Heterocycles with Nitrogen (N)

Applications 2-(tert-Butylamino)-4,6-dichloro-1,3,5-triazine (cas# 27282-85-5) is a compound useful in organic synthesis.

3-Amino-6-chloropyridazine is a synthetic compound that is soluble in hydrochloric acid. It has been shown to inhibit the proliferation of cells and induce apoptosis, which may be due to its inhibition of the growth factor receptor, factor. 3-Amino-6-chloropyridazine also inhibits bcr-abl kinase, an enzyme that is involved in the development of chronic myelogenous leukemia (CML). This chemical can be synthesized by coupling amino acids with chloropyridazine using cross coupling reactions. 3-Amino-6-chloropyridazine is a synthetic analogue of pyridoxal phosphate and may have use as an antiinflammatory agent.

1-Phenyl-piperidine is a psychoactive compound that has been shown to have strong binding affinity for the κ-opioid receptors. It has also been shown to increase locomotor activity in mice and produce hallucinations. 1-Phenyl-piperidine has a number of biological properties including inhibition of dopamine uptake, induction of myocardial infarcts, and toxicity to the ischemic brain. It binds with high affinity to the multidrug efflux pumps such as P-glycoprotein (Pgp) and MDR1, which are responsible for removing drugs from cells. Pgp is induced by cytochrome P450 3A4 (CYP3A4) inhibitors such as ketoconazole, erythromycin, fluconazole, itraconazole, clarithromycin, telithromycin, nefazodone, and grapefruit juice.

Purine nucleobase; component of nucleic acids and coenzymes

4-Amino-2-methoxypyridine is an antiviral agent that inhibits the activity of the NS5B polymerase, a key enzyme in the replication of the hepatitis C virus. It is a potent inhibitor with a wide range of activity and can be used for treatment and prevention of infection. 4-Amino-2-methoxypyridine has been shown to inhibit replication of hepatitis C virus in cell culture. This compound is stable in vivo and can be administered orally, making it an attractive candidate for oral prophylaxis against hepatitis C. 4-Amino-2-methoxypyridine also exhibits good pharmacokinetic properties, including a low clearance rate and high volume of distribution, which makes it suitable for chronic administration.

5-Chloro-3-pyridinamine is a catalyst that is used in the synthesis of polymers. It can be used in ring-opening polymerization reactions and is reactive with a variety of functional groups, including aliphatic and aromatic rings. 5-Chloro-3-pyridinamine also has high activity for ring opening polymerizations, which makes it an ideal choice for the synthesis of polymers. This catalyst can be used to control the molecular weight of polymers by dilution or by altering the amount of catalyst used. 5-Chloro-3-pyridinamine has been shown to be biocompatible and biodegradable, making it a good choice for biomedical applications.

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1,3,5-Triazine is a nitrogen-containing heterocyclic compound that is used as a precursor for the synthesis of other compounds. It has been shown to inhibit the polymerase chain reaction and to bind to the enzyme DNA polymerase. This binding prevents the formation of an enzyme-substrate complex required for DNA replication. 1,3,5-Triazine also inhibits oxidative injury in experimental models and inhibits cellular physiology by decreasing the production of growth factor-β1. 1,3,5-Triazine has been shown to be a natural compound with inhibitory properties against growth factors and cell proliferation. This chemical also exhibits antioxidant effects by scavenging reactive oxygen species or inhibiting lipid peroxidation.END>

2-Amino-4,6-dimethylpyridine is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandins and leukotrienes. 2-Amino-4,6-dimethylpyridine binds to the cyclooxygenase enzyme and blocks its conversion of arachidonic acid to prostaglandin H2. This compound has been shown to have potent inhibitory effects against Leishmania, with high values in reactive compounds. The molecular modeling of this compound shows that it has an unpaired amino function and an amide.

2,6-Dichloro-3-fluoropyridine is a synthetic organic chemical that can be used as a diazo compound in the synthesis of heterocycles. It is used in industrial applications for the production of nitrobenzene, an intermediate for the synthesis of pharmaceuticals. The reaction time and yield are high, and the selectivity is good. 2,6-Dichloro-3-fluoropyridine can be synthesized by reacting sodium nitrite with piperidine and acidifying with hydrochloric acid. This chemical is mainly used as an industrial intermediate to produce nitrobenzene.

2-Amino-5-iodopyridine (2-AI) is a water molecule that has been shown to have vibrational and optical properties. 2-AI is an orange pigment that is found in methyl ketones, such as 2,4,6-trimethylheptanone and 3,4,5-trimethylhexanone. 2-AI has also been used as a dye for wool in the past. 2-AI is not found naturally but can be synthesized from an aryl halide and ammonia or ammonium hydroxide. The synthesis of this compound involves the reaction of an aromatic amine and nitrous acid or diazonium salt. 2-AI can be used as an antimicrobial agent against bacteria by interfering with the nicotinic acetylcholine receptor on the bacterial cell membrane. FTIR spectroscopy can be used to identify its chemical structure.

2-(Pyridin-2-ylthio)ethyl]amine dihydrochloride is a chemical compound that has been used as a research reagent. It reacts with other compounds to produce new substances, and it can be used as a building block for more complex compounds. 2-(Pyridin-2-ylthio)ethyl]amine dihydrochloride is soluble in water and organic solvents such as acetone and ethanol, making it useful for reactions that require both types of solvents. This product also has CAS No. 40379-31-5, which means it is listed on the Chemical Abstracts Service registry. 2-(Pyridin-2-ylthio)ethyl]amine dihydrochloride has an interesting chemical structure that makes it a versatile building block or intermediate for many different reactions.

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3-Phenylacetylamino-2,6-piperidinedione is a trifluoroacetate analog of the amino acid phenylalanine. It has been shown to be effective against cancer cells. 3-Phenylacetylamino-2,6-piperidinedione inhibits protein synthesis in tumor cells and is used as an antiestrogen in clinical studies. The hydroxyl group on the 3rd carbon atom makes this compound more acidic than its parent compound, 2,6-piperidinedione. This analog also has a high affinity for cancer tissues and urine samples. Treatment with this drug inhibits the growth of carcinoma cell lines MCT7 and MCF7.

2-Aminoacridone is a fluorescent dye.  The applications of 2-Aminoacridone are extensive in biochemical and analytical research. It is commonly employed in glycoprotein and glycoconjugate studies, leveraging its high sensitivity and specificity in detecting saccharide structures. Researchers utilize this dye in various assays, including high-performance liquid chromatography (HPLC) and electrophoresis, to analyze carbohydrate content and structure. Its role is critical in advancing our understanding of carbohydrate-related biological processes, such as cell signaling and disease pathogenesis, facilitating developments in both diagnostics and therapeutic strategies.

6-Azaindole is a fine chemical that can be used as a reagent, building block, and intermediate. It is a versatile compound that has been shown to have high quality and complex chemistry. 6-Azaindole is an important reaction component in the synthesis of other compounds with pharmaceutical applications such as amide synthons, amino acid esters, and pharmaceutical intermediates. 6-Azaindole can also be used as a scaffold for the preparation of indoles. CAS No: 271-29-4

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Thiamine derivative; coenzyme of transketolase

2,5-Dichloropyrimidine is a cytotoxic drug that is activated by acetonitrile to form an intermediate, which is then converted to the active form. This drug has been shown to be neuroprotective in animal models of neurodegenerative diseases. 2,5-Dichloropyrimidine also blocks the production of nitric oxide by binding to the factor receptor and prevents activation of the growth factor. The drug has been shown to inhibit the growth of cancer cells in vitro and in vivo.

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