Heterocycles with Nitrogen (N)

Applications 2,4-DIHYDRO-[1,2,4]TRIAZOLE-3-THIONE (cas# 3179-31-5) is a useful research chemical.

Applications Intermediate in the preparation of various biological inhibitors.
References Chonan, T., et al.: Bioorg. Med. Chem. Lett., 19, 6645 (2009), Bunnage, M., et al.: J. Med. Chem., 50, 6095 (2007),

Stability Moisture Sensitive
Applications N-Acetoxysuccinimide (cas# 14464-29-0) is a useful research chemical.

Applications 5-(4’-Benzyloxyphenyl)-2-oxazolidone (cas# 88693-98-5) is a compound useful in organic synthesis.

Applications 2-Oxo-2-(1-phenyl-1H-pyrazol-4-yl)acetic Acid is a derivative of N-Phenylpyrazole, a reactant in the synthesis of candesartan cilexetil(C175580), an ester prodrug; hydrolized in vivo to the active carboxylic acid. Used in treatment of congestive heart failure. Antihypertensive.
References Seki, M. et. al: ACS Catalysis, 4, 4047 (2014); Shibouta, Y., et al.: J. Pharmacol. Exp. Ther., 266, 114 (1993; Ogihara, T., et al.: Clin. Ther., 16, 74 (1994)

Applications Used for preparation of substituted phenyl-containing imidazolium ionic liquid.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Peris, E., et al.: Coord. Chem. Rev., 248, 2239 (2004),

Applications Ethyl 2,5-Dibromo-1,3-oxazole-4-carboxylate is useful for the synthesis of substituted oxazoles.
References Hodgetts, K. J., et al.: Org. Lett., 4, 2905-2907 (2002)

Applications 4-Amino-1,5-dimethylpyrazole is used in the preparation of pyridine compounds as focal adhesion kinase inhibitors.

Applications 4-(2-Oxopyrrolidin-1-yl)butanoic acid (cas# 6739-80-6) is a useful research chemical.

Applications Methyl (αS)-α-(2-chlorophenyl)-2,6,7,7a-tetrahydro-2-oxothieno[3,2-c]pyridine-5(4H)-acetate is the essential intermediate metabolite from which the active metabolite of Clopidogel is formed.
References Feliste, R., et al.: Thromb. Res., 48, 403 (1987), Savi, P., et al.: Biochem. Pharmacol., 44, 527 (1992), Herbert, J., et al.: Cardiovasc Drug. Rev., 11, 180 (1993), Sugidachi, A., et al.: B. J. Pharmacol., 132, 47 (2001)

Applications 1-Pyridin-3-yl-piperazine Hydrochloride is a reactant used in discovery of N-aryl Piperazines as selective mGluR5 potentiators. It was also used in the synthesis of piperazine-pyridazinone derivatives that have binding affinity toward α1-, α2-adrenergic and 5-HT1A receptors.
References Betti, L., et al.: Bioorg. Med. Chem., 14, 2828 (2006); Zhou, Y., et al.: ACS Med. Chem. Lett., 1, 433 (2010);

Applications A pyrimidine derivative as inhibitor of Streptococcus faecium, Lactobacillus casei, and Pediococcus cerevisiae.
References Coats, E.A., et al.: Eur. J. Med. Chem., 14, 261 (1979),

Applications Picolinic acid (P437220) derivative used in the synthesis of oxazine derivatives that act as BACE inhibitors for treatment of diabetes and neurological disorders.

Applications 3-Cyano-4-oxo-piperidine-1-carboxylic Acid tert-Butyl Ester is a useful research reagent for organic synthesis and other chemical processes.
References Guo, X., et al.: Molecules, 16, 2626 (2011); Chai, Y., et al.: Bioorg. Med. Chem. Lett., 20, 5195 (2010); Chai, Y., et al.: Bioorg. Med. Chem. Lett., 21, 3377 (2011)

Applications 5-Amino-1-tert-butyl-3-(3-methylbenzyl)-4-cyanopyrazole (cas# 1185162-28-0) is a compound useful in organic synthesis.

Applications Used in the preparation of heterocyclic compounds of pharamaceutical interest.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Di Fabio, R., et al.: J. Med. Chem., 51, 7370 (2008), Vaccaro, W., et al.: Bioorg. Med. Chem. Lett., 18, 6381 (2008),

Applications 2-Acetyl-3,4,5,6-tetrahydropyridine-d4 Hydrochloride, is the labeled analogue of 2-Acetyl-3,4,5,6-tetrahydropyridine Hydrochloride (A188500), the most important bread flavor component.
References Buttery, R.G., et al.: J. Agric. Food Chem., 43, 1878 (1995),

Applications 5-Bromohexahydro-2,6-dioxo-4-pyrimidinecarboxylic Acid-15N2 is an intermediate used in the synthesis of Orotic Acid-15N2 Monohydrate (O691504), which is a labeled analogue of Orotic Acid Monohydrate (O691500) that is used in the preparation of therapeutic agents for chronic obstructive pulmonary disease (COPD) treatment. Also, it is the labeled form of 5-Bromohexahydro-2,6-dioxo-4-pyrimidinecarboxylic Acid (B699363), an intermediate in synthesizing Orotic Acid Monohydrate (O691500), which is used in the preparation of therapeutic agents for chronic obstructive pulmonary disease (COPD) treatment.

Applications (R)-4-isobutyl-1-(((2R,3S,4S,5R)-2,3,4,5-tetrahydroxytetrahydro-2H-pyran-2-yl)methyl)pyrrolidin-2-one is a useful chemical reagent.