl-thiadiazolone.<br>References Wu, A. et al.: Tetrahedron, 68, 7217 (2012); Clark, E. et al.: J. Med. Chem., 20, 1096 (1977); Al-Amiery, A. et al.: Chem. Nat. Comp., 48, 950 (2013);<br></p>

<p>Applications 3-Chloro-4-cyanopyridine (cas# 68325-15-5) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-Acetylimidazole (cas# 2466-76-4) is a useful research chemical.<br></p>

<p>Applications 1-α-D-Arabinofuranosyl-2-nitro-1H-imidazole is a synthon for a number of potential markers of tissue hypoxia.<br>References Naimi, E., et al.: Nucleosides. Nucleotides. Nuc. Acid., 24, 173 (2005); Schneider, R.F., et al.: J. Label. Comp. Radiopharma., 39, 541 (1997); Sakaguchi, M., et al.: J. Med. Chem., 26, 20 (1983);<br></p>

<p>Applications 4-(1H-1,2,4-Triazol-1-ylmethyl)benzenamine is an intermediate useful in organic synthesis and other chemical processes.<br>References Kumar, P. N., et al.: Org. Chem.: Indian J., 11, 1 (2015); Chandna, N., et al.: New J. Chem., 38, 3662 (2014)<br></p>

<p>Applications 1,2-DIHYDRO-2-OXO-6-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER (cas# 116548-02-8) is a useful research chemical.<br></p>

<p>Applications 6-(Dimethylamino)pyridine-3-boronic acid<br></p>

<p>Applications 4,5-Dicyanoimidazole is commonly used in activation of nucleoside phosphoramidites during solid-phase oligonucleotide synthesis, and synthesis of nucleoside phosphoramidites, synthesis of novel nucleosides. IT is often used as an alternative to Tetrazole (T307500).<br>References Vargeese, C., et al.: Nucleic Acid Res.,  26 1046 (1998); Jin, Y., et al.: Tetrahedron Lett., 37, 973 (1996); Lackey, J., et al.: J. Am. Chem. Soc., 131, 8496 (2009)<br></p>

<p>Applications OXAZOLE-5-CARBOXYLIC ACID HYDRAZIDE (cas# 885274-30-6) is a useful research chemical.<br></p>

<p>Applications tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-mesylaminopyrimidin-5-yl]-(3R,5S)-isopropylidine-(E)-6-heptenoate (cas# 371775-73-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Thiohydantoin is a useful synthetic intermediate. It is a reactant for synthesis of drugs with antidiabetic activity, barbituric acid and thiohydantoin derivatives with antimicrobial activity, and possible anticancer agents.<br>References Ceylan-Ünlüsoy, M., et al.: J. Enzyme. Inhib. Med. Chem., 25, 784 (2010); Hassanein, M., et al: Mol. Human Reprod., 15, 433 (2009); Subtel’na, I., et al.: Bioorg. Med. Chem., 18, 5090 (2010)<br></p>

<p>Applications Ethyl 5-(thiophen-2-yl)isoxazole-3-carboxylate is a useful reagent for organic synthesis.<br></p>

<p>Applications 5-Methoxybenzimidazole-4,6,7-d3 (CAS# 1219805-69-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Adenosine analog<br>References Barbieri, D., et al.: Bioorg. Med. Chem. Lett., 8, 2533 (1998),<br></p>

<p>Applications N-Boc-4-(hydroxymethyl)-pyrrolidin-2-ol is a chemical reagent used in organic synthesis for pharmaceutically active compounds.<br>References Yohannes, D. et al.: Org. Lett., 10, 5353 (2008);<br></p>

<p>Applications 5-Amino-4H-1,2,4-triazole-3-carboxylic Acid is a building block used in the synthesis of purine nucleotide analogs by a promiscuous hypoxanthine phosphoribosyltransferase.<br>References Scism, R.A., et. al.: Org. Lett., 9, 4179 (2007)<br></p>

<p>Applications 1-(2-Ethoxyphenyl)piperazine monohydrochloride 99 (cas# 83081-75-8) is a useful research chemical.<br></p>

<p>Applications Tetrazolo[1,5-a]pyridin-7-amine is a chemical intermediate for the synthesis of pharmaceutical goods.<br></p>