Building Blocks

Versatile small molecule scaffold

1-Chloroisoquinoline-4-carboxylic acid methyl ester is a potent compound that acts as an antagonist of the prostanoid receptor. It blocks the binding of prostanoids to the receptor and inhibits the production of inflammatory molecules, such as leukotrienes. 1CIQME has been shown to have affinity for both Cox-1 and Cox-2, but is selective for Cox-2. This drug also competitively inhibits the enzyme cyclooxygenase (COX), which produces prostaglandins from arachidonic acid. 1CIQME has been shown to inhibit chemotaxis in mice and to block chemoattractant effects in human neutrophils.

Versatile small molecule scaffold

Versatile small molecule scaffold

Pyrido[3,2-d]pyrimidin-4(3H)-one is a molecule that belongs to the class of antimalarial drugs. It inhibits plasmodium falciparum by inhibiting the biosynthesis of purine nucleotides. Pyrido[3,2-d]pyrimidin-4(3H)-one is chemically reactive and apolar. It was isolated from a chemically synthesized compound as an isomer mixture and has been shown to have high activity against erythrocytic stages of plasmodium falciparum in vitro. Pyrido[3,2-d]pyrimidin-4(3H)-one also has a clinical drug application in incrementing the response to other antimalarial drugs.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Ruthenium-based catalysts can be used for the synthesis of 2-amino-4-chlorophenylmethanol. This catalyst is a sustainable, low cost, and efficient solution to many industrial chemical production problems. The catalyst utilizes magnetic nanoparticles that are inexpensive and easy to produce. It also has a short reaction time, which helps to increase efficiency. The oxidation of this compound produces hydrogen peroxide as an oxidant, which reduces the need for other oxidizing agents in the reaction.

Versatile small molecule scaffold

3'-Chloro-4'-methoxyacetophenone (3'-CMA) is a chalcone that is used as an inhibitor of the enzyme acetylcholinesterase. It has been shown to inhibit the activity of acetylcholinesterase, which is responsible for the hydrolysis of acetylcholine. This inhibition leads to an increase in acetylcholine levels and therefore to an increase in the response time of skeletal muscle. 3'-CMA has been shown to have potentiating effects on other compounds, such as phenoxy, which are also inhibitors of acetylcholinesterase.

5-Acetyl-2H-pyrazole-3-carboxylic acid ethyl ester is a potent and selective inhibitor of the enzyme carboxamide ribonucleotide transformylase (CRT). The pharmacodynamic properties of this compound are still unknown. 5-Acetyl-2H-pyrazole-3-carboxylic acid ethyl ester has been shown to inhibit tumour growth in xenograft models, but not in mice. It was also found to inhibit the proliferation of myeloproliferative cells, but not normal cells, in vitro. Further research is required to elucidate its mechanism of action and potential clinical applications.

Versatile small molecule scaffold

Azepane-2,5-dione is a dopamine antagonist that blocks the activity of dopamine receptors by binding to them. It has been shown to antagonize the effects of dopamine in the brain and may be used for treatment of schizophrenia.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Bromo-2-(bromomethyl)naphthalene is an organic compound that has a chiral center. It is a ligand in coordination chemistry and can be used as a starting material for the synthesis of other compounds. 1-Bromo-2-(bromomethyl)naphthalene crystallizes in the orthorhombic space group Pna21, with cell dimensions of a = 15.02 Å, b = 13.77 Å, c = 13.91 Å, α = 90°, β = 90°, γ = 90°. The molecular structure has been determined by x-ray diffraction data collected at 100 K on beamline I06 at the Advanced Photon Source synchrotron facility in Illinois. The crystal structure contains two molecules per asymmetric unit, with an approximate Z value of 2 (atoms are ordered according to their atomic numbers). One molecule is oriented parallel to