Heterocycles with Nitrogen (N)

Applications 6-(2,3-Difluorophenyl)picolinic acid

Applications 5-Pyridin-4-yl-1H-indazole (cas# 885272-55-9) is a useful research chemical.

Applications 3-Bromopicolinic Acid Sodium Salt (cas# 1189933-55-8) is a compound useful in organic synthesis.
References See mercaptopicolinic acid file

Applications 4-(1H-1,2,3-benzotriazol-1-yl)pyrimidin-2-amine (cas# 1542059-06-2) is a useful research chemical.

Stability Moisture Sensitive
Applications 1-Oxyl-2,2,5,5-tetramethyl-∆3-(methanesulfonyloxymethyl)pyrroline is an intermediate in the synthesis of 3-Iodomethyl-(1-oxy-2,2,5,5-tetramethylpyrroline)-15N the isotope labelled analog of 3-Iodomethyl-(1-oxy-2,2,5,5-tetramethylpyrroline) (I709500); a thio-reactive spin label.
References Qin, P.Z., et al.: Biochemistry, 40, 6929 (2001);

Applications 2-Chloro-4(1H)-pyrimidinone Hydrochloride is a reactant in the preparation of aminobenzamide derivatives as glycogen synthase kinase 3β (GSK3β) inhibitors for preventing or treating GSK3β-mediated diseases (1).
References (1) Freyne, E.J.E., et al.: PCT Int. Appl., WO 2003037877 (2003

Stability Light Sensitive, Moisture Sensitive
Applications (1-Oxyl-2,2,5,5-tetramethyl-4-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-3-yl)methyl Methanesulfonate is an intermediate in the synthesis of highly active spin labelling reagents.

Applications 2-Oxo-2-(1-phenyl-1H-pyrazol-4-yl)acetic Acid is a derivative of N-Phenylpyrazole, a reactant in the synthesis of candesartan cilexetil(C175580), an ester prodrug; hydrolized in vivo to the active carboxylic acid. Used in treatment of congestive heart failure. Antihypertensive.
References Seki, M. et. al: ACS Catalysis, 4, 4047 (2014); Shibouta, Y., et al.: J. Pharmacol. Exp. Ther., 266, 114 (1993; Ogihara, T., et al.: Clin. Ther., 16, 74 (1994)

Applications 3-phenyl-1H-pyrrole-2-carboxylic acid (cas# 802052-63-7) is a useful research chemical.

Applications Pyrrole-2-carboxylic Acid is a reagent used in the synthesis of potent small molecule inhibitors of severe acute respiratory syndrome (SARS) coronavirus. Also used in the synthesis of [2,3-c]pyridine-7-one scaffolds.
References Jacobs, J. et al.: 56, 534 (2013); Nechayev, M. et al.: Mol. Div., 16, 749 (2012);

Stability Light Sensitive
Applications 4-(1-Naphthylvinyl)pyridine (cas# 16375-56-7) is a useful research chemical.

Applications Pyrrole-2,3,4,5-d4 (CAS# 17767-94-1) is a useful isotopically labeled research compound.

Applications 1-Pyridin-3-yl-piperazine Hydrochloride is a reactant used in discovery of N-aryl Piperazines as selective mGluR5 potentiators. It was also used in the synthesis of piperazine-pyridazinone derivatives that have binding affinity toward α1-, α2-adrenergic and 5-HT1A receptors.
References Betti, L., et al.: Bioorg. Med. Chem., 14, 2828 (2006); Zhou, Y., et al.: ACS Med. Chem. Lett., 1, 433 (2010);

Applications 4-Chloro-2-(trifluoromethoxy)pyrimidine (cas# 1261494-46-5) is a compound useful in organic synthesis.

Applications Intermediate in the preparation of Pioglitazone (P471000) impurities.
References Kitajima, H., et al.: Bioorg. Med. Chem. Lett., 10, 2453 (2000), Radhakrishna, T., et al.: J. Pharm. Biomed. Anal., 29, 593 (2002),

Applications Picolinic acid (P437220) derivative used in the synthesis of oxazine derivatives that act as BACE inhibitors for treatment of diabetes and neurological disorders.

Applications 4-(Piperazin-1-yl)thieno[3,2-c]pyridine (cas# 106261-27-2) is a useful research chemical.

Applications A reagent in the preparation of 4-phenyl-tetrahydrophenyl substituted oxazolidinone derivatives with potent central nervous depressant, analgetic, and antiinflammatory activities as well as α1A adrenergic receptor antagonists.
References Welstead, W.J. et al.: J. Med. Chem., 16, 1129 (1973); Lagu, B. et al.: J. Med. Chem., 43, 2775 (2000);

Applications 1-Acetyl-N-(5,6,7,8-tetrahydronaphthalen-1-yl)-4,5-dihydro-1h-imidazol-2-amine is a useful synthesis intermediate.

Applications Pyridine-3,5-dicarboxamide (cas# 4663-99-4) is a useful research chemical.

Applications Methyl 3,6-dichloropyridine-2-carboxylate

Applications Used in the preparation of heterocyclic compounds of pharamaceutical interest.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Di Fabio, R., et al.: J. Med. Chem., 51, 7370 (2008), Vaccaro, W., et al.: Bioorg. Med. Chem. Lett., 18, 6381 (2008),

Applications 5-BROMO-1H-IMIDAZO[4,5-b]PYRAZINE (cas# 91225-41-1) is a useful research chemical.