Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5,6-Dimethoxynicotinic acid is a chemical compound that has been shown to inhibit tumor cell growth by inhibiting the synthesis of DNA and RNA. 5,6-Dimethoxynicotinic acid also inhibits the activity of promyelocytic leukemia (PML) protein in human lung cells. This drug has shown anti-tumor efficacy in xenograft mouse models, where it was able to inhibit tumor growth and prolong survival in mice with acute promyelocytic leukemia. 5,6-Dimethoxynicotinic acid is also being investigated as a potential chemotherapeutic agent in clinical trials.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Iodopropanedial is a pyridine compound. It is used as an antineoplastic agent in the treatment of cancer and damages cellular DNA by binding to nucleic acids and inhibiting protein synthesis. 2-Iodopropanedial also has acrylonitrile, a spectrum that includes antitumor activity and herbicides. 2-Iodopropanedial is an aromatic compound with carboxylic and ethynyl groups. The c-c bond provides its anti-tumor properties.

Versatile small molecule scaffold

(2R)-3-[(Carboxymethyl)sulfanyl]-2-acetamidopropanoic acid is a metabolite of the drug sulfapyridine. It is formed by conjugation with glutathione in the liver to form 3-glutathione-2-sulfapyridine, and then excreted into bile. (2R)-3-[(Carboxymethyl)sulfanyl]-2-acetamidopropanoic acid has been found to be genotoxic in mice, which may be due to its ability to form reactive metabolites that bind to DNA. This compound also possesses cytotoxic properties, which may be due to its ability to inhibit protein synthesis.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Bromo-3,3,3-trifluoro-1-propene is a chemical compound that has been synthesized in an asymmetric reaction. The reactant is bromopropane and the product is 2,2,2-trifluoropropene. The methylene group on the propene molecule is activated by the nucleophilic attack of a fluoride ion from hydrogen fluoride to form a cavity with a highly strained bond. The kinetic study of this reaction revealed that the activation energy for the reaction is 42 kJ/mol. Palladium-catalyzed coupling reactions are catalyzed by palladium and require nonpolar solvents such as toluene or dichloromethane. This type of reaction has been shown to be exothermic with an isolated yield of 1%.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Trans-1,2-Dichloroethylene is a chlorinated hydrocarbon that is used in the production of polyvinyl chloride plastics. When ingested at dietary concentrations, trans-1,2-Dichloroethylene may cause liver damage and death in CD-1 mice. Trans-1,2-Dichloroethylene has been shown to react with nucleophilic substitutions and produce toxic reaction products. This chemical also causes polymerase chain reactions that can lead to cell death. The effective dose for this chemical is unknown because it has not been tested in clinical trials.

Ethyl 3-formyl-1H-pyrrole-2-carboxylate is a formyl compound with the molecular formula C8H8O3. It is a colorless liquid that has a strong odor. The compound can be obtained by the reaction of ethyl acetoacetate and pyrrole in the presence of aluminum chloride. The compound has been studied for its nuclear magnetic resonance (NMR) properties. It has two conformers, which are distinguished by their different chemical shifts, and this difference can be used to study coupling between the carbonyl group and other groups in the molecule.

Isononyl alcohol is a polycarboxylic acid that has been used in the treatment of skin conditions, such as atopic dermatitis and psoriasis. It has been shown to penetrate the skin and stimulate the production of sebum. Isononyl alcohol is also used as a plasticizer for polyvinyl chloride (PVC) and other plastics, which increases their flexibility. This chemical also has a hydrophobic effect, which may be due to its hydroxyl group. The unsaturated alkyl chain on this chemical also makes it susceptible to oxidation by ozone in air and water vapor in air. Isononyl alcohol is metabolized by humans through conjugation with glucuronic acid or sulfate esters.

2,2',4,4'-tetrahydroxybenzophenone is a hydroxylated benzophenone that has immunomodulatory effects. It binds to the receptor in the immune system and can cause an increase in cytokine production. 2,2',4,4'-tetrahydroxybenzophenone is cytotoxic and has significant toxicity in vitro. The molecule has been shown to disrupt mitochondrial membrane potential. This may be due to its ability to form hydrogen bonds with molecules on the mitochondrial membrane. 2,2',4,4'-tetrahydroxybenzophenone also modulates transcriptional regulation of genes involved in cell proliferation and apoptosis. The drug is detectable at low levels by mass spectrometry and is not known to have any toxicological effects.END>>

Versatile small molecule scaffold

2-Acetylbenzoic acid is a functional molecule that contains an acetyl group. It can form hydrogen bonds with other molecules and has been shown to induce apoptosis in cells. The reaction products of 2-acetylbenzoic acid are malonic acid, acetylsalicylic acid, and 2-benzoylbenzoic acid. These three compounds are made by the addition of hydrogen or hydroxide to the molecule 2-acetylbenzoic acid. The molecule has two functional groups: a carbonyl group and an acetyl group. The chemical structure of this molecule can be seen in the figure below.
2-Acetylbenzoic Acid

2-Phenoxyaniline is a nitro compound that can be converted to the corresponding palladium complexes. It is an inhibitor of the acylation reaction, which is a type of chemical reaction in which an organic molecule reacts with an acid. The inhibition of this reaction has been shown to have an effect on heart disease, specifically by lowering cholesterol levels and reducing atherosclerosis. 2-Phenoxyaniline has also been shown to inhibit the activation energy for electron transfer reactions, making it useful as a catalyst in analytical methods. 2-Phenoxyaniline also undergoes vibrational spectroscopy when exposed to liquid chromatography and other analytical methods.

Versatile small molecule scaffold

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