Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-{[(Furan-2-yl)methyl]amino}-1,2-dihydropyrimidin-2-one is a compound that has been shown to be an inhibitor of the enzyme citrate synthase. This inhibition causes a decrease in ATP production and an increase in heat production. 4-{[(Furan-2-yl)methyl]amino}-1,2-dihydropyrimidin-2-one has been used in modelling studies to study the biological properties of the citrate synthase enzyme. The graphical methods used include control agents, energy efficiency, and modelling.</p>

<p>Versatile small molecule scaffold</p>

<p>ML351 is a resolvin, which are lipid mediators that serve as precursors to other compounds. Resolvins have been shown to be active in the central nervous system and cardiovascular system. ML351 binds to an enzyme that is required for the production of these mediators. This binding prevents the enzyme from converting arachidonic acid into prostaglandin H2, leading to irreversible inhibition of this enzyme. ML351 has been shown to inhibit the inflammatory response in cells by preventing the production of pro-inflammatory molecules such as prostaglandins and platelet-activating factor (PAF). It also has potential drug targets in congestive heart failure, cardiac hypertrophy, and nonsteroidal anti-inflammatory drugs.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,5-Dichloro-4-hydroxypyridine is a strong oxidizing agent that can be used for the efficient synthesis of esters and peroxy esters. It can also be used to produce hydrogen peroxide from hydroxylamine and 2,5-dichloro-4-hydroxypyridine. The hydroxylation of alcohols with 2,5-dichloro-4-hydroxypyridine produces the corresponding n-oxides or peroxides in high yield. This reaction is regioselective, meaning it will only occur at one position on the molecule.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>8-Chloro-3-iodoquinoline is a functionalized aromatic ring that is used in coupling reactions with aryl halides, such as bromides and iodides. Palladium-catalyzed coupling reactions are often more selective than those catalyzed by copper. 8-Chloro-3-iodoquinoline has been shown to be selectively coupled to bromide, which can be used for the synthesis of aryl bromides.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-[3-(4-Methylphenyl)-5-sulfanyl-4H-1,2,4-triazol-4-yl]propanoic acid is a potent inhibitor of the transient receptor potential vanilloid 1 (TRPV1) ion channel. TRPV1 is a membrane protein activated by noxious heat or capsaicin and mediates responses to these stimuli. It also plays a role in inflammation and pain sensation. 3-[3-(4-Methylphenyl)-5-sulfanyl-4H-1,2,4-triazol-4-yl]propanoic acid blocks TRPV1 channels by binding to its intracellular region and thereby preventing activation. This agent can be used as a research tool for studying TRPV1 channels in vitro and in vivo.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl-pseudouridine-5'-triphosphate trisodium is the triphosphate of 1-Methylpseudouridine is a substitute for uridine in modified mRNA. This substitution has shown to increase transfection by reducing immuogenicity. UV max wavelength = 272nm</p>

<p>Applications 1,3,5-Trifluorotrichlorobenzene is a useful reagent.<br></p>

<p>Applications 4-Diazobenzenesulfonic acid (cas# 305-80-6) is a useful research chemical.<br></p>

<p>2-Aminoimidazole sulfate is a chemical compound that is used as a transfection reagent. It has been shown to have high transfection efficiency with low cytotoxicity. The diameter of the molecule is in the range of 2 - 3 nm, which allows it to be taken up by cells and thus be active in them. This chemical can be dehydrogenated to form imidazole-2-sulfonic acid, which may interact with other molecules. There have been many advances in this area, including modifications and gaseous forms of the molecule. Research into the interactions of this compound with other chemicals and their effects on cellular uptake are ongoing.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Adamantane is a potent antiviral drug for the treatment of influenza. It is an oxidation catalyst that also has biological properties, such as a potent antitumor activity and potent antiviral resistance. Adamantane has been used to treat many human pathogens, including viruses, fungi and bacteria. Adamantane is a skeleton-like structure with four carbons and six hydrogen atoms that can be oxidized to adamantane oxide or reduced to adamantane alcohol. The adamantane molecule binds to the viral protein at a site called the toll-like receptor. This binding prevents viral replication by inhibiting mRNA synthesis in the virus.</p>

<p>Versatile small molecule scaffold</p>

<p>Pentanimidamide hydrochloride is a drug that belongs to the group of aromatic hydrocarbon drugs. It is a potent antihypertensive agent with a rapid onset and long duration of action. Pentanimidamide hydrochloride has been shown to inhibit the production of reactive oxygen species, which are generated by the respiratory chain in mitochondria, and to prevent the formation of pyrazinoic acid, an inhibitor of blood vessel relaxation. This drug also has been shown to reduce blood pressure in animal models by binding to specific receptors on cells in the cardiovascular system. The active form is bound to plasma proteins such as albumin and alpha-1-acid glycoprotein, which are found in high concentrations in erythrocytes. Pentanimidamide hydrochloride also binds to alkynyl groups and phenyl groups, which may be due to its ability to form covalent bonds with these functional groups.</p>

<p>2-Amino-6-chloropurine is a nucleophilic substituent that is used in the synthesis of 2-amino-6-chloropurine. It reacts with hydroxyl groups to form a palladium-catalyzed coupling reaction solution, which is then treated with hydrochloric acid and trifluoroacetic acid. The product is purified by crystallization and recrystallization. This compound has potent antitumor activity against carcinoma cell lines, but it has not been shown to have any effect against Mycobacterium tuberculosis.</p>

FG-2216 is a peptide that activates the G protein-coupled receptor, leading to increased intracellular calcium. FG-2216 is a potent agonist of the GPRC6A receptor and has been shown to inhibit pain perception in animal models. FG-2216 has been shown to have no effect on ion channels and does not affect cellular proliferation or migration. FG-2216 may be useful as a research tool for studying the function of the GPRC6A receptor in animal models.

BMS-986165 is a P-glycoprotein (P-gp) inhibitor that has been shown to reduce the absorption of ciclosporin, tacrolimus, and everolimus in vitro. BMS-986165 has an activity index of 100% and inhibits the inflammatory response by inhibiting the production of cytokines. It has been found to be effective for treating bowel diseases, such as ulcerative colitis and Crohn's disease. The drug also may be used for the treatment of autoimmune diseases, such as psoriasis or rheumatoid arthritis. BMS-986165 is administered orally and is rapidly absorbed. It is metabolized by CYP3A4 and excreted in urine as metabolites. END>> END>>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Di(1-adamantyl)chlorophosphine is a bifunctional ligand that can be used for the palladium-catalyzed coupling of aryl chlorides and amines. Di(1-adamantyl)chlorophosphine is synthesized from adamantane, phosphorous pentachloride, and anhydrous ammonia in the presence of catalytic amounts of palladium. Di(1-adamantyl)chlorophosphine is immobilized on silica gel to prevent hydrolysis. This ligand reacts with primary amines to form iminophosphoranes, which can then be reacted with aryl chlorides to form aryl chloroamines.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3,4,5-Trimethoxybenzoyl Chloride is a reactive, active chemical that is used in the synthesis of cytotoxic amides. It is prepared by reacting 3,4,5-trimethoxybenzoic acid with an amine or ammonia in the presence of a base. The reaction yields an amide substituted at the 3- and 4-positions with trimethoxyphenyl groups.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

(4-(tert-Butoxy)phenyl)methanamine (BPMT) is a ligand that binds to the alpha-2 receptor and acts as an antagonist. This compound has been shown to be a molecular target for positron emission tomography imaging, which is used in the diagnosis of tumours. BPMT is also used in the treatment of neuropeptide-associated disorders such as Parkinson's disease. The chiral nature of this compound makes it useful for the production of radiopharmaceuticals and other diagnostic agents with different physical properties.

<p>Versatile small molecule scaffold</p>

<p>MW 20,000 - 30,000</p>

<p>Versatile small molecule scaffold</p>

<p>2-Methylthiazole-4-carboxaldehyde is an aldehyde that is the product of the condensation of 2,4-dibenzoylacetone and acetone in the presence of diazomethane. It has been used as a precursor to other compounds such as benzoyl chloride, glyoxal, and aldehydes. 2-Methylthiazole-4-carboxaldehyde can be synthesized using acetylation or nitration of thiols or with glyoxal or aldehyde. The reactivity of this compound is high and can be carried out in high yield.</p>

<p>Benzyl N,N,N',N'-tetraisopropylphosphorodiamidite is a reagent that reacts with hydroxybenzyl amine to form an ester. This product is used for the synthesis of phosphoramidites and benzyl esters. It is also used as a catalyst for the synthesis of diesters.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>